Wrinkling of Composite-facing Sandwich Panels Under Biaxial Loading

The problem of face wrinkling in sandwich structures was identified as an important failure mode and first analyzed in 1940 by Gough et al. [1], who used a Winkler-type elastic foundation to model the core. This work was followed by experiments and further analysis by many others. Until 1966 all of the research was devoted to uniaxial compression loading. However, in many applications, such as naval and aircraft structures, panels are subjected to biaxial loading. Such loadings were first analyzed by Plantema in 1966 [2] for the case of sandwich constructed of isotropic materials. Sullins et al. [3] suggested an interaction equation that can be used as a criterion of wrinkling under compression in the principal directions. This equation is formulated in terms of the ratios of the principal compressive stresses to the corresponding wrinkling stresses. More recently Fagerberg [4, 5] and Vonach and Rammerstorfer [6] considered the case of sandwich with orthotropic facings.Yeshttps://us.sagepub.com/en-us/nam/manuscript-submission-guideline

Shrimps of the genus Periclimenes (Crustacea, Decapoda, Palaemonidae) associated with mushroom corals (Scleractinia, Fungiidae): Linking DNA barcodes to morphology

Most marine palaemonid shrimp species live in symbiosis with invertebrates of various phyla. These associations range from weak epibiosis to obligatory endosymbiosis and from restricted commensalism to semi-parasitism. On coral reefs, such symbiotic shrimps can contribute to the associated biodiversity of reef corals. Among the host taxa, mushroom corals (Cnidaria: Anthozoa: Fungiidae) are known to harbour various groups of symbionts, including shrimps. Some but not all of these associated species are host-specific. Because data on the host specificity of shrimps on mushroom corals are scarce, shrimp species of the genus Periclimenes were collected from mushroom corals during fieldwork in Lembeh Strait, North Sulawesi, Indonesia. Using molecular (COI barcoding gene) and morphological methods, three species of Periclimenes were identified: P. diversipes, P. watamuae and a species new to science, P. subcorallum sp. nov., described herein. Their host specificity was variable, with eight, three and two fungiid host records, respectively. It is concluded that shrimp species of the genus Periclimenes show much overlap in their host choice and that particular morphological traits in the host species appear to play a more important role than phylogenetic affinities within the host group.publishedVersio

Free Vibrations of Unsymmetrically Laminated Anisotropic Plates with Clamped Edges

A linear analysis is presented for determining the natural frequen cies of vibration of laminated anisotropic rectangular plates. The plate may consist of an arbitrary number of thin orthotropic layers, the major material-symmetry axis of each layer oriented arbitrarily with respect to the longer plate edge. An approximate solution is obtained by the Rayleigh-Ritz energy method. Numerical results are presented for fully clamped boundary conditions and compared with experimental results for symmetrically and unsymmetrically laminated plates.Yeshttps://us.sagepub.com/en-us/nam/manuscript-submission-guideline

Structural Theory for Laminated Anisotropic Elastic Shells

A linear theory is formulated for analysis of small deflections of thin shells with arbitrary geometrical configuration and laminated of an arbitrary number of layers of different thicknesses, orientations, and anisotropic elastic coefficients. An accurate shell theory (Vlasov's) is used, and the composite-shell constitutive relation incorporates the anisotropic stretching-bending coupling effects considered by Stavsky. For shells of arbitrary geometry, it is found necessary to introduce a new parameter Fij ≡ ∫h z 3Qijdz in the con stitutive relation. This parameter is zero for homogeneous aniso tropic materials and for anisotropic materials laminated symmetri cally with respect to the middle surface. However, for a two-layer filament-wound shell, this parameter can increase the flexural rigidity by 3%, which is greater than a 2% effect considered in a previous layered-anisotropic cylindrical shell analysis.Yeshttps://us.sagepub.com/en-us/nam/manuscript-submission-guideline

Non-Q wave myocardial infarction: Identification of high and low risk subsets by clinical variables

[This corrects the article DOI: 10.1371/journal.pone.0160243.]

A Method for Measuring Planar Residual Stresses in Rectangularly Orthotropic Materials

A semidestructive method has been developed for determining the principal residual stresses and directions in rectangularly orthotropic materials. The reduction equations are based upon a set of functions that describe the surface strain-relaxation field about a hole drilled to a limited depth into the material. Three constants contained in the strain functions have to be determined by calibration tests; they are related to three general constants and the elastic material constants to establish applicability to an orthotropic material. Expressions for the planar residual-stress components in the material-symmetry directions are then devel oped, and from Mohr's stress circle, the principal residual stresses and directions are determined.Yeshttps://us.sagepub.com/en-us/nam/manuscript-submission-guideline

Soft Tissue Sarcoma: The Predominant Primary Malignancy in the Retroperitoneum

Purpose. In the clinical work-up of a retroperitoneal mass, the diagnosis of soft tissue sarcoma is often not considered. Incidence rates of various malignant and benign retroperitoneal tumours were studied to determine the incidence of soft tissue sarcoma in comparison with other neoplasms in the retroperitoneal space

Measuring the Physiologic Properties of Oral Lesions Receiving Fractionated Photodynamic Therapy

Photodynamic therapy (PDT) can treat superficial, early‐stage disease with minimal damage to underlying tissues and without cumulative dose‐limiting toxicity. Treatment efficacy is affected by disease physiologic properties, but these properties are not routinely measured. We assessed diffuse reflectance spectroscopy (DRS) for the noninvasive, contact measurement of tissue hemoglobin oxygen saturation (StO2) and total hemoglobin concentration ([tHb]) in the premalignant or superficial microinvasive oral lesions of patients treated with 5‐aminolevulinic acid (ALA)‐PDT. Patients were enrolled on a Phase 1 study of ALA‐PDT that evaluated fluences of 50, 100, 150 or 200 J cm−2 delivered at 100 mW cm−2. To test the feasibility of incorporating DRS measurements within the illumination period, studies were performed in patients who received fractionated (two‐part) illumination that included a dark interval of 90–180 s. Using DRS, tissue oxygenation at different depths within the lesion could also be assessed. DRS could be performed concurrently with contact measurements of photosensitizer levels by fluorescence spectroscopy, but a separate noncontact fluorescence spectroscopy system provided continuous assessment of photobleaching during illumination to greater tissue depths. Results establish that the integration of DRS into PDT of early‐stage oral disease is feasible, and motivates further studies to evaluate its predictive and dosimetric value.Diffuse reflectance spectroscopy with a contact probe was employed as part of a fluorescence and reflectance spectroscopy system to measure the tissue hemoglobin oxygen saturation and hemoglobin content of lesions of premalignant or early microinvasive cancer of the oral cavity. Studies demonstrate the feasibility of incorporating these measurements into treatment with fractionated (two‐part) photodynamic therapy (PDT) using 5‐aminolevulinic acid. Patient‐specific differences in physiologic parameters were detectable at baseline and at times during and after PDT. Photobleaching of photosensitizer was measured by its fluorescence. Results establish the utility of rationally designed spectroscopy probes toward personalized dosimetry in PDT of oral disease.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/113767/1/php12475.pd

A One Medicine Mission for an Effective Rabies Therapy

Despite the disease's long history, little progress has been made toward a treatment for rabies. The prognosis for patient recovery remains dire. For any prospect of survival, patients require aggressive critical care, which physicians in rabies endemic areas may be reluctant or unable to provide given the cost, clinical expertise required, and uncertain outcome. Systematic clinical research into combination therapies is further hampered by sporadic occurrence of cases. In this Perspective, we examine the case for a One Medicine approach to accelerate development of an effective therapy for rabies through the veterinary care and investigational treatment of naturally infected dogs in appropriate circumstances. We review the pathogenesis of rabies virus in humans and dogs, including recent advances in our understanding of the molecular basis for the severe neurological dysfunction. We propose that four categories of disease process need to be managed in patients: viral propagation, neuronal degeneration, inflammation and systemic compromise. Compassionate critical care and investigational treatment of naturally infected dogs receiving supportive therapy that mimics the human clinical scenario could increase opportunities to study combination therapies that address these processes, and to identify biomarkers for prognosis and therapeutic response. We discuss the safety and ethics of this approach, and introduce the Canine Rabies Treatment Initiative, a non-profit organization with the mission to apply a One Medicine approach to the investigation of diagnostic, prognostic, and therapeutic options for rabies in naturally infected dogs, to accelerate transformation of rabies into a treatable disease for all patients