A highly efficient engineering tool for three-dimensional scramjet flowfield and heat transfer computations

The SIMPLE-based parabolic flow code, SHIP3D, was under development for use as a parametric design and analysis tool for scramjets. Some capabilities and applications of the code are demonstrated, and a report on its current status is given. The focus is on the combustor for which the code was mostly used. Recently, it was also applied to nozzle flows. Code validation results are presented for combustor unit problems involving film cooling, transverse fuel injection, and nozzle test. A parametric study of a film cooled or transpiration cooled Mach 16 combustor is also conducted to illustrate the application of the code to a design problem

La estructura internacional de la investigación crítica e interpretativa en contabilidad

This article analyzes the historical development, the main characteristics and the scope of the international structure of critical and interpretative research in accounting, making distinctions with the normative and positivist tendencies of accounting research. The paper analyzes the theoretical and practical distinctions of research currents, the editorial construction of journals of greatest international impact and some trends of its editors. The document has a high contextual value to highlight the ways of researching and publishing in accounting, emphasizing some experiences and recommendations to achieve it.El presente artículo analiza el desarrollo histórico, las principales características y el alcance que ha tenido la estructura internacional de la investigación crítica e interpretativa en contabilidad, haciendo distinciones con las tendencias normativas y positivistas de la investigación contable. En el documento se analizan las distinciones teóricas y prácticas de las corrientes de investigación, la construcción editorial de las revistas de mayor impacto internacional y algunas tendencias de sus editores. El documento tiene un alto valor contextual para resaltar las formas de investigar y de publicar en contabilidad, haciendo hincapié en algunas experiencias y recomendaciones para lograrlo

An International Plant Sentinel Network

Invasive plant pests and pathogens pose a major threat to biodiversity around the world, amplified in recent years by the globalisation of trade in plants and plant material and the impacts of climate change. Botanic gardens and arboreta offer a unique opportunity for the identification and further investigation of new and emerging pest and pathogen risks, which can provide valuable information for the creation of prevention, eradication and control programmes. The International Plant Sentinel Network (IPSN) is being developed to provide a platform for coordination, information exchange and support for sentinel plant research within botanic gardens and arboreta. Alongside IPSN Member Gardens, the network includes plant protection professionals and National Plant Protection Organisations (NPPOs) from around the world. The IPSN provides tools which will help to enable gardens to contribute to research by increasing knowledge and awareness among garden staff, developing standardised approaches and providing training materials and methodologies for monitoring and surveying. The network also promotes links with local professional diagnostic support that can help aid the early detection and rapid response to new pest incursions, thus protecting valuable, and often unique, plant collections

Estrategias de formulación de los mercados de abasto y su influencia en la sociedad y cultura

Los mercados de abasto es una de las infraestructuras más antiguas de comercialización que convive con el retail moderno, manteniendo su posicionamiento, gracias no solo a la ventaja competitiva del producto fresco sino a los impactos sociales y culturales que generan. Por otro lado los supermercados y su gran desarrollo logístico operacional y fuerte crecimiento, han modificado los hábitos de compra del consumidor, con la creación de distintos formatos de venta, posicionándose cada vez más en la preferencia de compra, pudiéndose perder ese potencial beneficio sociocultural, por lo que los mercados de abasto tradicionales necesitan implementar nuevas estrategias que les permita seguir desarrollando esos aspectos relevantes de la sociedad, recuperando sus orígenes de ser edificaciones potencialmente influyentes de su entorno, a través de intervenciones que generan vinculaciones sociales y culturales, encontrándose en la investigación soluciones como: Beneficios sociales a través de la integración estratégica de comerciantes y vecinos, Beneficios urbanos a través de la integración con su entorno, Beneficios culturales a través de nuevos servicios con valor agregado, mejoras de los servicios internos implementando el diseño emocional y merchandising en la exhibición

Road-building materials in Texas

UT Librarie

Comparative Study of Intravaginal Metronidazole and Triple-Sulfa Therapy for Bacterial Vaginosis

Objective: We sought to compare the efficacy of metronidazole gel vs. triple-sulfa cream in the treatment of bacterial vaginosis (BV)

Ursinus College Alumni Journal, August 1965

First words • From the President • Storm warnings from the ancient world • Ferment: Change comes to Ursinus against a backdrop of widespread concern about higher education • A federal tax credit plan for expenses of higher education • The higher mathematics of public education • Pieces of mind, \u2765 • Class of \u2765: An end, a beginning • Grads return to campus on Alumni Day • 1965 Alumni Award • The Evening School breed • George S. Spohn, \u2742, will lead the Alumni Centennial Fund • 1965 Loyalty Fund annual report • This is not a drill!: Ursinus men play key roles in air strikes on North Vietnam communists • Art is a search • Letters: A gift that lives; Amman adventure • Campus clippings • The will to give • Sporting scene • Hydrologist studies the rise and fall of water supply • Class notebook • Weddings • Births • In memoriam • End quotes: Can we be equal and excellent too?https://digitalcommons.ursinus.edu/alumnijournal/1084/thumbnail.jp

Design Development of a Combined Deployment and Pointing System for the International Space Station Neutron Star Interior Composition Explorer Telescope

This paper describes the design of a unique suite of mechanisms which make up the Deployment and Pointing System (DAPS) for the Neutron Star Interior Composition Explorer (NICER/SEXTANT) instrument, an X-Ray telescope, which will be mounted on the International Space Station (ISS). The DAPS system uses 4 stepper motor actuators to deploy the telescope box, latch it in the deployed position, and allow it to track sky targets. The DAPS gimbal architecture provides full-hemisphere coverage, and is fully re-stowable. The compact design of the mechanism allowed the majority of total instrument volume to be used for science. Override features allow DAPS to be stowed by ISS robotics

Design Development of a Combined Deployment and Pointing System for the International Space Station Neutron Star Interior Composition Explorer Telescope

This paper describes the design of a unique suite of mechanisms that make up the Deployment and Pointing System (DAPS) for the Neutron Star Interior Composition Explorer (NICER/SEXTANT) instrument, an X-Ray telescope, which will be mounted on the International Space Station (ISS). The DAPS system uses four stepper motor actuators to deploy the telescope box, latch it in the deployed position, and allow it to track sky targets. The DAPS gimbal architecture provides full-hemisphere coverage, and is fully re-stowable. The compact design of the mechanism allowed the majority of total instrument volume to be used for science. Override features allow DAPS to be stowed by ISS robotics

Dbf4-dependent kinase (DDK)-mediated proteolysis of CENP-A prevents mislocalization of CENP-A in Saccharomyces cerevisiae

The evolutionarily conserved centromeric histone H3 variant (Cse4 in budding yeast, CENP-A in humans) is essential for faithful chromosome segregation. Mislocalization of CENP-A to non-centromeric chromatin contributes to chromosomal instability (CIN) in yeast, fly, and human cells and CENP-A is highly expressed and mislocalized in cancers. Defining mechanisms that prevent mislocalization of CENP-A is an area of active investigation. Ubiquitin-mediated proteolysis of overexpressed Cse4 (GALCSE4)byE3 ubiquitin ligases such as Psh1 prevents mislocalization of Cse4, and psh1D strains display synthetic dosage lethality (SDL) with GALCSE4. We previously performed a genome-wide screen and identified five alleles of CDC7 and DBF4 that encode the Dbf4-dependent kinase (DDK) complex, which regulates DNA replication initiation, among the top twelve hits that displayed SDL with GALCSE4. We determined that cdc7-7 strains exhibit defects in ubiquitin-mediated proteolysis of Cse4 and show mislocalization of Cse4. Mutation of MCM5 (mcm5-bob1) bypasses the requirement of Cdc7 for replication initiation and rescues replication defects in a cdc7-7 strain. We determined that mcm5-bob1 does not rescue the SDL and defects in proteolysis of GALCSE4 in a cdc7-7 strain, suggesting a DNA replication-independent role for Cdc7 in Cse4 proteolysis. The SDL phenotype, defects in ubiquitin-mediated proteolysis, and the mislocalization pattern of Cse4 in a cdc7-7 psh1D strain were similar to that of cdc7-7 and psh1D strains, suggesting that Cdc7 regulates Cse4 in a pathway that overlaps with Psh1. Our results define a DNA replication initiation-independent role of DDK as a regulator of Psh1-mediated proteolysis of Cse4 to prevent mislocalization of Cse4.Fil: Eisenstatt, Jessica R.. National Institutes of Health; Estados UnidosFil: Boeckmann, Lars. National Institutes of Health; Estados UnidosFil: Au, Wei Chun. National Institutes of Health; Estados UnidosFil: Garcia, Valerie. National Institutes of Health; Estados UnidosFil: Bursch, Levi. National Institutes of Health; Estados UnidosFil: Ocampo, Josefina. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones en Ingeniería Genética y Biología Molecular "Dr. Héctor N. Torres"; Argentina. National Instituto of Child Health & Human Development; Estados UnidosFil: Costanzo, Michael. National Institutes of Health; Estados Unidos. University of Toronto; CanadáFil: Weinreich, Michael. Van Andel Research Institute; Estados UnidosFil: Sclafani, Robert A.. University of Colorado; Estados UnidosFil: Baryshnikova, Anastasia. University of Princeton; Estados UnidosFil: Myers, Chad L.. University of Minnesota; Estados UnidosFil: Boone, Charles. University of Toronto; Canadá. National Institutes of Health; Estados UnidosFil: Clark, David J.. National Institutes of Health; Estados UnidosFil: Baker, Richard. University of Massachusetts; Estados UnidosFil: Basrai, Munira A.. National Institutes of Health; Estados Unido