A multi-element psychosocial intervention for early psychosis (GET UP PIANO TRIAL) conducted in a catchment area of 10 million inhabitants: study protocol for a pragmatic cluster randomized controlled trial

Multi-element interventions for first-episode psychosis (FEP) are promising, but have mostly been conducted in non-epidemiologically representative samples, thereby raising the risk of underestimating the complexities involved in treating FEP in 'real-world' services

CCDC 268366: Experimental Crystal Structure Determination

An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures

CCDC 268365: Experimental Crystal Structure Determination

An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures

Cascade complexation: a single cyano bridge links a pair of Cu(II) cations

A series of structurally characterised µ-cyanodicopper(II) cryptates shows moderately strong antiferromagnetic interaction in the range –2J = 150–200 cm–1, at the high end of the observed range for such assemblies. The lowest magnetic exchange coupling parameter is displayed where there is slight bending of the M–CN–M assembly, enforced by the constraints of cryptate encapsulation. Thermally accessible triplet EPR spectra are observed with zero-field splittings of the order of 0.13–0.14 cm–1, confirming collinear ground-state dz2 orbitals for Cu(II), consistent with their trigonal-bipyramidal coordination geometries

N-methylation of macrobicycles reduces encapsulation ability

N-methylation alters the conformation of octa-azacryptands leaving them unable to use all potential N-donors to coordinate copper(II) and anionic guests. This restriction, in the presence of other donors, normally results in exogenous coordination, with the exception of carbonate complexes, where two O-donors from the bridging anion along with three N-donors from the cryptand serve, in this series uniquely, to retain a pair of copper(II) ions within the basket-shaped cavity