The application of deep eutectic solvent ionic liquids for environmentally-friendly dissolution and recovery of precious metals

publisher: Elsevier articletitle: The application of deep eutectic solvent ionic liquids for environmentally-friendly dissolution and recovery of precious metals journaltitle: Minerals Engineering articlelink: http://dx.doi.org/10.1016/j.mineng.2015.09.026 content_type: article copyright: Copyright © 2015 The Authors. Published by Elsevier Ltd.© 2015 Elsevier Ltd. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/)

Counting on the motor system: Rapid action planning reveals the format- and magnitude-dependent extraction of numerical quantity

Symbolic numbers (e.g., 2 ) acquire their meaning by becoming linked to the core nonsymbolic quantities they represent (e.g., two items). However, the extent to which symbolic and nonsymbolic information converges onto the same internal core representations of quantity remains a point of considerable debate. As nearly all previous work on this topic has employed perceptual tasks requiring the conscious reporting of numerical magnitudes, here we question the extent to which numerical processing via the visual-motor system might shed further light on the fundamental basis of how different number formats are encoded.We show, using a rapid reaching task and a detailed analysis of initial arm trajectories, that there are key differences in how the quantity information extracted from symbolic Arabic numerals and nonsymbolic collections of discrete items are used to guide action planning. In particular, we found that the magnitude derived from discrete dots resulted in movements being biased by an amount directly proportional to the actual quantities presented whereasthe magnitude derived from numerals resulted in movements being biased only by the relative (e.g., larger than) quantities presented. In addition, we found that initial motor plans were more sensitive to changes in numerical quantity within small (1-3) than large (5-15) number ranges, irrespective of their format (dots or numerals). In light of previous work, our visual-motor results clearly show that the processing of numerical quantity information is both format and magnitude dependent. © 2014 ARVO

Relative roles of genetic variation and phenotypic plasticity in the invasion of monkeyflower Erythranthre gutatta in New Zealand (2022-06-07)

Evolutionary processes which increase the probability of an introduced plant species becoming invasive include high levels of genetic diversity and phenotypic plasticity. Naturalised in New Zealand, monkeyflower, (Erythranthre gutatta ), a clonally spreading herb of waterways and seepage areas native to the Western USA, shows marked variation in a range of vegetative, reproductive and inflorescence traits. We used two common gardens differing in elevation to explore the relative contribution of genetic versus plastic variation within nine traits among 34 monkeyflower clones from across the New Zealand South Island. We looked for evidence of clinal variation across elevation gradients and for home site advantage. We found both high genetic diversity and trait plasticity explain the observed variation, although less evidence for adaptive plasticity. Most genetic variation was observed in the lowland garden (9m a.s.l.), where the overall trend was for above ground dry weight to be lower, and horizontal shoot length greater, than at the montane garden (560m a.s.l). We found no evidence of local adaptation to any of the measured environmental variables. However, we observed a pattern of higher biomass and higher plasticity at lower versus higher elevations and in clones originating from lower elevation sites.</jats:p

Condensation of Hard Spheres Under Gravity: Exact Results in One Dimension

We present exact results for the density profile of the one dimensional array of N hard spheres of diameter D and mass m under gravity g. For a strictly one dimensional system, the liquid-solid transition occurs at zero temperature, because the close-pakced density, $\phi_c$, is one. However, if we relax this condition slightly such that $phi_c=1-\delta$, we find a series of critical temperatures T_c^i=mgD(N+1-i)/\mu_o with \mu_o=const, at which the i-th particle undergoes the liquid-solid transition. The functional form of the onset temperature, T_c^1=mgDN/\mu_o, is consistent with the previous result [Physica A 271, 192 (1999)] obtained by the Enskog equation. We also show that the increase in the center of mass is linear in T before the transition, but it becomes quadratic in T after the transition because of the formation of solid near the bottom

Femtosecond x-ray diffraction from an aerosolized beam of protein nanocrystals

We demonstrate near-atomic-resolution Bragg diffraction from aerosolized single granulovirus crystals using an x-ray free-electron laser. The form of the aerosol injector is nearly identical to conventional liquid-microjet nozzles, but the x-ray-scattering background is reduced by several orders of magnitude by the use of helium carrier gas rather than liquid. This approach provides a route to study the weak diffuse or lattice-transform signal arising from small crystals. The high speed of the particles is particularly well suited to upcoming MHz-repetition-rate x-ray free-electron lasers

Concurrent whole brain radiotherapy and bortezomib for brain metastasis

Abstract Background Survival of patients with brain metastasis particularly from historically more radio-resistant malignancies remains dismal. A phase I study of concurrent bortezomib and whole brain radiotherapy was conducted to determine the tolerance and safety of this approach in patients with previously untreated brain metastasis. Methods A phase I dose escalation study evaluated the safety of bortezomib (0.9, 1.1, 1.3, 1.5, and 1.7 mg/m2) given on days 1, 4, 8 and 11 of whole brain radiotherapy. Patients with confirmed brain metastasis were recruited for participation. The primary endpoint was the dose-limiting toxicity, defined as any ≥ grade 3 non-hematologic toxicity or grade ≥ 4 hematologic toxicity from the start of treatment to one month post irradiation. Time-to-Event Continual Reassessment Method (TITE-CRM) was used to determine dose escalation. A companion study of brain diffusion tensor imaging MRI was conducted on a subset of patients to assess changes in the brain that might predict delayed cognitive effects. Results Twenty-four patients were recruited and completed the planned therapy. Patients with melanoma accounted for 83% of all participants. The bortezomib dose was escalated as planned to the highest dose of 1.7 mg/m2/dose. No grade 4/5 toxicities related to treatment were observed. Two patients had grade 3 dose-limiting toxicities (hyponatremia and encephalopathy). A partial or minor response was observed in 38% of patients. Bortezomib showed greater demyelination in hippocampus-associated white matter structures on MRI one month after radiotherapy compared to patients not treated with bortezomib (increase in radial diffusivity +16.8% versus 4.8%; p = 0.0023). Conclusions Concurrent bortezomib and whole brain irradiation for brain metastasis is well tolerated at one month follow-up, but MRI changes that have been shown to predict delayed cognitive function can be detected within one month of treatment.http://deepblue.lib.umich.edu/bitstream/2027.42/112849/1/13014_2013_Article_928.pd

A Closer Look at Self-Esteem, Perceived Social Support, and Coping Strategy: A Prospective Study of Depressive Symptomatology Across the Transition to College

The first year of college is a significant life transition, which is often characterized by stress and may contribute to the development or exacerbation of depressive symptoms. Due to the considerable negative outcomes that are associated with depressive symptoms across the lifespan, it is important to understand the mechanisms and pathways through which depressive symptoms arise. This prospective study examines the mediating and moderating roles of perceived social support and disengagement coping on the association between self-esteem and depressive symptomatology in a sample of 1,118 first-year college students. Results of longitudinal cross-lagged path analyses indicate that self-esteem predicts depressive symptomatology via perceived social support and disengagement coping. The association between self-esteem and perceived social support appear to be bidirectional, in that level of self-esteem predicts perceived social support, and vice versa. Furthermore, disengagement coping was found to moderate the effect of self-esteem on depressive symptomatology, in that increased levels of disengagement coping led to greater depressive symptoms within the context of both high and low self-esteem. However, this pattern was not observed at lower levels of disengagement coping, which indicates high levels of disengagement coping as a particular risk factor for depressive symptomatology, diminishing the advantage of high self-esteem