A Study of Proportional Hazards Models: Its Applications in Prognostics

Prognostics and health management technology is proposed to satisfy the requirements of equipment autonomous maintenance and diagnosis, which is a new technique relying on condition-based maintenance. It mainly includes condition monitoring, fault diagnostics, life prediction, maintenance decision-making, and spare parts management. As one of the most commonly used reliability statistical modeling methods, proportional hazards model (PHM) is widely used in the field of prognostics, because it can effectively combine equipment service age and condition monitoring information to obtain more accurate condition prediction results. In the past decades, PHM-based methods have been widely employed, especially since the twenty-first century. However, after the rapid development of PHM, there is no systematic review and summary particularly focused on it. Therefore, this chapter comprehensively summarizes the research progress of PHM in prognostics

HopPG: Self-Iterative Program Generation for Multi-Hop Question Answering over Heterogeneous Knowledge

The semantic parsing-based method is an important research branch for knowledge-based question answering. It usually generates executable programs lean upon the question and then conduct them to reason answers over a knowledge base. Benefit from this inherent mechanism, it has advantages in the performance and the interpretability. However,traditional semantic parsing methods usually generate a complete program before executing it, which struggles with multi-hop question answering over heterogeneous knowledge. Firstly,a complete multi-hop program relies on multiple heterogeneous supporting facts, and it is difficult for models to receive these facts simultaneously. Secondly,these methods ignore the interaction information between the previous-hop execution result and the current-hop program generation. To alleviate these challenges, we propose a self-iterative framework for multi-hop program generation (HopPG) over heterogeneous knowledge, which leverages the previous-hop execution results to retrieve supporting facts and generate subsequent programs iteratively. We evaluate our model on MMQA-T^2. The experimental results show that HopPG outperforms existing semantic-parsing-based baselines, especially on the multi-hop questions

A pilot study on the efficacy of topical lotion containing anti-acne postbiotic in subjects with mild -to -moderate acne

IntroductionAcne can compromise facial esthetics and become a mental burden, especially when it occurs in puberty. Skincare cosmetics with anti-acne efficiency is more convenient than other treatment modalities, such as dietary supplements, in certain circumstances. The purpose of this study was to investigate the efficacy of an anti-acne lotion in alleviating acne.MethodsIn our study, an anti-acne lotion containing ferment lysate produced by Lactiplantibacillus plantarum VHProbi® E15 were applied to subjects with mild -to -moderate acne over 4 weeks. The efficacy was evaluated based on instrumental measurements using Visia®-CR and CK-MPA® system.Results and discussionThe anti-acne lotion exhibited favorable safety, meeting the stringent criteria for the detection of microbes, heavy metals, toxicity, and irritation. After 2 weeks of treatment, a statistically significant improvement in acne lesions was observed compared to baseline (P < 0.01), and this continued to the end of the study. After 4 weeks of treatment, the transepidermal water loss (P < 0.05) and sebum production (P < 0.05) were significantly decreased in subjects compared to baseline. In addition, the pore/area of interest (AOI) and stratum corneum hydration displayed slightly positive changes throughout treatment. Thus, we conclude that applying topical anti-acne lotion may be safe and confer effective benefits in people with mild -to -moderate acne and represents a promising therapeutic option for acne

Net exchanges of CO2, CH4, and N2O between China's terrestrial ecosystems and the atmosphere and their contributions to global climate warming

Author Posting. © American Geophysical Union, 2011. This article is posted here by permission of American Geophysical Union for personal use, not for redistribution. The definitive version was published in Journal of Geophysical Research 116 (2011): G02011, doi:10.1029/2010JG001393.China's terrestrial ecosystems have been recognized as an atmospheric CO2 sink; however, it is uncertain whether this sink can alleviate global warming given the fluxes of CH4 and N2O. In this study, we used a process-based ecosystem model driven by multiple environmental factors to examine the net warming potential resulting from net exchanges of CO2, CH4, and N2O between China's terrestrial ecosystems and the atmosphere during 1961–2005. In the past 45 years, China's terrestrial ecosystems were found to sequestrate CO2 at a rate of 179.3 Tg C yr−1 with a 95% confidence range of (62.0 Tg C yr−1, 264.9 Tg C yr−1) while emitting CH4 and N2O at rates of 8.3 Tg C yr−1 with a 95% confidence range of (3.3 Tg C yr−1, 12.4 Tg C yr−1) and 0.6 Tg N yr−1 with a 95% confidence range of (0.2 Tg N yr−1, 1.1 Tg N yr−1), respectively. When translated into global warming potential, it is highly possible that China's terrestrial ecosystems mitigated global climate warming at a rate of 96.9 Tg CO2eq yr−1 (1 Tg = 1012 g), substantially varying from a source of 766.8 Tg CO2eq yr−1 in 1997 to a sink of 705.2 Tg CO2eq yr−1 in 2002. The southeast and northeast of China slightly contributed to global climate warming; while the northwest, north, and southwest of China imposed cooling effects on the climate system. Paddy land, followed by natural wetland and dry cropland, was the largest contributor to national warming potential; forest, followed by woodland and grassland, played the most significant role in alleviating climate warming. Our simulated results indicate that CH4 and N2O emissions offset approximately 84.8% of terrestrial CO2 sink in China during 1961–2005. This study suggests that the relieving effects of China's terrestrial ecosystems on climate warming through sequestering CO2 might be gradually offset by increasing N2O emission, in combination with CH4 emission.This study has been supported by NASA LCLUC Program (NNX08AL73G_S01) , NASA IDS Program (NNG04GM39C), and China’s Ministry of Science and Technology (MOST) 973 Program (2002CB412500)

Prevalence, associated factors and outcomes of pressure injuries in adult intensive care unit patients: the DecubICUs study

Funder: European Society of Intensive Care Medicine; doi: http://dx.doi.org/10.13039/501100013347Funder: Flemish Society for Critical Care NursesAbstract: Purpose: Intensive care unit (ICU) patients are particularly susceptible to developing pressure injuries. Epidemiologic data is however unavailable. We aimed to provide an international picture of the extent of pressure injuries and factors associated with ICU-acquired pressure injuries in adult ICU patients. Methods: International 1-day point-prevalence study; follow-up for outcome assessment until hospital discharge (maximum 12 weeks). Factors associated with ICU-acquired pressure injury and hospital mortality were assessed by generalised linear mixed-effects regression analysis. Results: Data from 13,254 patients in 1117 ICUs (90 countries) revealed 6747 pressure injuries; 3997 (59.2%) were ICU-acquired. Overall prevalence was 26.6% (95% confidence interval [CI] 25.9–27.3). ICU-acquired prevalence was 16.2% (95% CI 15.6–16.8). Sacrum (37%) and heels (19.5%) were most affected. Factors independently associated with ICU-acquired pressure injuries were older age, male sex, being underweight, emergency surgery, higher Simplified Acute Physiology Score II, Braden score 3 days, comorbidities (chronic obstructive pulmonary disease, immunodeficiency), organ support (renal replacement, mechanical ventilation on ICU admission), and being in a low or lower-middle income-economy. Gradually increasing associations with mortality were identified for increasing severity of pressure injury: stage I (odds ratio [OR] 1.5; 95% CI 1.2–1.8), stage II (OR 1.6; 95% CI 1.4–1.9), and stage III or worse (OR 2.8; 95% CI 2.3–3.3). Conclusion: Pressure injuries are common in adult ICU patients. ICU-acquired pressure injuries are associated with mainly intrinsic factors and mortality. Optimal care standards, increased awareness, appropriate resource allocation, and further research into optimal prevention are pivotal to tackle this important patient safety threat

Correction to: Prevalence, associated factors and outcomes of pressure injuries in adult intensive care unit patients: the DecubICUs study

The original version of this article unfortunately contained a mistake

Prevalence, associated factors and outcomes of pressure injuries in adult intensive care unit patients: the DecubICUs study

Funder: European Society of Intensive Care Medicine; doi: http://dx.doi.org/10.13039/501100013347Funder: Flemish Society for Critical Care NursesAbstract: Purpose: Intensive care unit (ICU) patients are particularly susceptible to developing pressure injuries. Epidemiologic data is however unavailable. We aimed to provide an international picture of the extent of pressure injuries and factors associated with ICU-acquired pressure injuries in adult ICU patients. Methods: International 1-day point-prevalence study; follow-up for outcome assessment until hospital discharge (maximum 12 weeks). Factors associated with ICU-acquired pressure injury and hospital mortality were assessed by generalised linear mixed-effects regression analysis. Results: Data from 13,254 patients in 1117 ICUs (90 countries) revealed 6747 pressure injuries; 3997 (59.2%) were ICU-acquired. Overall prevalence was 26.6% (95% confidence interval [CI] 25.9–27.3). ICU-acquired prevalence was 16.2% (95% CI 15.6–16.8). Sacrum (37%) and heels (19.5%) were most affected. Factors independently associated with ICU-acquired pressure injuries were older age, male sex, being underweight, emergency surgery, higher Simplified Acute Physiology Score II, Braden score 3 days, comorbidities (chronic obstructive pulmonary disease, immunodeficiency), organ support (renal replacement, mechanical ventilation on ICU admission), and being in a low or lower-middle income-economy. Gradually increasing associations with mortality were identified for increasing severity of pressure injury: stage I (odds ratio [OR] 1.5; 95% CI 1.2–1.8), stage II (OR 1.6; 95% CI 1.4–1.9), and stage III or worse (OR 2.8; 95% CI 2.3–3.3). Conclusion: Pressure injuries are common in adult ICU patients. ICU-acquired pressure injuries are associated with mainly intrinsic factors and mortality. Optimal care standards, increased awareness, appropriate resource allocation, and further research into optimal prevention are pivotal to tackle this important patient safety threat