湖北省罗田凤凰关混合岩浅色体的类型及其锆石U-Pb年龄

Based on the principle of refolding transecting and overprinting, and eliminating the refolding pseudomorph resulting from the effect of viscous folds, 8-generation leucosomes have been distinguished in the Fenghuangguan migmatites in Luotian, Hubei Province, central China. The results of the major-, trace- and rare earth-element geochemistry indicate that the leucosome for dating the U-Pb age was derived from anatexis. The zircon U-Pb age suggests that there was a migmatization during the Yanshan Period, which may represent an important anatex is at the age, (129. 3 +/- 0. 8) Ma.根据混合岩浅色体的重褶、横切和叠加关系并剔除因粘性褶皱效应引起的重褶皱假象, 在湖北罗田凤凰关识别出8 个世代的浅色体。它们的主量、微量和稀土元素地球化学研究表明, 用于锆石U-Pb 定年的浅色体是深熔成因的。锆石U-Pb 定年结果表明, 在大别杂岩内存在燕山期的混合岩化作用, 其时代为（１２９．３．８）Ｍａ。published_or_final_versio

Development of the facility for model scramjet testing

A hypersonic propulsion test facility has been constructed in IMCAS (Institute of Mechanics, Chinese Academy of Sciences) in order to provide a high enthalpy hypersonic flow for a model scramjet testing. The vitiated air is produced by a hydrogen/air and oxygen replenishment combustion heater with flow rate of 3.5kg/s, total pressure of 5MPa and total temperature of 2000K in maximum, and accelerated up to Mach 5.6 by a two-dimensional nozzle. Test chamber of the facility is evacuated by a one-stage central air ejector. The preliminary facility performance tests showed that the vitiated air heater could provide the high enthalpy flow as expected. A copper model scramjet without cooling is ready for testing. © 2001 The American Institute of Aeronautics and Astronautics Inc. All rights reserved

Orexinergic Input to Dopaminergic Neurons of the Human Ventral Tegmental Area

The mesolimbic reward pathway arising from dopaminergic (DA) neurons of the ventral tegmental area (VTA) has been strongly implicated in reward processing and drug abuse. In rodents, behaviors associated with this projection are profoundly influenced by an orexinergic input from the lateral hypothalamus to the VTA. Because the existence and significance of an analogous orexigenic regulatory mechanism acting in the human VTA have been elusive, here we addressed the possibility that orexinergic neurons provide direct input to DA neurons of the human VTA. Dual-label immunohistochemistry was used and orexinergic projections to the VTA and to DA neurons of the neighboring substantia nigra (SN) were analyzed comparatively in adult male humans and rats. Orexin B-immunoreactive (IR) axons apposed to tyrosine hydroxylase (TH)-IR DA and to non-DA neurons were scarce in the VTA and SN of both species. In the VTA, 15.062.8% of TH-IR perikarya in humans and 3.260.3% in rats received orexin B-IR afferent contacts. On average, 0.2460.05 and 0.0560.005 orexinergic appositions per TH-IR perikaryon were detected in humans and rats, respectively. The majority(86–88%) of randomly encountered orexinergic contacts targeted the dendritic compartment of DA neurons. Finally, DA neurons of the SN also received orexinergic innervation in both species. Based on the observation of five times heavierorexinergic input to TH-IR neurons of the human, compared with the rat, VTA, we propose that orexinergic mechanism acting in the VTA may play just as important roles in reward processing and drug abuse in humans, as already established well in rodents

Modeling of non-point source nitrogen pollution from 1979 to 2008 in Jiaodong Peninsula, China

Efforts to reduce land-based non-point source (NPS) pollutions from watersheds to coastal waters are ongoing all around the world. In this study, annual yield of NPS nitrogen (NPS-N) pollution in Jiaodong Peninsula, China from 1979 to 2008 was estimated. The results showed that: from 1979 to 2008, NPS-N yields exhibited significant inter-annual variations and an increasing trend on decadal scale. High NPS-N yield was mainly found in east and south parts, as well as the urbanized coastal regions in Jiaodong Peninsula. Among the 32 river basins, the three largest basins yielded more than 41.16% of the NPS-N. However, some small coastal watersheds along the South Yellow Sea and Jiaozhou Bay had higher per unit area yield. Most of the small watersheds characterized by seasonal runoff had coastal waters pertain to mild and moderate pollution levels. The ratio of watershed area to shoreline length and the up-stream land use had significant impacts on NPS-N flux through the shoreline. Among the four adjacent coastal areas of Jiaodong Peninsula, Jiaozhou Bay was the most noteworthy one not only because of high levels of land-based NPS-N pollution but also because of its nearly enclosed structure. The combination between integrated coastal zone management and integrated river basin management, land use planning and landscape designing in Jiaodong Peninsula is recommended. Copyright (c) 2013 John Wiley & Sons, Ltd.Efforts to reduce land-based non-point source (NPS) pollutions from watersheds to coastal waters are ongoing all around the world. In this study, annual yield of NPS nitrogen (NPS-N) pollution in Jiaodong Peninsula, China from 1979 to 2008 was estimated. The results showed that: from 1979 to 2008, NPS-N yields exhibited significant inter-annual variations and an increasing trend on decadal scale. High NPS-N yield was mainly found in east and south parts, as well as the urbanized coastal regions in Jiaodong Peninsula. Among the 32 river basins, the three largest basins yielded more than 41.16% of the NPS-N. However, some small coastal watersheds along the South Yellow Sea and Jiaozhou Bay had higher per unit area yield. Most of the small watersheds characterized by seasonal runoff had coastal waters pertain to mild and moderate pollution levels. The ratio of watershed area to shoreline length and the up-stream land use had significant impacts on NPS-N flux through the shoreline. Among the four adjacent coastal areas of Jiaodong Peninsula, Jiaozhou Bay was the most noteworthy one not only because of high levels of land-based NPS-N pollution but also because of its nearly enclosed structure. The combination between integrated coastal zone management and integrated river basin management, land use planning and landscape designing in Jiaodong Peninsula is recommended. Copyright (c) 2013 John Wiley & Sons, Ltd

The Endogenous Th17 Response in NO<inf>2</inf>-Promoted Allergic Airway Disease Is Dispensable for Airway Hyperresponsiveness and Distinct from Th17 Adoptive Transfer

Severe, glucocorticoid-resistant asthma comprises 5-7% of patients with asthma. IL-17 is a biomarker of severe asthma, and the adoptive transfer of Th17 cells in mice is sufficient to induce glucocorticoid-resistant allergic airway disease. Nitrogen dioxide (NO2) is an environmental toxin that correlates with asthma severity, exacerbation, and risk of adverse outcomes. Mice that are allergically sensitized to the antigen ovalbumin by exposure to NO2 exhibit a mixed Th2/Th17 adaptive immune response and eosinophil and neutrophil recruitment to the airway following antigen challenge, a phenotype reminiscent of severe clinical asthma. Because IL-1 receptor (IL-1R) signaling is critical in the generation of the Th17 response in vivo, we hypothesized that the IL-1R/Th17 axis contributes to pulmonary inflammation and airway hyperresponsiveness (AHR) in NO2-promoted allergic airway disease and manifests in glucocorticoid-resistant cytokine production. IL-17A neutralization at the time of antigen challenge or genetic deficiency in IL-1R resulted in decreased neutrophil recruitment to the airway following antigen challenge but did not protect against the development of AHR. Instead, IL-1R-/- mice developed exacerbated AHR compared to WT mice. Lung cells from NO2-allergically inflamed mice that were treated in vitro with dexamethasone (Dex) during antigen restimulation exhibited reduced Th17 cytokine production, whereas Th17 cytokine production by lung cells from recipient mice of in vitro Th17-polarized OTII T-cells was resistant to Dex. These results demonstrate that the IL-1R/Th17 axis does not contribute to AHR development in NO2-promoted allergic airway disease, that Th17 adoptive transfer does not necessarily reflect an endogenously-generated Th17 response, and that functions of Th17 responses are contingent on the experimental conditions in which they are generated. © 2013 Martin et al

Glucosylsphingosine Is a Highly Sensitive and Specific Biomarker for Primary Diagnostic and Follow-Up Monitoring in Gaucher Disease in a Non-Jewish, Caucasian Cohort of Gaucher Disease Patients

Gaucher disease (GD) is the most common lysosomal storage disorder (LSD). Based on a deficient β-glucocerebrosidase it leads to an accumulation of glucosylceramide. Standard diagnostic procedures include measurement of enzyme activity, genetic testing as well as analysis of chitotriosidase and CCL18/PARC as biomarkers. Even though chitotriosidase is the most well-established biomarker in GD, it is not specific for GD. Furthermore, it may be false negative in a significant percentage of GD patients due to mutation. Additionally, chitotriosidase reflects the changes in the course of the disease belatedly. This further enhances the need for a reliable biomarker, especially for the monitoring of the disease and the impact of potential treatments.Here, we evaluated the sensitivity and specificity of the previously reported biomarker Glucosylsphingosine with regard to different control groups (healthy control vs. GD carriers vs. other LSDs).Only GD patients displayed elevated levels of Glucosylsphingosine higher than 12 ng/ml whereas the comparison controls groups revealed concentrations below the pathological cut-off, verifying the specificity of Glucosylsphingosine as a biomarker for GD. In addition, we evaluated the biomarker before and during enzyme replacement therapy (ERT) in 19 patients, demonstrating a decrease in Glucosylsphingosine over time with the most pronounced reduction within the first 6 months of ERT. Furthermore, our data reveals a correlation between the medical consequence of specific mutations and Glucosylsphingosine.In summary, Glucosylsphingosine is a very promising, reliable and specific biomarker for GD

A Plant Kavalactone Desmethoxyyangonin PreventsInflammation and Fulminant Hepatitis in Mice

Alpinia pricei Hayata is a Formosan plant which has been popularly used as nutraceutical or folk medicine for inflammation and various disorders. An active compound of the plant rhizomes, desmethoxyyangonin (DMY), was identified in this study for its novel effect against endotoxin lipopolysaccharide (LPS)-stimulated inflammation in murine macrophages and LPS/D-galactosamine (LPS/D-GalN)-induced fulminant hepatitis in mice. DMY was observed to significantly inhibit proliferation and activation of T cells ex vivo and the activity of several pro-inflammatory mediators in vitro. DMY also protected LPS/D-GalN−induced acute hepatic damages in mice through inhibiting aminotransferases activities and infiltrations of inflammatory macrophages, neutrophils and pathogenic T cells into the liver tissues. In addition, pretreatment with DMY significantly improved the survival rate of LPS/D-GalN−treated mice to 90% (9/10), compared to LPS/D-GalN−treated group (40%, 4/10). UPLC/MS platform-based comparative metabolomics approach was used to explore the serum metabolic profile in fulminant hepatic failure (FHF) mice with or without the DMY pretreatment. The results showed that LPS/D-GalN−induced hepatic damage is likely through perturbing amino acid metabolism, which leads to decreased pyruvate formation via catalysis of aminotransferases, and DMY treatment can prevent to a certain degree of these alterations in metabolic network in mouse caused by LPS/D-GalN. Mechanistic investigation demonstrated that DMY protects LPS or LPS/D-GalN−induced damages in cell or liver tissues mainly through de-regulating IKK/NFκB and Jak2/STAT3 signaling pathways. This report provides evidence-based knowledge to support the rationale for the use of A. pricei root extract in anti-inflammation and also its new function as hepatoprotetive agent against fulminant hepatitis

Genome-wide copy number variation study in anorectal malformations

Anorectal malformations (ARMs, congenital obstruction of the anal opening) are among the most common birth defects requiring surgical treatment (2-5/10 000 live-births) and carry significant chronic morbidity. ARMs present either as isolated or as part of the phenotypic spectrum of some chromosomal abnormalities or monogenic syndromes. The etiology is unknown. To assess the genetic contribution to ARMs, we investigated single-nucleotide polymorphisms and copy number variations (CNVs) at genome-wide scale. A total of 363 Han Chinese sporadic ARM patients and 4006 Han Chinese controls were included. Overall, we detected a 1.3-fold significant excess of rare CNVs in patients. Stratification of patients by presence/absence of other congenital anomalies showed that while syndromic ARM patients carried significantly longer rare duplications than controls (P = 0.049), non-syndromic patients were enriched with both rare deletions and duplications when compared with controls (P = 0.00031). Twelve chromosomal aberrations and 114 rare CNVs were observed in patients but not in 868 controls nor 11 943 healthy individuals from the Database of Genomic Variants. Importantly, these aberrations were observed in isolated ARM patients. Gene-based analysis revealed 79 genes interfered by CNVs in patients only. In particular, we identified a de novo DKK4 duplication. DKK4 is a member of the WNT signaling pathway which is involved in the development of the anorectal region. In mice, Wnt disruption results in ARMs. Our data suggest a role for rare CNVs not only in syndromic but also in isolated ARM patients and provide a list of plausible candidate genes for the disorder.postprin

Observation of a ppb mass threshoud enhancement in \psi^\prime\to\pi^+\pi^-J/\psi(J/\psi\to\gamma p\bar{p}) decay

The decay channel $\psi^\prime\to\pi^+\pi^-J/\psi(J/\psi\to\gamma p\bar{p})$ is studied using a sample of $1.06\times 10^8$ $\psi^\prime$ events collected by the BESIII experiment at BEPCII. A strong enhancement at threshold is observed in the $p\bar{p}$ invariant mass spectrum. The enhancement can be fit with an $S$-wave Breit-Wigner resonance function with a resulting peak mass of $M=1861^{+6}_{-13} {\rm (stat)}^{+7}_{-26} {\rm (syst)} {\rm MeV/}c^2$ and a narrow width that is $\Gamma<38 {\rm MeV/}c^2$ at the 90% confidence level. These results are consistent with published BESII results. These mass and width values do not match with those of any known meson resonance.Comment: 5 pages, 3 figures, submitted to Chinese Physics