The First Year IceCube-DeepCore Results

The IceCube Neutrino Observatory includes a tightly spaced inner array in the deepest ice, called DeepCore, which gives access to low-energy neutrinos with a sizable surrounding cosmic ray muon veto. Designed to be sensitive to neutrinos at energies as low as 10 GeV, DeepCore will be used to study diverse physics topics with neutrino signatures, such as dark matter annihilations and atmospheric neutrino oscillations. The first year of DeepCore physics data-taking has been completed, and the first observation of atmospheric neutrino-induced cascades with IceCube and DeepCore are presented.Comment: 4 pages, 3 figures, TAUP 2011 (Journal of Physics: Conference Series (JCPS)

4-Hydroxy­phenyl 4-fluoro­benzoate

In the title compound, C13H9FO3, the dihedral angle between the two benzene rings is 59.86 (4)°. In the crystal, inter­molecular O—H⋯H hydrogen bonds lead to molecular chains propagating in [010]

Polarity of the First Episode and Time to Diagnosis of Bipolar I Disorder

Objective The current study explored the relationship between the polarity of the first episode and the timing of eventual diagnosis of bipolar I disorder, and associated clinical implications. Methods Twelve years of clinical data from the medical records of 258 inpatients meeting DSM-III-R or DSM-IV criteria for bipolar I disorder were analyzed. Subjects were divided into two groups according to the polarity of the first episode: those with depressive polarity (FE-D), and those with manic polarity (FE-M). Comparisons were made between the two groups on variables associated with the timing of diagnosis and related outcomes. Results In Population with bipolar I disorder, a significant longer time lapse from the first major mood episode to the confirmed diagnosis was associated with the FE-D group compared to the FE-M group [5.6 (+/- 6.1) vs. 2.5 (+/- 5.5) years, p<0.001]. FE-D subjects tended to have prior diagnoses of schizophrenia and major depressive disorder while FE-M subjects tended to have prior diagnoses of bipolar disorder and schizophrenia. A significantly higher rate of suicide attempts was associated with the FE-D group compared to the FE-M group (12.7 vs. 1.7%, p<0.001). Conclusion The results of this study indicate that first-episode depressive polarity is likely to be followed by a considerable delay until an eventual confirmed diagnosis of bipolar I disorder. Given that first-episode depressive patients are particularly vulnerable to unfavorable clinical Outcomes Such as suicide attempts, a more systematic approach is needed to differentiate bipolar disorder among depressed patients in their early stages.Rosa AR, 2008, J AFFECT DISORDERS, V107, P45, DOI 10.1016/j.jad.2007.07.021Chaudhury SR, 2007, J AFFECT DISORDERS, V104, P245, DOI 10.1016/j.jad.2007.02.022Berk M, 2007, J AFFECT DISORDERS, V103, P181, DOI 10.1016/j.jad.2007.01.027Benazzi F, 2007, LANCET, V369, P935GOODWIN FK, 2007, MANIC DEPRESSIVE ILLDaban C, 2006, COMPR PSYCHIAT, V47, P433, DOI 10.1016/j.comppsych.2006.03.009McElroy SL, 2006, BIPOLAR DISORD, V8, P596Kassem L, 2006, AM J PSYCHIAT, V163, P1754Colom F, 2006, J AFFECT DISORDERS, V93, P13, DOI 10.1016/j.jad.2006.01.032Perlis RH, 2005, AM J MANAG CARE, V11, pS271Perlis RH, 2005, BIOL PSYCHIAT, V58, P549, DOI 10.1016/j.biopsych.2005.07.029Gazalle FK, 2005, J AFFECT DISORDERS, V86, P313, DOI 10.1016/j.jad.2005.01.003Ghaemi SN, 2005, J AFFECT DISORDERS, V84, P273, DOI 10.1016/S0165-0327(03)00196-4Post JC, 2005, CURR OPIN ALLERGY CL, V5, P5Mitchell PB, 2004, BIPOLAR DISORD, V6, P530Goodwin FK, 2003, JAMA-J AM MED ASSOC, V290, P1467Morselli PL, 2003, BIPOLAR DISORD, V5, P265Daniels BA, 2003, J AFFECT DISORDERS, V75, P163, DOI 10.1016/S0165-0327(02)00041-1Baethge C, 2003, ACTA PSYCHIAT SCAND, V107, P260Hirschfeld RMA, 2003, J CLIN PSYCHIAT, V64, P161Goldberg JF, 2002, J CLIN PSYCHIAT, V63, P985Ghaemi SN, 2002, CAN J PSYCHIAT, V47, P125Suppes T, 2001, J AFFECT DISORDERS, V67, P45Hirsch M, 2001, YALE J CRIT, V14, P5Bowden CL, 2001, PSYCHIATR SERV, V52, P51Hirschfeld RMA, 2000, AM J PSYCHIAT, V157, P1873Ghaemi SN, 2000, J CLIN PSYCHIAT, V61, P804Perugi G, 2000, COMPR PSYCHIAT, V41, P13GHAEMI SN, 2000, J CLIN PSYCHIAT, V61, P809Ghaemi SN, 1999, J AFFECT DISORDERS, V52, P135Baldessarini RJ, 1999, J CLIN PSYCHIAT, V60, P77BALDESSARINI RJ, 1999, J CLIN PSYCHIAT S2, V60, P111LISH JD, 1994, J AFFECT DISORDERS, V31, P281WEHR TA, 1988, AM J PSYCHIAT, V145, P179

Induction of Remission is Difficult due to Frequent Relapse during Tapering Steroids in Korean Patients with Polymyalgia Rheumatica

Polymyalgia rheumatica is an inflammatory disease affecting elderly and involving the shoulder and pelvic girdles. No epidemiological study of polymyalgia rheumatica was conducted in Korea. We retrospectively evaluated patients with polymyalgia rheumatica followed up at the rheumatology clinics of 10 tertiary hospitals. In total 51 patients, 36 patients (70.6%) were female. Age at disease onset was 67.4 yr. Twenty-three patients (45.1%) developed polymyalgia rheumatica in winter. Shoulder girdle ache was observed in 45 patients (90%) and elevated erythrocyte sedimentation rate (> 40 mm/h) in 49 patients (96.1%). Initial steroid dose was 23.3 mg/d prednisolone equivalent. Time to normal erythrocyte sedimentation rate was 4.1 months. Only 8 patients (15.7%) achieved remission. Among 41 patients followed up, 28 patients (68.3%) had flare at least once. Number of flares was 1.5 ± 1.6. The frequency of flare was significantly lower in patients with remission (P = 0.02). In Korea, polymyalgia rheumatica commonly develops during winter. Initial response to steroid is fairly good, but the prognosis is not benign because remission is rare with frequent relapse requiring long-term steroid treatment

Impact of Anxiety Disorder on Gray Matter Volume Changes in Patients with Bipolar II Disorder

Background: Comorbid anxiety disorders are frequently found in patients with bipolar disorder and may complicate the treatment of the disorder. Little is known about the interplay between bipolar disorder and anxiety disorder. The purpose of the current study was to investigate the effects of comorbid anxiety disorders on volumetric changes in brain of patients with bipolar II disorder.

Feasibility of a slower lamotrigine titration schedule for bipolar depression: a naturalistic study

The development of a skin rash is often associated with a rapid escalation of lamotrigine dose. We used lamotrigine to treat 259 patients with Diagnostic and Statistical Manual of Mental Disorders, 4th edition, bipolar depression using either the standard titration schedule (n=132) or a slower titration schedule (n=127) and compared the clinical efficacy and safety of both groups. Clinical efficacy of lamotrigine treatment was assessed using changes in the Clinical Global Impression Scale for Bipolar Disorder-Modified scores during the course of the 12-week treatment A significant reduction of the Clinical Global Impression Scale for Bipolar Disorder-Modified score was observed in both groups and the effect size was large for both groups (standard, 0.75; slower, 0.71). A mixed-effect model of repeated measurement. revealed an increased rate of improvement in the standard titration group that was significant during the first 5 weeks (P<0.001) but became nonsignificant by the final 7 weeks of treatment. The statistically significant reduction in the development of rashes (P=0.005) was a major advantage for patients in the slower titration group. Although the standard titration schedule generally led to faster recovery from depressive symptoms, the slower titration schedule may be an option for patients with a high risk of rash development.Ketter TA, 2008, J PSYCHIATR RES, V43, P13, DOI 10.1016/j.jpsychires.2008.02.007Calabrese JR, 2008, BIPOLAR DISORD, V10, P323Alvestad S, 2007, EPILEPSIA, V48, P1360, DOI 10.1111/j.1528-1167.2007.01109.xKeck PE, 2007, CNS SPECTRUMS, V12, P1Man CBL, 2007, EPILEPSIA, V48, P1015, DOI 10.1111/j.1528-1167.2007.01022.xHirsch LJ, 2006, EPILEPSIA, V47, P318Ostacher MJ, 2006, J CLIN PSYCHIAT, V67, P18*GLAXOSMITHKLINE, 2006, PRESCR INF LAM LAM TKetter TA, 2005, J CLIN PSYCHIAT, V66, P642P-Codrea S, 2005, ACTA NEUROL SCAND, V111, P191, DOI 10.1111/j.1600-0404.2005.00381.xSilverstone PH, 2004, INT CLIN PSYCHOPHARM, V19, P113, DOI 10.1091/01.yic.0000125754.83499.55Chung WH, 2004, NATURE, V428, P486, DOI 10.1038/428486aGueorguieva R, 2004, ARCH GEN PSYCHIAT, V61, P310Katz MM, 2004, NEUROPSYCHOPHARMACOL, V29, P566, DOI 10.1038/sj.npp.1300341Goodwin GM, 2004, J CLIN PSYCHIAT, V65, P432Calabrese JR, 2003, J CLIN PSYCHIAT, V64, P1013Bowden CL, 2003, ARCH GEN PSYCHIAT, V60, P392Choi H, 2003, EXPERT OPIN PHARMACO, V4, P243Calabrese JR, 2002, J CLIN PSYCHIAT, V63, P1012Calabrese JR, 2002, J CLIN PSYCHIAT, V63, P18Frye MA, 2000, J CLIN PSYCHOPHARM, V20, P607Rzany B, 1999, LANCET, V353, P2190Calabrese JR, 1999, J CLIN PSYCHIAT, V60, P79Messenheimer JA, 1998, CAN J NEUROL SCI, V25, pS14Spearing MK, 1997, PSYCHIAT RES, V73, P159COHEN J, 1988, STAT POWER ANAL BEHA

A Study of NaI(Tl) crystal encapsulation using organic scintillators for the dark matter search

© 2019 Elsevier B.V.Scintillating NaI(Tl) crystals are used for various rare decay experiments, such as dark matter searches. However, the hygroscopicity of NaI(Tl) crystals makes the construction of crystal detectors in these experiments challenging. Therefore, the crystal requires a tight encapsulation to prevent from air contact. More importantly, in a low radioactivity measurement, identification of external radiations and surface contamination is crucial to characterize the origin of total crystal radioactivities. Studies for the NaI(Tl) crystal encapsulation with active organic scintillator vetoes have been performed to mitigate the above-mentioned issues simultaneously. A bare crystal is directly coupled with liquid and plastic scintillators to tag external radiations that penetrate from the outer part of the crystal. We report the pulse shape discrimination between organic scintillator and the crystal scintillator in a single detector setup and their long-term stabilit

NaI(Tl) crystal scintillator encapsulated in two organic-scintillator layers with pulse shape data analysis

Thallium-doped sodium iodide (NaI(Tl)) crystals are widely used in radiation detection applications, from gamma-ray spectroscopy to particle dark matter searches. However, if the crystal is exposed to relative humidity of even a few percent, its light emission degrades, making the crystal impractical as a detector. Surrounding the crystal with organic scintillators not only protects the surface of the crystal from humid air but also offers a new capability to tag backgrounds such as external gamma rays and surface contaminations. We developed a detector that is constructed by fully encasing a NaI(Tl) crystal in a plastic scintillator and then immersing the plastic-crystal assembly in liquid scintillator. Using data collected from this triple phoswich detector, a pulse shape analysis is able to identify the various radiation signals from the three scintillators. Additionally, we find that the crystal's emission quality is maintained for a month.Comment: 14pages,7figure