Grip Suppression using a Machine-Learned Technique

This publication describes techniques for grip suppression of a touchscreen display of a computing device using a machine-learned technique. When a user intentionally or unintentionally touches the display (e.g., with a hand or a finger), a Touch Manager of the computing device performs operations to determine a user intent associated with the touch input to prevent false triggering of the display (e.g., by a grip of a hand holding the device). A machine-learned (ML) model calculates the likeliness of an intentional touch input (e.g., a tap, a swipe, or a scroll of a hand or a finger to input or manage information on the device) by identifying and assigning weights to features of the touch input. A total weight is calculated for each touch input and compared to a default threshold (e.g., an accepted threshold associated with an intentional touch input), which may be adjusted to ensure accuracy of user-intent predictions. After the Touch Manager verifies the user-intent predictions using heuristic and/or hysteresis logic, the computing device may perform operations to suppress or enable the touch input

Do as I say, not as I do:a lexical distributional account of English locative verb class acquisition

Children overgeneralise verbs to ungrammatical structures early in acquisition, but retreat from these overgeneralisations as they learn semantic verb classes. In a large corpus of English locative utterances (e.g., the woman sprayed water onto the wall/wall with water), we found structural biases which changed over development and which could explain overgeneralisation behaviour. Children and adults had similar verb classes and a correspondence analysis suggested that lexical distributional regularities in the adult input could help to explain the acquisition of these classes. A connectionist model provided an explicit account of how structural biases could be learned over development and how these biases could be reduced by learning verb classes from distributional regularities

Classification of User Input using System Contextual Information for Grip Suppression

This publication describes techniques for classification of user input using system contextual information for grip suppression on a mobile device (e.g., smartphone). In an example technique, a classification threshold is determined based on contextual information related to a current state of the mobile device and a heatmap is used to determine spatial features (e.g., amplitude, shape, size) relating to a user input on a touch panel of the mobile device. Based on a combination of the classification threshold and the spatial features, the user input is classified as intentional or unintentional. Using the techniques, unintentional user input, for example, those resulting from the user’s grip on the mobile device, may be filtered out while intentional user input is accepted as valid

Lexical distributional cues, but not situational cues, are readily used to learn abstract locative verb-structure associations.

Children must learn the structural biases of locative verbs in order to avoid making overgeneralisation errors (e.g., *I filled water into the glass). It is thought that they use linguistic and situational information to learn verb classes that encode structural biases. In addition to situational cues, we examined whether children and adults could use the lexical distribution of nouns in the post-verbal noun phrase to assign novel verbs to locative classes. In Experiment 1, children and adults used lexical distributional cues to assign verb classes, but were unable to use situational cues appropriately. In Experiment 2, adults generalised distributionally-learned classes to novel verb arguments, demonstrating that distributional information can cue abstract verb classes. Taken together, these studies show that human language learners can use a lexical distributional mechanism that is similar to that used by computational linguistic systems that use large unlabelled corpora to learn verb meaning

BRCA1’s Phosphorylation Dependent Interaction with Abraxas, BACH1, and CtIP: Elucidation of the BRCA1 Mediated DNA Damage Response

Women carrying germline mutations of the BRCA1 gene show an increased risk of breast and ovarian cancer, implying that the BRCA1 protein acts as a tumor suppressor in mammary and ovarian epithelial cells. The rationale of this thesis is to elucidate how BRCA1 suppresses tumor development.. To investigate BRCA1’s tumor suppression activity, our lab has recently developed a mouse model of the basal-like breast tumors that arise in women who carry BRCA1 mutations. Furthermore, this model was used successfully to define specific functions of BRCA1 that are and are not required for tumor suppression. Our lab has shown that deletion of Brca1 results in embryonic lethality, implying that the Brca1 protein is essential in embryonic development. Inactivation of Brca1 in mammary epithelial cells resulted in development of mammary tumors similar to the basal-like tumors observed in patients carrying BRCA1 mutations. These studies indicate that BRCA1 is essential for tumor suppression. Many tumor-associated BRCA1 alleles have frameshift or nonsense mutations that delete one or both of the BRCT motifs (Fig. 1), suggesting that these motifs may operate either directly or through interaction with other proteins to suppress tumor development1. Our lab has shown that these BRCT repeats are essential for tumor suppression in part by playing a key role in homology directed DNA repair (HDR) of double-stranded breaks (DSBs), and repair of DNA interstrand cross-linking (ICL) damage. Specifically, the phosphoserine interaction of BRCA1 to other partners is essential in mediating error-proof DNA repair1. In addition, mice carrying Brca1 BRCT mutations are susceptible to spontaneous tumor development 1; 2. These results indicate that the BRCT motifs in BRCA1 facilitate DNA repair and tumor suppression either directly and/or via interactions with other DNA repair proteins. In particular, we are interested in the interaction with three phosphorylated isoforms of repair proteins: Abraxas, BACH1, and CtIP. The goal of this thesis is to elucidate the BRCT interacting partners of BRCA1 and their particular functions in maintaining genomic stability and facilitating DNA repair. To accomplish this, our lab will cross mice to generate primary embryonic fibroblasts (pMEFs) containing mutations that ablate the phosphoserine interaction capability of the three phosphorylated isoforms of repair proteins,individually or in combination with the intact Brca1 protein. Further, a combination of mutations in the three repair proteins will be generated in cells with a deleted 53BP1 gene to study their specific role in ICL repair or HDR. Cells expressing these mutant alleles will be tested for sensitivity to DNA damaging agents, proliferation in culture, and HDR.Pelotonia Undergraduate Research FellowshipNo embargoAcademic Major: Biochemistr

Evidence for active maintenance of inverted repeat structures identified by a comparative genomic approach

Inverted repeats have been found to occur in both prokaryotic and eukaryotic genomes. Usually they are short and some have important functions in various biological processes. However, long inverted repeats are rare and can cause genome instability. Analyses of C. elegans genome identified long, nearly-perfect inverted repeat sequences involving both divergently and convergently oriented homologous gene pairs and complete intergenic sequences. Comparisons with the orthologous regions from the genomes of C. briggsae and C. remanei show that the inverted repeat structures are often far more conserved than the sequences. This observation implies that there is an active mechanism for maintaining the inverted repeat nature of the sequences

Perfil profesional del obstetra y competencias formativas en estudiantes de una universidad privada, 2019

La finalidad del estudio fue determinar la relación que existe entre el perfil profesional del obstetra y las competencias formativas en estudiantes del X ciclo de la Facultad de Obstetricia de la Universidad San Martín de Porres, 2019. Se tuvo como muestra 103 estudiantes. Se recolectó la información a través de cuestionarios sobres las variables perfil profesional del obstetra y las competencias formativas ambos validados por expertos y confiables. El procesamiento estadístico descriptivo e inferencial se realizaron con el programa estadístico SPSS 24. Los resultados de la investigación determinaron que el perfil profesional se relaciona directa (Rho=0, 748) y significativamente (p=0.000) con las competencias formativas en estudiantes del X ciclo de la Facultad de Obstetricia de la Universidad San Martín de Porres, se acepta la hipótesis alterna y la relación es alta

Perspectives about and approaches to weight gain in pregnancy: a qualitative study of physicians and nurse midwives

Abstract Background Over one third of reproductive age women in the US are obese. Pregnancy is a strong risk factor for obesity, with excess weight gain as the greatest predictor of long term obesity. The majority of pregnant women gain more weight than recommended by the Institute of Medicine guidelines. The objective of this study was to understand prenatal care providers’ perspectives on weight gain during pregnancy. Methods Semi-structured qualitative interviews of 10 prenatal care providers (three family physicians, three obstetricians, and four nurse midwives) at a University Hospital in the Midwest, that included the ranking of important prenatal issues, and open-ended questions addressing: 1) general perceptions; 2) approach with patients; and 3) clinical care challenges. Results Providers felt that appropriate weight gain during pregnancy was not a high priority. Many providers waited until patients had gained excess weight before addressing the issue, were not familiar with established guidelines, and lacked resources for patients. Providers also believed that their counseling had low impact on patients, avoided counseling due to sensitivity of the topic, and believed that patients were more influenced by other factors, such as their family, habits, and culture. Conclusions Both providers and patients may benefit from increased awareness of the morbidity of excess weight gain during pregnancy. Practice-level policies that support the monitoring and management of weight gain during pregnancy could also improve care. Research that further investigates the barriers to appropriate weight gain is warranted.http://deepblue.lib.umich.edu/bitstream/2027.42/112570/1/12884_2012_Article_736.pd