Radiation therapy for locally recurrent breast cancer.

Approximately one-third of all breast cancer patients experience local recurrence of their tumor after initial treatment. As initial treatment often employs the use of radiation therapy (RT), the standard of care for local breast cancer recurrence after initial breast conserving therapy has traditionally been surgical intervention with mastectomy. However, recent attempts to preserve the intact breast after recurrence with local excision have revealed a potential need for RT in addition to repeat breast conserving surgery as rates of local failure with resection alone remain high. Additionally, local recurrence following initial mastectomy and chest wall RT can be treated with reirradiation to increase local control. Repeating RT, however, in a previously irradiated area, is a complex treatment strategy, as the clinician must carefully balance maximizing treatment effectiveness while minimizing treatment-related toxicity. As a result, physicians have been hesitant to treat recurrent disease with repeat RT with limited data. Results from the current literature are promising and current clinical trials are underway to explore reirradiation modalities which will provide additional information on treatment-related toxicity and outcomes. This paper will review the current literature on repeat radiation therapy for locally recurrent breast cancer

Cost Shared Wildfire Risk Mitigation in Log Hill Mesa, Colorado: Survey Evidence on Participation and Willingness to Pay

Wildland–urban interface (WUI) homeowners who do not mitigate the wildfire risk on their properties impose a negative externality on society. To reduce the social costs of wildfire and incentivise homeowners to take action, cost sharing programs seek to reduce the barriers that impede wildfire risk mitigation. Using survey data from a WUI community in western Colorado and a two-stage decision framework, we examine residents’ willingness to participate in a cost sharing program for removing vegetation on their properties and the amount they are willing to contribute to the cost of that removal. Wefind that different factors motivate decisions about participation and about how much to pay. Willingness to participate correlates with both financial and non-monetary considerations, including informational barriers and wildfire risk perceptions, but not with concerns about effectiveness or visual impacts. Residents of properties with higher wildfire risk levels are less likely to participate in the cost sharing than those with lower levels of wildfire risk. We find widespread, positive willingness to pay for vegetation removal, with the amount associated negatively with property size and positively with respondent income. These results can inform the development of cost sharing programs to encourage wildfire risk mitigation on private property

Stakeholder understandings of wildfire mitigation: A case of shared and contested meanings

This article identifies and compares meanings of wildfire risk mitigation for stakeholders in the Front Range of Colorado, USA. We examine the case of a collaborative partnership sponsored by government agencies and directed to decrease hazardous fuels in interface areas. Data were collected by way of key informant interviews and focus groups. The analysis is guided by the Circuit of Culture model in communication research. We found both shared and differing meanings between members of this partnership (the ‘‘producers’’) and other stakeholders not formally in the partnership (the ‘‘consumers’’). We conclude that those promoting the partnership’s project to mitigate risk are primarily aligned with a discourse of scientific management. Stakeholders outside the partnership follow a discourse of community. We argue that failure to recognize and account for differences in the way risk mitigation is framed and related power dynamics could hamper the communicational efforts of the collaborative partnership and impact goals for fuels reduction. We recommend ways that both groups can capitalize on shared meanings and how agency managers and decision makers can build better working relationships with interface communities and other external stakeholders

Women’s participation in teacher unions: Implications of a ‘triple burden’ for union gender equality strategies

Amidst declining union influence, teacher unions have retained power. However, work intensification, arising from increasing reform in school education, has potentially undermined union participation, particularly women’s. Using a mixed-method approach, this article examines how the tangled combination of women’s paid work, union participation and family/domestic responsibilities (the ‘triple burden’) affects women’s roles as unionists. Examining the case of Australian teachers, the article finds that while demands of ‘work’ and ‘life’ can stifle union participation, it is specifically the cultural and historical legacies in unions that hinder women’s participation. The findings offer new insights around issues affecting the participation of women in female-dominated unions, and the intersection between union organisation and operation and the member-workers whom they represent. </jats:p

Transport of <i>Sporosarcina pasteurii</i> in sandstone and its significance for subsurface engineering technologies

The development of microbially mediated technologies for subsurface remediation and rock engineering is steadily increasing; however, we are lacking experimental data and models to predict bacterial movement through rock matrices. Here, breakthrough curves (BTCs) were obtained to quantify the transport of the ureolytic bacterium, Sporosarcina pasteurii, through sandstone cores, as a function of core length (1.8–7.5 cm), bacterial density (4 × 10&lt;sup&gt;6&lt;/sup&gt; to 9 × 10&lt;sup&gt;7&lt;/sup&gt; cells/ml) and flow rate (5.8–17.5 m/s). &lt;i&gt;S. pasteurii&lt;/i&gt; was easily immobilised within the homogeneous sandstone matrix (&gt;80%) in comparison to a packed sand column (&lt;20%; under similar experimental conditions), and percentage recovery decreased almost linearly with increasing rock core length. Moreover, a decrease in bacterial density or flow rate enhanced bacterial retention. A numerical model based on 1D advection dispersion models used for unconsolidated sand was fitted to the BTC data obtained here for sandstone. Good agreement between data and model was obtained at shorter rock core lengths (&lt;4 cm), suggesting that physicochemical filtration processes are similar in homogeneous packed sand and sandstones at these lengths. Discrepancies were, however observed at longer core lengths and with varying flow rates, indicating that the attributes of consolidated rock might impact bacterial transport progressively more with increasing core length. Implications of these results on microbial mineralisation technologies currently being developed for sealing fluid paths in subsurface environment is discussed

Development of a Web-Based Human Resource Sourcing System for Labour Only Contracts

Nowadays in some areas of Nigeria, it has been noticed that the search for a satisfactory team of labourers (skilled and unskilled) or even the right amount of people to undertake the job has become a laborious activity. Therefore, there is need to build a two-way partnership system linking construction firms with the required skilled labour and vice versa. The aim of this research is to develop a web-based human resource sourcing system for labour only contracts. The study made use of a questionnaire instrument and developed a web-based interface for skilled labour sourcing. The questionnaire was distributed to fifty (50) construction professionals who were selected through a convenience sampling technique. The data collected was analyzed using SPSS v.21. The design of the system was done using hypertext markup language (HTML) for authoring web pages. The study revealed that contractors’ sourcing techniques for skilled labour on construction projects were mostly by referral from colleagues and workers from past projects. The study identified the major barriers in sourcing for skilled labour on construction projects as the unavailability of trained skilled labour. The study revealed that years of experience, wages charged and behavior of the worker were major criteria considered while sourcing for skilled labour on construction projects. In conclusion, the study developed a web based human resource sourcing system for labour only contracts that incorporated the needs of the skilled labour and requirement of construction firms. It was recommended that construction professionals and contractors need to harness the benefits of web-based technologies. In addition, there is need to increase the information and communication technology (ICT) trainings of workers in the construction industry so has to have a successful integration of ICT and the construction industry

Relating Spatial Patterns of Stream Metabolism to Distributions of Juveniles Salmonids at the River Network Scale

Understanding the factors that drive spatial patterns in stream ecosystem processes and the distribution of aquatic biota is important to effective management of these systems and the conservation of biota at the network scale. In this study, we conducted field surveys throughout an extensive river network in NE Oregon that supports diminishing populations of wild salmonids. We collected data on physical habitat, nutrient concentrations, biofilm standing stocks, stream metabolism (gross primary production [GPP] and ecosystem respiration [ER]), and ESA‐listed juvenile salmonid density from approximately 50 sites across two sub‐basins. Our goals were to (1) to evaluate network patterns in these metrics, and (2) determine network‐scale linkages among these metrics, thus providing inference of processes driving observed patterns. Ambient nitrate‐N and phosphate‐P concentrations were low across both sub‐basins (\u3c40 μg/L). Nitrate‐N decreased with watershed area in both sub‐basins, but phosphate‐P only decreased in one sub‐basin. These spatial patterns suggest co‐limitation in one sub‐basin but N limitation in the other; experimental results using nutrient diffusing substrates across both sub‐basins supported these predictions. Solar exposure, temperature, GPP, ER, and GPP:ER increased with watershed area, but biofilm Chl a and ash‐free dry mass (AFDM) did not. Spatial statistical network (SSN) models explained between 70% and 75% of the total variation in biofilm Chl a, AFDM, and GPP, but only 21% of the variation in ER. Temperature and nutrient concentrations were the most supported predictors of Chl aand AFDM standing stocks, but these variables explained little of the total variation compared to spatial autocorrelation. In contrast, solar exposure and temperature were the most supported variables explaining GPP, and these variables explained far more variation than autocorrelation. Solar exposure, temperature, and nutrient concentrations explained almost none of the variation in ER. Juvenile salmonids—a key management focus in these sub‐basins—were most abundant in cool stream sections where rates of GPP were low, suggesting temperature constraints on these species restrict their distribution to oligotrophic areas where energy production at the base of the food web may be limited

A central review of histopathology reports after breast cancer neoadjuvant chemotherapy in the neo-tango trial.

BACKGROUND: Neo-tAnGo, a National Cancer Research Network (NCRN) multicentre randomised neoadjuvant chemotherapy trial in early breast cancer, enroled 831 patients in the United Kingdom. We report a central review of post-chemotherapy histopathology reports on the surgical specimens, to assess the presence and degree of response. METHODS: A central independent two-reader review (EP and HME) of histopathology reports from post-treatment surgical specimens was performed. The quality and completeness of pathology reporting across all centres was assessed. The reviews included pathological response to chemotherapy (pathological complete response (pCR); minimal residual disease (MRD); and lesser degrees of response), laterality, the number of axillary metastases and axillary nodes, and the type of surgery. A consensus was reached after discussion. RESULTS: In all, 825 surgical reports from 816 patients were available for review. Out of 4125 data items there were 347 discrepant results (8.4% of classifications), which involved 281 patients. These involved grading of breast response (169 but only 9 involving pCR vs MRD); laterality (6); presence of axillary metastasis (35); lymph node counts (108); and type of axillary surgery (29). Excluding cases with pCR, only 45% of reports included any comment regarding response in the breast and 30% in the axillary lymph nodes. CONCLUSION: We found considerable variability in the completeness of reporting of surgical specimens within this national neoadjuvant breast cancer trial. This highlights the need for consensus guidelines among trial groups on histopathology reporting, and the participation of histopathologists throughout the development and analysis of neoadjuvant trials

CTCF genetic alterations in endometrial carcinoma are pro-tumorigenic

CTCF is a haploinsufficient tumour suppressor gene with diverse normal functions in genome structure and gene regulation. However the mechanism by which CTCF haploinsufficiency contributes to cancer development is not well understood. CTCF is frequently mutated in endometrial cancer. Here we show that most CTCF mutations effectively result in CTCF haploinsufficiency through nonsense-mediated decay of mutant transcripts, or loss-of-function missense mutation. Conversely, we identified a recurrent CTCF mutation K365T, which alters a DNA binding residue, and acts as a gain-of-function mutation enhancing cell survival. CTCF genetic deletion occurs predominantly in poor prognosis serous subtype tumours, and this genetic deletion is associated with poor overall survival. In addition, we have shown that CTCF haploinsufficiency also occurs in poor prognosis endometrial clear cell carcinomas and has some association with endometrial cancer relapse and metastasis. Using shRNA targeting CTCF to recapitulate CTCF haploinsufficiency, we have identified a novel role for CTCF in the regulation of cellular polarity of endometrial glandular epithelium. Overall, we have identified two novel pro-tumorigenic roles (promoting cell survival and altering cell polarity) for genetic alterations of CTCF in endometrial cance