Fear and loathing of central banks in America

The Federal Reserve System is America’s uneasy compromise between our dislike of concentrated financial power and our desire to promote efficiency in our national payments system. In fact, the Federal Reserve is the nation’s third attempt to establish a large national bank—what we now call a central bank—that is in a unique position to influence a nation’s money and credit. This Commentary retells the story of the rise and fall of the two earlier national banks, the Banks of the United States.Banks and banking, Central ; Banks and banking - History

The definition of dietary fiber – discussions at the Ninth Vahouny Fiber Symposium: building scientific agreement

A definition for dietary fiber was adopted in June 2009 by the Codex Alimentarius Commission based on the recommendation for endorsement of the Codex Committee on Nutrition and Foods for Special Dietary Uses (CCNFSDU) in November 2008. The definition listed three categories of carbohydrate polymers that are not hydrolyzed by the endogenous enzymes in the small intestine of humans. However, the definition left the inclusion of carbohydrates with degrees of polymerization (DP) in the range of 3 and 9 to the discretion of national authorities and left the ‘physiological effect(s) of benefit to health’ as undefined. The ILSI Europe and ILSI North America's committees on dietary carbohydrates organized a forum at the Ninth Vahouny Fiber Symposium in 2010 to discuss these implementation issues with the objective of building scientific consensus on how to resolve them. The results of this session are encouraging and indicated that the scientific community agrees on maintaining a worldwide consensus regarding the inclusion of non-digestible carbohydrates with ≥DP3 as dietary fiber and on a core, non-exhaustive list of beneficial physiological effects that dietary fibers have. These results are consistent with previous worldwide agreements

Confidentiality and surveillance challenges for psychologists working in men’s football academies in England

We examine challenges to confidentiality experienced by sports psychologists in men’s English football academies. Sixteen psychologists, six women, and ten men working in English football academies participated in two semi-structured interviews. We carried out a reflexive thematic analysis after each round of interviews and developed two themes: (1) challenges to client-psychologist confidentiality; (2) a context of normalized surveillance. First, participants explained that several staff members (e.g., coaches, managers, and support staff) would use covert and subtle ways to make psychologists break confidentiality. This included trying to get the psychologist to “slip up.” Second, the football academy context was characterized by widespread surveillance of players. It was evident that it is common practice for clubs to gather objective and self-report data creating extreme transparency in the young people’s lives. We also propose two research-based solutions allowing psychologists to handle these issues

Confidentiality and surveillance challenges for psychologists working in men’s football academies in England

We examine challenges to confidentiality experienced by sports psychologists in men’s English football academies. Sixteen psychologists, six women, and ten men working in English football academies participated in two semi-structured interviews. We carried out a reflexive thematic analysis after each round of interviews and developed two themes: (1) challenges to client-psychologist confidentiality; (2) a context of normalized surveillance. First, participants explained that several staff members (e.g., coaches, managers, and support staff) would use covert and subtle ways to make psychologists break confidentiality. This included trying to get the psychologist to “slip up.” Second, the football academy context was characterized by widespread surveillance of players. It was evident that it is common practice for clubs to gather objective and self-report data creating extreme transparency in the young people’s lives. We also propose two research-based solutions allowing psychologists to handle these issues

‘Through the lens of ethnography’: Perceptions, challenges, and experiences of an early career practitioner-researcher in professional football

The present study critically explores the use of practitioner-researcher ethnography in professional football, and illustrates some of the challenges that the first author experienced as a result of the dual-role occupation. The first author occupied the position of insider sport psychology practitioner-researcher within one professional football club over a 3-year duration. Traditional ethnographic research methods were employed, including; observations, field notes, and reflections. Following thematic analysis, research on the potential for conflict and tension in ethnography, and ethical guidelines from caring professions (e.g. sport psychology, health, and nursing) were used to make sense of the data. A series of reflective extracts highlight moral, ethical, and personal challenges of occupying a dual role, including threats to identity, acceptance of academics in elite sport, and confidentiality. For those individuals whose livelihood is dependent on their successes as a practitioner-researcher an understanding of how to overcome methodological challenges will be beneficial in improving their organisational status. From the results of this study, we suggest that a range of support mechanisms (e.g. ethnographers club, regional support hubs, supervisor/researcher training and education), and the development of a clear sense of self are essential for the ethnographic practitioner-researcher

Community Health Information Resource Guide: Volume 1 - Data

This resource guide contains useful information for those who would like to use data to assess the health status of an Indiana community. Targeted users include local organizations such as county health departments and community health coalitions. Being able to access and use relevant data and information resources is a common hurdle for those interested in assessing and advancing community health. As a result of this need and at the request of the Community Advisory Council of the Community Health Engagement Program, we developed this resource guide to assist individuals, organizations, and coalitions in Indiana in identifying appropriate resources that guide their community health research and evaluation activities. The term “data” is used in this volume in reference to both data and information sources. While data consist of raw facts and figures, information is formed by analyzing the data and applying knowledge to it so that the findings are more meaningful and valuable to the community. The benefit of using data is that you can often manipulate it for your specific purposes. The benefit of using information sources is that the work of generating meaning from the data might already have been done, while a potential downside is that the available sources might not answer your specific questions. There are diverse sources of data that can be used as a basis for community health evaluation and decision making. Those looking to use data must consider multiple factors before determining the appropriate data to seek and use.Community Health Engagement Program (CHEP) Indiana Clinical and Translational Sciences Institute (Indiana CTSI

Lycopene reduces ovarian tumor growth and intraperitoneal metastatic load

Mutagens like oxidants cause lesions in the DNA of ovarian and fallopian tube epithelial cells, resulting in neoplastic transformation. Reduced exposure of surface epithelia to oxidative stress may prevent the onset or reduce the growth of ovarian cancer. Lycopene is well-known for its excellent antioxidant properties. In this study, the potential of lycopene in the prevention and treatment of ovarian cancer was investigated using an intraperitoneal animal model. Lycopene prevention significantly reduced the metastatic load of ovarian cancer-bearing mice, whereas treatment of already established ovarian tumors with lycopene significantly diminished the tumor burden. Lycopene treatment synergistically enhanced anti-tumorigenic effects of paclitaxel and carboplatin. Immunostaining of tumor and metastatic tissues for Ki67 revealed that lycopene reduced the number of proliferating cancer cells. Lycopene decreased the expression of the ovarian cancer biomarker, CA125. The anti-metastatic and anti-proliferative effects were accompanied by down-regulated expression of ITGA5, ITGB1, MMP9, FAK, ILK and EMT markers, decreased protein expression of integrin α5 and reduced activation of MAPK. These findings indicate that lycopene interferes with mechanisms involved in the development and progression of ovarian cancer and that its preventive and therapeutic use, combined with chemotherapeutics, reduces the tumor and metastatic burden of ovarian cancer in vivo

Primary prevention with a defibrillator: are therapies always really optimized before implantation?

AIMS:Left ventricle ejection fraction (LVEF) ≤ 30-35% is widely accepted as a cut-off for primary prevention with an implantable cardiac defibrillator (ICD) in patients with both ischaemic and non-ischaemic cardiomyopathy supposedly on optimal medical therapy. This study reports evolutions of LVEF and treatments of patients implanted in our institution with an ICD for primary prevention of sudden death, after 2 years of follow-up. METHODS AND RESULTS: Among 84 patients with LVEF under 35% implanted between 2005 and 2007, 28 (33%) had improved their LVEF >35% after the 2 years of follow-up. During this period, even if Beta-blockers (98%) and renin-angiotensin system (RAS) blockers (95%) were already initially prescribed, treatments were significantly optimized with improvement of maximal doses of beta-blockers and RAS blockers at 2 year follow-up compared with initial prescription (62 vs. 37% and 68 vs. 45%, respectively). In patients with improved LVEF, a trend toward a better treatment optimization and revascularization procedures (in the sub-group of ischaemic patients) were observed compared with non-improved LVEF patients. CONCLUSIONS: In our study of patients with prophylactic ICD, one-third of them have improved their LVEF after a 2 year follow-up. Despite an optimal medical therapy at the time of implantation, we were able to further improve the maximal treatment doses after implantation. This study highlights the issue of what should be considered as \u27optimal\u27 therapy and the possibility of improvement of LVEF related to a real optimized treatment before implantation

Maternal supplementation with n-3 long chain polyunsaturated fatty acids during perinatal period alleviates the metabolic syndrome disturbances in adult hamster pups fed a high-fat diet after weaning

Perinatal nutrition is thought to affect the long-term risk of the adult to develop metabolic syndrome. We hypothesized that maternal supplementation with eicosapentaenoic acid and docosahexaenoic acid during pregnancy and lactation would protect offspring fed a high-fat diet from developing metabolic disturbances. Thus, two groups of female hamsters were fed a low-fat control diet, either alone (LC) or enriched with n-3 long chain polyunsaturated fatty acids (LC-PUFA) (LO), through the gestational and lactation periods. After weaning, male pups were randomized to separate groups that received either a control low-fat diet (LC) or a high-fat diet (HC) for 16 weeks. Four groups of pups were defined (LC-LC, LC-HC, LO-LC and LO-HC), based on the combinations of maternal and weaned diets. Maternal n-3 LC-PUFA supplementation was associated with reduced levels of basal plasma glucose, hepatic triglycerides secretion and postprandial lipemia in the LO-HC group compared to the LC-HC group. Respiratory parameters were not affected by maternal supplementation. In contrast, n-3 LC-PUFA supplementation significantly enhanced the activities of citrate synthase, isocitrate dehydrogenase and α-ketoglutarate dehydrogenase compared to the offspring of unsupplemented mothers. Sterol regulatory element binding protein-1c, diacylglycerol O-acyltransferase 2, fatty acid synthase, stearoyl CoA desaturase 1 and tumor necrosis factor α expression levels were not affected by n-3 LC-PUFA supplementation. These results provide evidence for a beneficial effect of n-3 LC-PUFA maternal supplementation in hamsters on the subsequent risk of metabolic syndrome. Underlying mechanisms may include improved lipid metabolism and activation of the mitochondrial oxidative pathway