Supervision of milk coagulation with scatter red LED light

For cheese production clotting time is prederteminated using a proteolytic enzyme titulation test (Chamorro and Losada 2002). Thus an expert operator decides the optimum cutting time (always delayed compared to clotting time) based on his own subjective evaluation of textural and visual properties of the curd (Castillo et al. 2000). Expert judgment usually gives acceptable results, yet variability in the optimal assessment of cutting time leads to affects further cheese processing operations (pressing and ripening). The aforementioned reasons suggest the importance of an objective and non-destructive method to determinate optimal cutting time, which would allow indeed the automatic supervision of the cheese clotting process. The goal of this work is a prospective study for the supervision of milk coagulation with scatter red LED light

Hannibal's trek across the alps: Geomorphological Analysis of sites of geoarchaeological interest

International audienceA ~2200 year-old question related to Hannibal's invasion route across the Alps into Italia, has been argued by classicists without recovery of material evidence. A comparison of topographical descriptions in the ancient literature with environmental parameters in the Alps, attempted here for the first time, provides a database against which various pathways can be assessed. Identification of sites using geological, geomorphological, astronomical, chemical and petrological methods leads to the exclusion of certain transit points and targeting of others where geoarchaeological excavation might yield important evidence related to the military culture of ancient Carthage

COVID-19 symptoms at hospital admission vary with age and sex: results from the ISARIC prospective multinational observational study

Background: The ISARIC prospective multinational observational study is the largest cohort of hospitalized patients with COVID-19. We present relationships of age, sex, and nationality to presenting symptoms. Methods: International, prospective observational study of 60 109 hospitalized symptomatic patients with laboratory-confirmed COVID-19 recruited from 43 countries between 30 January and 3 August 2020. Logistic regression was performed to evaluate relationships of age and sex to published COVID-19 case definitions and the most commonly reported symptoms. Results: ‘Typical’ symptoms of fever (69%), cough (68%) and shortness of breath (66%) were the most commonly reported. 92% of patients experienced at least one of these. Prevalence of typical symptoms was greatest in 30- to 60-year-olds (respectively 80, 79, 69%; at least one 95%). They were reported less frequently in children (≤ 18 years: 69, 48, 23; 85%), older adults (≥ 70 years: 61, 62, 65; 90%), and women (66, 66, 64; 90%; vs. men 71, 70, 67; 93%, each P < 0.001). The most common atypical presentations under 60 years of age were nausea and vomiting and abdominal pain, and over 60 years was confusion. Regression models showed significant differences in symptoms with sex, age and country. Interpretation: This international collaboration has allowed us to report reliable symptom data from the largest cohort of patients admitted to hospital with COVID-19. Adults over 60 and children admitted to hospital with COVID-19 are less likely to present with typical symptoms. Nausea and vomiting are common atypical presentations under 30 years. Confusion is a frequent atypical presentation of COVID-19 in adults over 60 years. Women are less likely to experience typical symptoms than men

Retention of Xenon in Quartz and Earth's missing Xenon

International audienceThe reactivity of xenon with terrestrial oxides was investigated by in situ synchrotron x-ray diffraction. At high temperature (T 9 500 kelvin), some silicon was reduced, and the pressure stability of quartz was expanded, attesting to the substitution of some xenon for silicon. When the quartz was quenched, xenon diffused out and only a few weight percent remained trapped in samples. These results show that xenon can be covalently bonded to oxygen in quartz in the lower continental crust, providing an answer to the missing xenon problem; synthesis paths of rare gas compounds are also opened

Synchrotron IR study of hydrous ringwoodite (γ-Mg2SiO4) up to 30 GPa

International audienceHigh-pressure synchrotron infrared (IR) absorption spectra were collected between 650 and 4,000 cm−1 at ambient temperature for hydrous Mg-ringwoodite (γ-Mg2SiO4) up to 30 GPa. The main feature in the OH− stretching region is an extremely broad band centred at 3,150 cm−1. The hydrogen bond is strong for most protons and the most probable site for protonation is the tetrahedral edge. With increasing pressure, this band shifts downward while decreasing its integrated intensity until disappearance at a pressure of 25 GPa. Only one band at 2,450 cm−1 and an absorption plateau persist with a maximum wavenumber of 3,800 cm−1. This behaviour is reversible upon pressure release. We interpret this as a second-order phase transition occurring in hydrated Mg-ringwoodite at high pressure (beyond ∼ 25 GPa). This result is compatible with the observation by Kleppe et al. (Phys Chem Miner 29:473–476, 2002a) who suggested the presence of Si–O–Si linkages and/or partial increase in the coordination of Si. Beyond the phase transition, the protons are delocalized and their environment on the ringwoodite structure is probably quite different from that at low pressure. Data obtained in situ at high pressures and temperatures are needed to better understand the effect of protonation on the structure and to better constrain this phase transition

Effectiveness of a Spectacle Lens with a Specific Asymmetric Myopic Peripheral Defocus: 12-Month Results in a Spanish Population

Background: Different designs of ophthalmic lenses have been studied to control the progression of myopia in children. This study aims to evaluate the short-term efficacy of a new design of ophthalmic lens with asymmetric myopic peripheral defocus (MPDL) on myopia progression in children compared to a control group wearing a single-vision lens (SVL). Methods: Children aged 5 to 12 with myopia up to −0.50 D, astigmatism and anisometropia under 1.50 D, and corrected visual acuity over 20/20 were randomized to either the study group (MPDL) or control group (SVL). The myopia progression was evaluated by measuring axial length (AL) growth (IOL Master; Zeiss) over a period of one year. Results: Ninety-two subjects were recruited. Forty-six children were randomly assigned to the control group, and 46 to the study group. In total, 83 children completed the clinical trial, with a mean age of 10.81 [9.53–11.92] years, among which 59.04% were female. After one year of treatment, there was less AL elongation in the study group compared to the control group (0.16 ± 0.16 mm vs. 0.24 ± 0.16 mm, p = 0.034). Conclusions: The MPDL significantly reduced the absolute growth of AL by 39% (p = 0.014) and relative growth of AL by 37.3% (p = 0.012) after 12 months in comparison to the control group in a Spanish population

Analysis of burnt schist outcrops in the alps: Relation to historical archaeology and Hannibal's crossing in 218 B.C.

International audienceIdentification of the exact route followed by Hannibal during his invasion of Italia in the Second Punic War is one of the major questions of antiquity and one that historians/archaeologists have long studied. One of the many clues in the ancient literature that can help answer this question is the mention of fired rock, the result of a conflagration Hannibal is reputed to have employed to reduce the size of boulders in a blocking rockslide some distance down from the high col on the Italian side. The only route with evidence of fired rock along the roadway leading into Italia follows the Col du Clapier, one of the possible northern routes discussed by historians. Radiocarbon dating of calcined rocks is not possible, but whereas Time-of-Flight Secondary Ion Mass Spectrometry (ToF-SIMS), Field Emission Scanning Electron Microscope (FESEM-EDS), backscatter electron scanning microscopy (BSE), High Resolution Transmission Electron Microscope (HRTEM), and Raman Spectroscopic data do not provide an age for the burnt rock, compositional evidence of the conflagration derived from these analyses may shed light on Hannibal's actual route