Tidal and Subtidal Processes at the Mouth of a Macrotidal Estuary

Secondary flows and mixing have been shown to influence sediment transport, the vertical salinity gradient, and the exchange flow in estuaries. Typically, these hydrodynamic properties are investigated with respect to time and depth and their variability across the estuary is neglected. However, recent studies have shown that secondary flows and mixing, along with mechanisms that influence them, can exhibit lateral variability. Additionally, the variability of these hydrodynamic properties has not been studied in macrotidal estuaries, where the increased tidal forcing could affect the strength and cross channel variability. There are two primary objectives of this thesis. The first objective is to investigate the cross sectional and temporal variations in forcing mechanisms of secondary flows and analyze their impact on the observed flow structure. The second is to investigate the cross sectional and temporal variations in mixing and to link the observed patterns to variations in influencing mechanisms of mixing, such as density and vertical shear. To address these research objectives, in-situ collected data and numerical modeling techniques were utilized. Data include horizontal current velocities and TKE dissipation, which were complemented by salinity provided by the numerical model. These data were collected in the Gironde estuary located in southwestern France, a partially mixed macrotidal estuary. The results indicate that the forcing mechanisms of secondary flows vary intratidally, with the baroclinic pressure gradient forcing a circulation pattern during flood tide and the combination of Coriolis and curvature driving an opposing circulation pattern during ebb tide. The magnitude of the forcing mechanisms vary across the estuary, and this variation is attributed to lateral variations in axial flows and density. Additionally, mixing, quantified through the vertical eddy viscosity, was found to vary across the estuary and exhibited an asymmetric pattern over flood and ebb tides. The lateral variation in mixing was attributed to the lateral asymmetry in peak axial flows, and the tidal asymmetry in mixing was attributed to temporal variations in TKE dissipation, shear, and axial flows. Observed magnitudes of mixing were found to be less than previous studies which was the result of a low dissipation to production ratio, instigated by elevated squared vertical shear. These results imply that lateral variations in hydrodynamics of a macrotidal estuary with complex bathymetric and topographic features cannot be ignored. The sensitivity to bathymetry and topography suggests that changes in channel geometry could alter internal dynamics and have a wide spread effect on sediment transport and exchange flow

Site investigation techniques for DNAPL source and plume zone characterisation

Establishing the location of the Source Area BioREmediation (SABRE) research cell was a primary objective of the site characterisation programme. This bulletin describes the development of a two-stage site characterisation methodology that combined qualitative and quantitative data to guide and inform an assessment of dense nonaqueous phase liquid (DNAPL) distribution at the site. DNAPL site characterisation has traditionally involved multiple phases of site investigation, characterised by rigid sampling and analysis programmes, expensive mobilisations and long decision-making timeframes (Crumbling, 2001a) , resulting in site investigations that are costly and long in duration. Here we follow the principles of an innovative framework, termed Triad (Crumbling, 2001a, 2001b; Crumbling et al., 2001, Crumbling et al. 2003), which describes a systematic approach for the characterisation and remediation of contaminated sites. The Triad approach to site characterisation focuses on three main components: a) systematic planning which is implemented with a preliminary conceptual site model from existing data. The desired outcomes are planned and decision uncertainties are evaluated; b) dynamic work strategies that focus on the need for flexibility as site characterisation progresses so that new information can guide the investigation in real-time and c) real-time measurement technologies that are critical in making dynamic work strategies possible. Key to this approach is the selection of suitable measurement technologies, of which there are two main categories (Crumbling et al., 2003). The first category provides qualitative, dense spatial data, often with detection limits over a preset value. These methods are generally of lower cost, produce real-time data and are primarily used to identify site areas that require further investigation. Examples of such "decisionquality" methods are laser induced fluorescence (Kram et al., 2001), membrane interface probing (McAndrews et al., 2003) and cone penetrometer testing (Robertson, 1990), all of which produce data in continuous vertical profiles. Because these methods are rapid, many profiles can be generated and hence the subsurface data density is greatly improved. These qualitative results are used to guide the sampling strategy for the application of the second category of technologies that generate quantitative, precise data that have low detection limits and are analyte-specific. These methods tend to be high cost with long turnaround times that preclude on-site decision making, hence applying them to quantify rather than produce a conceptual model facilitates a key cost saving. Examples include instrumental laboratory analyses such as soil solvent extractions (Parker et al., 2004)and water analyses (USEPA, 1996). Where these two categories of measurement technologies are used in tandem, a more complete and accurate dataset is achieved without additional site mobilisations. The aim of the site characterisation programme at the SABRE site was to delineate the DNAPL source zone rapidly and identify a location for the in situ research cell. The site characterisation objectives were to; a) test whether semi-quantitative measurement techniques could reliably determine geological interfaces, contaminant mass distribution and inform the initial site conceptual model; and b) quantitatively determine DNAPL source zone distribution, guided by the qualitative site conceptual model

The Influence of Adjacent Forest and Agriculture on Restored Grassland Diversity and Composition

Little native grassland remains in North America due to land-use changes. Conversion to agriculture is a common means of loss. This fragmentation creates edges in the landscape and associated edge effects. Grassland plant communities are susceptible to edge effects, directly via dispersal and indirectly through environment. This study took place in Norfolk County, Ontario, Canada, in a landscape of agriculture, forest, rural development, and patches of grassland restored by Nature Conservancy Canada. I examined restored grassland edges bordering forest and crops. An intensive study at a single site identified spatial and soil environmental influences on plant diversity and composition. I also sampled vegetation at six replicate restored grassland sites bordering both forest and crops to find patterns. Environment and space explained plant composition, but plant traits did not. Site attributes can likely explain edge effects case by case. Distinguishing between site and temporal effects will be important for future studies

Coagulation and coagulation signalling in fibrosis

AbstractFollowing tissue injury, a complex and coordinated wound healing response comprising coagulation, inflammation, fibroproliferation and tissue remodelling has evolved to nullify the impact of the original insult and reinstate the normal physiological function of the affected organ. Tissue fibrosis is thought to result from a dysregulated wound healing response as a result of continual local injury or impaired control mechanisms. Although the initial insult is highly variable for different organs, in most cases, uncontrolled or sustained activation of mesenchymal cells into highly synthetic myofibroblasts leads to the excessive deposition of extracellular matrix proteins and eventually loss of tissue function. Coagulation was originally thought to be an acute and transient response to tissue injury, responsible primarily for promoting haemostasis by initiating the formation of fibrin plugs to enmesh activated platelets within the walls of damaged blood vessels. However, the last 20years has seen a major re-evaluation of the role of the coagulation cascade following tissue injury and there is now mounting evidence that coagulation plays a critical role in orchestrating subsequent inflammatory and fibroproliferative responses during normal wound healing, as well as in a range of pathological contexts across all major organ systems. This review summarises our current understanding of the role of coagulation and coagulation initiated signalling in the response to tissue injury, as well as the contribution of uncontrolled coagulation to fibrosis of the lung, liver, kidney and heart. This article is part of a Special Issue entitled: Fibrosis: Translation of basic research to human disease

Proactive motor control reduces monetary risk taking in gambling.

This is a postprint of an article published in Psychological Science © 2012 copyright SAGE Publications. Psychological Science is available online at: http://pss.sagepub.com/content/by/yearLess supervision by the executive system after disruption of the right prefrontal cortex leads to increased risk taking in gambling because superficially attractive-but risky-choices are not suppressed. Similarly, people might gamble more in multitask situations than in single-task situations because concurrent executive processes usually interfere with each other. In the study reported here, we used a novel monetary decision-making paradigm to investigate whether multitasking could reduce rather than increase risk taking in gambling. We found that performing a task that induced cautious motor responding reduced gambling in a multitask situation (Experiment 1). We then found that a short period of inhibitory training lessened risk taking in gambling at least 2 hr later (Experiments 2 and 3). Our findings indicate that proactive motor control strongly affects monetary risk taking in gambling. The link between control systems at different cognitive levels might be exploited to develop new methods for rehabilitation of addiction and impulse-control disorders

The Process and Impact of Professional Collaboration in an Arts Integration Education

In the fall of 20 14, I began student teaching at Wallace School of Integrated Arts in Kokomo, Indiana. Under the guidance of my cooperating teacher, Lashaya Williams, and our co-teacher, Abigail McClure, I was given the chance to educate fifth grade students and further develop my personal understanding of authentic arts integration (AAI), which is defined by the Kennedy Center as follows: Arts Integration is an approach to teaching in which students construct and demonstrate understanding through an art form. Students engage in a creative process which connects an art form and another subject area and meets evolving objectives in both. The thesis topic I have selected was born from my desire to connect my experiences in the teaching profession with my background in theatre arts. It was my hope that, in using my past theatrical experiences as a source of inspiration, my instruction would ultimately support both my students\u27 education as well as the nature of AAI. In today\u27s elementary schools, it is not uncommon for teaching artists or traveling acting troupes to visit a school and perform for the students. During these shows, the typical expectation for the children is to simply observe as the actors do all of the work. While there are many aspects to be admired about the quick show-and-go mentality of these programs= such as the exposure to live artistic works and connection to real-world professionals--, I could not help but ponder the numerous possibilities one could encounter by going beyond the normal audience see, actor do mentality and allow for audience-actor interaction. Or, taking it a step further, what could be the result of students and professional actors collaborating together to create and perform a content-based theatrical piece? Pulling from my personal experiences in theatre, I decided to investigate these inquiries in the fall of my student teaching by establishing a partnership between my fifth grade students and the actors of the Butler University Theatre Department. It was my belief that these two entities could learn a great deal from one another, and I felt as though valuable research could be obtained from their collaboration as they created a work of theatre based on academic content and enriched with professional theatre practices. Thus, I propose the following thesis question: What is the process and impact of having professional actors and fifth graders create and perform a content-rich theatrical piece

Training response inhibition to reduce food consumption: Mechanisms, stimulus specificity and appropriate training protocols

Training individuals to inhibit their responses towards unhealthy foods has been shown to reduce food intake relative to a control group. Here we aimed to further explore these effects by investigating the role of stimulus devaluation, training protocol, and choice of control group. Restrained eaters received either inhibition or control training using a modified version of either the stop-signal or go/no-go task. Following training we measured implicit attitudes towards food (Study 1) and food consumption (Studies 1 and 2). In Study 1 we used a modified stop-signal training task with increased demands on top-down control (using a tracking procedure and feedback to maintain competition between the stop and go processes). With this task, we found no evidence for an effect of training on implicit attitudes or food consumption, with Bayesian inferential analyses revealing substantial evidence for the null hypothesis. In Study 2 we removed the feedback in the stop-signal training to increase the rate of successful inhibition and revealed a significant effect of both stop-signal and go/no-go training on food intake (compared to double-response and go training, respectively) with a greater difference in consumption in the go/no-go task, compared with the stop-signal task. However, results from an additional passive control group suggest that training effects could be partly caused by increased consumption in the go control group whereas evidence for reduced consumption in the inhibition groups was inconclusive. Our findings therefore support evidence that inhibition training tasks with higher rates of inhibition accuracy are more effective, but prompt caution for interpreting the efficacy of laboratory-based inhibition training as an intervention for behaviour change

The adverse childhood experiences questionnaire: Two decades of research on childhood trauma as a primary cause of adult mental illness, addiction, and medical diseases

Objective. In 1998, Felitti and colleagues published the first study of the Adverse Childhood Experiences-Questionnaire (ACE-Q), a 10-item scale used to correlate childhood maltreatment and adverse rearing contexts with adult health outcomes. This paper qualitatively reviews nearly two decades of research utilizing the ACE-Q, highlighting its contribution to our understanding of the causal roots of common, interlinked comorbidities of the brain and body.Methods. An OVID/PubMed search was conducted for English language articles published before 2016, containing the phrase “Adverse Childhood Experiences” in which the ACE-Q was utilized. Source review included a manual search of bibliographies, resulting in 134 articles, including 44 based on the original ACE-Q study population.Results. ACE-Q research has demonstrated that exposures to adverse childhood experiences converge dose-dependently to potently increase the risk for a wide array of causally interlinked mental illnesses, addictions, and multi-organ medical diseases. The intergenerational transmission of this disease burden via disrupted parenting and insecure rearing contexts is apparent throughout this literature. However, the ACE-Q does not tease out genetic or fetal drug exposure components of this transmission.Conclusions. Adverse childhood experiences and rearing may generate a public health burden that could rival or exceed all other root causes. Translating this information to health-care reform will require strengthening brain-behavioral health as core public and preventative health-care missions. Greater integration of mental health and addiction services for parents should be accompanied by more research into brain mechanisms impacted by different forms and interactions between adverse childhood experiences