Analysis of Automotive Cyber-Attacks on Highways using Partial Differential Equation Models

This is the author accepted manuscript.This paper considers scenarios wherein a group of malicious vehicles on a highway perform a cooperative attack with the motive of creating undesirable wave effects among other vehicles on the highway. The two species of vehicles - malicious vehicles and normal vehicles, and their associated interaction effects, are modeled using Partial Differential Equations (PDEs). The malicious vehicles, which may be arbitrarily distributed on the highway, perform a sequence of velocity changes with the objective of making the density/velocity profile on the highway, track a reference profile. This reference profile (chosen by the malicious vehicles) has the property that once generated, it spontaneously evolves into a shock wave that propagates along the highway. Analytical expressions governing the velocity inputs of the malicious vehicles with which they can generate such waves are determined, for perfect as well as imperfect information scenarios. Simulation results are presented to validate the theoryThe first two authors would like to acknowledge support from the National Science Foundation. This material is based upon work supported by the National Science Foundation under Grant IIS-1351677

Adapting Stream Processing Framework for Video Analysis

AbstractStream processing (SP) became relevant mainly due to inexpensive and hence ubiquitous deployment of sensors in many domains (e.g., environmental monitoring, battle field monitoring). Other continuous data generators (surveillance, traffic data) have also prompted processing and analysis of these streams for applications such as traffic congestion/accidents and personalized marketing. Image processing has been researched for several decades. Recently there is emphasis on video stream analysis for situation monitoring due to the ubiquitous deployment of video cameras and unmanned aerial vehicles for security and other applications.This paper elaborates on the research and development issues that need to be addressed for extending the traditional stream processing framework for video analysis, especially for situation awareness. This entails extensions to: data model, operators and language for expressing complex situations, QoS (Quality of service) specifications and algorithms needed for their satisfaction. Specifically, this paper demonstrates inadequacy of current data representation (e.g., relation and arrable) and querying capabilities to infer long-term research and development issues

Management of Thrips, Scirtothrips dorsalis Hood, on Rose under Open-Field and Protected Conditions

Investigation on management of thrips, Scirtothrips dorsalis Hood on roses under open-field and protected conditions was conducted during 2008-10 at Bengaluru. Clothianidin 50 WDG 20g a.i./ha proved best in terms of efficacy and cost. Vertimac, spinosad and Garlic Barrier agriculture (GB Ag ) were comparable in efficacy. GB Ag was on par with clothianidin besides being eco-friendly. GB Ag was found effective as a new molecule. Neem seed kernel extract (NSKE) proved to be superior to neem oil, pongamia oil and the commercial neem product, Nimbecidine. NSKE was also found to reduce thrips density to the extent of 64% - 88%. In rose fields where pest suppression measures are hardly practised, farmers can apply NSKE, monocrotophos or imidacloprid. Based on the cost of vertimac and spinosad, these can be recommended where cost-effective, as in commercial polyhouses growing roses

Consistent Anisotropic Repulsions for Simple Molecules

We extract atom-atom potentials from the effective spherical potentials that suc cessfully model Hugoniot experiments on molecular fluids, e.g., $O_2$ and $N_2$. In the case of $O_2$ the resulting potentials compare very well with the atom-atom potentials used in studies of solid-state propertie s, while for $N_2$ they are considerably softer at short distances. Ground state (T=0K) and room temperatu re calculations performed with the new $N-N$ potential resolve the previous discrepancy between experimental and theoretical results.Comment: RevTeX, 5 figure

Motor symptoms in Parkinson's disease: A unified framework

Parkinson’s disease (PD) is characterized by a range of motor symptoms. Besides the cardinal symptoms (akinesia and bradykinesia, tremor and rigidity), PD patients show additional motor deficits, including: gait disturbance, impaired handwriting, grip force and speech deficits, among others. Some of these motor symptoms (e.g., deficits of gait, speech, and handwriting) have similar clinical profiles, neural substrates, and respond similarly to dopaminergic medication and deep brain stimulation (DBS). Here, we provide an extensive review of the clinical characteristics and neural substrates of each of these motor symptoms, to highlight precisely how PD and its medical and surgical treatments impact motor symptoms. In conclusion, we offer a unified framework for understanding the range of motor symptoms in PD. We argue that various motor symptoms in PD reflect dysfunction of neural structures responsible for action selection, motor sequencing, and coordination and execution of movement

Molecular analysis of autosomal dominant hereditary ataxias in the Indian population: high frequency of SCA2 and evidence for a common founder mutation

Expansion of CTG/CAG trinucleotide repeats has been shown to cause a number of autosomal dominant cerebellar ataxias (ADCA) such as SCA1, SCA2, SCA3/MJD, SCA6, SCA7, SCA8 and DRPLA. There is a wide variation in the clinical phenotype and prevalence of these ataxias in different populations. An analysis of ataxias in 42 Indian families indicates that SCA2 is the most frequent amongst all the ADCAs we have studied. In the SCA2 families, together with an intergenerational increase in repeat size, a horizontal increase with the birth order of the offspring was also observed, indicating an important role for parental age in repeat instability. This was strengthened by the detection of a pair of dizygotic twins with expanded alleles showing the same repeat number. Haplotype analysis indicates the presence of a common founder chromosome for the expanded allele in the Indian population. Polymorphism of CAG repeats in 135 normal individuals at the SCA loci studied showed similarity to the Caucasian population but was significantly different from the Japanese population

Heat release rate estimation in laminar premixed flames using laser-induced fluorescence of CH2O and H-atom

The present work demonstrates the feasibility of heat release rate imaging using the laser-induced fluorescence (LIF) of atomic hydrogen (H-atom) and formaldehyde (CH2O) in laminar premixed flames. The product of H-atom LIF and CH2O LIF signals is evaluated on a pixel-by-pixel basis and is compared with that of the OH × CH2O technique. These results for equivalence ratio ranging from 0.8 to 1.1 are compared with computations of one-dimensional freely-propagating flames. The performance of these markers is studied based on the following two aspects: the spatial accuracy of the local heat release rate and the trend in the total heat release rate with equivalence ratio. The measured trend in the spatial distribution of radicals and the deduced heat release rate agree well with the computational values. The variation in the spatially integrated heat release rate as a function of equivalence ratio is also investigated. The results suggest that the trend in the variation of the integrated heat release rate and the spatial location of heat release rate can be evaluated by either of these markers. The OH-based marker showed certain sensitivity to the chemical mechanism as compared to the H-atom based marker. Both the OH-based and H-atom based techniques provide close estimates of heat release rate. The OH based technique has practical advantage when compared to the H-atom based method, primarily due to the fact that the H-atom LIF is a two-photon process

Pan-cancer deconvolution of cellular composition identifies molecular correlates of antitumour immunity and checkpoint blockade response

The nature and extent of immune cell infiltration into solid tumours are key determinants of therapeutic response. Here, using a novel DNA methylation-based approach to tumour cell fraction deconvolution, we report the integrated analysis of tumour composition and genomics across a wide spectrum of solid cancers. Initially studying head and neck squamous cell carcinoma, we identify two distinct tumour subgroups: ‘immune hot’ and ‘immune cold’, which display differing prognosis, mutation burden, cytokine signalling, cytolytic activity, and oncogenic driver events. We demonstrate the existence of such tumour subgroups pan-cancer, link clonal-neoantigen burden to hot tumours, and show that transcriptional signatures of hot tumours are selectively engaged in immunotherapy responders. We also find that treatment-naive hot tumours are markedly enriched for known immune-resistance genomic alterations and define a catalogue of novel and known mediators of active antitumour immunity, deriving biomarkers and potential targets for precision immunotherapy

Answering SPARQL queries over databases under OWL 2 QL entailment regime

We present an extension of the ontology-based data access platform Ontop that supports answering SPARQL queries under the OWL 2 QL direct semantics entailment regime for data instances stored in relational databases. On the theoretical side, we show how any input SPARQL query, OWL 2 QL ontology and R2RML mappings can be rewritten to an equivalent SQL query solely over the data. On the practical side, we present initial experimental results demonstrating that by applying the Ontop technologies—the tree-witness query rewriting, T-mappings compiling R2RML mappings with ontology hierarchies, and T-mapping optimisations using SQL expressivity and database integrity constraints—the system produces scalable SQL queries

1H-Indole-3-carbaldehyde

In the title compound, C9H7NO, the benzene ring forms a dihedral angle of 3.98 (12)° with the pyrrole ring. In the crystal, N–H⋯O hydrogen bonds links the mol­ecules into chains which run parallel to [02-1]