236 research outputs found
Theoretical constraints on masses of heavy particles in Left-Right Symmetric Models
Left-Right symmetric models with general gauge couplings which
include bidoublet and triplet scalar multiplets are studied. Possible scalar
mass spectra are outlined by imposing Tree-Unitarity, and Vacuum Stability
criteria and also using the bounds on neutral scalar masses
which assure the absence of Flavour Changing Neutral Currents (FCNC). We are
focusing on mass spectra relevant for the LHC analysis, i.e., the scalar masses
are around TeV scale. As all non-standard heavy particle masses are related to
the vacuum expectation value (VEV) of the right-handed triplet (), the
combined effects of relevant Higgs potential parameters and
regulate the lower limits of heavy gauge boson masses. The complete set of
Renormalization Group Evolutions for all couplings are provided at the 1-loop
level, including the mixing effects in the Yukawa sector. Most of the scalar
couplings suffer from the Landau poles at the intermediate scale GeV, which in general coincides with violation of the Tree-Unitarity
bounds.Comment: 9 pages, 5 figures, pdflatex, Matches published versio
Resonant Leptogenesis with nonholomorphic R-Parity violation and LHC Phenomenology
In R-parity violating supersymmetric models both leptogenesis and the correct
neutrino masses are hard to achieve together. The presence of certain soft
nonholomorphic R-parity violating terms helps to resolve this problem. We
consider a scenario where the lightest and the second-lightest neutralino are
nearly degenerate in mass and enough CP-asymmetry can be produced through
resonant leptogenesis. In this model, the lighter chargino and the lightest
neutralino are highly degenerate. We have relatively lighter gauginos which can
be produced at the LHC leading to heavily ionizing charged tracks. At the same
time this model can also generate the correct neutrino mass scale. Thus our
scenario is phenomenologically rich and testable at colliders.Comment: 17 pages, 7 figures, Numerical results are improved and new plots are
added, Journal version. arXiv admin note: text overlap with
arXiv:hep-ph/0006173 by other author
Extracellular vesicle-mediated transfer of processed and functional RNY5 RNA
Extracellular vesicles (EVs) have been proposed as a means to promote intercellular communication. We show that when human primary cells are exposed to cancer cell EVs, rapid cell death of the primary cells is observed, while cancer cells treated with primary or cancer cell EVs do not display this response. The active agents that trigger cell death are 29- to 31-nucleotide (nt) or 22- to 23-nt processed fragments of an 83-nt primary transcript of the human RNY5 gene that are highly likely to be formed within the EVs. Primary cells treated with either cancer cell EVs, deproteinized total RNA from either primary or cancer cell EVs, or synthetic versions of 31- and 23-nt fragments trigger rapid cell death in a dose-dependent manner. The transfer of processed RNY5 fragments through EVs may reflect a novel strategy used by cancer cells toward the establishment of a favorable microenvironment for their proliferation and invasion
Back reaction effects on the dynamics of heavy probes in heavy quark cloud
We holographically study the effect of back reaction on the hydrodynamical
properties of strongly coupled super Yang-Mills (SYM) thermal
plasma. The back reaction we consider arises from the presence of static heavy
quarks uniformly distributed over SYM plasma. In order to
study the hydrodynamical properties, we use heavy quark as well as heavy
quark-antiquark bound state as probes and compute the jet quenching parameter,
screening length and binding energy. We also consider the rotational dynamics
of heavy probe quark in the back-reacted plasma and analyse associated energy
loss. We observe that the presence of back reaction enhances the energy-loss in
the thermal plasma. Finally, we show that there is no effect of angular drag on
the rotational motion of quark-antiquark bound state probing the back reacted
thermal plasma.Comment: 29 pages, 21 figure
Patchy Amphiphilic Dendrimers Bind Adenovirus and Control Its Host Interactions and in Vivo Distribution
The surface of proteins is heterogeneous with sophisticated but precise hydrophobic and hydrophilic patches, which is essential for their diverse biological functions. To emulate such distinct surface patterns on macromolecules, we used rigid spherical synthetic dendrimers (polyphenylene dendrimers) to provide controlled amphiphilic surface patches with molecular precision. We identified an,. I optimal spatial arrangement of these patches on certain dendrimers that enabled their interaction with human adenovirus 5 (Ads). Patchy dendrimers bound to the surface of Ads formed a synthetic polymer corona that greatly altered various host interactions of Ads as well as in vivo distribution. The dendrimer corona (1) improved the ability of Ad5-derived gene transfer vectors to transduce cells deficient for the primary Ad5 cell membrane receptor and (2) modulated the binding of Ads to blood coagulation factor X, one of the most critical virus host interactions in the bloodstream. It significantly enhanced the transduction efficiency of Ad5 while also protecting it from neutralization by natural antibodies and the complement system in human whole blood. Ads with a synthetic dendrimer corona revealed profoundly altered in vivo distribution, improved transduction of heart, and dampened vector sequestration by liver and spleen. We propose the design of bioactive polymers that bind protein surfaces solely based on their amphiphilic surface patches and protect against a naturally occurring protein corona, which is highly attractive to improve Ad5-based in vivo gene therapy applications
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