71 research outputs found

    COMMAND VOICES AND AGGRESSION IN A LEBANESE SAMPLE PATIENTS WITH SCHIZOPHRENIA

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    Background: The impact of command voices (CV) on violent behaviors in patients with schizophrenia remains unclear. The literature has produced mixed results, with no research existing on CV and violence among the Lebanese population. The study objecttives were to (1) evaluate the association between voice beliefs, psychosis severity, treatment, demographic factors and command voices, and (2) evaluate the association between command voices and violence among patients with schizophrenia in Lebanon. Methods: A cross-sectional study, conducted between April and August 2019, enrolled 280 patients with schizophrenia. Results: The results showed that 111 (39.6%) patients with schizophrenia had auditory hallucinations, among whom 93 (83.8%) patients had command voices; from these 93 patients, 53 (57.0%) were compliant with voices. Higher positive (ORa=1.09) and general psychopathology (ORa=1.04) PANSS subscales scores were significantly associated with higher compliance to voices. A higher resistance to beliefs about voices (ORa=0.91) was significantly associated with lower compliance to voices. Conclusions: The prevalence of CV in patients with schizophrenia that report auditory hallucinations, was high in our sample. The vast majority of violent acts committed by patients was in compliance to CV, with a significantly high rate of the violence committed being directed towards property. Our findings were able to connect positive symptoms to higher probability of compliance to CV

    The association between fear of COVID-19 and depression, anxiety, and psychosis among Lebanese chronic patients with schizophrenia: any moderating effect of spirituality?

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    Aim To assess whether fear of coronavirus disease 2019 (COVID-19) is associated with depression, anxiety, and psychosis and to evaluate if these variables are correlated with the interaction between spirituality and fear of COVID-19. Methods Between September and November 2020, this cross-sectional study enrolled 118 chronic schizophrenia patients. The interview with patients included Fear of COVID-19 Scale, Lebanese Anxiety Scale-10, Montgomery-Asberg Depression Rating Scale, Positive and Negative Syndrome Scale (PANSS), and Functional Assessment of Chronic Illness Therapy-Spiritual Well-Being-12. The results were analyzed by using linear regressions (Enter method), with anxiety, depression, total PANSS score, positive PANSS, negative PANSS, and general psychopathology PANSS subscales as dependent variables. Spirituality, fear of COVID19, and the interaction of spirituality with fear of COVID-19 were independents variables. Results Fear of COVID-19 was positively correlated with increased total PANSS scores (Beta=0.90, P=0.030). Higher spirituality was significantly associated with lower anxiety (Beta=-0.14, P=0.009), lower depression (Beta=-0.21, P=0.001), lower total PANSS score (Beta=-0.90, P=0.004), lower negative PANSS score (Beta=-0.23, P=0.009), and lower general psychopathology PANSS score (Beta=-0.61, P=0.001). In patients with high fear of COVID-19, having low spirituality was significantly associated with higher anxiety, depression, and psychotic symptoms. Conclusion This study suggests a positive correlation between fear of COVID-19 and higher psychosis among inpatients with schizophrenia. The interaction of spirituality with fear of COVID-19 was correlated with reduced anxiety, depression, and psychosis

    Managing acutely aggressive or agitated people in a psychiatric setting: a survey in Lebanon

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    Background: Violent patients constitute 10% of all psychiatric admissions. Treatment options and clinical practice interventions vary across the globe and no survey of practice in a Middle Eastern setting exists. Surveying treatments in Lebanon will show treatment interventions used in this part of the world and, most importantly, provide the treatment options that could potentially be used for clinical trials pertaining to emergency psychiatry. Methods: A survey of clinicians’ opinions and practice was conducted between July and August 2017 at the largest psychiatric hospital in Lebanon. Results: Five of seven experienced psychiatrists provided opinions when interviewed of their preferred intervention when dealing with an emergency psychiatric episode. Whilst this varied in detail, there was a consistent view that there should first be verbal control, then use of medications, and finally physical restrain of the patient. A total of 39 emergency episodes (28 people) occurred in the one month (64% men in their 30s). Bipolar disorder was the most frequent single diagnosis behind the aggression (n=16, 41%; 12 people 43%) but the combined schizophrenia-like illnesses underlay 18 of the 39 episodes (46%; 13/28 people 46%). In clinical life, we found evidence of high family involvement, but little attempts made at initial verbal control in the hospital. All 39 episodes involved administration of pharmacological interventions. Medications were used in 29 of cases (74%) and non-medication interventions used in the remaining 10/39 (26%). Conclusion: This survey provides some evidence that clinicians’ preferences may not fully reflect clinical practice but also that experienced clinicians are using several clearly effective techniques to manage these very difficult situations. However, as for other parts of the world, treatment in Lebanon has limited or no underpinning by evidence from well-designed, conducted and reported evaluative studies

    CORRELATES OF SELF-ESTEEM AMONG THE LEBANESE POPULATION: A CROSS-SECTIONAL STUDY

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    Background: To the best of our knowledge, no studies have been conducted in order to assess the correlation of these factors with the self-esteem in Lebanon. Therefore, this study aims to assess risk factors associated with self- esteem among a representative sample of the Lebanese population. Subjects and methods: A cross-sectional, conducted between November 2017 and March 2018, enrolled 789 participants. Selfesteem was measured using the Rosenberg scale. An exploratory factor analysis was executed to detect patterns of risk factors associated with self-esteem from our sample. A cluster analysis was then performed with the identified factor scores to identify the different profiles of the participants. Results: Relationship management (Beta=0.117), emotional awareness(Beta=0.074) and personal accomplishment (Beta=0.064)were associated with a higher self-esteem, whereas high depression (Beta=-0.102), alexithymia (Beta=-0.077), burnout depersonalization(Beta=-0.078), suicidal ideation (Beta=-0.391) were associated with a lower self-esteem. Factor 1 (High emotional intelligence & low depersonalization) (Beta=1.819) was associated with increased self-esteem, whereas Factor 2 (High suicidal ideation, high alcohol dependence, high depression and anxiety) and Factor 3 (Highburnout, high stress and high alexithymia) were associated with decreased self-esteem (Beta=-1.380 and Beta=-0.751) respectively. Being widowed (Beta=-2.332), belonging to cluster 1 (People with emotional dysregulation) (Beta=-2.850) and cluster 2 (People in distress) (Beta=-3.660) were significantly associated with decreased self-esteem. Conclusions: Depression, anxiety, burnout, stress, low emotional intelligence, alexithymia, suicide ideation, alcohol dependence and many other factors can be prevented, or reduced, by interventions that improve self-esteem

    Using a pharmacist-led educational tool to teach elementary and middle-school students in Lebanon about microbes, antibiotic use and antimicrobial resistance: A pilot study

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    Background: Teaching school students about antibiotic use and antimicrobial resistance (AMR) can shape their future behaviour to become antibiotic guardians. This study aims to assess the impact of a pharmacist-led educational tool in boosting knowledge of these topics at elementary and middle school educational stages. Methods: A prospective web-based cross-sectional pre-post study was conducted in Lebanese private schools from April 2020 to December 2021. Results: The results showed that the pharmacist-led intervention increased the general knowledge (p = 0.01) and understanding of microbes (junior versus senior, p = 0.003 versus p = 0.004). In middle school, the spread of infection (p < 0.001) and the AMR concept (p = 0.001) significantly changed post-test, while antibiotics use and AMR concept remained unchanged in elementary students. Conclusion: The successful learning impact of the educational tool designed and led by pharmacists shows their importance as antibiotic experts in influencing early pedagogic learning about antibiotics and AMR starting at the middle-school stage.Scopu

    Study protocol for a randomised controlled trial of haloperidol plus promethazine plus chlorpromazine versus haloperidol plus promethazine for rapid tranquilisation for agitated psychiatric patients in the emergency setting (TREC-Lebanon)

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    Background: Agitated and aggressive behaviours are common in the psychiatric setting and rapid tranquilisation is sometimes unavoidable. A survey of Lebanese practice has shown that an intramuscular haloperidol, promethazine and chlorpromazine combination is a preferred form of treatment but there are no randomised trials of this triple therapy.Methods: This is a pragmatic randomised trial. Setting - the psychiatric wards of the Psychiatric Hospital of the Cross, Jal Eddib, Lebanon. Participants - any adult patient in the hospital who displays an aggressive episode for whom rapid tranquilisation is unavoidable, who has not been randomised before, for whom there are no known contraindications. Randomisation – stratified (by ward) randomisation and concealed in closed opaque envelope by independent parties. Procedure – if the clinical situation arises requiring rapid tranquilisation, medical residents overseeing the patient will open a TREC-Lebanon envelope in which will be notification of which group of treatments should be preferred [Haloperidol + Promethazine + Chlorpromazine (HPC) or Haloperidol + Promethazine (HP)], along with forms for primary, secondary and serious adverse effects. Treatment is not given blindly. Outcome - primary outcome is calm or tranquil at 20 minutes post intervention. Secondary outcomes are calm/tranquil at 40, 60 and 120 minutes post intervention, asleep, adverse effects, use of straitjacket and leaving the ward. Follow-up will be up to two weeks post randomisation.Discussion: Findings from this study will compare the HPC versus HP combination used in Lebanon’s psychiatry emergency routine practice.Trial registration: ClinicalTrials.gov NCT03639558. Registration date, August 21, 2018

    EVALUATION OF COGNITIVE FUNCTIONS AMONG LEBANESE PATIENTS WITH SCHIZOPHRENIA

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    International audienceSchizophrenia is a mental disorder characterized by disruptions in thought processes, perceptions, emotional responsiveness, and social interaction

    Evaluations des fonctions cognitives chez les patients schizophrènes au Liban

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    Cognitive deficits is a fundamental characteristic of schizophrenia where the most affected function are particularly memory, attention, motor skills, executive functions and social cognition. Cognitive assessment is one of the best indicators of the functional and social prognosis of individuals. This assessment becomes a fundamental part in clinical practice and in research using batteries that differ widely in their content. In addition, subjective assessment of cognitive functions can give a more complete view of an individual's cognitive profile, but it cannot replace objective assessment measures, as patients' self-assessment of their neurocognitive functioning may not be entirely correct. Subjective cognitive complaints is recognized as indicators of potential cognitive dysfunction, with evidence suggesting that such complaints are a precursor to cognitive impairment. Thus, it is essential to understand and assess patients' awareness of their cognitive state.The thesis work presented here has several objectives. First, we deal with generalities concerning schizophrenia, impaired cognitive functions and their evaluations while also giving an overview of their evaluation in Lebanon. Secondly, in order to be able to assess cognitive functions in institutionalized schizophrenic patients, we worked at validating diagnostic and screening tools for cognitive disorders in schizophrenic subjects. Finally, we assess the subjective cognitive complaints in schizophrenic patients and the factors related to them. The results of this work led to the validation of the cognitive battery, BACS, in schizophrenic patients. The Arabic BACS is a reliable and useful tool for measuring cognitive performance in hospitalized patients with schizophrenia. In addition, the satisfactory psychometric qualities of MoCA make it a rapid screening tool for the cognitive functions of these patients. In addition, our results showed that patients with objective cognitive impairment could be aware of their cognitive impairment despite low disease awareness (insight). The most contributing factors of the subjective cognitive complaint were the general psychopathology subscale of the PANSS, the autonomy scale of the daily living scale (ADL) while those predictive of social cognitive complaint were the Depression Scale (Calgary).All of our work has demonstrated adequate psychometric properties of a neurocognitive battery, BACS and a screening tool, MOCA in Arabic, respectively in the diagnosis and screening of cognitive deficits in schizophrenic patients. Our studies could help clinicians apply these valid instruments in their daily clinical practice and include cognitive rehabilitation strategies in the treatment plan for patients with schizophrenia; which is currently lacking in the countries of the Middle East. Finally, our studies have shown that schizophrenic patients complain about their cognition. Further prospective studies are needed to better understand cognitive impairment in schizophrenic patients in order to help remedy it and thus allow better day-to-day functioning and life outside psychiatric institutions.Les déficits cognitifs sont perçus comme une caractéristique fondamentale de la schizophrénie. Les fonctions cognitives les plus affectées sont particulièrement la mémoire, l'attention, la motricité, les fonctions exécutives et la cognition sociale. L’évaluation cognitive est l’un des meilleurs indicateurs du pronostic fonctionnel et social des individus. Cette évaluation devient une partie fondamentale dans la pratique clinique et dans la recherche et utilise des batteries qui diffèrent largement dans leurs contenus. En plus, l'évaluation subjective des fonctions cognitives peut donner une vue plus complète du profil cognitif d'un individu, mais elle ne peut pas remplacer les mesures d'évaluation objectives, car l'autoévaluation par les patients de leur fonctionnement neurocognitif peut ne pas être tout à fait exacte. Les plaintes cognitives subjectives sont de plus en plus largement reconnues comme des indicateurs de dysfonctionnement cognitif potentiel, avec des preuves suggérant que de telles plaintes sont un précurseur de troubles cognitifs. Ainsi, il est essentiel de comprendre et d'évaluer la conscience qu’ont les patients de leur état cognitif.Le travail de thèse présenté ici à plusieurs objectifs. Dans un premier temps, nous traitons des généralités concernant la schizophrénie, les fonctions cognitives altérées et leurs évaluations en faisant par ailleurs un état des lieux de leur évaluation au Liban. Dans un deuxième temps, afin de pouvoir évaluer les fonctions cognitives chez des patients schizophrènes institutionnalisés, nous exposons nos travaux de validation d’outils de diagnostic et de dépistage des troubles cognitifs chez les sujets schizophrènes. Dans un dernier temps, nous exposons notre étude des plaintes cognitives subjective chez les patients schizophrènes et les facteurs reliés à celles-ci.Les résultats de ce travail ont abouti à la validation en langue arabe d’une batterie cognitive, le BACS chez des patients schizophrènes. Le BACS arabe est un outil fiable et utile pour mesurer les performances cognitives chez les patients hospitalisés atteints de schizophrénie. De plus, les qualités psychométriques satisfaisantes du MoCA en font un outil de dépistage rapide des fonctions cognitives de ces patients. En outre, nos résultats ont montré que les patients ayant un déficit cognitif objectif pouvaient être conscients de leur déficit cognitif malgré une conscience de la maladie (insight) faible. Les facteurs les plus contributifs de la plainte cognitive subjective étaient la sous-échelle de psychopathologie générale de la PANSS, l’échelle d’autonomie dans les actes de la vie quotidienne (ADL) alors que celles prédictives plus spécifiquement de la plainte dans le domaine de la cognition sociale étaient l’échelle de dépression (Calgary).L’ensemble de nos travaux a démontré des propriétés psychométriques adéquates d’une batterie neurocognitive, le BACS et d’un outil de dépistage, le MOCA en langue Arabe, respectivement dans le diagnostic et le dépistage des déficits cognitifs chez les patients schizophrènes. Nos études pourraient aider les cliniciens à appliquer ces instruments valides dans leur pratique clinique quotidienne et à inclure des stratégies de réadaptation cognitive dans le plan de traitement des patients atteints de schizophrénie ; ce qui fait défaut à l’heure actuelle dans les pays du Moyen Orient. Enfin, nos études ont montré que les patients schizophrènes se plaignent de leur cognition. D'autres études prospectives sont nécessaires pour mieux comprendre les atteintes cognitives chez les patients schizophrènes afin d'aider à y remédier et permettre ainsi un meilleur fonctionnement au quotidien et une vie hors des institutions psychiatriques

    Evaluation of cognitive functions among Lebanese patients with schizophrenia

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    Les déficits cognitifs sont perçus comme une caractéristique fondamentale de la schizophrénie. Les fonctions cognitives les plus affectées sont particulièrement la mémoire, l'attention, la motricité, les fonctions exécutives et la cognition sociale. L’évaluation cognitive est l’un des meilleurs indicateurs du pronostic fonctionnel et social des individus. Cette évaluation devient une partie fondamentale dans la pratique clinique et dans la recherche et utilise des batteries qui diffèrent largement dans leurs contenus. En plus, l'évaluation subjective des fonctions cognitives peut donner une vue plus complète du profil cognitif d'un individu, mais elle ne peut pas remplacer les mesures d'évaluation objectives, car l'autoévaluation par les patients de leur fonctionnement neurocognitif peut ne pas être tout à fait exacte. Les plaintes cognitives subjectives sont de plus en plus largement reconnues comme des indicateurs de dysfonctionnement cognitif potentiel, avec des preuves suggérant que de telles plaintes sont un précurseur de troubles cognitifs. Ainsi, il est essentiel de comprendre et d'évaluer la conscience qu’ont les patients de leur état cognitif.Le travail de thèse présenté ici à plusieurs objectifs. Dans un premier temps, nous traitons des généralités concernant la schizophrénie, les fonctions cognitives altérées et leurs évaluations en faisant par ailleurs un état des lieux de leur évaluation au Liban. Dans un deuxième temps, afin de pouvoir évaluer les fonctions cognitives chez des patients schizophrènes institutionnalisés, nous exposons nos travaux de validation d’outils de diagnostic et de dépistage des troubles cognitifs chez les sujets schizophrènes. Dans un dernier temps, nous exposons notre étude des plaintes cognitives subjective chez les patients schizophrènes et les facteurs reliés à celles-ci.Les résultats de ce travail ont abouti à la validation en langue arabe d’une batterie cognitive, le BACS chez des patients schizophrènes. Le BACS arabe est un outil fiable et utile pour mesurer les performances cognitives chez les patients hospitalisés atteints de schizophrénie. De plus, les qualités psychométriques satisfaisantes du MoCA en font un outil de dépistage rapide des fonctions cognitives de ces patients. En outre, nos résultats ont montré que les patients ayant un déficit cognitif objectif pouvaient être conscients de leur déficit cognitif malgré une conscience de la maladie (insight) faible. Les facteurs les plus contributifs de la plainte cognitive subjective étaient la sous-échelle de psychopathologie générale de la PANSS, l’échelle d’autonomie dans les actes de la vie quotidienne (ADL) alors que celles prédictives plus spécifiquement de la plainte dans le domaine de la cognition sociale étaient l’échelle de dépression (Calgary).L’ensemble de nos travaux a démontré des propriétés psychométriques adéquates d’une batterie neurocognitive, le BACS et d’un outil de dépistage, le MOCA en langue Arabe, respectivement dans le diagnostic et le dépistage des déficits cognitifs chez les patients schizophrènes. Nos études pourraient aider les cliniciens à appliquer ces instruments valides dans leur pratique clinique quotidienne et à inclure des stratégies de réadaptation cognitive dans le plan de traitement des patients atteints de schizophrénie ; ce qui fait défaut à l’heure actuelle dans les pays du Moyen Orient. Enfin, nos études ont montré que les patients schizophrènes se plaignent de leur cognition. D'autres études prospectives sont nécessaires pour mieux comprendre les atteintes cognitives chez les patients schizophrènes afin d'aider à y remédier et permettre ainsi un meilleur fonctionnement au quotidien et une vie hors des institutions psychiatriques.Cognitive deficits is a fundamental characteristic of schizophrenia where the most affected function are particularly memory, attention, motor skills, executive functions and social cognition. Cognitive assessment is one of the best indicators of the functional and social prognosis of individuals. This assessment becomes a fundamental part in clinical practice and in research using batteries that differ widely in their content. In addition, subjective assessment of cognitive functions can give a more complete view of an individual's cognitive profile, but it cannot replace objective assessment measures, as patients' self-assessment of their neurocognitive functioning may not be entirely correct. Subjective cognitive complaints is recognized as indicators of potential cognitive dysfunction, with evidence suggesting that such complaints are a precursor to cognitive impairment. Thus, it is essential to understand and assess patients' awareness of their cognitive state.The thesis work presented here has several objectives. First, we deal with generalities concerning schizophrenia, impaired cognitive functions and their evaluations while also giving an overview of their evaluation in Lebanon. Secondly, in order to be able to assess cognitive functions in institutionalized schizophrenic patients, we worked at validating diagnostic and screening tools for cognitive disorders in schizophrenic subjects. Finally, we assess the subjective cognitive complaints in schizophrenic patients and the factors related to them. The results of this work led to the validation of the cognitive battery, BACS, in schizophrenic patients. The Arabic BACS is a reliable and useful tool for measuring cognitive performance in hospitalized patients with schizophrenia. In addition, the satisfactory psychometric qualities of MoCA make it a rapid screening tool for the cognitive functions of these patients. In addition, our results showed that patients with objective cognitive impairment could be aware of their cognitive impairment despite low disease awareness (insight). The most contributing factors of the subjective cognitive complaint were the general psychopathology subscale of the PANSS, the autonomy scale of the daily living scale (ADL) while those predictive of social cognitive complaint were the Depression Scale (Calgary).All of our work has demonstrated adequate psychometric properties of a neurocognitive battery, BACS and a screening tool, MOCA in Arabic, respectively in the diagnosis and screening of cognitive deficits in schizophrenic patients. Our studies could help clinicians apply these valid instruments in their daily clinical practice and include cognitive rehabilitation strategies in the treatment plan for patients with schizophrenia; which is currently lacking in the countries of the Middle East. Finally, our studies have shown that schizophrenic patients complain about their cognition. Further prospective studies are needed to better understand cognitive impairment in schizophrenic patients in order to help remedy it and thus allow better day-to-day functioning and life outside psychiatric institutions

    Evaluations des fonctions cognitives chez les patients schizophrènes au Liban

    No full text
    Cognitive deficits is a fundamental characteristic of schizophrenia where the most affected function are particularly memory, attention, motor skills, executive functions and social cognition. Cognitive assessment is one of the best indicators of the functional and social prognosis of individuals. This assessment becomes a fundamental part in clinical practice and in research using batteries that differ widely in their content. In addition, subjective assessment of cognitive functions can give a more complete view of an individual's cognitive profile, but it cannot replace objective assessment measures, as patients' self-assessment of their neurocognitive functioning may not be entirely correct. Subjective cognitive complaints is recognized as indicators of potential cognitive dysfunction, with evidence suggesting that such complaints are a precursor to cognitive impairment. Thus, it is essential to understand and assess patients' awareness of their cognitive state.The thesis work presented here has several objectives. First, we deal with generalities concerning schizophrenia, impaired cognitive functions and their evaluations while also giving an overview of their evaluation in Lebanon. Secondly, in order to be able to assess cognitive functions in institutionalized schizophrenic patients, we worked at validating diagnostic and screening tools for cognitive disorders in schizophrenic subjects. Finally, we assess the subjective cognitive complaints in schizophrenic patients and the factors related to them. The results of this work led to the validation of the cognitive battery, BACS, in schizophrenic patients. The Arabic BACS is a reliable and useful tool for measuring cognitive performance in hospitalized patients with schizophrenia. In addition, the satisfactory psychometric qualities of MoCA make it a rapid screening tool for the cognitive functions of these patients. In addition, our results showed that patients with objective cognitive impairment could be aware of their cognitive impairment despite low disease awareness (insight). The most contributing factors of the subjective cognitive complaint were the general psychopathology subscale of the PANSS, the autonomy scale of the daily living scale (ADL) while those predictive of social cognitive complaint were the Depression Scale (Calgary).All of our work has demonstrated adequate psychometric properties of a neurocognitive battery, BACS and a screening tool, MOCA in Arabic, respectively in the diagnosis and screening of cognitive deficits in schizophrenic patients. Our studies could help clinicians apply these valid instruments in their daily clinical practice and include cognitive rehabilitation strategies in the treatment plan for patients with schizophrenia; which is currently lacking in the countries of the Middle East. Finally, our studies have shown that schizophrenic patients complain about their cognition. Further prospective studies are needed to better understand cognitive impairment in schizophrenic patients in order to help remedy it and thus allow better day-to-day functioning and life outside psychiatric institutions.Les déficits cognitifs sont perçus comme une caractéristique fondamentale de la schizophrénie. Les fonctions cognitives les plus affectées sont particulièrement la mémoire, l'attention, la motricité, les fonctions exécutives et la cognition sociale. L’évaluation cognitive est l’un des meilleurs indicateurs du pronostic fonctionnel et social des individus. Cette évaluation devient une partie fondamentale dans la pratique clinique et dans la recherche et utilise des batteries qui diffèrent largement dans leurs contenus. En plus, l'évaluation subjective des fonctions cognitives peut donner une vue plus complète du profil cognitif d'un individu, mais elle ne peut pas remplacer les mesures d'évaluation objectives, car l'autoévaluation par les patients de leur fonctionnement neurocognitif peut ne pas être tout à fait exacte. Les plaintes cognitives subjectives sont de plus en plus largement reconnues comme des indicateurs de dysfonctionnement cognitif potentiel, avec des preuves suggérant que de telles plaintes sont un précurseur de troubles cognitifs. Ainsi, il est essentiel de comprendre et d'évaluer la conscience qu’ont les patients de leur état cognitif.Le travail de thèse présenté ici à plusieurs objectifs. Dans un premier temps, nous traitons des généralités concernant la schizophrénie, les fonctions cognitives altérées et leurs évaluations en faisant par ailleurs un état des lieux de leur évaluation au Liban. Dans un deuxième temps, afin de pouvoir évaluer les fonctions cognitives chez des patients schizophrènes institutionnalisés, nous exposons nos travaux de validation d’outils de diagnostic et de dépistage des troubles cognitifs chez les sujets schizophrènes. Dans un dernier temps, nous exposons notre étude des plaintes cognitives subjective chez les patients schizophrènes et les facteurs reliés à celles-ci.Les résultats de ce travail ont abouti à la validation en langue arabe d’une batterie cognitive, le BACS chez des patients schizophrènes. Le BACS arabe est un outil fiable et utile pour mesurer les performances cognitives chez les patients hospitalisés atteints de schizophrénie. De plus, les qualités psychométriques satisfaisantes du MoCA en font un outil de dépistage rapide des fonctions cognitives de ces patients. En outre, nos résultats ont montré que les patients ayant un déficit cognitif objectif pouvaient être conscients de leur déficit cognitif malgré une conscience de la maladie (insight) faible. Les facteurs les plus contributifs de la plainte cognitive subjective étaient la sous-échelle de psychopathologie générale de la PANSS, l’échelle d’autonomie dans les actes de la vie quotidienne (ADL) alors que celles prédictives plus spécifiquement de la plainte dans le domaine de la cognition sociale étaient l’échelle de dépression (Calgary).L’ensemble de nos travaux a démontré des propriétés psychométriques adéquates d’une batterie neurocognitive, le BACS et d’un outil de dépistage, le MOCA en langue Arabe, respectivement dans le diagnostic et le dépistage des déficits cognitifs chez les patients schizophrènes. Nos études pourraient aider les cliniciens à appliquer ces instruments valides dans leur pratique clinique quotidienne et à inclure des stratégies de réadaptation cognitive dans le plan de traitement des patients atteints de schizophrénie ; ce qui fait défaut à l’heure actuelle dans les pays du Moyen Orient. Enfin, nos études ont montré que les patients schizophrènes se plaignent de leur cognition. D'autres études prospectives sont nécessaires pour mieux comprendre les atteintes cognitives chez les patients schizophrènes afin d'aider à y remédier et permettre ainsi un meilleur fonctionnement au quotidien et une vie hors des institutions psychiatriques
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