Assessing Gender Identity and Sex in Diverse Low, Middle, and High-Income Settings: Findings from a WHO/HRP Consultative Process

Obtaining detailed data on gender identity and sex in population-based sexual health studies is important. We convened a group to develop consensus survey items. We identified two items to capture data on gender identity and sex that can be used in diverse settings

Stuck in the Adoption Funnel: The Effect of Interruptions in the Adoption Process on Usage

Many firms have introduced Internet-based customer self-service applications such as online payments or brokerage services. Despite high initial sign-up rates, not all customers actually shift their dealings online. We investigate whether the multistage nature of the adoption process (an “adoption funnel”) for such technologies can explain this low take-up. We use exogenous variation in events that possibly interrupt adoption, in the form of vacations and public holidays in different German states, to identify the effect on regular usage of being interrupted earlier in the adoption process. We find that interruptions in the early stages of the adoption process reduce a customer's probability of using the technology regularly. Our results suggest significant cost-saving opportunities from eliminating interruptions in the adoption funnel.NET InstituteLondon Business School. Centre for MarketingMack Center for Managing Technological InnovationDeutsche Forschungsgemeinschaf

Transforming Post-Secondary Education in Mathematics

In this manuscript, I introduce and describe the work of mathematicians and mathematics educators in the group Transforming Post-Secondary Education in Mathematics (TPSE Math or TPSE, pronounced "tipsy", for short). TPSE aims to coordinate and drive constructive change in education in the mathematical sciences at two-year colleges, four-year colleges, and universities across the nation. It seeks to build on the successes of the entire mathematical sciences community. This manuscript reviews the events that led to the founding of TPSE Math and articulates its vision and mission. In its first phase with national events, TPSE found broad consensus with the mathematical sciences community on the challenges facing the community. Learning from educational transformations experiences in other scientific fields, and with the support of the Mathematical Advisory Group of 34 mathematical sciences department chairs and leaders, TPSE moves into a second phase focused on action. This is a snapshot in time, and TPSE's ongoing activities will continue to be documented and disseminated. The piece concludes with a reflection of the impact that my involvement in this work has had on my career.Comment: 17 page

Effects of Cyclin Dependent Kinase 9 inhibition on zebrafish larvae

CDK9 is a known regulator of cellular transcription, growth and proliferation. Small molecule inhibitors are currently being developed and assessed in clinical trials as anti-cancer drugs. The zebrafish embryo provides an ideal model to explore the effects of CDK9 inhibition in-vivo. This has not been adequately explored previously at the level of a whole organism. We have compared and contrasted the effects of pharmacological and molecular inhibition of CDK9 on somatic growth, apoptosis and cellular proliferation in zebrafish larvae between 0 to 120 hours post fertilisation (hpf) using flavopiridol, a selective CDK9 antagonist, and CDK9-targeting morpholino. We demonstrate that the inhibition of CDK9 diminishes cellular proliferation and increases apoptosis. Subsequently, it affects somatic growth and development of a number of key embryonic structures including the brain, heart, eye and blood vessels. For the first time, we have localized CDK9 at a subcellular level in whole-mounted larvae. This works shows, at a high-throughput level, that CDK9 clearly plays a fundamental role in early cellular growth and proliferation

Metastable and localized Ising magnetism in α−CoV2O6 magnetization plateaus

$\alpha$-CoV$_{2}$O$_{6}$ consists of $j_{\mathrm{eff}}={1 \over 2}$ Ising spins located on an anisotropic triangular motif with magnetization plateaus in an applied field. We combine neutron diffraction with low temperature magnetization to investigate the magnetic periodicity in the vicinity of these plateaus. We find these steps to be characterized by metastable and spatially short-range ($\xi\sim$ 10 $\r{A}$) magnetic correlations with antiphase boundaries defining a local periodicity of $\langle \hat{T}^{2} \rangle =\ \uparrow \downarrow$to$\langle \hat{T}^{3} \rangle =\ \uparrow \uparrow \downarrow$, and$\langle \hat{T}^{4} \rangle=\ \uparrow \uparrow \downarrow \downarrow$or$\uparrow \uparrow \uparrow \downarrow$ spin arrangements. This shows the presence of spatially short range and metastable/hysteretic, commensurate magnetism in Ising magnetization steps.Comment: 9 pages, 6 figures, to be published in Phys. Rev.

Strong interconversion of non-polar phonons and Josephson plasma oscillations induced by equilibrium Josephson currents in high T_c superconductors

We analyze consequences of dynamical modulations of Josephson current by non-polar lattice mode in the Josephson junction barrier. In the high $T_c$ junctions, the effect of such modulations can be anomalously strong due to the proximity of the insulating barrier to the superconducting state. Accordingly, the interconversion of sound (as well as other non-polar phonons) and the Josephson plasma oscillations mediated by stationary Josephson currents, which may be present in the junction due to various reasons, becomes possible. We suggest that this effect can be employed for imaging of the stationary Josephson currents. Estimates of the effect are given.Comment: 11 RevTeX pages, no figure

Stimulation of Na⁺/H⁺ Exchanger Isoform 1 Promotes Microglial Migration

Regulation of microglial migration is not well understood. In this study, we proposed that Na+/H+ exchanger isoform 1 (NHE-1) is important in microglial migration. NHE-1 protein was co-localized with cytoskeletal protein ezrin in lamellipodia of microglia and maintained its more alkaline intracellular pH (pHi). Chemoattractant bradykinin (BK) stimulated microglial migration by increasing lamellipodial area and protrusion rate, but reducing lamellipodial persistence time. Interestingly, blocking NHE-1 activity with its potent inhibitor HOE 642 not only acidified microglia, abolished the BK-triggered dynamic changes of lamellipodia, but also reduced microglial motility and microchemotaxis in response to BK. In addition, NHE-1 activation resulted in intracellular Na+ loading as well as intracellular Ca2+ elevation mediated by stimulating reverse mode operation of Na+/Ca2+ exchange (NCXrev). Taken together, our study shows that NHE-1 protein is abundantly expressed in microglial lamellipodia and maintains alkaline pHi in response to BK stimulation. In addition, NHE-1 and NCXrev play a concerted role in BK-induced microglial migration via Na+ and Ca2+ signaling. © 2013 Shi et al

Physics and Applications of Laser Diode Chaos

An overview of chaos in laser diodes is provided which surveys experimental achievements in the area and explains the theory behind the phenomenon. The fundamental physics underpinning this behaviour and also the opportunities for harnessing laser diode chaos for potential applications are discussed. The availability and ease of operation of laser diodes, in a wide range of configurations, make them a convenient test-bed for exploring basic aspects of nonlinear and chaotic dynamics. It also makes them attractive for practical tasks, such as chaos-based secure communications and random number generation. Avenues for future research and development of chaotic laser diodes are also identified.Comment: Published in Nature Photonic