Dark Matter Searche with GLAST

The Gamma-Ray Large Area Space Telescope (GLAST), scheduled to be launched in fall 2007, is the next generation satellite for high-energy gamma-ray astronomy. The Large Area Telescope (LAT), GLAST main instrument, with a wide field of view (> 2 sr), a large effective area (> 8000 cm^2 at 1 GeV) and 20 MeV - 300 GeV energy range, will provide excellent high energy gamma-ray observations for Dark Matter searches. In this paper we examine the potential of the LAT to detect gamma-rays coming from WIMPS annihilation in the context of supersymmetry. As an example, two search regions are investigated: the galactic center and the galactic satellites.Comment: Comment: 6 pages, 3 figures, 36th COSPAR proceeding accepted for publication in "Advances in Space Research

Endothelial cells, endoplasmic reticulum stress and oxysterols

Oxysterols are bioactive lipids that act as regulators of lipid metabolism, inflammation, cell viability and are involved in several diseases, including atherosclerosis. Mounting evidence linked the atherosclerosis to endothelium dysfunction; in fact, the endothelium regulates the vascular system with roles in processes such as hemostasis, cell cholesterol, hormone trafficking, signal transduction and inflammation. Several papers shed light the ability of oxysterols to induce apoptosis in different cell lines including endothelial cells. Apoptotic endothelial cell and endothelial denudation may constitute a critical step in the transition to plaque erosion and vessel thrombosis, so preventing the endothelial damaged has garnered considerable attention as a novel means of treating atherosclerosis. Endoplasmic reticulum (ER) is the site where the proteins are synthetized and folded and is necessary for most cellular activity; perturbations of ER homeostasis leads to a condition known as endoplasmic reticulum stress. This condition evokes the unfolded protein response (UPR) an adaptive pathway that aims to restore ER homeostasis. Mounting evidence suggests that chronic activation of UPR leads to cell dysfunction and death and recently has been implicated in pathogenesis of endothelial dysfunction. Autophagy is an essential catabolic mechanism that delivers misfolded proteins and damaged organelles to the lysosome for degradation, maintaining basal levels of autophagic activity it is critical for cell survival. Several evidence suggests that persistent ER stress often results in stimulation of autophagic activities, likely as a compensatory mechanism to relieve ER stress and consequently cell death. In this review, we summarize evidence for the effect of oxysterols on endothelial cells, especially focusing on oxysterols-mediated induction of endoplasmic reticulum stress

The Role of Antimatter Searches in the Hunt for Supersymmetric Dark Matter

We analyze the antimatter yield of supersymmetric (SUSY) models with large neutralino annihilation cross sections. We introduce three benchmark scenarios, respectively featuring bino, wino and higgsino-like lightest neutralinos, and we study in detail the resulting antimatter spectral features. We carry out a systematic and transparent comparison between current and future prospects for direct detection, neutrino telescopes and antimatter searches. We demonstrate that often, in the models we consider, antimatter searches are the only detection channel which already constrains the SUSY parameter space. Particularly large antiprotons fluxes are expected for wino-like lightest neutralinos, while significant antideuteron fluxes result from resonantly annihilating binos. We introduce a simple and general recipe which allows to assess the visibility of a given SUSY model at future antimatter search facilities. We provide evidence that upcoming space-based experiments, like PAMELA or AMS, are going to be, in many cases, the unique open road towards dark matter discovery.Comment: 34 pages, 18 figures; V2: misprints in the labels of fig. 2,3 and 5 correcte

SEEMP: A marketplace for the Labour Market

Employment Services are an important topic in the agenda of local governments and in the EU due to their social implications, such as sustainability, workforce mobility, workers’ re-qualification paths, training for fresh graduates and students. Many administrations started their own E-Government projects whose imitations emerge as the demand of workers mobility increases. The SEEMP system presented in this paper overcomes this issue in different ways: starting bilateral communications with near-border similar offices, building a federation of the local employment services, and merging isolate trials. The SEEMP approach relies on a distributed semantic service oriented infrastructure able to federate local projects, in order to create geographically aggregated services for employment by leveraging existing local ones. The social and technical aspects of the SEEMP project are presented, showing how the SEEMP system is integrated with National level systems

Detection of Extended VHE Gamma Ray Emission from G106.3+2.7 with VERITAS

We report the detection of very-high-energy (VHE) gamma-ray emission from supernova remnant (SNR) G106.3+2.7. Observations performed in 2008 with the VERITAS atmospheric Cherenkov gamma-ray telescope resolve extended emission overlapping the elongated radio SNR. The 7.3 sigma (pre-trials) detection has a full angular extent of roughly 0.6deg by 0.4deg. Most notably, the centroid of the VHE emission is centered near the peak of the coincident 12CO (J = 1-0) emission, 0.4deg away from the pulsar PSR J2229+6114, situated at the northern end of the SNR. Evidently the current-epoch particles from the pulsar wind nebula are not participating in the gamma-ray production. The VHE energy spectrum measured with VERITAS is well characterized by a power law dN/dE = N_0(E/3 TeV)^{-G} with a differential index of G = 2.29 +/- 0.33stat +/- 0.30sys and a flux of N_0 = (1.15 +/- 0.27stat +/- 0.35sys)x 10^{-13} cm^{-2} s^{-1} TeV^{-1}. The integral flux above 1 TeV corresponds to ~5 percent of the steady Crab Nebula emission above the same energy. We describe the observations and analysis of the object and briefly discuss the implications of the detection in a multiwavelength context.Comment: 5 pages, 2 figure

Status of the VERITAS Observatory

VERITAS, an Imaging Atmospheric Cherenkov Telescope (IACT) system for gammma-ray astronomy in the GeV-TeV range, has recently completed its first season of observations with a full array of four telescopes. A number of astrophysical gamma-ray sources have been detected, both galactic and extragalactic, including sources previously unknown at TeV energies. We describe the status of the array and some highlight results, and assess the technical performance, sensitivity and shower reconstruction capabilities.Comment: Submitted to Proceedings of "4th Heidelberg International Symposium on High Energy Gamma-Ray Astronomy 2008

Beyond the required LISA free-fall performance: new LISA pathfinder results down to 20 μHz

In the months since the publication of the first results, the noise performance of LISA Pathfinder has improved because of reduced Brownian noise due to the continued decrease in pressure around the test masses, from a better correction of noninertial effects, and from a better calibration of the electrostatic force actuation. In addition, the availability of numerous long noise measurement runs, during which no perturbation is purposely applied to the test masses, has allowed the measurement of noise with good statistics down to 20  μHz. The Letter presents the measured differential acceleration noise figure, which is at (1.74±0.05)  fm s^{-2}/sqrt[Hz] above 2 mHz and (6±1)×10  fm s^{-2}/sqrt[Hz] at 20  μHz, and discusses the physical sources for the measured noise. This performance provides an experimental benchmark demonstrating the ability to realize the low-frequency science potential of the LISA mission, recently selected by the European Space Agency

A Statistical Analysis of Supersymmetric Dark Matter in the MSSM after WMAP

We study supersymmetric dark matter in the general flavor diagonal MSSM by means of an extensive random scan of its parameter space. We find that, in contrast with the standard mSUGRA lore, the large majority of viable models features either a higgsino or a wino-like lightest neutralino, and yields a relic abundance well below the WMAP bound. Among the models with neutralino relic density within the WMAP range, higgsino-like neutralinos are still dominant, though a sizeable fraction of binos is also present. In this latter case, relic density suppression mechanisms are shown to be essential in order to obtain the correct neutralino abundance. We then carry out a statistical analysis and a general discussion of neutralino dark matter direct detection and of indirect neutralino detection at neutrino telescopes and at antimatter search experiments. We point out that current data exclude only a marginal portion of the viable parameter space, and that models whose thermal relic abundance lies in the WMAP range will be significantly probed only at future direct detection experiments. Finally, we emphasize the importance of relic density enhancement mechanisms for indirect detection perspectives, in particular at future antimatter search experiments.Comment: 39 pages, 25 figure

VERITAS Observations of the BL Lac Object 1ES 1218+304

The VERITAS collaboration reports the detection of very-high-energy (VHE) gamma-ray emission from the high-frequency-peaked BL Lac object 1ES 1218+304 located at a redshift of z=0.182. A gamma-ray signal was detected with high statistical significance for the observations taken during several months in the 2006-2007 observing season. The photon spectrum between ~160 GeV and ~1.8 TeV is well described by a power law with an index of Gamma = 3.08 +/- 0.34(stat) +/- 0.2(sys). The integral flux above 200 GeV corresponds to ~6% of that of the Crab Nebula. The light curve does not show any evidence for VHE flux variability. Using lower limits on the density of the extragalactic background light (EBL) in the near-IR to mid-IR we are able to limit the range of intrinsic energy spectra for 1ES 1218+304. We show that the intrinsic photon spectrum is harder than a power law with an index of Gamma = 2.32 +/- 0.37. When including constraints from the spectra of 1ES 1101-232 and 1ES 0229+200, the spectrum of 1ES 1218+304 is likely to be harder than Gamma = 1.86 +/- 0.37.Comment: Submitted to Proceedings of "4th Heidelberg International Symposium on High Energy Gamma-Ray Astronomy 2008