16 research outputs found
Demographic and clinical determinants of neck pain in idiopathic cervical dystonia.
Cervical dystonia is associated with neck pain in a significant proportion of cases, but the mechanisms underlying pain are largely unknown. In this exploratory study, we compared demographic and clinical variables in cervical dystonia patients with and without neck pain from the Italian Dystonia Registry. Univariable and multivariable logistic regression analysis indicated a higher frequency of sensory trick and a lower educational level among patients with pain
Validation of the Italian version of the Movement Disorder SocietyâUnified Parkinsonâs Disease Rating Scale
An in vivo proton magnetic resonance spectroscopy study of brain metabolism in early-onset Parkinsonâs disease
Quality of life in patients with craniocervical dystonia: Italian validation of the "Cervical Dystonia Impact Profile (CDIP-58)" and the "Craniocervical Dystonia Questionnaire (CDQ-24)"
Dystonia is a disabling and disfiguring disorder that can often affect many aspects of patients' daily lives, and lower their self-esteem. To date, quality of life (QoL) has been assessed in dystonic patients using generic measures that do not address the specific problems of this diagnostic group. Recently, two disease-specific scales "The Cervical Dystonia Impact Profile (CDIP-58)" and the "Craniocervical Dystonia Questionnaire (CDQ-24)" were validated for measuring QoL in craniocervical dystonia patients. No disease-specific scales for QoL for dystonic patients are currently available in Italian. The aim of our study was to produce and validate the Italian version of the CDIP-58 and CDQ-24. We obtained the Italian version of CDQ-24 and CDIP-58 with a back-translation design. Both scales were applied to a population of 94 craniocervical dystonia patients along with the Short Form 36 health-survey questionnaire (SF-36), both before and 4 weeks after botulinum toxin therapy. A group of 65 controls matched for sex, age and comorbidity underwent the SF-36. Internal consistency was satisfactory for all subscales. Both the CDIP-58 and CDQ-24 showed moderate to high correlations with similar items of the SF-36. Sensitivity to change was confirmed by highly significant improvements in all CDQ-24 subscales and by moderate improvements in three out of eight CDIP-58 subscales and total score. This is the first Italian study on QoL in dystonia patients. We validated the Italian version of two disease-specific questionnaires to evaluate QoL in craniocervical dystonia patients. These scales could be useful for both clinical practice and clinical trials
Observing movement disorders: best practice proposal in the use of video recording in clinical practice
Clinical evaluation is of utmost importance in the semeiological description of motor disorders which often require video recording to highlight subtle signs and their subsequent evolution. After reviewing 1858 video recordings, we composed a suitable list of video-documentation maneuvers, classified semeiologically in the form of a \u201cvideo recording protocol\u201d, to guarantee appropriate documentation when filming movement disorders. Aware that our proposed filming protocol is far from being exhaustive, by suggesting a more detailed documenting approach, it could help not only to achieve a better definition of some disorders, but also to guide neurologists towards the correct subsequent examinations. Moreover, it could be an important tool for the longitudinal evaluation of patients and their response to therapy. Finally, video recording is a powerful teaching tool as visual teaching highly improves educational training
Oromandibular dystonia: from onset to spread a multicenter italian study
BackgroundDetailed information about the epidemiological and phenomenological differences among the aetiological subtypes of oromandibular dystonia (OMD) is lacking. Moreover, the OMD tendency to spread to other body sites has never been investigated.AimTo compare the main demographic and clinical features of OMD in different aetiological groups and assess the risk of spread.Materials and methodsWe retrospectively analysed data from patients contained in the Italian Dystonia Registry. The risk of spread was assessed by Kaplan Meyer curves and Cox regression analysis.ResultsThe study included 273 patients (175 women) aged 55.7 years (SD 12.7) at OMD onset. Female predominance was observed. Idiopathic dystonia was diagnosed in 241 patients, acquired dystonia in 22. In 50/273 patients, dystonia started in the oromandibular region (focal OMD onset); in 96/273 patients the onset involved the oromandibular region and a neighbouring body site (segmental/multifocal OMD onset); and in 127/273 patients OMD was a site of spread from another body region. Sensory trick (ST) and positive family history predominated in the idiopathic group. No dystonia spread was detected in the acquired group, whereas spread mostly occurred within the first five years of history in 34% of the focal OMD onset idiopathic patients. Cox regression analysis revealed ST as a significant predictor of spread (HR, 12.1; 95% CI, 2.5 - 18.8; P = 0.002).ConclusionThis large study provides novel information about the clinical phenomenology of idiopathic and acquired OMD. We pointed out a possible role of oestrogens in favouring dystonia development. Moreover, we described for the first time the association between ST and dystonia spread, revealing possible common pathophysiological mechanisms. Our findings may be suggested as a referral point for future pathophysiological and therapeutic studies on OMD
Observing movement disorders: best practice proposal in the use of video recording in clinical practice
Validation of the Italian version of Parkinson's disease-cognitive rating scale (PD-CRS)
Quality of life in patients with craniocervical dystonia: Italian validation of the âCervical Dystonia Impact Profile (CDIP-58)â and the âCraniocervical Dystonia Questionnaire (CDQ-24)â
Dystonia is a disabling and disfiguring disorder
that can often affect many aspects of patientsâ daily lives, and
lower their self-esteem. To date, quality of life (QoL) has
been assessed in dystonic patients using generic measures
that do not address the specific problems of this diagnostic
group. Recently, two disease-specific scales ââThe Cervical
Dystonia Impact Profile (CDIP-58)ââ and the ââCraniocervical
Dystonia Questionnaire (CDQ-24)ââ were validated for
measuring QoL in craniocervical dystonia patients. No disease-
specific scales for QoL for dystonic patients are currently
available in Italian. The aim of our study was to
produce and validate the Italian version of the CDIP-58 and
CDQ-24. We obtained the Italian version of CDQ-24 and
CDIP-58 with a back-translation design. Both scales were
applied to a population of 94 craniocervical dystonia patients
along with the Short Form 36 health-survey questionnaire
(SF-36), both before and 4 weeks after botulinum toxin
therapy. A group of 65 controls matched for sex, age and
comorbidity underwent the SF-36. Internal consistency was
satisfactory for all subscales. Both the CDIP-58 and CDQ-24
showed moderate to high correlations with similar items of
the SF-36. Sensitivity to change was confirmed by highly
significant improvements in all CDQ-24 subscales and by
moderate improvements in three out of eight CDIP-58 subscales
and total score. This is the first Italian study on QoL in
dystonia patients. We validated the Italian version of two
disease-specific questionnaires to evaluate QoL in craniocervical
dystonia patients. These scales could be useful for
both clinical practice and clinical trials
Correction to: Demographic and clinical determinants of neck pain in idiopathic cervical dystonia (Journal of Neural Transmission, (2020), 127, 10, (1435-1439), 10.1007/s00702-020-02245-4)
Cervical dystonia is associated with neck pain in a signifcant proportion of cases, but the mechanisms underlying pain are
largely unknown. In this exploratory study, we compared demographic and clinical variables in cervical dystonia patients
with and without neck pain from the Italian Dystonia Registry. Univariable and multivariable logistic regression analysis
indicated a higher frequency of sensory trick and a lower educational level among patients with pain