Influência da modelação de núcleos de betão armado no cálculo automático de estruturas de edifícios

O presente trabalho aborda a questão do comportamento e influência estrutural da modelação de um núcleo de secção aberta de parede fina no modelo tridimensional de elementos finitos de um edifício de betão armado, composto por 5 pisos sujeito à acção sísmica regulamentar. Para o efeito, foram considerados os Eurocódigos estruturais, nomeadamente o Eurocódigo 0, Eurocódigo 1 e Eurocódigo 8. A fim de avaliar a importância do tipo de modelação destes elementos estruturais, elemento fundamental para a caracterização da resposta dinâmica, foi desenvolvido um estudo paramétrico, fazendo-se a análise de quatro formas distintas de modelação do mesmo núcleo. Para os mesmos casos de carregamento, é feita uma análise comparativa entre os resultados obtidos a nível de períodos, percentagem de armadura nos pilares e no próprio núcleo bem como os deslocamentos para os modelos em estudo, com recurso a um programa de cálculo automático. O edifício considerado neste trabalho foi modelado com base no programa comercial de cálculo automático SAP 2000 versão 14.4. Posteriormente apresentam-se e discutem-se os resultados obtidos nos vários modelos em causa e para as várias situações propostas ao longo do trabalho.This work presents the question of structural influence on the modeling a core thin-walled open section of concrete in a building consisting of 5 floors, subject to seismic regulations. To this effect, we considered the structural Eurocodes, in particular Eurocode 0, Eurocode 1 and Eurocode 8. In order to assess the importance of the type of modeling these structural elements, a key factorto characterize the dynamic response, a parametric study was developed, making the analysis of four distinct forms of the same core model. For the same loading cases, a comparative analysis are made between the results obtained in levels of periods, reinforcement percentage in the columns and core and displacements for the model under study, using an automatic calculation program. The building considered in this work was modeled on the basis commercial program for automatic calculation, SAP2000 V14.4 Subsequently, we present and discuss the results obtained for the various models involved and proposals for the various situations along the work

Contribution to drug discovery and development for tauopathies using yeast as a model

This work aimed to contribute to drug discovery and development (DDD) for tauopathies, while expanding our knowledge on this group of neurodegenerative disorders, including Alzheimer’s disease (AD). Using yeast, a recognized model for neurodegeneration studies, useful models were produced for the study of tau interaction with beta-amyloid (Aβ), both AD hallmark proteins. The characterization of these models suggests that these proteins co-localize and that Aβ1-42, which is toxic to yeast, is involved in tau40 phosphorylation (Ser396/404) via the GSK-3β yeast orthologue, whereas tau seems to facilitate Aβ1-42 oligomerization. The mapping of tau’s interactome in yeast, achieved with a tau toxicity enhancer screen using the yeast deletion collection, provided a novel framework, composed of 31 genes, to identify new mechanisms associated with tau pathology, as well as to identify new drug targets or biomarkers. This genomic screen also allowed to select the yeast strain mir1Δ-tau40 for development of a new GPSD2TM drug discovery screening system. A library of unique 138 marine bacteria extracts, obtained from the Mid-Atlantic Ridge hydrothermal vents, was screened with mir1Δ-tau40. Three extracts were identified as suppressors of tau toxicity and constitute good starting points for DDD programs. mir1Δ strain was sensitive to tau toxicity, relating tau pathology with mitochondrial function. SLC25A3, the human homologue of MIR1, codes for the mitochondrial phosphate carrier protein (PiC). Resorting to iRNA, SLC25A3 expression was silenced in human neuroglioma cells, as a first step towards the engineering of a neural model for replicating the results obtained in yeast. This model is essential to understand the mechanisms of tau toxicity at the mitochondrial level and to validate PiC as a relevant drug target. The set of DDD tools here presented will foster the development of innovative and efficacious therapies, urgently needed to cope with tau-related disorders of high human and social-economic impact

Behavioral and cardiopulmonary effects of dexmedetomidine alone and in combination with butorphanol, methadone, morphine or tramadol in conscious sheep

Objective: To compare cardiopulmonary and sedative effects following administration of dexmedetomidine alone or with butorphanol, methadone, morphine or tramadol in healthy sheep. Study design: Randomized crossover study. Animals: Six Santa Inês sheep, five females, one male, aged 12–28 months and weighing 40.1 ± 6.2 kg. Methods: Sheep were assigned treatments of dexmedetomidine (0.005 mg kg−1; D); D and butorphanol (0.15 mg kg−1; DB); D and methadone (0.5 mg kg−1; DM); D and morphine (0.5 mg kg−1; DMO); or D and tramadol (5.0 mg kg−1; DT). All drugs were administered intravenously with at least 7 days between each treatment. Rectal temperature, heart rate (HR), respiratory rate (fR), invasive arterial pressure, blood gases and electrolytes were measured prior to administration of drugs (baseline, T0) and every 15 minutes following drug administration for 120 minutes (T15–T120). Sedation was scored by three observers blinded to treatment. Results: HR decreased in all treatments and fR decreased in DM at T30 and DMO at T30 and T45. PaCO2 was increased in D, DB and DM compared with baseline, and PaO2 decreased in D at T15 and T45; in DB at T15 to T75; in DM at T15 to T60; in DMO at T15; and in DT at T15, T30 and T75. There was a decrease in temperature in D, DB and DM. An increased pH was measured in D at all time points and in DT at T30–T120. inline image and base excess were increased in all treatments compared with baseline. There were no statistical differences in sedation scores. Conclusions and clinical relevance: The combination of dexmedetomidine with butorphanol, methadone, morphine or tramadol resulted in similar changes in cardiopulmonary function and did not improve sedation when compared with dexmedetomidine alone

Traumatismo Crânio-Encefálico em Portugal: Tendências em Doentes Internados de 2000 a 2010

Introduction: Traumatic brain injury has a considerable socio-economic impact, being a major cause of morbi-mortality, often with permanent disability. We sought to characterize health resource utilization of adult traumatic brain injury patients in Portugal between 2000 and 2010. Material and Methods: Retrospective study of medical records of adult patients with ICD9 diagnostic code of traumatic brain injury included in the National Diagnosis Related Groups Database from 2000-2010. Descriptive statistical analysis was performed and trends during the decade were evaluated. Results: We analysed 72 865 admissions to 111 hospitals, 64.1% males, mean age 57.9 ± 21.8 years (18-107). We found a decrease in number of traumatic brain injury in younger patients and an increase in older ones. The number of traffic accidents decreased and the number of falls increased. There was an increase of moderate to severe traumatic brain injury admissions: 47.2% in 2000 / 80% in 2010. Patients admitted in Intensive Care have nearly doubled (15.8% vs 29.5%) as well as the number submitted to neurosurgical procedures (8.2% vs 15.2%). Total mortality increased from 7.1% to 10.6%. Discussion: The decrease of traumatic brain injury may be associated with the trauma prevention campaigns, road network improvement and health politics. The increase in mortality may be related to better pre-hospital care, enabling more severe cases to arrive in hospital alive, and although treated more frequently in Intensive Care and requiring more neurosurgical procedures, they end up having higher mortality. Also this may be due to an increase in patients' age and worse pre-morbid status. Conclusion: Traumatic brain injury in Portugal is changing. Although hospital admissions due to global traumatic brain injury have decreased, mortality rate has increased

Health care costs of domestic violence against women – evidence from Portugal

Our main objective is to estimate the additional health care costs to the Portuguese National Health Service (NHS) due to domestic violence against women. We collected information through a survey addressed to health care centres’ female users. Both victims and non-victims of violence were inquired. We estimate costs according to five different groups – consultation costs, health care treatment and therapeutic costs, costs of complementary and diagnostic exams, drugs costs and transport costs. The estimations have been split into two perspectives – the NHS perspective (public perspective) and private perspective of inquired women (out of pocket payments). The timeframe of our calculations is one year, referring to all costs generated by domestic violence situations in the last twelve months. Essentially costs were estimated through the product of total number of episodes by the average estimated price per episode. Additionally, for the private costs, we also considered the costs originated by income losses, the opportunity cost of time spent on health care treatments and the work inability caused by sickness. The results suggest that the victims of domestic violence’s additional demand for health care is valued €140 per annum, that is about 22% higher than health care costs of non-victims. These results match those of similar studies for the United States, taking account of per capita differences in health care spending. A large proportion (90%) of the additional costs associated with domestic violence is supported by the NHS, where consultations and drugs are the most important contributors of such costs. Health consequences of domestic violence result from losses in quality of life and worst health status of victims and correspond to additional permanent economic costs of domestic violence episodes

In search of the optimal conditions to process shape memory alloys (NiTi) using fused filament fabrication (FFF)

This research is sponsored by FEDER funds through COMPETE, Programa Operacional Factores de Competividade, Add.Powder (39910), and by national funds provided by FCT, Fundação para a Ciência e a Tecnologia, (project references UIDB/00285/2020 and UIDB/04044/2020) and Centro2020 through PAMI ROTEIRO/0328/2013 (no. 022158).This research was performed so as to investigate the additive manufacturing of NiTi shape memory alloys, which is associated with direct processes, such as selective laser melting. In addition to its expensive production costs, NiTi readily undergoes chemical and phase modifications, mainly as a result of Ni loss during processing as a result of high temperatures. This research explores the potential usefulness of NiTi as well as its limitations using indirect additive processes, such as fused filament fabrication (FFF). The first step was to evaluate the NiTi critical powder volume content (CPVC) needed to process high-quality filaments (via extrusion). A typical 3D printer can build a selected part/system/device layer-by-layer from the filaments, followed by debinding and sintering (SDS), in order to generate a near-net-shape object. The mixing, extruding (filament), printing (shaping), debinding, and sintering steps were extensively studied in order to optimize their parameters. Moreover, for the sintering step, two main targets should be met, namely: the reduction of contamination during the process in order to avoid the formation of secondary phases, and the decrease in sintering temperature, which also contributes to reducing the production costs. This study aims to demonstrate the possibility of using FFF as an additive manufacturing technology for processing NiTi.info:eu-repo/semantics/publishedVersio

Aprisionamento e transformação na literatura medieval: estudo comparado dos Lais de Marie de France e das Mil e Uma Noites.

TCC (graduação) - Universidade Federal de Santa Catarina. Centro de Filosofia e Ciências Humanas. HistóriaCom esta pesquisa busca-se estudar o motivo literário do aprisionamento, a partir da comparação e análise entre um conto das Mil e Uma Noites: “A história dos amores de Camaralzaman, príncipe das ilhas de Kaledan e Badura, a princesa da China” e dos Lais de Marie de France: Guigemar e Yonec, com especial atenção para a forma que este motivo expressa um aspecto da relação entre homens e mulheres, no contexto da nobreza medieval. É parte também do desenvolvimento psicológico dos personagens aprisionados nas narrativas e das estruturas míticas que permeiam o imaginário medieval. O primeiro capítulo divide-se em três partes: a primeira discorre sobre o contexto e legitimação da escrita de Marie de France, e as duas partes seguintes analisam os contos Yonec e Guigemar, respectivamente. Já no segundo capítulo, discorre-se sobre os caminhos do saber entre Oriente e Ocidente, seguindo, em especial, duas rotas: a valorização do conhecimento dentre os árabes em seu processo de expansão territorial e as possíveis influências árabes no fenômeno do amor cortês e na poesia trovadoresca provençal. Como metodologia usamos a História Comparada e a análise Hermenêutica das fontes. Compreendemos a Literatura como uma rica fonte histórica que reflete, transforma e cria a realidade e utilizamos a mitologia medieval, o imaginário, e a translatio studii como conceitos principais. Os resultados desta pesquisa apontam para a conexão entre o aprisionamento e o processo de individuação dos personagens das narrativas. Sendo assim, o confinamento não representa inércia ou falta de agência e sim é alegoria para profundas transformações psicológicas

Relatório de Estágio Profissional

Este relatório apresenta os estágios realizados durante o período compreendido entre de outubro de 2016 e fevereiro de 2018, inseridos nas unidades curriculares de Prática Profissional I, II e III do Mestrado em Educação Pré-Escolar realizado na Escola Superior de Educação João de Deus. O presente relatório inclui as minhas experiências de ensino aprendizagem realizadas e observadas na Educação Pré-Escolar. Numa primeira parte é feita uma breve introdução onde se definem os objetivos deste relatório, e onde se aborda a importância da prática profissional, a identificação e contextualização das escolas onde realizei a prática pedagógica e a calendarização da mesma. O primeiro capítulo é destinado aos Relatos de Estágio Profissional. Nele são apresentados dez relatos da prática pedagógica, sendo que sete desses relatos são de observações de situações significativas lecionadas pelas educadoras titulares e colegas de estágio, e três dos relatos correspondem a atividades planificadas e realizadas por mim, abrangendo as várias áreas curriculares, bem como as diferentes faixas etárias. O segundo capítulo é reservado às Planificações, onde é feita uma reflexão sobre o que é planificar e a importância de o fazer. Nele são apresentadas seis atividades planificadas e realizadas durante a prática profissinal nas diferentes escolas, inseridas nas diferentes áreas curriculares da Educação Pré-Escolar e faixas etárias. O terceiro capítulo apresentado corresponde aos Dispositivos de Avaliação onde reforço a significância da avaliação formativa nestas faixas etárias e apresento três atividades realizadas com crianças nas faixas etárias da Educação Pré-Escolar. Avalio as mesmas analisando as aprendizagens, as capacidades, as destrezas e atitudes. No quarto capítulo e último, do Relatório de Estágio, apresento uma proposta de trabalho de projeto que objetiva a interdisciplinaridade nas várias áreas curriculares da Educação Pré-Escolar. Para a realização desta proposta escolhi um tema relacionado com a educação ambiental cujo o nome é “Quem recicla, amigo é”. Por fim, efetiva-se uma perspetiva final sobre todo o trabalho realizado no presente relatório e sobre o valor da sua importância na minha formação enquanto futura educadora. Após esta reflexão crítica final são apresentadas as referências bibliográficas que utilizei para a elaboração do relatório tal como todos os anexos

Uso não-problemático de drogas em Portugal : a lei e as experiências dos utilizadores

A investigação sobre uso de substâncias psicoativas em Portugal foca-se, sobretudo no uso que apresenta um caráter problemático. Este estudo pretende contribuir para complementar e diversificar este enfoque, a partir da exploração do consumo não problemático de drogas e do conhecimento das experiências destes utilizadores. Entendemos como sendo crucial compreender de que forma se carateriza um consumo não problemático e como este é gerido, pelos utilizadores, de modo a não se despoletarem consequências negativas em alguma área do funcionamento dos mesmos. Para além das suas experiências relativas ao seu consumo, é importante conhecer a sua posição face à política de drogas atual do nosso país. Em vários estudos, os utilizadores afirmam que, por diversas vezes, estabelecem contacto com elementos representantes da lei portuguesa, sendo que consideramos fundamental perceber de que forma este contacto é percecionado pelo consumidor e o impacto que este tem na sua vida. Nesse sentido, o nosso objetivo passa por conhecer e compreender as experiências dos consumidores não problemáticos portugueses, com a política de drogas atual e seus representantes. Foram realizadas entrevistas semiestruturadas, através de uma metodologia qualitativa, a onze participantes residentes no distrito do Porto. Estes consumidores não problemáticos, foram convidados a partilhar todas caraterísticas do seu consumo e trajetória do mesmo, assim como todas as experiências ocorridas relativamente à política de drogas portuguesa. Como principais resultados, todos os participantes partilharam experiências com figuras de autoridade, que ocorreram diretamente consigo, ou com amigos e conhecidos. Os sentimentos e perceções associados a estas experiências são descritos, maioritariamente, como negativos. Os dados revelam que estes utilizadores estão familiarizados com a lei em vigor, no entanto os dados relativamente à avaliação da perceção sobre a mesma, divide-se entre os participantes. Por fim, mais de metade dos utilizadores afirmam a existência de impacto negativo no que se refere à atuação da lei, na vida dos mesmos.Research on the psychoactive substances use in Portugal focuses, especially on the use that has a problematic character. Our study aims to contribute to complement and diversify this approach, based on the exploration of non-problematic drug use and knowledge of the experiences of these users. We believe it is crucial to understand how non-problematic consumption is characterized and how those users manage their consumption, in order to prevent negative consequences in any area of their functioning. In addition to their experiences with consumption, it is important to know their position in relation to our country’s current drug policy. In several studies, users claim that, on several occasions, they establish contact with elements representing portuguese law, and we consider fundamental to understand how this contact is perceived by the user and the impact it has on his life. In this sense, our goal is to know and understand the experiences of non-problematic portuguese users, with the current drug policy and its representatives. Semi-structured interviews were conducted, using a qualitative methodology, to eleven participants living in Porto. These non-problematic consumers were invited to share all the characteristics of their consumption and its trajectory, as well as all the experiences regarding the portuguese drug policy. As main results, all participants shared expericences with authority figures, wich occurred directly with them, or with friends. The feelings and perceptions associated with these experiences are mostly described as negative. The data reveals that these users are familiar with the law in force, however the data regarding the assessment of perception about it, is divided among the participants. Finally, more than half of the users affirms the existence of a negative impact regarding the performance of the law, in their live