Nitrogen Abundances in Damped Ly alpha Galaxies

Nitrogen abundances have been derived in Damped Ly alpha (DLA) galaxies at Zabs = 2.309, 2.827 and 3.025 toward the QSOs 0100+1300, 1425+6039 and 0347-3819 respectively. The behaviour of nitrogen relative to iron-peak and alpha-elements has been investigated by considering all the extant NI determinations for a total of 9 DLA galaxies. We have estimated the fraction of iron locked into dust grains to convert the observed [N/Fe] ratios into overall (dust plus gas) relative abundances, [N/Fe]corr. The ratios [N/alpha] have been mostly determined by using sulphur as a tracer of alpha-elements which is unaffected by dust. The [N/Fe] and [N/alpha] ratios show high dispersions, of one order of magnitude or more, which have no equivalent in other element-to-element ratios in DLAs. The lowest values of the [N/Fe]corr and [N/alpha] ratios are at variance with the values measured in Galactic halo stars of similar metallicity suggesting that part of the DLA galaxies do not follow the chemical evolution of the Milky Way. The DLA nitrogen abundances and their dispersion show some similarities with those observed in dwarf galaxies. The behaviour of nitrogen abundance ratios can be ascribed, in general to the delayed release of nitrogen in the course of evolution. However it is difficult to conciliate this interpretation with the lowest [N/alpha] values measured, since an expected enhancement of alpha-elements respect to the iron-peak elements is not observed simultaneously in these DLA galaxies. In two cases, relatively high [N/alpha] values are observed which require also a more complex chemical evolution to be explained.Comment: 29 pages including 5 tables and figure captions,LaTeX, 8 figures, ApJ accepte

Complete Genome Sequence of Treponema paraluiscuniculi, Strain Cuniculi A: The Loss of Infectivity to Humans Is Associated with Genome Decay

Treponema paraluiscuniculi is the causative agent of rabbit venereal spirochetosis. It is not infectious to humans, although its genome structure is very closely related to other pathogenic Treponema species including Treponema pallidum subspecies pallidum, the etiological agent of syphilis. In this study, the genome sequence of Treponema paraluiscuniculi, strain Cuniculi A, was determined by a combination of several high-throughput sequencing strategies. Whereas the overall size (1,133,390 bp), arrangement, and gene content of the Cuniculi A genome closely resembled those of the T. pallidum genome, the T. paraluiscuniculi genome contained a markedly higher number of pseudogenes and gene fragments (51). In addition to pseudogenes, 33 divergent genes were also found in the T. paraluiscuniculi genome. A set of 32 (out of 84) affected genes encoded proteins of known or predicted function in the Nichols genome. These proteins included virulence factors, gene regulators and components of DNA repair and recombination. The majority (52 or 61.9%) of the Cuniculi A pseudogenes and divergent genes were of unknown function. Our results indicate that T. paraluiscuniculi has evolved from a T. pallidum-like ancestor and adapted to a specialized host-associated niche (rabbits) during loss of infectivity to humans. The genes that are inactivated or altered in T. paraluiscuniculi are candidates for virulence factors important in the infectivity and pathogenesis of T. pallidum subspecies

Distances and Metallicities of High- and Intermediate-Velocity Clouds

A table is presented that summarizes published absorption line measurements for the high- and intermediate velocity clouds (HVCs and IVCs). New values are derived for N(HI) in the direction of observed probes, in order to arrive at reliable abundances and abundance limits (the HI data are described in Paper II). Distances to stellar probes are revisited and calculated consistently, in order to derive distance brackets or limits for many of the clouds, taking care to properly interpret non-detections. The main conclusions are the following. 1) Absolute abundances have been measured using lines of SII, NI and OI, with the following resulting values: ~0.1 solar for one HVC (complex C), ~0.3 solar for the Magellanic Stream, ~0.5 solar for a southern IVC, and ~ solar for two northern IVCs (the IV Arch and LLIV Arch). Finally, approximate values in the range 0.5-2 solar are found for three more IVCs. 2) Depletion patterns in IVCs are like those in warm disk or halo gas. 3) Most distance limits are based on strong UV lines of CII, SiII and MgII, a few on CaII. Distance limits for major HVCs are >5 kpc, while distance brackets for several IVCs are in the range 0.5-2 kpc. 4) Mass limits for major IVCs are 0.5-8x10^5 M_sun, but for major HVCs they are >10^6 M_sun. 5) The CaII/HI ratio varies by up to a factor 2-5 within a single cloud, somewhat more between clouds. 6) The NaIHI ratio varies by a factor >10 within a cloud, and even more between clouds. Thus, CaII can be useful for determining both lower and upper distance limits, but NaI only yields upper limits.Comment: To appear in the "Astrophysical Journal Supplement"; 82 pages; figures 6, 9 and 10 are in color; degraded figures (astro-ph restriction) - ask for good version

Gain through losses in nonlinear optics

Instabilities of uniform states are ubiquitous processes occurring in a variety of spatially extended nonlinear systems. These instabilities are at the heart of symmetry breaking, condensate dynamics, self-organization, pattern formation and noise amplification across diverse disciplines, including physics, chemistry, engineering and biology. In nonlinear optics, modulation instabilities are generally linked to the so-called parametric amplification process, which occurs when certain phase-matching or quasi-phase-matching conditions are satisfied. In the present review article, we summarize the principle results on modulation instabilities and parametric amplification in nonlinear optics, with special emphasis on optical fibres. We then review state-of-the-art research about a peculiar class of modulation instabilities and signal amplification processes induced by dissipation in nonlinear optical systems. Losses applied to certain parts of the spectrum counterintuitively lead to the exponential growth of the damped mode themselves, causing gain through losses. We discuss the concept of imaging of losses into gain, showing how to map a given spectral loss profile into a gain spectrum. We demonstrate with concrete examples that dissipation-induced modulation instability, apart from being of fundamental theoretical interest, may pave the way towards the design of a new class of tuneable fibre-based optical amplifiers, optical parametric oscillators, frequency comb sources and pulsed lasers

Improved risk stratification of patients with atrial fibrillation: an integrated GARFIELD-AF tool for the prediction of mortality, stroke and bleed in patients with and without anticoagulation.

OBJECTIVES: To provide an accurate, web-based tool for stratifying patients with atrial fibrillation to facilitate decisions on the potential benefits/risks of anticoagulation, based on mortality, stroke and bleeding risks. DESIGN: The new tool was developed, using stepwise regression, for all and then applied to lower risk patients. C-statistics were compared with CHA2DS2-VASc using 30-fold cross-validation to control for overfitting. External validation was undertaken in an independent dataset, Outcome Registry for Better Informed Treatment of Atrial Fibrillation (ORBIT-AF). PARTICIPANTS: Data from 39 898 patients enrolled in the prospective GARFIELD-AF registry provided the basis for deriving and validating an integrated risk tool to predict stroke risk, mortality and bleeding risk. RESULTS: The discriminatory value of the GARFIELD-AF risk model was superior to CHA2DS2-VASc for patients with or without anticoagulation. C-statistics (95% CI) for all-cause mortality, ischaemic stroke/systemic embolism and haemorrhagic stroke/major bleeding (treated patients) were: 0.77 (0.76 to 0.78), 0.69 (0.67 to 0.71) and 0.66 (0.62 to 0.69), respectively, for the GARFIELD-AF risk models, and 0.66 (0.64-0.67), 0.64 (0.61-0.66) and 0.64 (0.61-0.68), respectively, for CHA2DS2-VASc (or HAS-BLED for bleeding). In very low to low risk patients (CHA2DS2-VASc 0 or 1 (men) and 1 or 2 (women)), the CHA2DS2-VASc and HAS-BLED (for bleeding) scores offered weak discriminatory value for mortality, stroke/systemic embolism and major bleeding. C-statistics for the GARFIELD-AF risk tool were 0.69 (0.64 to 0.75), 0.65 (0.56 to 0.73) and 0.60 (0.47 to 0.73) for each end point, respectively, versus 0.50 (0.45 to 0.55), 0.59 (0.50 to 0.67) and 0.55 (0.53 to 0.56) for CHA2DS2-VASc (or HAS-BLED for bleeding). Upon validation in the ORBIT-AF population, C-statistics showed that the GARFIELD-AF risk tool was effective for predicting 1-year all-cause mortality using the full and simplified model for all-cause mortality: C-statistics 0.75 (0.73 to 0.77) and 0.75 (0.73 to 0.77), respectively, and for predicting for any stroke or systemic embolism over 1 year, C-statistics 0.68 (0.62 to 0.74). CONCLUSIONS: Performance of the GARFIELD-AF risk tool was superior to CHA2DS2-VASc in predicting stroke and mortality and superior to HAS-BLED for bleeding, overall and in lower risk patients. The GARFIELD-AF tool has the potential for incorporation in routine electronic systems, and for the first time, permits simultaneous evaluation of ischaemic stroke, mortality and bleeding risks. CLINICAL TRIAL REGISTRATION: URL: http://www.clinicaltrials.gov. Unique identifier for GARFIELD-AF (NCT01090362) and for ORBIT-AF (NCT01165710)