Renal complications of lipodystrophy: A closer look at the natural history of kidney disease

Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/144612/1/cen13732_am.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/144612/2/cen13732.pd

Serum and Amniotic Fluid Eosinophil Cationic Protein Levels in Misoprostol Induced Pregnancies

Objectives: The aim of this study was to determine the concentration of eosinophil cationic protein (ECP) in maternal serum (MS) and amniotic fluid (AF) at term and assess misoprostol induced changes in their mean concentrations. Methods: A total of 53 pregnant women were included in the study: 24 were in active labor, and a further 29 were not in labor and misoprostol induction was performed. The initial 3 mL of amniotic fluid was collected and processed. In all pregnant subjects, maternal blood samples were obtained from the cubital vein at the time of amniotic fluid sampling. The concentration of ECP in serum and AF was measured by chemiluminescence method with the immulite 2000 analyzer (Immulite2000® ECP, DPC Diagnostic Products Corporation 5700 West 96th Street Los Angeles, CA, USA). Results: Misoprostol induced pregnant showed significantly higher concentrations ECP than the control pregnant women in serum. AF-ECP concentrations were not significantly different between two groups. There was no significant difference between MS and AF-ECP concentrations in control subjects. Conclusion: The association we encountered between labor induction with misoprostol and increased systemic production of ECP should be investigated further. [Med-Science 2013; 2(1.000): 436-44

Comparing Trans Obturator Tension Free Vaginal Tape Surgery with Needleless Suburethral Sling

Aim: Urinary incontinence is described by the International Continence Society as an involuntary urinal discharge that can be objectively proved to cause hygenic and social problems. We aim to share our surgical experience in 51 patients in which trans obturator tension free vaginal tape procedure [TOT] is compared with needleless suburethral sling placement, also known as minisling. Material and Method: 51 patients complaining of genuine stress incontinence between December 2011 and December 2012 were retrospectively involved in the study group. All patients were examined and urodynamically tested for diagnosis. After getting positive results as genuine stress incontinence, surgery was planned. Patients were operated using outside-inside TOT technique and minisling technique, results were compared in terms of blood loss, operation time, and the surgical effectiveness of the technique. Results: Operation time was 27 +/- 6 minutes for TOT and 11 +/- 4 minutes for minisling respectively. Comparison of operation time and blood loss was in favor of the minisling group. Disscussion: TOT and minisling are both described as minimally invasive procedures that can be performed under regional anesthesia to an outpatient with minisling bearing all the advantages of TOT without needle complications

Progesterone Supplement and Luteal Phase Deficiency in Unifollicular Intrauterine Insemination Cycles

Aim: Intrauterine insemination is a widely used technique with advantages of being a simple and less invasive method with a lower cost when compared to other assisted reproductive techniques. In the present prospective randomized controlled study we aim to prove that progesterone supplementation is a beneficial factor in pregnancies achieved with intra uterine insemination and also we want to emphasise that luteal phase deficiency does not always occur in multifollicular cycles but can be seen in unifollicular cycles as well. Material and Method: Patients diagnosed with unexplained infertility between December 2011 and December 2012 were admitted to the study group. 278 IUI cycles with COH using recombinant FSH induction were recorded. Results: The effect of progesterone supplement on achieving pregnancy was statistically significant (p<0.05) with a rate of 33.66% when compared to the non-receiving group that had a rate of 12.22%. Discussion: Progesterone supplementation, either in defective luteal phase or not has a chance of improving pregnancy rates in general and contrary to the notion that luteal phase deficiency mainly occurs in multifollicular cycles, it can be seen in unifollicular patients as well

Multimodality Treatment in the Management of Anorectal Melanoma: A Case Report and Review of the Literature

Anorectal melanoma represents approximately 0.2-1% of all malignant melanomas and has a poor prognosis, with a median survival of 8 to 23 months after the time of diagnosis. The typical treatment modalities include surgery, radiotherapy and chemotherapy. The particular approach taken depends on the patient’s status and disease stage. Although there are different treatment options for this rare condition, there are not enough studies on multimodality treatment. Here, we present the case of a 54-year-old female with anorectal melanoma that had metastasized to an inguinal lymph node. She underwent local excision of the rectal mass and inguinal lymph-node dissection. Temozolomide treatment was started after radiotherapy and was given for 24 months. Follow-up revealed that the patient has been doing well with no signs of recurrence three years after the completion of treatment. We aim to discuss combined treatment modalities for ARM in light of the pertinent literature

Laparoscopic Ovarian Drilling Improves Endometrial Homeobox Gene Expression in PCOS

WOS: 000525433100026PubMed: 32046414The study was designed to investigate whether laparoscopic ovarian drilling (LOD) of ovaries alters the expression levels of HOXA-10 and HOXA-11 mRNA in the endometrium of infertile women with clomiphene-resistant PCOS. Expression of HOXA-10 and HOXA-11 mRNA in the endometrium obtained before and after LOD during the midsecretory phase was measured. Expression of each gene was evaluated using real-time reverse transcriptase polymerase chain reaction (RT-PCR). Expression levels of HOXA-10 and HOXA-11 mRNA were lower in endometrium of patients with PCOS before LOD compared with fertile controls. But the differences failed to show statistical significance. Compared with fertile subjects, LOD of PCOS ovaries up-regulated endometrial HOXA-10 and HOXA-11 mRNA expression. Fold changes of HOXA-10 and HOXA-11 mRNA after LOD were found to be 4.46 and 4.19, respectively. Fold change increase in HOXA-10 and HOXA-11 mRNA was found to be statistically significant (P < .01, P < .02). There is a receptivity defect in the endometrium of women with PCOS that affects fertility regardless of other causes of infertility. LOD increases endometrial HOXA-10 and HOXA-11 mRNA expressions and improves receptivity in patients with clomiphene-resistant PCOS

Maternal and fetal serum orexin-A levels in gestational diabetes mellitus

Aim: Evidence suggests that orexin regulates food consumption, glucose metabolism and insulin secretion. Orexin may have a role in the pathogenesis of type II diabetes mellitus, however its role in gestational diabetes mellitus is not known. We aimed to assess maternal serum and cord blood orexin-A (OXA) concentrations in pregnant women with gestational diabetes mellitus (GDM). Material and Methods: Thirty-five pregnant women with GDM and 35 gestational-age-matched healthy pregnant subjects participated in the study. Maternal serum and cord blood OXA levels were measured with enzyme immunoassay at the time of birth. The correlations between maternal serum and cord blood OXA levels, anthropometric and metabolic parameters were also assessed. Results: The mean maternal and cord serum OXA (1.16 +/- 0.37 and 1.35 +/- 0.20 ng/mL, respectively) in the GDM group were significantly different from those of the controls (1.58 +/- 0.59 and 1.25 +/- 0.21 ng/mL, respectively). The mean maternal fasting-glucose-to-OXA ratio was significantly higher in the GDM group. In the GDM group, the mean maternal serum OXA levels were similar in the insulin (n = 24) and diet (n = 11) treated cases, respectively (1.13 +/- 0.36 ng/mL and 1.21 +/- 0.41 ng/mL). Maternal serum OXA levels positively correlated with fetal serum OXA and maternal glucose levels. OXA concentrations in maternal serum were negatively correlated with the fasting glucose, fasting insulin and homeostasis model assessment insulin resistance index. Conclusions: Maternal serum OXA levels decrease, and fetal serum OXA levels increase in women with GDM

Disappointment of patients on antidepressant therapy after excimer laser treatment

We describe 2 patients who were receiving antidepressant therapy before excimer laser surgery, at the time of surgery, and after surgery. Both patients experienced the ocular side effects of antidepressant drugs, ie, symptoms due to dry eyes and mydriasis. (c) 2006 ASCRS and ESCRS