Spectroscopic Transit Search: a self-calibrating method for detecting planets around bright stars

We search for transiting exoplanets around the star $\beta$ Pictoris using high resolution spectroscopy and Doppler imaging that removes the need for standard star observations. These data were obtained on the VLT with UVES during the course of an observing campaign throughout 2017 that monitored the Hill sphere transit of the exoplanet $\beta$ Pictoris b. We utilize line profile tomography as a method for the discovery of transiting exoplanets. By measuring the exoplanet distortion of the stellar line profile, we remove the need for reference star measurements. We demonstrate the method with white noise simulations, and then look at the case of $\beta$ Pictoris, which is a $\delta$ Scuti pulsator. We describe a method to remove the stellar pulsations and perform a search for any transiting exoplanets in the resultant data set. We inject fake planet transits with varying orbital periods and planet radii into the spectra and determine the recovery fraction. In the photon noise limited case we can recover planets down to a Neptune radius with an $\sim$80% success rate, using an 8 m telescope with a $R\sim 100,000$ spectrograph and 20 minutes of observations per night. The pulsations of $\beta$ Pictoris limit our sensitivity to Jupiter-sized planets, but a pulsation removal algorithm improves this limit to Saturn-sized planets. We present two planet candidates, but argue that their signals are most likely caused by other phenomena. We have demonstrated a method for searching for transiting exoplanets that (i) does not require ancillary calibration observations, (ii) can work on any star whose rotational broadening can be resolved with a high spectral dispersion spectrograph and (iii) provides the lowest limits so far on the radii of transiting Jupiter-sized exoplanets around $\beta$ Pictoris with orbital periods from 15 days to 200 days with >50% coverage.Comment: Accepted for publication in A&A, 8 pages, 8 figures. The Github repository can be found at https://github.com/lennartvansluijs/Spectroscopic-Transit-Searc

Creación de un programa motivacional para un buen afrontamiento de los cambios psicológicos en el adulto mayor enfocado al Grupo Hilos de Plata de la Parroquia Beata Madre Encarnación Rosal.

El ejercicio Profesional Supervisado, “Creación de un programa motivacional para un buen afrontamiento de los cambios psicológicos en el adulto mayor, enfocado al grupo “Hilos de Plata” de la parroquia Beata Madre Encarnación Rosal de Villa Hermosa I, San Miguel Petapa”, se realizó de marzo de 2012 a marzo 2013. Se desarrolló en tres subprogramas: servicio docencia e investigación. El subprograma de servicio: brindó terapia psicológica a una población de 60 personas, en su mayoría niños, adolescentes, adultos y adultos mayores. Orientó a los integrantes del grupo “Hilos de Plata” para desarrollar salud mental. Fortaleció al grupo para que siga funcionando como una red de apoyo. El subprograma de docencia: contribuyó al fortalecimiento de los cambios psicológicos del adulto mayor en el grupo “Hilos de Plata”, por medio de talleres interactivos. Logró fortalecer la red de “Hilos de Plata”. El subprograma de docencia: dirigió al grupo del adulto mayor “Hilos de Plata”, con la finalidad de contribuir a que los adultos mayores tengan una perspectiva adecuada para afrontar los diferentes cambios psicológicos que causa la etapa. Logró que los integrantes del grupo tuvieran la distensión y escape de las tensiones y que aprendieran técnicas encaminadas a lograr la estabilidad emocional. Desarrolló actividades educativas, recreativas y espirituales, con el apoyo de estudiantes de Trabajo social. El subprograma de investigación, se enfocó a explorar el contexto de las relaciones básicas de las personas que asisten al grupo del adulto mayor “Hilos de Plata” y la valoración que le dan a la participación dentro del grupo. Se aplicó una entrevista estructurada, se observación las actitudes, relatos y sentimientos que los integrantes del grupo mostraron en las reuniones. Los resultados obtenidos permitieron establecer que, la afectividad y las relaciones familiares que se les brinda o niega al adulto mayor son determinantes para que los adultos mayores enfrentar de una manera sana las dificultades que representa esta etapa de la vid

Introducing two improved methods for approximating radiative cooling in hydrodynamical simulations of accretion discs

The evolution of many astrophysical systems depends strongly on the balance between heating and cooling, in particular star formation in giant molecular clouds and the evolution of young protostellar systems. Protostellar discs are susceptible to the gravitational instability, which can play a key role in their evolution and in planet formation. The strength of the instability depends on the rate at which the system loses thermal energy. To study the evolution of these systems, we require radiative cooling approximations because full radiative transfer is generally too expensive to be coupled to hydrodynamical models. Here we present two new approximate methods for computing radiative cooling that make use of the polytropic cooling approximation. This approach invokes the assumption that each parcel of gas is located within a spherical pseudo-cloud which can then be used to approximate the optical depth. The first method combines the methods introduced by Stamatellos et al. and Lombardi et al. to overcome the limitations of each method at low and high optical depths respectively. The second, the "Modified Lombardi" method, is specifically tailored for self-gravitating discs. This modifies the scale height estimate from the method of Lombardi et al. using the analytical scale height for a self-gravitating disc. We show that the Modified Lombardi method provides an excellent approximation for the column density in a fragmenting disc, a regime in which the existing methods fail to recover the clumps and spiral structures. We therefore recommend this improved radiative cooling method for more realistic simulations of self-gravitating discs

Sequence variants affecting eosinophil numbers associate with asthma and myocardial infarction

To access publisher full text version of this article. Please click on the hyperlink in Additional Links fieldEosinophils are pleiotropic multifunctional leukocytes involved in initiation and propagation of inflammatory responses and thus have important roles in the pathogenesis of inflammatory diseases. Here we describe a genome-wide association scan for sequence variants affecting eosinophil counts in blood of 9,392 Icelanders. The most significant SNPs were studied further in 12,118 Europeans and 5,212 East Asians. SNPs at 2q12 (rs1420101), 2q13 (rs12619285), 3q21 (rs4857855), 5q31 (rs4143832) and 12q24 (rs3184504) reached genome-wide significance (P = 5.3 x 10(-14), 5.4 x 10(-10), 8.6 x 10(-17), 1.2 x 10(-10) and 6.5 x 10(-19), respectively). A SNP at IL1RL1 associated with asthma (P = 5.5 x 10(-12)) in a collection of ten different populations (7,996 cases and 44,890 controls). SNPs at WDR36, IL33 and MYB that showed suggestive association with eosinophil counts were also associated with atopic asthma (P = 4.2 x 10(-6), 2.2 x 10(-5) and 2.4 x 10(-4), respectively). We also found that a nonsynonymous SNP at 12q24, in SH2B3, associated significantly (P = 8.6 x 10(-8)) with myocardial infarction in six different populations (6,650 cases and 40,621 controls)

PHarmacist Avoidance or Reductions in Medical Costs in Patients Presenting the EMergency Department: PHARM-EM Study

Objectives:. To comprehensively classify interventions performed by emergency medicine clinical pharmacists and quantify cost avoidance generated through their accepted interventions. Design:. A multicenter, prospective, observational study was performed between August 2018 and January 2019. Setting:. Community and academic hospitals in the United States. Participants:. Emergency medicine clinical pharmacists. Interventions:. Recommendations classified into one of 38 intervention categories associated with cost avoidance. Measurements and Main Results:. Eighty-eight emergency medicine pharmacists at 49 centers performed 13,984 interventions during 917 shifts that were accepted on 8,602 patients and generated $7,531,862 of cost avoidance. The quantity of accepted interventions and cost avoidance generated in six established categories were as follows: adverse drug event prevention (1,631 interventions;$2,225,049 cost avoidance), resource utilization (628; $310,582), individualization of patient care (6,122;$1,787,170), prophylaxis (24; $22,804), hands-on care (3,533;$2,836,811), and administrative/supportive tasks (2,046; $342,881). Mean cost avoidance was$538.61 per intervention, $875.60 per patient, and$8,213.59 per emergency medicine pharmacist shift. The annualized cost avoidance from an emergency medicine pharmacist was $1,971,262. The monetary cost avoidance to pharmacist salary ratio was between$1.4:1 and $10.6:1. Conclusions:. Pharmacist involvement in the care of patients presenting to the emergency department results in significant avoidance of healthcare costs, particularly in the areas of hands-on care and adverse drug event prevention. The potential monetary benefit-to-cost ratio for emergency medicine pharmacists is between$1.4:1 and $10.6:1

Sequence variants affecting eosinophil numbers associate with asthma and myocardial infarction

Eosinophils are pleiotropic multifunctional leukocytes involved in initiation and propagation of inflammatory responses and thus have important roles in the pathogenesis of inflammatory diseases. Here we describe a genome-wide association scan for sequence variants affecting eosinophil counts in blood of 9,392 Icelanders. The most significant SNPs were studied further in 12,118 Europeans and 5,212 East Asians. SNPs at 2q12 (rs1420101), 2q13 (rs12619285), 3q21 (rs4857855), 5q31 (rs4143832) and 12q24 (rs3184504) reached genome-wide significance (P = 5.3 x 10(-14), 5.4 x 10(-10), 8.6 x 10(-17), 1.2 x 10(-10) and 6.5 x 10(-19), respectively). A SNP at IL1RL1 associated with asthma (P = 5.5 x 10(-12)) in a collection of ten different populations (7,996 cases and 44,890 controls). SNPs at WDR36, IL33 and MYB that showed suggestive association with eosinophil counts were also associated with atopic asthma (P = 4.2 x 10(-6), 2.2 x 10(-5) and 2.4 x 10(-4), respectively). We also found that a nonsynonymous SNP at 12q24, in SH2B3, associated significantly (P = 8.6 x 10(-8)) with myocardial infarction in six different populations (6,650 cases and 40,621 controls)