Resistance training and redox homeostasis: Correlation with age-associated genomic changes

Regular physical activity is effective as prevention and treatment for different chronic conditions related to the ageing processes. In fact, a sedentary lifestyle has been linked to a worsening of cellular ageing biomarkers such as telomere length (TL) and/or specific epigenetic changes (e.g. DNA methylation), with increase of the propensity to aging-related diseases and premature death. Extending our previous findings, we aimed to test the hypothesis that 12 weeks of low frequency, moderate intensity, explosive-type resistance training (EMRT) may attenuate age-associated genomic changes. To this aim, TL, global DNA methylation, TRF2, Ku80, SIRT1, SIRT2 and global protein acetylation, as well as other proteins involved in apoptotic pathway (Bcl-2, Bax and Caspase-3), antioxidant response (TrxR1 and MnSOD) and oxidative damage (myeloperoxidase) were evaluated before and after EMRT in whole blood or peripheral mononuclear cells (PBMCs) of elderly subjects. Our findings confirm the potential of EMRT to induce an adaptive change in the antioxidant protein systems at systemic level and suggest a putative role of resistance training in the reduction of global DNA methylation. Moreover, we observed that EMRT counteracts the telomeres’ shortening in a manner that proved to be directly correlated with the amelioration of redox homeostasis and efficacy of training regime, evaluated as improvement of both muscle's power/strength and functional parameters

Practicing a Musical Instrument in Childhood is Associated with Enhanced Verbal Ability and Nonverbal Reasoning

Background: In this study we investigated the association between instrumental music training in childhood and outcomes closely related to music training as well as those more distantly related. Methodology/Principal Findings: Children who received at least three years (M = 4.6 years) of instrumental music training outperformed their control counterparts on two outcomes closely related to music (auditory discrimination abilities and fine motor skills) and on two outcomes distantly related to music (vocabulary and nonverbal reasoning skills). Duration of training also predicted these outcomes. Contrary to previous research, instrumental music training was not associated with heightened spatial skills, phonemic awareness, or mathematical abilities. Conclusions/Significance: While these results are correlational only, the strong predictive effect of training duration suggests that instrumental music training may enhance auditory discrimination, fine motor skills, vocabulary, and nonverba

The impact of experienced versus non-experienced suggestions on children\u27s recall of repeated events

Three experiments were conducted to test the proposition that children’s suggestibility about an occurrence of a repeated event is heightened when an interviewer suggests false details that were experienced in non-target occurrences of the event as opposed to new details that never occurred. In each experiment, children participated in a repeated event during which specific items varied each time (e.g., the children always got a sticker but the theme of the sticker was different in each occurrence). Separate biasing and memory interviews were then conducted. In Experiment 1, the interviewer merely suggested that the false details might have occurred in the event. In the remaining experiments, the suggested details were clearly linked to the target occurrence with either a contextual or temporal cue. The potential moderating effect of the child’s age (Experiment 1) and the retention interval (Experiments 1 and 2) were also examined. Consistent with the initial hypothesis, suggestions about experienced (non-target) details were more likely to be repeated by the children compared to suggestions about non-experienced details. In Experiments 2 and 3, experienced suggestions were also more likely to inhibit children’s recall of the target occurrence. The relevance and generalisability of these findings to the legal setting are discussed