THE SMALL FATAL CHOROIDAL MELANOMA STUDY A Survey by the European Ophthalmic Oncology Group

PURPOSE: To determine the size at which choroidal melanomas can metastasize and to report the characteristics of small fatal choroidal melanomas (SFCM). DESIGN: Retrospective case series. METHODS: Ten ocular oncology services submitted 45 patients with a choroidal melanoma 3 mm or less in thickness and 9 mm or less in largest basal diameter (LBD), when treated, who developed metastases. RESULTS: Median tumor thickness was 2.4 mm (range, 1.0-3.0 mm) and LBD 7.3 mm (range, 3.0-9.0 mm). Of 14 (31%) tumors that were first observed, 12 grew a median of 0.5 mm (range, 0.1-1.2 mm) in thickness and 1.0 mm (range, 0-3.0 mm) in LBD within a median of 7 months; 3 were initially smaller than 3 mm in LBD. Number of risk factors for growth and metastasis was 0 for 4% of the tumors; 60% were over 2 mm in thickness, 63% had subretinal fluid, 84% caused symptoms, 57% had orange pigment, and 92% were within 3 mm of the disc. Local recurrence occurred in 8 of 31 eyes (26%) treated conservatively. Median metastasis-free survival was 4.5 years (range, 0.8-15.7 years). Kaplan-Meier estimate of metastasis developing was 15% (95% confidence interval [CI], 7-26), 51% (95% CI, 36-64) and 85% (95% CI, 71-92) by 2, 5, and 10 years, respectively. By the time of analysis, 37 patients had died of metastasis after a median of 7 months. CONCLUSIONS: Choroidal melanomas less than 3.0 mm in LBD are highly unlikely to metastasize. Risk factors of an SFCM are similar to those for all choroidal melanomas of similar size. (C) 2019 The Author(s). Published by Elsevier Inc.Peer reviewe

Résultats de 16 ans de traitement des mélanomes uvéaux postérieurs par protonthérapie et de collaboration entre le CHU de Nice et le Centre Antoine Lacassagne

NICE-BU Médecine Odontologie (060882102) / SudocPARIS-BIUM (751062103) / SudocSudocFranceF

Traitement par protonthérapie des mélanomes choroïdiens de grande taille

NICE-BU Médecine Odontologie (060882102) / SudocSudocFranceF

Traitements actuels des hémangiomes circonscrits de la choroïde

NICE-BU Médecine Odontologie (060882102) / SudocSudocFranceF

Récidives locales des mélanomes uveaux traités par protonthérapie

NICE-BU Médecine Odontologie (060882102) / SudocSudocFranceF

Choroidal Metastasis From Melanoma Treated by Cyberknife Irradiation

International audienceA 36-year-old woman presented with visual deterioration and headache. Ophthalmologic examination results showed a 5-mm-thick choroidal mass in her right eye. Head and chest computed tomography scans showed brain and lung metastases. A resection of her lung nodule revealed metastatic BRAF V600–mutated melanoma. The patient underwent systemic targeted therapy followed by 6 sessions of Gamma Knife (Elekta) irradiation for her brain metastases. Ocular Cyberknife (Accuray) stereotactic radiotherapy was performed with a macular- and optic nerve–sparing approach. Despite disease progression in the brain, the abnormal thickness resolved in her eye and her visual acuity increased from 20/200 OD to 16/20 OD at 3 months

Optimizing the treatment of liver metastases from uveal melanomas with transarterial chemoembolization using melphalan and calibrated microspheres

International audienc