Development Scenarios of Sustainability for Golf: The Algarve Case

Golf is becoming a major industry worldwide. The majority of the Portuguese golf courses are located in the Algarve region. Golf tourism has a great economic impact on the Algarve and is regarded by local tourism developers as a vehicle for tackling the seasonal patterns of “mass tourism”. In consideration of the concerns of those involved in regional tourism and golf, the University of Algarve has developed a prospective study on the sustainability paths of this activity, starting from an integrated analysis of the reference conditions of golf in the Algarve, with respect to environmental, economic and social dimensions. This paper presents the sustainability assessment framework developed in this study and the results from its application to the Algarve’s golf courses through the definition and evaluation of three alternative development scenarios and their associated impacts. The application of economic, social and environmental indicators was a key tool for the construction of the “baseline”, “moderate” and “intensive scenarios”. It was concluded that the development of further golf activity in the Algarve should be framed within high service and environmental quality standards. The sustainability area for golf course development should vary between 29 and 41 gold courses (equivalent of 18 holes).

GINÁSTICA GERAL NA BNCC: PERCEPÇÃO DE ALUNOS DE LICENCIATURA EM EDUCAÇÃO FÍSICA

In this article we aim to investigate the perception about the teaching of General Gymnastics at school from the perspective of the trainees of the Physical Education Degree course at ESEF / UFPel. The study of qualitative approach, used a semi-structured interview, the sample was composed of students from the disciplines of stage II, IV and VI. Through this study it was possible to verify that the General Gymnastics is still a subject little known by the students and therefore little found in the classes given by the interns. In addition, it was noticed that probably some degree courses in Physical Education are not paying due attention to gymnastics, making students have a view of General Gymnastics that does not come close to the concept expressed in BNCC, and in some way does not feel prepared or motivated to develop this content in their classes.En este artículo, nuestro objetivo es investigar la percepción de enseñar Gimnasia General en la escuela desde la perspectiva de los alumnos del curso de Educación Física en ESEF / UFPel. El estudio de enfoque cualitativo, utilizó una entrevista semiestructurada, la muestra estuvo compuesta por estudiantes de las disciplinas de las etapas II, IV y VI. A través de este estudio fue posible verificar que la Gimnasia general sigue siendo una asignatura poco conocida por los alumnos y, por lo tanto, poco encontrada en las clases impartidas por los pasantes. Además, se observó que probablemente algunos cursos de grado en Educación Física no están prestando la debida atención a la gimnasia, lo que hace que los estudiantes tengan una visión de la Gimnasia general que no se acerca al concepto expresado en BNCC, y de alguna manera no sentirse preparado o motivado para desarrollar este contenido en sus clases.Neste artigo temos como objetivo investigar a percepção sobre o ensino da Ginástica Geral na escola a partir da visão dos estagiários (as) do curso de Licenciatura em Educação Física da ESEF/UFPel. O estudo de abordagem qualitativa, se utilizou de entrevista semiestruturada, a amostra foi composta por alunos (as) das disciplinas de estágio II, IV e VI. Através do presente estudo foi possível constatar que a Ginástica Geral ainda é um assunto pouco conhecido pelos discentes e por isso pouco encontrada nas aulas ministradas pelos estagiários. Além disso, percebeu-se que provavelmente alguns cursos de licenciatura em Educação Física não estejam dando devida atenção as modalidades gímnicas, fazendo com que os alunos tenham uma visão da Ginástica Geral que não se aproxima do conceito expresso na BNCC, e de algum modo não se sintam preparados ou motivados para desenvolver esse conteúdo nas suas aulas

Genetic and microenvironmental intra-tumor heterogeneity impacts colorectal cancer evolution and metastatic development

© The Author(s) 2022 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.Colorectal cancer (CRC) is a highly diverse disease, where different genomic instability pathways shape genetic clonal diversity and tumor microenvironment. Although intra-tumor heterogeneity has been characterized in primary tumors, its origin and consequences in CRC outcome is not fully understood. Therefore, we assessed intra- and inter-tumor heterogeneity of a prospective cohort of 136 CRC samples. We demonstrate that CRC diversity is forged by asynchronous forms of molecular alterations, where mutational and chromosomal instability collectively boost CRC genetic and microenvironment intra-tumor heterogeneity. We were able to depict predictor signatures of cancer-related genes that can foresee heterogeneity levels across the different tumor consensus molecular subtypes (CMS) and primary tumor location. Finally, we show that high genetic and microenvironment heterogeneity are associated with lower metastatic potential, whereas late-emerging copy number variations favor metastasis development and polyclonal seeding. This study provides an exhaustive portrait of the interplay between genetic and microenvironment intra-tumor heterogeneity across CMS subtypes, depicting molecular events with predictive value of CRC progression and metastasis development.This work was financed by national funds from FCT - Fundação para a Ciência e a Tecnologia, I.P., in the scope of the project UIDP/04378/2020 and UIDB/04378/2020 of the Research Unit on Applied Molecular Biosciences - UCIBIO and the project LA/P/0140/2020 of the Associate Laboratory Institute for Health and Bioeconomy - i4HB. This research was also funded by: PTDC/MED-ONC/28660/2017 from Fundação para a Ciência e Tecnologia (FCT) to A.R.G. A.R.G is recipient of Researcher Grant CEECIND/02699/2017 from FCT. The biobanking of CRC samples from Hospital Santa Maria, Lisbon, Portugal was supported by FCT research grant PIC/IC/82821/2007. This work was produced with the support of INCD funded by FCT and FEDER under the project 22153-01/SAICT/2016.info:eu-repo/semantics/publishedVersio

Early mobilisation in critically ill COVID-19 patients: a subanalysis of the ESICM-initiated UNITE-COVID observational study

Background Early mobilisation (EM) is an intervention that may improve the outcome of critically ill patients. There is limited data on EM in COVID-19 patients and its use during the first pandemic wave. Methods This is a pre-planned subanalysis of the ESICM UNITE-COVID, an international multicenter observational study involving critically ill COVID-19 patients in the ICU between February 15th and May 15th, 2020. We analysed variables associated with the initiation of EM (within 72 h of ICU admission) and explored the impact of EM on mortality, ICU and hospital length of stay, as well as discharge location. Statistical analyses were done using (generalised) linear mixed-effect models and ANOVAs. Results Mobilisation data from 4190 patients from 280 ICUs in 45 countries were analysed. 1114 (26.6%) of these patients received mobilisation within 72 h after ICU admission; 3076 (73.4%) did not. In our analysis of factors associated with EM, mechanical ventilation at admission (OR 0.29; 95% CI 0.25, 0.35; p = 0.001), higher age (OR 0.99; 95% CI 0.98, 1.00; p ≤ 0.001), pre-existing asthma (OR 0.84; 95% CI 0.73, 0.98; p = 0.028), and pre-existing kidney disease (OR 0.84; 95% CI 0.71, 0.99; p = 0.036) were negatively associated with the initiation of EM. EM was associated with a higher chance of being discharged home (OR 1.31; 95% CI 1.08, 1.58; p = 0.007) but was not associated with length of stay in ICU (adj. difference 0.91 days; 95% CI − 0.47, 1.37, p = 0.34) and hospital (adj. difference 1.4 days; 95% CI − 0.62, 2.35, p = 0.24) or mortality (OR 0.88; 95% CI 0.7, 1.09, p = 0.24) when adjusted for covariates. Conclusions Our findings demonstrate that a quarter of COVID-19 patients received EM. There was no association found between EM in COVID-19 patients' ICU and hospital length of stay or mortality. However, EM in COVID-19 patients was associated with increased odds of being discharged home rather than to a care facility. Trial registration ClinicalTrials.gov: NCT04836065 (retrospectively registered April 8th 2021)

Determinação de flúor em fígado animal por cromatografia de íons após a combustão iniciada por micro-ondas

O presente trabalho teve por objetivo desenvolver um método analítico adequado para determinação de flúor em fígado utilizando a IC-CD após decomposição por MIC