Effects of hydrogen on metals

Several rules to guide choice of materials, and methods of welding, electroplating, and heat treatment will provide a method for minimizing failures in storage tanks and related hardware. Failures are caused by high-pressure hydrogen effects, the formation of hydrides in titanium, and hydrogen absorption through various metals processing techniques

Hierarchy and assortativity as new tools for affinity investigation: the case of the TBA aptamer-ligand complex

Aptamers are single stranded DNA, RNA or peptide sequences having the ability to bind a variety of specific targets (proteins, molecules as well as ions). Therefore, aptamer production and selection for therapeutic and diagnostic applications is very challenging. Usually they are in vitro generated, but, recently, computational approaches have been developed for the in silico selection, with a higher affinity for the specific target. Anyway, the mechanism of aptamer-ligand formation is not completely clear, and not obvious to predict. This paper aims to develop a computational model able to describe aptamer-ligand affinity performance by using the topological structure of the corresponding graphs, assessed by means of numerical tools such as the conventional degree distribution, but also the rank-degree distribution (hierarchy) and the node assortativity. Calculations are applied to the thrombin binding aptamer (TBA), and the TBA-thrombin complex, produced in the presence of Na+ or K+. The topological analysis reveals different affinity performances between the macromolecules in the presence of the two cations, as expected by previous investigations in literature. These results nominate the graph topological analysis as a novel theoretical tool for testing affinity. Otherwise, starting from the graphs, an electrical network can be obtained by using the specific electrical properties of amino acids and nucleobases. Therefore, a further analysis concerns with the electrical response, which reveals that the resistance sensitively depends on the presence of sodium or potassium thus posing resistance as a crucial physical parameter for testing affinity.Comment: 12 pages, 5 figure

Lightweight magnesium-lithium alloys show promise

Evaluation tests show that magnesium-lithium alloys are lighter and more ductile than other magnesium alloys. They are being used for packaging, housings, containers, where light weight is more important than strength

The client-oriented model of cultural competence in healthcare organizations

The paper aims to propose a new model of cultural competence in health organizations based on the paradigm of client orientation. Starting from a literature review, this study takes inspiration from dimensions that characterize the cultural competence of health organizations, and re-articulates them in more detail by applying a client orientation view. The resulting framework is articulated into six dimensions (formal references; procedures and practices; cultural competences of human resources; cultural orientation toward client; partnership with community; and self-assessment) that define the ability of a health organization to achieve its mission, acknowledging, understanding, and valorizing cultural differences of internal clients (staff) and external clients (consumers). This study makes an effort to address the paucity of studies linking approaches to managing cultural diversity in health organizations with cultural competence within the framework of client orientation

Static Einstein-Maxwell Solutions in 2+1 dimensions

We obtain the Einstein-Maxwell equations for (2+1)-dimensional static space-time, which are invariant under the transformation $q_0=i\,q_2,q_2=i\,q_0,\alpha \rightleftharpoons \gamma$. It is shown that the magnetic solution obtained with the help of the procedure used in Ref.~\cite{Cataldo}, can be obtained from the static BTZ solution using an appropriate transformation. Superpositions of a perfect fluid and an electric or a magnetic field are separately studied and their corresponding solutions found.Comment: 8 pages, LaTeX, no figures, to appear in Physical Review

Lox/Gox related failures during Space Shuttle Main Engine development

Specific rocket engine hardware and test facility system failures are described which were caused by high pressure liquid and/or gaseous oxygen reactions. The failures were encountered during the development and testing of the space shuttle main engine. Failure mechanisms are discussed as well as corrective actions taken to prevent or reduce the potential of future failures

Friction force on a vortex due to the scattering of superfluid excitations in helium II

The longitudinal friction acting on a vortex line in superfluid $^4$He is investigated within a simple model based on the analogy between such vortex dynamics and that of the quantal Brownian motion of a charged point particle in a uniform magnetic field. The scattering of superfluid quasiparticle excitations by the vortex stems from a translationally invariant interaction potential which, expanded to first order in the vortex velocity operator, gives rise to vortex transitions between nearest Landau levels. The corresponding friction coefficient is shown to be, in the limit of elastic scattering (vanishing cyclotron frequency), equivalent to that arising from the Iordanskii formula. Proposing a simple functional form for the scattering amplitude, with only one adjustable parameter whose value is set in order to get agreement to the Iordanskii result for phonons, an excellent agreement is also found with the values derived from experimental data up to temperatures about 1.5 K. Finite values of the cyclotron frequency arising from recent theories are shown to yield similar results. The incidence of vortex-induced quasiparticle transitions on the friction process is estimated to be, in the roton dominated regime, about 50 % of the value of the friction coefficient, $\sim$8 % of which corresponds to roton-phonon transitions and $\sim$42 % to roton $R^+\leftrightarrow R^-$ ones.Comment: 15 pages, 4 figures; typos corrected, to be published in PR

Achieving the Way for Automated Segmentation of Nuclei in Cancer Tissue Images through Morphology-Based Approach: a Quantitative Evaluation

In this paper we address the problem of nuclear segmentation in cancer tissue images, that is critical for specific protein activity quantification and for cancer diagnosis and therapy. We present a fully automated morphology-based technique able to perform accurate nuclear segmentations in images with heterogeneous staining and multiple tissue layers and we compare it with an alternate semi-automated method based on a well established segmentation approach, namely active contours. We discuss active contours’ limitations in the segmentation of immunohistochemical images and we demonstrate and motivate through extensive experiments the better accuracy of our fully automated approach compared to various active contours implementations

Regular (2+1)-dimensional black holes within non-linear Electrodynamics

(2+1)-regular static black hole solutions with a nonlinear electric field are derived. The source to the Einstein equations is an energy momentum tensor of nonlinear electrodynamics, which satisfies the weak energy conditions and in the weak field limit becomes the (2+1)-Maxwell field tensor. The derived class of solutions is regular; the metric, curvature invariants and electric field are regular everywhere. The metric becomes, for a vanishing parameter, the (2+1)-static charged BTZ solution. A general procedure to derive solutions for the static BTZ (2+1)-spacetime, for any nonlinear Lagrangian depending on the electric field is formulated; for relevant electric fields one requires the fulfillment of the weak energy conditions.Comment: 5 pages, Latex, 2 figure