Fisioterapia tras fractura de radio y escafoides: A propósito de un caso clínico

Introducción: Las fracturas distales de radio representan la sexta parte de las fracturas atendidas en traumatología. Afectan sobre todo a mujeres de raza blanca y su incidencia se extiende cada día más en una franja de edad de 40-69 años. Existen multitud de clasificaciones para dichas fracturas, contraponiéndose con la ausencia de un programa estándar de tratamiento. Además, son una causa importante de baja laboral debido a las secuelas que dejan. Objetivos: El objetivo de este estudio es el seguimiento de un paciente a lo largo de un programa de tratamiento confeccionado en base a la bibliografía existente. Metodología: Se realizó el seguimiento de una paciente de 46 años tras consolidación y periodo de inmovilización por una fractura de la apófisis estiloides radial izquierda y tercio medio de escafoides, a lo largo de 19 sesiones. Desarrollo: A lo largo de las 19 sesiones se realizó un programa de fisioterapia basado en el uso de cinesiterapia, terapia manual, hidroterapia de contraste, electroterapia y magnetoterapia. Conclusión: El tratamiento se ha visto efectivo en este caso a la hora de reducir el dolor y mejorar el ROM y la funcionalidad, a pesar de las limitaciones que han ido surgiendo en el proceso

La desigualdad frente al espejo: una herramienta para el aprendizaje de la estratificación social a través del autoanálisis sociológico 2

Elaboración de una aplicación para el aprendizaje de la desigualdad social a partir de una intervención experiencial en el aula en la que se visualiza la comparación de las situaciones y percepciones del estudiantado con la realidad social general

Non-motor symptom burden in patients with Parkinson's disease with impulse control disorders and compulsive behaviours : results from the COPPADIS cohort

The study was aimed at analysing the frequency of impulse control disorders (ICDs) and compulsive behaviours (CBs) in patients with Parkinson's disease (PD) and in control subjects (CS) as well as the relationship between ICDs/CBs and motor, nonmotor features and dopaminergic treatment in PD patients. Data came from COPPADIS-2015, an observational, descriptive, nationwide (Spain) study. We used the validated Questionnaire for Impulsive-Compulsive Disorders in Parkinson's Disease-Rating Scale (QUIP-RS) for ICD/CB screening. The association between demographic data and ICDs/CBs was analyzed in both groups. In PD, this relationship was evaluated using clinical features and treatment-related data. As result, 613 PD patients (mean age 62.47 ± 9.09 years, 59.87% men) and 179 CS (mean age 60.84 ± 8.33 years, 47.48% men) were included. ICDs and CBs were more frequent in PD (ICDs 12.7% vs. 1.6%, p < 0.001; CBs 7.18% vs. 1.67%, p = 0.01). PD patients had more frequent previous ICDs history, premorbid impulsive personality and antidepressant treatment (p < 0.05) compared with CS. In PD, patients with ICDs/CBs presented younger age at disease onset, more frequent history of previous ICDs and premorbid personality (p < 0.05), as well as higher comorbidity with nonmotor symptoms, including depression and poor quality of life. Treatment with dopamine agonists increased the risk of ICDs/CBs, being dose dependent (p < 0.05). As conclusions, ICDs and CBs were more frequent in patients with PD than in CS. More nonmotor symptoms were present in patients with PD who had ICDs/CBs compared with those without. Dopamine agonists have a prominent effect on ICDs/CBs, which could be influenced by dose

Estudio químico cuántico de la relación estructura-actividad antirreumática en los compuestos hidroxibenzoicos

Tesis doctoral inédita leída en la Universidad Autónoma de Madrid. Facultad de Ciencias. Departamento de Química Cuántica. Fecha de lectura: Junio de 197

Acidity and basicity of indazole and its N-methyl derivatives in the ground and in the excited state

The tautomeric equilibrium between 1H- and 2H-indazoles both in the ground (S0) and in the excited state (S1) have been investigated by photophysical and thermochemical techniques, as well as by theoretical calculations. In the excited state indazole is 3.8 pKa units more acid (pKa* = 10.10) and 1.8 pKa units more basic (pKa* = 2.87) than in the ground state. The complete thermodynamical cycle connecting the ground and excited states in the gas and condensed phases for 1-methyl- and 2-methylindazoles has been built, allowing us to discuss the relative stability of the 1H- and 2H-indazole tautomers. Our results indicate that the 1H tautomer is more stable than the 2H tautomer and that the difference in energy between them (2.3 kcal mol-1) is the same in the ground and the excited states. The theoretical calculations performed at 6-31G//6-31G level show that this trend is only attenuated but never reversed by the solvation effect of either two water molecules or one formic acid molecule. Both experimental and theoretical results lead to the conclusion that 1-methylindazole is 3.2 kcal mol-1 more stable than 2-methylindazole. However, in order to adequately reproduce the relative stability of benzazoles, the ab initio calculations must include correlation effects (MP2/ /6-31G**//6-31G*). © 1994 American Chemical Society

Effect of the replacement of a methyl by a trifluoromethyl group on the acid-base properties of pyrazoles

Experimental determinations have been carried out of the thermodynamic basicities and acidities in the gas phase and in aqueous solution of pyrazoles substituted at positions 3 and 5 with methyl and trifluoromethyl groups. Corresponding theoretical calculations at the STO-3G level have also been done. The results are highly consistent both between relative gas-phase properties and theoretical calculations (including STO-3G calculations of anions) and between gas-phase and aqueous solution values. The trifluoromethyl group is found to considerably decrease the basicity (more in position 3 than in position 5) and increase the acidity (more in position 5 than in position 3)

Obesity and prostate cancer: gene expression signature of human periprostatic adipose tissue

<p>Abstract</p> <p>Background</p> <p>Periprostatic (PP) adipose tissue surrounds the prostate, an organ with a high predisposition to become malignant. Frequently, growing prostatic tumor cells extend beyond the prostatic organ towards this fat depot. This study aimed to determine the genome-wide expression of genes in PP adipose tissue in obesity/overweight (OB/OW) and prostate cancer patients.</p> <p>Methods</p> <p>Differentially expressed genes in human PP adipose tissue were identified using microarrays. Analyses were conducted according to the donors' body mass index characteristics (OB/OW versus lean) and prostate disease (extra prostatic cancer versus organ confined prostate cancer versus benign prostatic hyperplasia). Selected genes with altered expression were validated by real-time PCR. Ingenuity Pathway Analysis (IPA) was used to investigate gene ontology, canonical pathways and functional networks.</p> <p>Results</p> <p>In the PP adipose tissue of OB/OW subjects, we found altered expression of genes encoding molecules involved in adipogenic/anti-lipolytic, proliferative/anti-apoptotic, and mild immunoinflammatory processes (for example, <it>FADS1</it>, down-regulated, and <it>LEP </it>and <it>ANGPT1</it>, both up-regulated). Conversely, in the PP adipose tissue of subjects with prostate cancer, altered genes were related to adipose tissue cellular activity (increased cell proliferation/differentiation, cell cycle activation and anti-apoptosis), whereas a downward impact on immunity and inflammation was also observed, mostly related to the complement (down-regulation of <it>CFH</it>). Interestingly, we found that the microRNA <it>MIRLET7A2 </it>was overexpressed in the PP adipose tissue of prostate cancer patients.</p> <p>Conclusions</p> <p>Obesity and excess adiposity modified the expression of PP adipose tissue genes to ultimately foster fat mass growth. In patients with prostate cancer the expression profile of PP adipose tissue accounted for hypercellularity and reduced immunosurveillance. Both findings may be liable to promote a favorable environment for prostate cancer progression.</p

XIV Seminario Internacional de Investigación en Urbanismo. ACTAS

La presente publicación recoge los resúmenes de todas las ponencias presentadas oralmente en la decimocuarta edición del Seminario Internacional de Investigación en Urbanismo (SIIU), celebrada en la Escuela Técnica Superior de Arquitectura de Madrid (Universidad Politécnica de Madrid) y presentadas durante los días 16 y 17 de junio de 2022. El Seminario Internacional de Investigación en Urbanismo tuvo su origen en el año 2007, como iniciativa de un grupo de profesores y doctorandos del Departamento de Urbanismo y Ordenación del Territorio de la Universidad Politécnica de Catalunya. Este seminario, originalmente interno y dirigido a investigadores en formación, pretendía ser un espacio de encuentro anual de los doctorandos del programa para debatir y recibir feedback sobre sus trabajos. Su condición pionera, como espacio de reflexión en torno a temas sobre la ciudad, el territorio y el paisaje en el ámbito hispanoamericano, provocó que muy pronto excediera el ámbito local y se transformara en un espacio de interés internacional. Por esta razón, a partir de la quinta edición, celebrada en 2013, se realiza cada año de manera conjunta entre la sede de Barcelona (Universidad Politécnica de Cataluña) y una sede latinoamericana. Hasta ahora han sido sede del SIIU en América, al otro lado del Atlántico: Buenos Aires, Córdoba (Argentina), Santiago de Chile, Bogotá, São Paulo, Camboriú y Curitiba. Asimismo, a partir del año 2020, el gran interés que estaba generando de este lado del Atlántico impulsa su realización en universidades de la Península Ibérica en conjunto con la UPC. De esta manera, Lisboa fue ese año la sede que, en colaboración con Barcelona, acogió el seminario, con el fin de responder al gran interés que éste tiene en el ámbito lusitano. Y en junio de 2022, Madrid ha sido la sede del seminario en España, con la voluntad de estrechar lazos entre dos de las escuelas de arquitectura más importantes del país, y compartir experiencias y miradas sobre los temas relacionados con el urbanismo. Del otro lado del Atlántico, Curitiba fue la sede latinoamericana que, con gran éxito, celebró la segunda parte del evento en la semana siguiente al evento de Madrid

Non-motor symptoms burden, mood, and gait problems are the most significant factors contributing to a poor quality of life in non-demented Parkinson's disease patients: Results from the COPPADIS Study Cohort

[Objective] To identify factors related to a poor health-related and global quality of life (QoL) in a cohort of non-demented Parkinson's disease (PD) patients and compare to a control group.[Methods] The data correspond to the baseline evaluation of the COPPADIS-2015 Study, an observational, 5-year follow-up, multicenter, evaluation study. Three instruments were used to assess QoL: (1) the 39-item Parkinson's disease Questionnaire (PDQ-39), (2) a subjective rating of global QoL (PQ-10), and (3) the EUROHIS-QOL 8-item index (EUROHIS-QOL8). Multiple linear regression methods were used to evaluate the direct impact of different variables on these QoL measures.[Results] QoL was worse in PD patients (n = 692; 62.6 ± 8.9 years old, 60.3% males) than controls (n = 206; 61 ± 8.3 years old, 49.5% males): PDQ-39, 17.1 ± 13.5 vs 4.4 ± 6.3 (p < 0.0001); PQ-10, 7.3 ± 1.6 vs 8.1 ± 1.2 (p < 0.0001); EUROHIS-QOL8, 3.8 ± 0.6 vs 4.2 ± 0.5 (p < 0.0001). A high correlation was observed between PDQ-39 and Non-Motor Symptoms Scale (NMSS) (r = 0.72; p < 0.0001), and PDQ-39 and Beck Depression Inventory-II (BDI-II) (r = 0.65; p < 0.0001). For health-related QoL (PDQ-39), non-motor symptoms burden (NMSS), mood (BDI-II), and gait problems (Freezing Of Gait Questionnaire [FOGQ]) provided the highest contribution to the model (β = 0.32, 0.28, and 0.27, respectively; p < 0.0001); whereas mood and gait problems contributed the most to global QoL (PQ-10, β = -0.46 and −0.21, respectively; EUROHIS-QOL8, β = -0.44 and −0.23, respectively).[Conclusions] QoL is worse in PD patients than in controls. Mood, non-motor symptoms burden, and gait problems seem to be the most relevant factors affecting health-related and global perceived QoL in non-demented PD patients.Peer reviewe

Contemporary use of cefazolin for MSSA infective endocarditis: analysis of a national prospective cohort

Objectives: This study aimed to assess the real use of cefazolin for methicillin-susceptible Staphylococcus aureus (MSSA) infective endocarditis (IE) in the Spanish National Endocarditis Database (GAMES) and to compare it with antistaphylococcal penicillin (ASP). Methods: Prospective cohort study with retrospective analysis of a cohort of MSSA IE treated with cloxacillin and/or cefazolin. Outcomes assessed were relapse; intra-hospital, overall, and endocarditis-related mortality; and adverse events. Risk of renal toxicity with each treatment was evaluated separately. Results: We included 631 IE episodes caused by MSSA treated with cloxacillin and/or cefazolin. Antibiotic treatment was cloxacillin, cefazolin, or both in 537 (85%), 57 (9%), and 37 (6%) episodes, respectively. Patients treated with cefazolin had significantly higher rates of comorbidities (median Charlson Index 7, P <0.01) and previous renal failure (57.9%, P <0.01). Patients treated with cloxacillin presented higher rates of septic shock (25%, P = 0.033) and new-onset or worsening renal failure (47.3%, P = 0.024) with significantly higher rates of in-hospital mortality (38.5%, P = 0.017). One-year IE-related mortality and rate of relapses were similar between treatment groups. None of the treatments were identified as risk or protective factors. Conclusion: Our results suggest that cefazolin is a valuable option for the treatment of MSSA IE, without differences in 1-year mortality or relapses compared with cloxacillin, and might be considered equally effective