579 research outputs found

    Semileptonic decays, magnetic moments and spin distributions of spin-1/2 baryons with sea contribution

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    Spin-1/2 baryons are considered as a composite system made out of a "core" of three quarks surrounded by a "sea" (of gluons and qqˉq\bar{q}-pairs) which is specified by its total quantum numbers. Specifically, we assume this sea to be a flavor octet with spin-0 or 1 but no color. We show our model can provide very goods fits to magnetic moments and semileptonic decay data using experimental errors. The predictions for spin distributions are in reasonable agreement with experiment.Comment: To be published in Int. J. of Mod. Phys.

    Oral microbiota, health, and cancer: the dual face of the same coin in the field of the host-microbe interactome

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    In recent years, within the extensive research regarding human microbiota and chronic diseases, new medical and laboratory technologies have played a crucial role in understanding more complex biological pathways between human cells and microbes. On the other hand, molecular and cellular diversity and their involvement in health responses to changing host conditions have only recently been understood, through the development of brand-new laboratory tools based on ‘omics approaches. The continuous insertion of already conceptualized, new experimental large datasets and raw data onto bibliographic platforms means that they are now accessible for subsequent elaboration by other researchers. This aspect has allowed the creation of an interactive mesh of proteins, genes, and small molecules, usually called, interactome or interactomics

    Development and validation of The Breaking Bad News Attitudes Scale

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    Background: Communication of bad news plays a critical role in the physician-patient relationship, and a variety of consensus guidelines have been developed to this purpose, including the SPIKES protocol. However, little is known about physicians’ attitudes towards breaking bad news and to be trained to deliver it. This study aimed to develop and validate a self-report questionnaire to assess physicians’ attitudes towards principles of the SPIKES protocol and training on them. Methods: The Breaking Bad News Attitudes Scale (BBNAS) was administered to 484 pediatricians and 79 medical students, recruited at two scientific conferences and two medical schools in Brazil. The questionnaire structural validity, reliability, and associations with other variables were tested. Results: The BBNAS showed adequate validity and good reliability, with two factors measuring attitudes towards the SPIKES strategy for braking bad news (α = 0.81) and the possibility to be trained on it (α = 0.77), respectively. Conclusion: The novel questionnaire is a psychometrically sound measure that provides information on physicians’ agreement with the SPIKES protocol. The BBNAS can provide useful information for planning training and continuing education programs for clinicians on communication of bad news using the SPIKES as a framework

    Promoting mental health and well‐being among adolescent young carers in Europe: A randomized controlled trial protocol

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    It is estimated that 4–8% of youth in Europe carry out substantial care for a family member or significant other. To prevent adverse psychosocial outcomes in young carers (YCs), primary prevention resilience building interventions have been recommended. We describe the study protocol of an international randomized controlled trial (RCT) of an innovative group intervention designed to promote the mental health and well‐being of adolescent YCs (AYCs) aged 15–17. The RCT will be conducted in six European countries in the context of the Horizon 2020 European funded research and innovation project “Psychosocial support for promoting mental health and well‐being among adolescent young caregivers in Europe” (“ME‐WE”). The ME‐WE intervention is based on Hayes and Ciarrochi’s psychoeducational model for adolescents and will consist of seven 2‐h sessions in a group format, aimed to help AYCs build psychological flexibility and live according to their values. The control group will be a waitlist. Primary and secondary outcomes and control variables will be measured at baseline (T0), post‐intervention (T1) and 3 months follow‐up (T2). The COVID‐19 pandemic has made amendments necessary to the original study protocol methodology, which we describe in detail. This study will contribute to building an evidence‐based manualized program that educators and health and social care professionals can use to support AYCs in their transition to adulthood. From a research perspective, the outcomes of this study will contribute to evidence‐based practices in primary prevention of psychosocial difficulties in AYCs and will gather novel knowledge on the effectiveness of Hayes and Ciarrochi’s model for use with middle adolescents with caring responsibilities. The trial has been preregistered (registration number: NCT04114864)

    Sperm quality assessment in Ficopomatus enigmaticus (Fauvel, 1923): Effects of selected organic and inorganic chemicals across salinity levels

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    Contamination by organic and inorganic compounds remains one of the most complex problems in both brackish and marine environments, causing potential implications for the reproductive success and survival of several broadcast spawners. Ficopomatus enigmaticus is a tubeworm polychaete that has previously been used as a model organism for ecotoxicological analysis, due to its sensitivity and ecological relevance. In the present study, the effects of five trace elements (zinc, copper, cadmium, arsenic and lead), one surfactant (sodium dodecyl sulfate, SDS) and one polycyclic aromatic hydrocarbon (benzo(a)pyrene, B(a)P) on the sperm quality of F. enigmaticus were investigated. Sperm suspensions were exposed in vitro to different concentrations of each selected contaminant under four salinity conditions (10, 20, 30, 35). Possible adverse effects on sperm function were assessed by measuring oxidative stress, membrane integrity, viability and DNA damage. Sperm quality impairments induced by organic contaminants were more evident than those induced by inorganic compounds. SDS exerted the largest effect on sperm. In addition, F. enigmaticus sperm showed high tolerance to salinity variation, supporting the wide use of this species as a promising model organism for ecotoxicological assays. Easy and rapid methods on polychaete spermatozoids were shown to be effective as integrated sperm quality parameters or as an alternative analysis for early assessment of marine and brackish water pollution

    The Infertility-Related Stress Scale: Validation of a Brazilian–Portuguese Version and Measurement Invariance Across Brazil and Italy

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    Infertility constitutes an essential source of stress in the individual and couple's life. The Infertility-Related Stress Scale (IRSS) is of clinical interest for exploring infertility-related stress affecting the intrapersonal and interpersonal domains of infertile individuals' lives. In the present study, the IRSS was translated into Brazilian-Portuguese, and its factor structure, reliability, and relations to sociodemographic and infertility-related characteristics and depression were examined. A sample of 553 Brazilian infertile individuals (54.2% female, mean aged 36 ± 6 years) completed the Brazilian-Portuguese IRSS (IRSS-BP), and a subsample of 222 participants also completed the BDI-II. A sample of 526 Italian infertile individuals (54.2% female, mean aged 38 ± 6 years) was used to test for the IRSS measurement invariance across Brazil and Italy. Results of exploratory structural equation modeling (ESEM) indicated that a bifactor solution best represented the structure underlying the IRSS-BP. Both the general and the two specific intrapersonal and interpersonal IRSS-BP factors showed satisfactory levels of composite reliability. The bifactor ESEM solution replicated well across countries. As evidence of relations to other variables, female gender, a longer duration of infertility, and higher depression were associated with higher scores in global and domain-specific infertility-related stress. The findings offer initial evidence of validity and reliability of the IRSS-BP, which could be used by fertility clinic staff to rapidly identify patients who need support to deal with the stressful impact of infertility in the intrapersonal and interpersonal life domains, as recommended by international guidelines for routine psychosocial care in infertility settings

    Rare jaw bone tumor: The importance of multidisciplinary management and minimally invasive treatment

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    Objective: The aim of this study was to present a mini review of oral Cementoblastoma and to report a particular case of this tumor. The Cementoblastoma is a rare benign lesion that represents less than 1-6% of all odontogenic tumors. Cementoblastoma, in the current WHO classification of odontogenic tumors, falls under the category of mesenchymal tumors (WHO 2017) and it is characterized by the proliferation of cementum-like tissue and, in all cases, tends to be associated with an erupting permanent tooth, most often the first molar. Case Presentation: A 15-year-old female presented a great Cementoblastoma with cortical expansion that affected the left mandibular body, extending from the canine to the first premolar (size 28x24 mm) and involving the mandibular canal. Surgery was performed under general anesthesia with total excision of the lesion, which was then sent for histological analysis. Due to the high risk of nerve injuries and the extreme fragility of the remaining bone after surgery, which required plates and intermaxillary blockage, the surgical site was regenerated with an iliac crest graft together with autologous and synthetic bone. Results: For the mini-review, 107 articles were found, but only 26 were selected. The patient was monitored for 12 months after surgery; a perfect healing was reported without complications, and she showed no signs of recurrence. Conclusions: This case report emphasizes the usefulness of clinical choices in a rare case of cementoblastoma of great size in a very young patient. In this condition, finding the most effective eradicative and reconstructive treatment, following the last published protocols, could achieve optimal clinical and psychological patient outcomes

    approach to a water safety plan for recreational waters disinfection of a drainage pumping station as an unconventional point source of fecal contamination

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    Abstract In the context of the management of bathing water quality, the intermittent contamination of rainwater drainage pumps (unconventional point sources) could be controlled by peracetic acid disinfection. Thus, a field experimental study was carried out to set up a water safety plan, determining the monitoring parameters and the critical limit for corrective actions. With a 0.5 mg/l dosage, the average logarithmic microbial reduction was 0.50 ± 0.48 for Escherichia coli (EC) and 0.43 ± 0.54 for intestinal enterococci. Among the chemical and physical parameters that could be monitored in real time, the oxidation–reduction potential was the only one able to predict the microbial concentration discharged from a drainage pump and the logarithmic abatement of EC. Considering the possible impact of this source on bathing waters in terms of additional risk of gastrointestinal infections, the critical limit for continuous monitoring was established using a quantitative microbial risk assessment (QMRA) model

    Synthesis of highly luminescent wurtzite CdSe/CdS giant-shell nanocrystals using a fast continuous injection route

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    We synthesized CdSe/CdS giant-shell nanocrystals, with a CdSe core diameter between 2.8 nm and 5.5 nm, and a CdS shell thickness of up to 7–8 nm (equivalent to about 20 monolayers of CdS). Both the core and shell have a wurtzite crystal structure, yielding epitaxial growth of the shell and nearly defect-free crystals. As a result, the photoluminescence (PL) quantum efficiency (QE) is as high as 90%. Quantitative PL measurements at various excitation wavelengths allow us to separate the nonradiative decay into contributions from interface and surface trapping, giving us pathways for future optimization of the structure. In addition, the NCs do not blink, and the giant shell and concurring strong electron delocalization efficiently suppress Auger recombination, yielding a biexciton lifetime of about 15 ns. The corresponding biexciton PL QE equals 11% in 5.5/18.1 nm CdSe/CdS. Variable-temperature time-resolved PL and PL under magnetic fields further reveal that the emission at cryogenic temperature originates from a negative trion-state, in agreement with other CdSe/CdS giant-shell systems reported in the literature
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