Evaluación in vitro de la actividad antihelmíntica de extractosmetanólicos de Guazuma ulmifolia frente anematodos Cyathostominae

The study evaluated the anti-hatching effect of methanolic extracts from the bark and leaf of Guazuma ulmifolia using the in vitro Nematode Egg Hatching Inhibition test. Concentrations of 1000, 500 and 250 µg/ml of each extract, a negative control (Dimethyl sulfoxide) and two positive controls (Fenbendazole and Lugol) were evaluated against nematodes of the Cyathostominae subfamily as a biological model. The three concentrations of the two extracts, as well as the two positive controls showed statistically similar results, but different compared to the negative control. The mean inhibition of egg hatching using bark and leaf was 49.73 and 45.22%, respectively, at the 1000 µg/ml concentration, 61.93 and 59.20% at the 500 µg/ml concentration, and 75.60 and 75.82% at the concentration of 250 µg/ml. The methanolic extracts of the bark and leaf of Guazuma ulmifolia showed an anti-hatching effect against Cyathostominae nematodes at the concentrations testedEl estudio evaluó el efecto anti-eclosión de extractos metanólicos de corteza y hojade Guazuma ulmifolia mediante la prueba in vitro de Inhibición de la Eclosión de huevosde nematodos. Se evaluaron las concentraciones de 1000, 500 y 250 μg/ml de cada extrac-to, un control negativo (Dimetil sulfóxido) y dos controles positivos (Fenbendazol yLugol) contra nematodos de la subfamilia Cyathostominae como modelo biológico. Lastres concentraciones de los dos extractos, así como los dos controles positivos presen-taron resultados estadísticamente similares, pero diferentes frente al control negativo. Lainhibición media de la eclosión de huevos usando corteza y hoja fue de 49.73 y 45.22%,respectivamente, en la concentración de 1000 μg/ml, de 61.93 y 59.20% en la concentra-ción de 500 μg/ml y de 75.60 y 75.82% en la concentración de 250 μg/ml. Los extractosmetanólicos de corteza y hoja de Guazuma ulmifolia mostraron un efecto anti-eclosióncontra nematodos Cyathostominae en las concentraciones evaluadasIncluye referencias bibliográfica

Evaluación in vitro de la actividad antihelmíntica de extractos metanólicos de Guazuma ulmifolia frente a nematodos Cyathostominae

The study evaluated the anti-hatching effect of methanolic extracts from the bark and leaf of Guazuma ulmifolia using the in vitro Nematode Egg Hatching Inhibition test. Concentrations of 1000, 500 and 250 µg/ml of each extract, a negative control (Dimethyl sulfoxide) and two positive controls (Fenbendazole and Lugol) were evaluated against nematodes of the Cyathostominae subfamily as a biological model. The three concentrations of the two extracts, as well as the two positive controls showed statistically similar results, but different compared to the negative control. The mean inhibition of egg hatching using bark and leaf was 49.73 and 45.22%, respectively, at the 1000 µg/ml concentration, 61.93 and 59.20% at the 500 µg/ml concentration, and 75.60 and 75.82% at the concentration of 250 µg/ml. The methanolic extracts of the bark and leaf of Guazuma ulmifolia showed an anti-hatching effect against Cyathostominae nematodes at the concentrations tested.El estudio evaluó el efecto anti-eclosión de extractos metanólicos de corteza y hoja de Guazuma ulmifolia mediante la prueba in vitro de Inhibición de la Eclosión de huevos de nematodos. Se evaluaron las concentraciones de 1000, 500 y 250 µg/ml de cada extracto, un control negativo (Dimetil sulfóxido) y dos controles positivos (Fenbendazol y Lugol) contra nematodos de la subfamilia Cyathostominae como modelo biológico. Las tres concentraciones de los dos extractos, así como los dos controles positivos presentaron resultados estadísticamente similares, pero diferentes frente al control negativo. La inhibición media de la eclosión de huevos usando corteza y hoja fue de 49.73 y 45.22%, respectivamente, en la concentración de 1000 µg/ml, de 61.93 y 59.20% en la concentración de 500 µg/ml y de 75.60 y 75.82% en la concentración de 250 µg/ml. Los extractos metanólicos de corteza y hoja de Guazuma ulmifolia mostraron un efecto anti-eclosión contra nematodos Cyathostominae en las concentraciones evaluadas

Introducing the FAIR Principles for research software

Research software is a fundamental and vital part of research, yet significant challenges to discoverability, productivity, quality, reproducibility, and sustainability exist. Improving the practice of scholarship is a common goal of the open science, open source, and FAIR (Findable, Accessible, Interoperable and Reusable) communities and research software is now being understood as a type of digital object to which FAIR should be applied. This emergence reflects a maturation of the research community to better understand the crucial role of FAIR research software in maximising research value. The FAIR for Research Software (FAIR4RS) Working Group has adapted the FAIR Guiding Principles to create the FAIR Principles for Research Software (FAIR4RS Principles). The contents and context of the FAIR4RS Principles are summarised here to provide the basis for discussion of their adoption. Examples of implementation by organisations are provided to share information on how to maximise the value of research outputs, and to encourage others to amplify the importance and impact of this work

ABORDAJE FISIOTERAPÉUTICO EN USUARIO DE LA CLÍNICA DE LA POLICÍA REGIONAL CARIBE CON PARÁLISIS DE LOS NERVIOS FACIAL Y MOTOR OCULAR. REPORTE DE CASO

Introducción: La parálisis facial es un trastorno neuromuscular relativamente frecuente generado por la lesión de las vías centrales o periféricas del nervio facial como consecuencia de una lesión, se presenta con asimetría, disfunción  y disminución en el desempeño de los músculos de la expresión facial. A nivel mundial se estima una incidencia anual de 23/100.000 habitantes afectando a ambos géneros por igual entre los 10 y los 45 años. Resumen del caso: El objetivo de este artículo es la presentación del caso clínico de un paciente que presentó este trastorno por secuela de fractura ósea del occipital y del peñasco a causa de traumatismo craneoencefálico, con un periodo de evolución de 9 meses. Discusión: Se justifica la importancia y pertinencia de las modalidades cinéticas en la recuperación de la funcionalidad del paciente con este tipo de trastorno. Conclusiones: La parálisis facial genera un impacto funcional y psicológico importante para la persona que la padece, por tanto la intervención fisioterapéutica debe enfocarse desde la rehabilitación integral tanto funcional como de integración social

Measurement of the cosmic ray spectrum above 4×10184{\times}10^{18} eV using inclined events detected with the Pierre Auger Observatory

A measurement of the cosmic-ray spectrum for energies exceeding $4{\times}10^{18}$ eV is presented, which is based on the analysis of showers with zenith angles greater than $60^{\circ}$ detected with the Pierre Auger Observatory between 1 January 2004 and 31 December 2013. The measured spectrum confirms a flux suppression at the highest energies. Above $5.3{\times}10^{18}$ eV, the "ankle", the flux can be described by a power law $E^{-\gamma}$ with index $\gamma=2.70 \pm 0.02 \,\text{(stat)} \pm 0.1\,\text{(sys)}$ followed by a smooth suppression region. For the energy ($E_\text{s}$) at which the spectral flux has fallen to one-half of its extrapolated value in the absence of suppression, we find $E_\text{s}=(5.12\pm0.25\,\text{(stat)}^{+1.0}_{-1.2}\,\text{(sys)}){\times}10^{19}$ eV.Comment: Replaced with published version. Added journal reference and DO

Energy Estimation of Cosmic Rays with the Engineering Radio Array of the Pierre Auger Observatory

The Auger Engineering Radio Array (AERA) is part of the Pierre Auger Observatory and is used to detect the radio emission of cosmic-ray air showers. These observations are compared to the data of the surface detector stations of the Observatory, which provide well-calibrated information on the cosmic-ray energies and arrival directions. The response of the radio stations in the 30 to 80 MHz regime has been thoroughly calibrated to enable the reconstruction of the incoming electric field. For the latter, the energy deposit per area is determined from the radio pulses at each observer position and is interpolated using a two-dimensional function that takes into account signal asymmetries due to interference between the geomagnetic and charge-excess emission components. The spatial integral over the signal distribution gives a direct measurement of the energy transferred from the primary cosmic ray into radio emission in the AERA frequency range. We measure 15.8 MeV of radiation energy for a 1 EeV air shower arriving perpendicularly to the geomagnetic field. This radiation energy -- corrected for geometrical effects -- is used as a cosmic-ray energy estimator. Performing an absolute energy calibration against the surface-detector information, we observe that this radio-energy estimator scales quadratically with the cosmic-ray energy as expected for coherent emission. We find an energy resolution of the radio reconstruction of 22% for the data set and 17% for a high-quality subset containing only events with at least five radio stations with signal.Comment: Replaced with published version. Added journal reference and DO

Measurement of the Radiation Energy in the Radio Signal of Extensive Air Showers as a Universal Estimator of Cosmic-Ray Energy

We measure the energy emitted by extensive air showers in the form of radio emission in the frequency range from 30 to 80 MHz. Exploiting the accurate energy scale of the Pierre Auger Observatory, we obtain a radiation energy of 15.8 \pm 0.7 (stat) \pm 6.7 (sys) MeV for cosmic rays with an energy of 1 EeV arriving perpendicularly to a geomagnetic field of 0.24 G, scaling quadratically with the cosmic-ray energy. A comparison with predictions from state-of-the-art first-principle calculations shows agreement with our measurement. The radiation energy provides direct access to the calorimetric energy in the electromagnetic cascade of extensive air showers. Comparison with our result thus allows the direct calibration of any cosmic-ray radio detector against the well-established energy scale of the Pierre Auger Observatory.Comment: Replaced with published version. Added journal reference and DOI. Supplemental material in the ancillary file

Jardins per a la salut

Facultat de Farmàcia, Universitat de Barcelona. Ensenyament: Grau de Farmàcia. Assignatura: Botànica farmacèutica. Curs: 2014-2015. Coordinadors: Joan Simon, Cèsar Blanché i Maria Bosch.Els materials que aquí es presenten són el recull de les fitxes botàniques de 128 espècies presents en el Jardí Ferran Soldevila de l’Edifici Històric de la UB. Els treballs han estat realitzats manera individual per part dels estudiants dels grups M-3 i T-1 de l’assignatura Botànica Farmacèutica durant els mesos de febrer a maig del curs 2014-15 com a resultat final del Projecte d’Innovació Docent «Jardins per a la salut: aprenentatge servei a Botànica farmacèutica» (codi 2014PID-UB/054). Tots els treballs s’han dut a terme a través de la plataforma de GoogleDocs i han estat tutoritzats pels professors de l’assignatura. L’objectiu principal de l’activitat ha estat fomentar l’aprenentatge autònom i col·laboratiu en Botànica farmacèutica. També s’ha pretès motivar els estudiants a través del retorn de part del seu esforç a la societat a través d’una experiència d’Aprenentatge-Servei, deixant disponible finalment el treball dels estudiants per a poder ser consultable a través d’una Web pública amb la possibilitat de poder-ho fer in-situ en el propi jardí mitjançant codis QR amb un smartphone