Primary pleural myxoid liposarcoma: case report and literature review

Myxoid liposarcoma is a histological subtype of malignant tumors within the group of sarcomas. It is more common in men between the ages of 40 and 50 years. Diagnosis is difficult because they are usually asymptomatic lesions, computed tomography (CT) scan and magnetic resonance are the studies of choice. The gold of treatment is surgical resection with free margins. Chemotherapy and radiotherapy have shown a good response. A 46-year-old male was detected incidental mediastinal lesion by radiography, CT scan showed a hypodense lesion in the right hemithorax that extended to the left hemithorax, infiltrating the diaphragm and large vessels. The patient underwent an exploratory thoracotomy, finding a multilobulated tumor and mucous content approximately 600 ml, adjacent structures were infiltrated, so complete resection was not possible. Subsequently, adjuvant chemotherapy given. The histopathological diagnosis was myxoid liposarcoma. Myxoid liposarcoma is a malignant lesion. The primary pleural origin is rare. Surgical resection with free margins has a good prognosis. Due to advanced disease, a complete resection in this case was not possible, that compromised the patient prognosis

Evaluating Molecular Cobalt Complexes for the Conversion of N_2 to NH_3

We report a molecular Co−N_2 complex that generates a greater-than-stoichiometric yield of NH_3 (>200% NH_3 per Co−N_2 precursor) via the direct reduction of N_2 with protons and electrons. A comparison of the featured Co−N_2 complex with structurally related Co−N_2 and Fe−N_2 species shows how remarkably sensitive the N_2 reduction performance of potential precatalysts is. As discussed, structural and electronic effects are relevant to Co/Fe−N_2 conversion activity, including π basicity, charge state, and geometric flexibility

Longitudinal differences in the injury profile of professional male handball players according to competitive-level

The aim was to analyze the differences in professional handball players` injury profile according to the team`s competitive-level (i.e., First division vs. Second division). Fifty-three professional male handball players participated in this study during 4 consecutive seasons in the same team (2015-16 and 2016-17 for the First division league and 2017-18 and 2018-19 for the Second division league). No significant differences in overall incidence was observed between groups (3.69 vs 4.19 injuries/1000 h, RR = 0.88, 95% CI 0.64-1.22, P = 0.44), although significantly greater injury incidence during training sessions was observed in the Second division group (3.06 vs 1.61 injuries/1000 h, RR = 0.52, 95% CI 0.34-0.81, P = 0.01), while greater injury incidence during matches was reported in the First division group (84.03 vs 49.88 injuries/1000 h, RR = 1.68, 95% CI 1.00-2.83, P = 0.05). The second division group presented the greatest injury burden attending to overall, training and match exposure, as well as in most locations and injury types, but no statistically significant differences were observed between groups. Given the between groups differences found in the injury profile of handball player, it is suggested to implement specific preventive strategies attending to the characteristics of each level-group

Retrospective survey for sialidase activity in Mycoplasma pneumoniae isolates from cases of community-acquired pneumonia

<p>Abstract</p> <p>Background</p> <p>Sialidase is a well-known virulence factor of other respiratory pathogens, but was only recently documented to occur in some species of <it>Mycoplasma</it>. The sialidase activity expressed can vary quantitatively among strains within a species of mycoplasma, from undetectable to amounts that correlate positively with strain virulence. Very few isolates of <it>Mycoplasma pneumoniae </it>had ever been examined for sialidase activity, so it was unknown whether sialidase may contribute to diseases involving this species.</p> <p>Findings</p> <p>No sialidase activity was detected by spectrofluorometric assay of 15 laboratory strains and 91 clinical isolates of <it>M. pneumoniae </it>banked over many years from patients having radiologically-confirmed, uncomplicated community-acquired pneumonia.</p> <p>Conclusions</p> <p>The annotated genome of strain M129 (GenBank <ext-link ext-link-id="NC_000912" ext-link-type="gen">NC_000912</ext-link>, <ext-link ext-link-id="ATCC29342" ext-link-type="gen">ATCC 29342</ext-link>), also isolated from a patient with pneumonia, accurately represents the absence of sialidase genes from strains of <it>M. pneumoniae </it>typically associated with uncomplicated community-acquired pneumonia. A possible involvement of sialidase in neurologic or other extra-respiratory manifestations of <it>M. pneumoniae </it>mycoplasmosis remains to be investigated.</p

Pyrimidine biosynthesis is not an essential function for trypanosoma brucei bloodstream forms

&lt;p&gt;Background: African trypanosomes are capable of both pyrimidine biosynthesis and salvage of preformed pyrimidines from the host, but it is unknown whether either process is essential to the parasite.&lt;/p&gt; &lt;p&gt;Methodology/Principal Findings: Pyrimidine requirements for growth were investigated using strictly pyrimidine-free media, with or without single added pyrimidine sources. Growth rates of wild-type bloodstream form Trypanosoma brucei brucei were unchanged in pyrimidine-free medium. The essentiality of the de novo pyrimidine biosynthesis pathway was studied by knocking out the PYR6-5 locus that produces a fusion product of orotate phosphoribosyltransferase (OPRT) and Orotidine Monophosphate Decarboxylase (OMPDCase). The pyrimidine auxotroph was dependent on a suitable extracellular pyrimidine source. Pyrimidine starvation was rapidly lethal and non-reversible, causing incomplete DNA content in new cells. The phenotype could be rescued by addition of uracil; supplementation with uridine, 2′deoxyuridine, and cytidine allowed a diminished growth rate and density. PYR6-5−/− trypanosomes were more sensitive to pyrimidine antimetabolites and displayed increased uracil transport rates and uridine phosphorylase activity. Pyrimidine auxotrophs were able to infect mice although the infection developed much more slowly than infection with the parental, prototrophic trypanosome line.&lt;/p&gt; &lt;p&gt;Conclusions/Significance: Pyrimidine salvage was not an essential function for bloodstream T. b. brucei. However, trypanosomes lacking de novo pyrimidine biosynthesis are completely dependent on an extracellular pyrimidine source, strongly preferring uracil, and display reduced infectivity. As T. brucei are able to salvage sufficient pyrimidines from the host environment, the pyrimidine biosynthesis pathway is not a viable drug target, although any interruption of pyrimidine supply was lethal.&lt;/p&gt

Extendibility of bilinear forms on banach sequence spaces

[EN] We study Hahn-Banach extensions of multilinear forms defined on Banach sequence spaces. We characterize c(0) in terms of extension of bilinear forms, and describe the Banach sequence spaces in which every bilinear form admits extensions to any superspace.The second author was supported by MICINN Project MTM2011-22417.DANIEL CARANDO; Sevilla Peris, P. (2014). Extendibility of bilinear forms on banach sequence spaces. Israel Journal of Mathematics. 199(2):941-954. https://doi.org/10.1007/s11856-014-0003-9S9419541992F. Albiac and N. J. Kalton, Topics in Banach Space Theory, Graduate Texts in Mathematics, Vol. 233, Springer, New York, 2006.R. Arens, The adjoint of a bilinear operation, Proceedings of the American Mathematical Society 2 (1951), 839–848.R. Arens, Operations induced in function classes, Monatshefte für Mathematik 55 (1951), 1–19.R. M. Aron and P. D. Berner, A Hahn-Banach extension theorem for analytic mappings, Bulletin de la Société Mathématique de France 106 (1978), 3–24.S. Banach, Sur les fonctionelles linéaires, Studia Mathematica 1 (1929), 211–216.S. Banach, Théorie des opérations linéaires, (Monogr. Mat. 1) Warszawa: Subwncji Funduszu Narodowej. VII, 254 S., Warsaw, 1932.D. Carando, Extendible polynomials on Banach spaces, Journal of Mathematical Analysis and Applications 233 (1999), 359–372.D. Carando, Extendibility of polynomials and analytic functions on l p, Studia Mathematica 145 (2001), 63–73.D. Carando, V. Dimant and P. Sevilla-Peris, Limit orders and multilinear forms on lp spaces, Publications of the Research Institute for Mathematical Sciences 42 (2006), 507–522.J. M. F. Castillo, R. García, A. Defant, D. Pérez-García and J. Suárez, Local complementation and the extension of bilinear mappings, Mathematical Proceedings of the Cambridge Philosophical Society 152 (2012), 153–166.J. M. F. Castillo, R. García and J. A. Jaramillo, Extension of bilinear forms on Banach spaces, Proceedings of the American Mathematical Society 129 (2001), 3647–3656.P. Cembranos and J. Mendoza, The Banach spaces ℓ ∞(c 0) and c 0(ℓ ∞) are not isomorphic, Journal of Mathematical Analysis and Applications 367 (2010), 461–463.A. Defant and K. Floret, Tensor Norms and Operator Ideals, North-Holland Mathematics Studies, Vol. 176, North-Holland Publishing Co., Amsterdam, 1993.A. Defant and C. Michels, Norms of tensor product identities, Note di Matematica 25 (2005/06), 129–166.J. Diestel, H. Jarchow and A. Tonge, Absolutely Summing Operators, Cambridge Studies in Advanced Mathematics, Vol. 43, Cambridge University Press, Cambridge, 1995.D. J. H. Garling, On symmetric sequence spaces, Proceedings of the London Mathematical Society (3) 16 (1966), 85–106.A. Grothendieck, Résumé de la théorie métrique des produits tensoriels topologiques, Bol. Soc. Mat. São Paulo 8 (1953), 1–79.H. Hahn, Über lineare Gleichungssysteme in linearen Räumen, Journal für die Reine und Angewandte Mathematik 157 (1927), 214–229.R. C. James, Bases and reflexivity of Banach spaces, Annals of Mathematics (2) 52 (1950), 518–527.H. Jarchow, C. Palazuelos, D. Pérez-García and I. Villanueva, Hahn-Banach extension of multilinear forms and summability, Journal of Mathematical Analysis and Applications 336 (2007), 1161–1177.W. B. Johnson and L. Tzafriri, On the local structure of subspaces of Banach lattices, Israel Journal of Mathematics 20 (1975), 292–299.P. Kirwan and R. A. Ryan, Extendibility of homogeneous polynomials on Banach spaces, Proceedings of the American Mathematical Society 126 (1998), 1023–1029.J. Lindenstrauss and A. Pełczyński, Absolutely summing operators in Lp-spaces and their applications, Studia Mathematica 29 (1968), 275–326.J. Lindenstrauss and L. Tzafriri, Classical Banach Spaces. II, Ergebnisse der Mathematik und ihrer Grenzgebiete [Results in Mathematics and Related Areas], Vol. 97, Springer-Verlag, Berlin, 1979. Function spaces.G. Pisier, Factorization of Linear Operators and Geometry of Banach Spaces, CBMS Regional Conference Series in Mathematics, Vol. 60, Published for the Conference Board of the Mathematical Sciences, Washington, DC, 1986.M. Fernndez-Unzueta and A. Prieto, Extension of polynomials defined on subspaces, Mathematical Proceedings of the Cambridge Philosophical Society 148 (2010), 505–518.W. L. C. Sargent, Some sequence spaces related to the lp spaces, Journal of the London Mathematical Society 35 (1960), 161–171.N. Tomczak-Jaegermann, Banach-Mazur Distances and Finite-Dimensional Operator Ideals, Pitman Monographs and Surveys in Pure and Applied Mathematics, Vol. 38, Longman Scientific & Technical, Harlow, 1989

Highlights from the Pierre Auger Observatory

The Pierre Auger Observatory is the world's largest cosmic ray observatory. Our current exposure reaches nearly 40,000 km$^2$ str and provides us with an unprecedented quality data set. The performance and stability of the detectors and their enhancements are described. Data analyses have led to a number of major breakthroughs. Among these we discuss the energy spectrum and the searches for large-scale anisotropies. We present analyses of our X$_{max}$ data and show how it can be interpreted in terms of mass composition. We also describe some new analyses that extract mass sensitive parameters from the 100% duty cycle SD data. A coherent interpretation of all these recent results opens new directions. The consequences regarding the cosmic ray composition and the properties of UHECR sources are briefly discussed.Comment: 9 pages, 12 figures, talk given at the 33rd International Cosmic Ray Conference, Rio de Janeiro 201

Effect of Aspirin Versus Low-Molecular-Weight Heparin Thromboprophylaxis on Medication Satisfaction and Out-of-Pocket Costs: A Secondary Analysis of a Randomized Clinical Trial

BACKGROUND: Current guidelines recommend low-molecular-weight heparin for thromboprophylaxis after orthopaedic trauma. However, recent evidence suggests that aspirin is similar in efficacy and safety. To understand patients\u27 experiences with these medications, we compared patients\u27 satisfaction and out-of-pocket costs after thromboprophylaxis with aspirin versus low-molecular-weight heparin. METHODS: This study was a secondary analysis of the PREVENTion of CLots in Orthopaedic Trauma (PREVENT CLOT) trial, conducted at 21 trauma centers in the U.S. and Canada. We included adult patients with an operatively treated extremity fracture or a pelvic or acetabular fracture. Patients were randomly assigned to receive 30 mg of low-molecular-weight heparin (enoxaparin) twice daily or 81 mg of aspirin twice daily for thromboprophylaxis. The duration of the thromboprophylaxis, including post-discharge prescription, was based on hospital protocols. The study outcomes included patient satisfaction with and out-of-pocket costs for their thromboprophylactic medication measured on ordinal scales. RESULTS: The trial enrolled 12,211 patients (mean age and standard deviation [SD], 45 ± 18 years; 62% male), 9725 of whom completed the question regarding their satisfaction with the medication and 6723 of whom reported their out-of-pocket costs. The odds of greater satisfaction were 2.6 times higher for patients assigned to aspirin than those assigned to low-molecular-weight heparin (odds ratio [OR]: 2.59; 95% confidence interval [CI]: 2.39 to 2.80; p \u3c 0.001). Overall, the odds of incurring any out-of-pocket costs for thromboprophylaxis medication were 51% higher for patients assigned to aspirin compared with low-molecular-weight heparin (OR: 1.51; 95% CI: 1.37 to 1.66; p \u3c 0.001). However, patients assigned to aspirin had substantially lower odds of out-of-pocket costs of at least $25 (OR: 0.15; 95CONCLUSIONS: Use of aspirin substantially improved patients\u27 satisfaction with their medication after orthopaedic trauma. While aspirin use increased the odds of incurring any out-of-pocket costs, it protected against costs of ≥$25, potentially improving health equity for thromboprophylaxis. LEVEL OF EVIDENCE: Therapeutic Level II . See Instructions for Authors for a complete description of levels of evidence

A search for point sources of EeV photons

Measurements of air showers made using the hybrid technique developed with the fluorescence and surface detectors of the Pierre Auger Observatory allow a sensitive search for point sources of EeV photons anywhere in the exposed sky. A multivariate analysis reduces the background of hadronic cosmic rays. The search is sensitive to a declination band from -85{\deg} to +20{\deg}, in an energy range from 10^17.3 eV to 10^18.5 eV. No photon point source has been detected. An upper limit on the photon flux has been derived for every direction. The mean value of the energy flux limit that results from this, assuming a photon spectral index of -2, is 0.06 eV cm^-2 s^-1, and no celestial direction exceeds 0.25 eV cm^-2 s^-1. These upper limits constrain scenarios in which EeV cosmic ray protons are emitted by non-transient sources in the Galaxy.Comment: 28 pages, 10 figures, accepted for publication in The Astrophysical Journa