7 research outputs found
Insights of Active Extension Within a Collisional Orogen From GNSS (Central Betic Cordillera, S Spain)
The coexistence of shortening and extensional tectonic regimes is a common feature in orogenic belts. The westernmost end of the Western Mediterranean is an area undergoing shortening related to the 5 mm/yr NNWâSSE convergence of the Nubia and Eurasia Plates. In this region, the Central Betic Cordillera shows a regional ENEâWSW extension. Here, we present GNSS-derived geodetic data along a 170 km-long transect orthogonal to the main active normal faults of the Central Betic Cordillera. Our data indicate that the total extension rate along the Central Betic Cordillera is 2.0 ± 0.3 mm/yr. Extension is accommodated in the eastern (0.8 ± 0.3 mm/yr in the Guadix-Baza Basin) and western (1.3 ± 0.3 mm/yr in the Granada Basin) parts of the Central Betic Cordillera, while no extension is recorded in the central part of the study area. Moreover, our data permit us to quantify, for the first time, short-term fault slip rates of the Granada Fault System, which is one of the main seismogenic sources of the Iberian Peninsula. We deduce a fault slip rate of âŒ1.3 ± 0.3 mm/yr for the whole Granada Basin, with 0.9 ± 0.3 mm/yr being accommodated in the Granada Fault System and 0.4 ± 0.3 mm/yr being accommodated in the southwestern sector of the Granada Basin, where no active faults have been previously described at the surface. The heterogeneous extension in the Central Betic Cordillera could be accommodated by shallow high-angle normal faults that merge with a detachment at depth. Part of the active extension could be derived from gravitational instability because of underlying over-thickened crust.This research was funded by the Generalitat Valenciana (Valencian Regional Government, Research project AICO/2021/196), Spanish Ministry of Science, Innovation and University (Research Projects RTI2018-100737-B-I00 and PID2021-127967NB-I00), the University of Alicante (Research Project VIGROB053), the University of JaĂ©n (POAIUJA 2021â2022, CEACTEMA and Programa Operativo FEDER AndalucĂa, 2014â2020âcall made by UJA, 2018, Ref. 1263446), P18-RT-3275 (Junta de AndalucĂa/FEDER), and the Junta de AndalucĂa regional government (RNM282 and RNM 148 research groups). The Institut CartogrĂ fic ValenciĂ , Agencia Valenciana de Seguridad y Respuesta a las Emergencias (Generalitat Valenciana), Consorcio Provincial para el Servicio de PrevenciĂłn y ExtinciĂłn de Incendios y Salvamento de Alicante, ExcelentĂsimas Diputaciones Provinciales de Alicante y CastellĂłn, and the Ayuntamiento de AlmoradĂ also provided partial funding
VIII Encuentro de Docentes e Investigadores en Historia del Diseño, la Arquitectura y la Ciudad
Acta de congresoLa conmemoraciĂłn de los cien años de la Reforma Universitaria de 1918 se presentĂł como una ocasiĂłn propicia para debatir el rol de la historia, la teorĂa y la crĂtica en la formaciĂłn y en la prĂĄctica profesional de diseñadores, arquitectos y urbanistas.
En ese marco el VIII Encuentro de Docentes e Investigadores en Historia del Diseño, la Arquitectura y la Ciudad constituyĂł un espacio de intercambio y reflexiĂłn cuya realizaciĂłn ha sido posible gracias a la colaboraciĂłn entre Facultades de Arquitectura, Urbanismo y Diseño de la Universidad Nacional y la Facultad de Arquitectura de la Universidad CatĂłlica de CĂłrdoba, contando ademĂĄs con la activa participaciĂłn de mayorĂa de las Facultades, Centros e Institutos de Historia de la Arquitectura del paĂs y la regiĂłn.
Orientado en su convocatoria tanto a docentes como a estudiantes de Arquitectura y Diseño Industrial de todos los niveles de la FAUD-UNC promovió el debate de ideas a partir de experiencias concretas en instancias tales como mesas temåticas de caråcter interdisciplinario, que adoptaron la modalidad de presentación de ponencias, entre otras actividades.
En el ĂĄmbito de VIII Encuentro, desarrollado en la sede Ciudad Universitaria de CĂłrdoba, se desplegaron numerosas posiciones sobre la enseñanza, la investigaciĂłn y la formaciĂłn en historia, teorĂa y crĂtica del diseño, la arquitectura y la ciudad; sumĂĄndose el aporte realizado a travĂ©s de sus respectivas conferencias de Ana Clarisa AgĂŒero, Bibiana Cicutti, Fernando Aliata y Alberto Petrina. El conjunto de ponencias que se publican en este Repositorio de la UNC son el resultado de dos intensas jornadas de exposiciones, cuyos contenidos han posibilitado actualizar viejos dilemas y promover nuevos debates.
El evento recibiĂł el apoyo de las autoridades de la FAUD-UNC, en especial de la SecretarĂa de InvestigaciĂłn y de la Biblioteca de nuestra casa, como asĂ tambiĂ©n de la Facultad de Arquitectura de la UCC; va para todos ellos un especial agradecimiento
Mortality from gastrointestinal congenital anomalies at 264 hospitals in 74 low-income, middle-income, and high-income countries: a multicentre, international, prospective cohort study
Summary
Background Congenital anomalies are the fifth leading cause of mortality in children younger than 5 years globally.
Many gastrointestinal congenital anomalies are fatal without timely access to neonatal surgical care, but few studies
have been done on these conditions in low-income and middle-income countries (LMICs). We compared outcomes of
the seven most common gastrointestinal congenital anomalies in low-income, middle-income, and high-income
countries globally, and identified factors associated with mortality.
Methods We did a multicentre, international prospective cohort study of patients younger than 16 years, presenting to
hospital for the first time with oesophageal atresia, congenital diaphragmatic hernia, intestinal atresia, gastroschisis,
exomphalos, anorectal malformation, and Hirschsprungâs disease. Recruitment was of consecutive patients for a
minimum of 1 month between October, 2018, and April, 2019. We collected data on patient demographics, clinical
status, interventions, and outcomes using the REDCap platform. Patients were followed up for 30 days after primary
intervention, or 30 days after admission if they did not receive an intervention. The primary outcome was all-cause,
in-hospital mortality for all conditions combined and each condition individually, stratified by country income status.
We did a complete case analysis.
Findings We included 3849 patients with 3975 study conditions (560 with oesophageal atresia, 448 with congenital
diaphragmatic hernia, 681 with intestinal atresia, 453 with gastroschisis, 325 with exomphalos, 991 with anorectal
malformation, and 517 with Hirschsprungâs disease) from 264 hospitals (89 in high-income countries, 166 in middleincome
countries, and nine in low-income countries) in 74 countries. Of the 3849 patients, 2231 (58·0%) were male.
Median gestational age at birth was 38 weeks (IQR 36â39) and median bodyweight at presentation was 2·8 kg (2·3â3·3).
Mortality among all patients was 37 (39·8%) of 93 in low-income countries, 583 (20·4%) of 2860 in middle-income
countries, and 50 (5·6%) of 896 in high-income countries (p<0·0001 between all country income groups).
Gastroschisis had the greatest difference in mortality between country income strata (nine [90·0%] of ten in lowincome
countries, 97 [31·9%] of 304 in middle-income countries, and two [1·4%] of 139 in high-income countries;
pâ€0·0001 between all country income groups). Factors significantly associated with higher mortality for all patients
combined included country income status (low-income vs high-income countries, risk ratio 2·78 [95% CI 1·88â4·11],
p<0·0001; middle-income vs high-income countries, 2·11 [1·59â2·79], p<0·0001), sepsis at presentation (1·20
[1·04â1·40], p=0·016), higher American Society of Anesthesiologists (ASA) score at primary intervention
(ASA 4â5 vs ASA 1â2, 1·82 [1·40â2·35], p<0·0001; ASA 3 vs ASA 1â2, 1·58, [1·30â1·92], p<0·0001]), surgical safety
checklist not used (1·39 [1·02â1·90], p=0·035), and ventilation or parenteral nutrition unavailable when needed
(ventilation 1·96, [1·41â2·71], p=0·0001; parenteral nutrition 1·35, [1·05â1·74], p=0·018). Administration of
parenteral nutrition (0·61, [0·47â0·79], p=0·0002) and use of a peripherally inserted central catheter (0·65
[0·50â0·86], p=0·0024) or percutaneous central line (0·69 [0·48â1·00], p=0·049) were associated with lower mortality.
Interpretation Unacceptable differences in mortality exist for gastrointestinal congenital anomalies between lowincome,
middle-income, and high-income countries. Improving access to quality neonatal surgical care in LMICs will
be vital to achieve Sustainable Development Goal 3.2 of ending preventable deaths in neonates and children younger
than 5 years by 2030
Active structures and geological hazards in the central sector of the Betic-Rif Cordillera and the Alboran Sea
X Congreso GeolĂłgico de España, 5-7 de julio 2021, Vitoria-Gasteiz.-- 1 page[EN] The recent geodynamic activity in the Betic-Rif Cordillera and the Alboran Sea is determined by the interaction of subduction processes with roll-back in the West and tectonic indentation in the East. The integration of sea and land data in the DAMAGE project characterizes the central area of interaction. At the northern end, the seismicity of the frontal region of Sierra de Cazorla is associated with incipient tectonic indentation. To the South, seismic and aseismic extensional faults of high and low angle interact in the Granada Basin. The active normal faults in the Campo de DalĂas are connected with recent and new strike-slip faults that affect the Alboran Sea, being responsible of the 2016 Alhoceima earthquake (M 6.3). Towards the Rif, new areas of deformation in the Al Hoceima region are identified on blind faults with significant seismogenic activity in 1993 and 2004. These structures represent an important geological hazard related to slope instability and tsunami development in the Alboran Sea and in water reservoirs. The economic and social impact of this geological hazard should be considered and quantified[ES] La actividad geodinĂĄmica reciente en la Cordillera BĂ©tico-Rifeña y el Mar de AlborĂĄn estĂĄ determinada por la interacciĂłn entre los procesos de subducciĂłn con roll-back en el Oeste y la indentaciĂłn tectĂłnica en el Este. La integraciĂłn de datos en mar y tierra en el proyecto DAMAGE caracteriza la zona central de interacciĂłn. En el extremo septentrional, la sismicidad de la regiĂłn frontal de Sierra de Cazorla estĂĄ asociada a indentaciĂłn tectĂłnica incipiente. Hacia el Sur, en la Cuenca de Granada, interaccionan fallas extensionales sĂsmicas y asĂsmicas de alto y bajo buzamiento. Las fallas normales activas en el Campo de DalĂas, estĂĄn conectadas con fallas de salto en direcciĂłn neoformadas que afectan el Mar de AlborĂĄn, y son responsables del terremoto de Alhucemas de 2016 (M 6.3). Hacia el Rif se identifican nuevas zonas de deformaciĂłn en Alhucemas sobre fallas ciegas con importante actividad sismogĂ©nica en 1993 y 2004. Estas estructuras tienen asociada una importante peligrosidad geolĂłgica relacionada con la estabilidad de los taludes y la generaciĂłn de tsunamis en el Mar de AlborĂĄn y estabilidad de masas de agua en embalses, cuya incidencia econĂłmica y social se debe considerar y cuantificarPeer reviewe
CompilaciĂłn de Proyectos de Investigacion de 1984-2002
Instituto Politecnico Nacional. UPIICS
Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)
In 2008, we published the first set of guidelines for standardizing research in autophagy. Since then, this topic has received increasing attention, and many scientists have entered the field. Our knowledge base and relevant new technologies have also been expanding. Thus, it is important to formulate on a regular basis updated guidelines for monitoring autophagy in different organisms. Despite numerous reviews, there continues to be confusion regarding acceptable methods to evaluate autophagy, especially in multicellular eukaryotes. Here, we present a set of guidelines for investigators to select and interpret methods to examine autophagy and related processes, and for reviewers to provide realistic and reasonable critiques of reports that are focused on these processes. These guidelines are not meant to be a dogmatic set of rules, because the appropriateness of any assay largely depends on the question being asked and the system being used. Moreover, no individual assay is perfect for every situation, calling for the use of multiple techniques to properly monitor autophagy in each experimental setting. Finally, several core components of the autophagy machinery have been implicated in distinct autophagic processes (canonical and noncanonical autophagy), implying that genetic approaches to block autophagy should rely on targeting two or more autophagy-related genes that ideally participate in distinct steps of the pathway. Along similar lines, because multiple proteins involved in autophagy also regulate other cellular pathways including apoptosis, not all of them can be used as a specific marker for bona fide autophagic responses. Here, we critically discuss current methods of assessing autophagy and the information they can, or cannot, provide. Our ultimate goal is to encourage intellectual and technical innovation in the field