El diseño observacional en investigación clínica

Discurso como Académico Numerario de la Real Academia de Medicina y Cirugía de Sevilla

Stereovideo youtube channel: short educational videos for the on-line learning of the the stereographic projection technique in Structural Geology

Stereovideo channel https://www.youtube.com/user/geostereovideo) is a YouTube channel of short educational videos (<5 min) focused on learning the handling of the stereographic projection technique applied to Structural Geology (also to Engineering Geology). This type of videos aims to reinforce the traditional classroom lessons with the use of communication technologies resources. Such a einforcing facilitates the possibility to deepen more on conceptual aspects once the students dominate the representation tool helping them to develop their own critical thinking skills. After three years of being launched on-line (on 2014), we analyze the broadcast and acceptance of the channel by the academic community. For this purpose we have taken into account two different sources: (1) the analytics tool from YouTube (subscriptions, views, countries, comments from the users, type of device for viewing), and (2) our own survey among users (students and teachers) to get their opinion about the videos. By January, 2017 (date of sending of this abstract), the channel has a total of 650 subscriptions, with more than 85,000 views all around the world, mainly in Spanish speaking countries (as the videos are in Spanish). The main devices for viewing the videos are PCs, but is noteworthy the use of smart phones and tablets. The video users, both students and teachers, value this type of content positively

Stereovideo youtube channel: short educational videos for the on-line learning of the the stereographic projection technique in Structural Geology

Stereovideo channel https://www.youtube.com/user/geostereovideo) is a YouTube channel of short educational videos (<5 min) focused on learning the handling of the stereographic projection technique applied to Structural Geology (also to Engineering Geology). This type of videos aims to reinforce the traditional classroom lessons with the use of communication technologies resources. Such a einforcing facilitates the possibility to deepen more on conceptual aspects once the students dominate the representation tool helping them to develop their own critical thinking skills. After three years of being launched on-line (on 2014), we analyze the broadcast and acceptance of the channel by the academic community. For this purpose we have taken into account two different sources: (1) the analytics tool from YouTube (subscriptions, views, countries, comments from the users, type of device for viewing), and (2) our own survey among users (students and teachers) to get their opinion about the videos. By January, 2017 (date of sending of this abstract), the channel has a total of 650 subscriptions, with more than 85,000 views all around the world, mainly in Spanish speaking countries (as the videos are in Spanish). The main devices for viewing the videos are PCs, but is noteworthy the use of smart phones and tablets. The video users, both students and teachers, value this type of content positively

Prediction of Anti-Glioblastoma Drug-Decorated Nanoparticle Delivery Systems Using Molecular Descriptors and Machine Learning

The theoretical prediction of drug-decorated nanoparticles (DDNPs) has become a very important task in medical applications. For the current paper, Perturbation Theory Machine Learning (PTML) models were built to predict the probability of different pairs of drugs and nanoparticles creating DDNP complexes with anti-glioblastoma activity. PTML models use the perturbations of molecular descriptors of drugs and nanoparticles as inputs in experimental conditions. The raw dataset was obtained by mixing the nanoparticle experimental data with drug assays from the ChEMBL database. Ten types of machine learning methods have been tested. Only 41 features have been selected for 855,129 drug-nanoparticle complexes. The best model was obtained with the Bagging classifier, an ensemble meta-estimator based on 20 decision trees, with an area under the receiver operating characteristic curve (AUROC) of 0.96, and an accuracy of 87% (test subset). This model could be useful for the virtual screening of nanoparticle-drug complexes in glioblastoma. All the calculations can be reproduced with the datasets and python scripts, which are freely available as a GitHub repository from authors. View Full-TextThe APC was funded by IKERDATA, S.L. under grant 3/12/DP/2021/00102—Area 1: Development of innovative business projects, from Provincial Council of Vizcaya (BEAZ for the Creation of Innovative Business Innovative business ventures)

STEREOVIDEO Channel: on line short videos to learn the stereographic projection technique in Structural Geology and Engineering Geology

En este trabajo se presenta el canal de vídeos online STEREOVIDEO ubicado en el sitio web YouTube (https://www.youtube.com/user/geostereovideo). Se trata de un canal de vídeos didácticos de corta duración (< 5 min) destinados al aprendizaje del manejo de la técnica de la proyección estereográfica aplicada a la Geología Estructural y a la Ingeniería Geológica. Este tipo de vídeos pretenden reforzar el tradicional método didáctico presencial con la utilización de recursos virtuales. De esta manera se facilita la posibilidad de profundizar en aspectos más conceptuales de cada disciplina una vez dominado el manejo de la herramienta de representación. La presente comunicación muestra las características de los vídeos: desde su propio contenido didáctico, a aspectos más técnicos relacionados con la estructura, grabación y edición de los mismos, en los que se detalla tanto el material audiovisual, como el software utilizado.We present here the online video channel STEREOVIDEO sited on the YouTube website (https://www.youtube.com/user/geostereovideo). STEREOVIDEO is a channel of educational videos of short duration (<5 min) focused on learning the stereographic projection technique applied to Structural Geology and Engineering Geology. This type of videos aims to reinforce the traditional classroom teaching method with the use of virtual resources. Such a reinforcing facilitates the possibility to deepen more conceptual aspects of each discipline once the students dominate the representation tool. This communication shows the characteristics of the videos: from the educational content of each video itself, to more technical aspects related to the structure, record and edition, including the used audiovisual devices, as well as the software.Depto. de Mineralogía y PetrologíaFac. de Ciencias GeológicasTRUEUniversidad Complutense de Madridpu

Search for supersymmetry in electroweak production with photons and large missing transverse energy in pp collisions at √s=8TeV

Open Access funded by SCOAP³ - Sponsoring Consortium for Open Access Publishing in Particle Physics.-- et al.Results are reported from a search for supersymmetry with gauge-mediated supersymmetry breaking in electroweak production. Final states with photons and large missing transverse energy ( EmissT ) were examined. The data sample was collected in pp collisions at √s=8TeV with the CMS detector at the LHC and corresponds to 7.4fb. The analysis focuses on scenarios in which the lightest neutralino has bino- or wino-like components, resulting in decays to photons and gravitinos, where the gravitinos escape undetected. The data were obtained using a specially designed trigger with dedicated low thresholds, providing good sensitivity to signatures with photons, EmissT , and low hadronic energy. No excess of events over the standard model expectation is observed. The results are interpreted using the model of general gauge mediation. With the wino mass fixed at 10GeV above that of the bino, wino masses below 710GeV are excluded at 95% confidence level. Constraints are also set in the context of two simplified models, for which the analysis sets the lowest cross section limits on the electroweak production of supersymmetric particles.Funded by SCOAP3.Peer Reviewe

Search for narrow resonances decaying to dijets in proton-proton collisions at √s=13 TeV

et al.A search for narrow resonances in proton-proton collisions at √s=13  TeV is presented. The invariant mass distribution of the two leading jets is measured with the CMS detector using a data set corresponding to an integrated luminosity of 2.4  fb−1. The highest observed dijet mass is 6.1 TeV. The distribution is smooth and no evidence for resonant particles is observed. Upper limits at 95% confidence level are set on the production cross section for narrow resonances with masses above 1.5 TeV. When interpreted in the context of specific models, the limits exclude string resonances with masses below 7.0 TeV, scalar diquarks below 6.0 TeV, axigluons and colorons below 5.1 TeV, excited quarks below 5.0 TeV, color-octet scalars below 3.1 TeV, and W′ bosons below 2.6 TeV. These results significantly extend previously published limits.Peer Reviewe

Measurements of tt¯ spin correlations and top quark polarization using dilepton final states in pp collisions at √s=8 TeV

et al.Measurements of the top quark-antiquark (tt¯) spin correlations and the top quark polarization are presented for tt¯ pairs produced in pp collisions at √s=8  TeV. The data correspond to an integrated luminosity of 19.5  fb−1 collected with the CMS detector at the LHC. The measurements are performed using events with two oppositely charged leptons (electrons or muons) and two or more jets, where at least one of the jets is identified as originating from a bottom quark. The spin correlations and polarization are measured from the angular distributions of the two selected leptons, both inclusively and differentially, with respect to the invariant mass, rapidity, and transverse momentum of the tt¯ system. The measurements are unfolded to the parton level and found to be in agreement with predictions of the standard model. A search for new physics in the form of anomalous top quark chromo moments is performed. No evidence of new physics is observed, and exclusion limits on the real part of the chromo-magnetic dipole moment and the imaginary part of the chromo-electric dipole moment are evaluated.Individuals have received support from the Marie-Curie programme and the European Research Council and EPLANET (European Union); the Leventis Foundation; the A. P. Sloan Foundation; the Alexander von Humboldt Foundation; the Belgian Federal Science Policy Office; the Fonds pour la Formation à la Recherche dans l’Industrie et dans l’Agriculture (FRIA-Belgium); the Agentschap voor Innovatie door Wetenschap en Technologie (IWTBelgium); the Ministry of Education, Youth and Sports (MEYS) of the Czech Republic; the Council of Science and Industrial Research, India; the HOMING PLUS programme of the Foundation for Polish Science, cofinanced from European Union, Regional Development Fund; the OPUS programme of the National Science Center (Poland); the Compagnia di San Paolo (Torino); MIUR project 20108T4XTM (Italy); the Thalis and Aristeia programmes cofinanced by EU-ESF and the Greek NSRF; the National Priorities Research Program by Qatar National Research Fund; the Rachadapisek Sompot Fund for Postdoctoral Fellowship, Chulalongkorn University (Thailand); the Chulalongkorn Academic into Its 2nd Century Project Advancement Project (Thailand); and the Welch Foundation, Contract No. C-1845.Peer Reviewe

Search for third-generation scalar leptoquarks in the tt channel in proton-proton collisions at √s=8 TeV

A search for pair production of third-generation scalar leptoquarks decaying to top quark and t lepton pairs is presented using proton-proton collision data at a center-of-mass energy of vs=8 TeV collected with the CMS detector at the LHC and corresponding to an integrated luminosity of 19.7 fb-1. The search is performed using events that contain an electron or a muon, a hadronically decaying t lepton, and two or more jets. The observations are found to be consistent with the standard model predictions. Assuming that all leptoquarks decay to a top quark and a t lepton, the existence of pair produced, charge -1/3, third-generation leptoquarks up to a mass of 685 GeV is excluded at 95% confidence level. This result constitutes the first direct limit for leptoquarks decaying into a top quark and a t lepton, and may also be applied directly to the pair production of bottom squarks decaying predominantly via the R-parity violating coupling λ′333