Finite element analysis of narrow dental implants

Narrow-diameter implants (NDIs) traditionally have been associated to higher rates of failure in comparison with regular-diameter implants (RDIs) and wide-diameter implants (WDIs), since they generate a more unfavorable stress distribution in peri-implant bone. However, it is well known that the load sharing effect associated with prostheses supported by multiple implants (also called splinted prostheses) affords mechanical benefits. The present study involves finite element analysis (FEA) to determine whether the risks linked to NDIs could be mitigated by the mechanical advantages afforded by the splinting concept. For this purpose, a three-dimensional (3D) model of a real maxilla was reconstructed from computed tomography (CT) images, and different implants (NDIs, RDIs and WDIs) and prostheses were created using computer-aided design (CAD) tools. Biting forces were simulated on the prostheses corresponding to three different rehabilitation solutions: single-implant restoration, three-unit bridge and all-on-four treatment. Stress distribution around the implants was calculated, and overloading in bone was quantified within peri-implant volumes enclosed by cylinders with a diameter 0.1 mm greater than that of each implant. The mechanical benefits of the splinting concept were confirmed: the peri-implant overloaded volume around NDIs splinted by means of the three-unit bridge was significantly reduced in comparison with the nonsplinted condition and, most importantly, proved even smaller than that around nonsplinted implants with a larger diameter (RDIs). However, splinted NDIs supporting the all-on-four prosthesis led to the highest risk of overloading found in the study, due to the increase in compressive stress generated around the tilted implant when loading the cantilevered molar.Peer ReviewedPostprint (author's final draft

The carbon-rich type Ic supernova 2016adj in the iconic dust lane of Centaurus A: signatures of interaction with circumstellar hydrogen?

We present a comprehensive data set of supernova (SN) 2016adj located within the central dust lane of Centaurus A. SN 2016adj is significantly reddened and after correcting the peak apparent $B$-band magnitude ($m_B = 17.48\pm0.05$) for Milky Way reddening and our inferred host-galaxy reddening parameters (i.e., $R_{V}^{host} = 5.7\pm0.7$ and $A_{V}^{host} = 6.3\pm0.2$), we estimate it reached a peak absolute magnitude of $M_B \sim -18$. Detailed inspection of the optical/NIR spectroscopic time-series reveals a carbon-rich SN Ic and not a SN Ib/IIb as previously suggested in the literature. The NIR spectra shows prevalent carbon-monoxide formation occurring already by +41 days past $B$-band maximum, which is $\approx 11$ days earlier than previously reported in the literature for this object. Interestingly around two months past maximum, the NIR spectrum of SN~2016adj begins to exhibit H features, with a +97~d medium resolution spectrum revealing both Paschen and Bracket lines with absorption minima of $\sim 2000$ km/s, full-width-half-maximum emission velocities of $\sim 1000$ km/s, and emission line ratios consistent with a dense emission region. We speculate these attributes are due to circumstellar interaction (CSI) between the rapidly expanding SN ejecta and a H-rich shell of material formed during the pre-SN phase. A bolometric light curve is constructed and a semi-analytical model fit suggests the supernova synthesized 0.5 solar masses of $^{56}$Ni and ejected 4.2 solar masses of material, though these values should be approached with caution given the large uncertainties associated with the adopted reddening parameters, possible CSI contamination, and known light echo emission. Finally, inspection of Hubble Space Telescope archival data yielded no progenitor detection.Comment: Submitted to A&A, comments are welcom

MULTI-WAVELENGTH OBSERVATIONS OF THE ENDURING TYPE IIn SUPERNOVAE 2005ip AND 2006jd

We present an observational study of the Type IIn supernovae (SNe IIn) 2005ip and 2006jd. Broad-band UV, optical and near-IR photometry, and visual-wavelength spectroscopy of SN 2005ip complement and extend upon published observations to 6.5 years past discovery. Our observations of SN 2006jd extend from UV to mid-infrared wavelengths, and like SN 2005ip, are compared to reported X-ray measurements to understand the nature of the progenitor. Both objects display a number of similarities with the 1988Z-like subclass of SN IIn including: (i) remarkably similar early- and late-phase optical spectra, (ii) a variety of high ionization coronal lines, (iii) long-duration optical and near-IR emission and, (iv) evidence of cold and warm dust components. However, diversity is apparent including an unprecedented late-time r-band excess in SN 2006jd.The observed differences are attributed to differences between the mass-loss history of the progenitor stars. We conclude that the progenitor of SN 2006jd likely experienced a significant mass-loss event during its pre-SN evolution akin to the great 19th century eruption of \eta Carinae. Contrarily, as advocated by Smith et al. (2009), we find the circumstellar environment of SN 2005ip to be more consistent with a clumpy wind progenitor.Comment: Submitted May 2012 and to appear in ApJ. Manuscript consists of 61 pages, including 19 figures and 11 tables. Comments welcome; referee approves for publicatio

A snapshot of cancer in Chile: analytical frameworks for developing a cancer policy

INTRODUCTION: The South American country Chile now boasts a life expectancy of over 80 years. As a consequence, Chile now faces the increasing social and economic burden of cancer and must implement political policy to deliver equitable cancer care. Hindering the development of a national cancer policy is the lack of comprehensive analysis of cancer infrastructure and economic impact. OBJECTIVES: Evaluate existing cancer policy, the extent of national investigation and the socio-economic impact of cancer to deliver guidelines for the framing of an equitable national cancer policy. METHODS: Burden, research and care-policy systems were assessed by triangulating objective system metrics -epidemiological, economic, etc. - with political and policy analysis. Analysis of the literature and governmental databases was performed. The oncology community was interviewed and surveyed. RESULTS: Chile utilizes 1% of its gross domestic product on cancer care and treatment. We estimate that the economic impact as measured in Disability Adjusted Life Years to be US$ 3.5 billion. Persistent inequalities still occur in cancer distribution and treatment. A high quality cancer research community is expanding, however, insufficient funding is directed towards disproportionally prevalent stomach, lung and gallbladder cancers. CONCLUSIONS: Chile has a rapidly ageing population wherein 40% smoke, 67% are overweight and 18% abuse alcohol, and thus the corresponding burden of cancer will have a negative impact on an affordable health care system. We conclude that the Chilean government must develop a national cancer strategy, which the authors outline herein and believe is essential to permit equitable cancer care for the country

Suicide risk and prevalence of major depressive disorder (MDD) among individuals infected with HIV-1 subtype C versus B in Southern Brazil

Major depressive disorder (MDD) is among the most prevalent neuropsychiatric disorders associated with HIV infection; however, its risks and neurobiologic correlates in diverse cultures are poorly understood. This study aimed to examine the frequency of MDD among HIV+ participants in southern Brazil. We hypothesized that the frequency and severity of MDD would be higher among individuals HIV+ compared with HIV−, and higher in HIV subtype B compared with C. Individuals with HIV (n=39) as well as seronegative controls (n=22) were enrolled in a cross-sectional, prospective, observational study. Current and lifetime history of MDD was diagnosed by MINI-Plus; symptom severity was assessed by BDI-II. Current and past episodes of MDD were significantly more frequent in the HIV+ versus HIV− group: current MDD, 15 (38.5%) vs. 0 (0%), p = 0.0004; past MDD, 24 (61.5%) vs. 3 (13.6%), p = 0.0004. The median BDI-II score in the HIV+ group was significantly higher than in the HIV− (13 [8–27.5] vs. 2.5 [1–5.5]; p < 0.0001). Current suicide risk, defined as during the last month, was found in 18% of participants in the HIV-positive and in none in the HIV-negative group. Neither current MDD frequency (8 (57.1%) vs. 6 (40%), p = 0.47) nor BDI-II score differed across subtypes B and C. CONCLUSIONS: HIV+ group may be more likely to experience current MMD than HIV−. This was the first study to compare the frequency and severity of MDD in HIV subtype B and C; we found no difference between HIV subtypes B or C