Lifting representations of finite reductive groups: a character relation

Given a connected reductive group $\tilde{G}$ over a finite field $k$, and a semisimple $k$-automorphism $\varepsilon$ of $\tilde{G}$ of finite order, let $G$ denote the connected part of the group of $\varepsilon$-fixed points. Then there exists a lifting from packets of representations of $G(k)$ to packets for $\tilde{G}(k)$. In the case of Deligne-Lusztig representations, we show that this lifting satisfies a character relation analogous to that of Shintani.Comment: Minor errors corrected, proofs streamlined. Main result slightly generalized, restated to emphasize analogy with stabilit

Gambaran Motivasi Kerja Dan Pelayanan Prima Perawat Di Rumah Sakit Umum Bethesda Gmim Tomohon

:Motivation of nurses is the important thing because motivation is the one of caused, to lead, and human support for someone to do the best and get the best result. Excellent Service is the first element in the hospital and health sector, that the patients need. The aims of the research to see the picture of work motivation and excellent service of nurses at Bethesda GMIM Tomohon Hospital. Desain research The study was descriptive-qualitative, the population was all of nurses and patients in Bethesda GMIM Tomohon Hospital This research sample 60 respondent (nurse and patient), with the purposive sampling. Data analysis used of this study was data processor software SPSS. The result: The result of the study showed that intrinsic motivation of good category (48,3%), less category (51,7%), extrinsic motivation of good category (50%), less category (50%). Excellent service nurse when first meet the patient of good category (71,7%), less category (28,3%), when will start of good category (53,3%), less category (46,7%), and after they do the excellent service in good category (70%), less category (30%). The conclution more nurses are motivated by extrisic than intrinsic, and patiens feel that is provided nurses already do the excellent service. Advice would be able to add more information to researcher and to the hospital to maintain the excellent service provided to patients

Real-time ultrasound elastography in 180 axillary lymph nodes: elasticity distribution in healthy lymph nodes and prediction of breast cancer metastases

BACKGROUND: To determine the general appearance of normal axillary lymph nodes (LNs) in real-time tissue sonoelastography and to explore the method′s potential value in the prediction of LN metastases. METHODS: Axillary LNs in healthy probands (n=165) and metastatic LNs in breast cancer patients (n=15) were examined with palpation, B-mode ultrasound, Doppler and sonoelastography (assessment of the elasticity of the cortex and the medulla). The elasticity distributions were compared and sensitivity (SE) and specificity (SP) were calculated. In an exploratory analysis, positive and negative predictive values (PPV, NPV) were calculated based upon the estimated prevalence of LN metastases in different risk groups. RESULTS: In the elastogram, the LN cortex was significantly harder than the medulla in both healthy (p=0.004) and metastatic LNs (p=0.005). Comparing healthy and metastatic LNs, there was no difference in the elasticity distribution of the medulla (p=0.281), but we found a significantly harder cortex in metastatic LNs (p=0.006). The SE of clinical examination, B-mode ultrasound, Doppler ultrasound and sonoelastography was revealed to be 13.3%, 40.0%, 14.3% and 60.0%, respectively, and SP was 88.4%, 96.8%, 95.6% and 79.6%, respectively. The highest SE was achieved by the disjunctive combination of B-mode and elastographic features (cortex >3mm in B-mode or blue cortex in the elastogram, SE=73.3%). The highest SP was achieved by the conjunctive combination of B-mode ultrasound and elastography (cortex >3mm in B-mode and blue cortex in the elastogram, SP=99.3%). CONCLUSIONS: Sonoelastography is a feasible method to visualize the elasticity distribution of LNs. Moreover, sonoelastography is capable of detecting elasticity differences between the cortex and medulla, and between metastatic and healthy LNs. Therefore, sonoelastography yields additional information about axillary LN status and can improve the PPV, although this method is still experimental

Practical Application of Sociology in Systems Engineering

Systems engineering involves both the integration of the system and the integration of the disciplines which develop and operate the system. Integrating the disciplines is a sociological effort to bring together different groups, who often have different terminology, to achieve a common goal, the system. The focus for the systems engineer is information flow through the organization, between the disciplines, to ensure the system is developed and operated will all relevant information informing system decisions. The practical application of the sociology in systems engineering brings in various organizational development concepts including the principles of planned renegotiation and the application of principles to address information barriers created by organizational culture. Concepts such as specification of ignorance, consistent terminology, opportunity structures, role-sets, and the reclama (reconsideration) process are all important sociological approaches that help address the organizational social structure (culture). In bringing the disciplines together, the systems engineer must also be wary of social ambivalence, social anomie, social dysfunction, and insider-outsider behavior. Unintended consequences can result when these social issues are present. These issues can occur when localized subcultures shift from the overarching organizational culture, or when the organizational culture prevents achievement of system goals. These sociological principles provide the systems engineer with key approaches to manage the information flow through the organization as the disciplines are integrated and share their information and provides key sociological barriers to information flow through the organization. This paper will discuss the practical application of sociological principles to systems engineering

Reporting and transparent research practices in sports medicine and orthopaedic clinical trials: a meta-research study

Objectives: Transparent reporting of clinical trials is essential to assess the risk of bias and translate research findings into clinical practice. While existing studies have shown that deficiencies are common, detailed empirical and field-specific data are scarce. Therefore, this study aimed to examine current clinical trial reporting and transparent research practices in sports medicine and orthopaedics. Setting: Exploratory meta-research study on reporting quality and transparent research practices in orthopaedics and sports medicine clinical trials. Participants: The sample included clinical trials published in the top 25% of sports medicine and orthopaedics journals over 9 months. Primary and secondary outcome measures: Two independent reviewers assessed pre-registration, open data and criteria related to scientific rigour, like randomisation, blinding, and sample size calculations, as well as the study sample, and data analysis. Results: The sample included 163 clinical trials from 27 journals. While the majority of trials mentioned rigour criteria, essential details were often missing. Sixty per cent (95% confidence interval (CI) 53% to 68%) of trials reported sample size calculations, but only 32% (95% CI 25% to 39%) justified the expected effect size. Few trials indicated the blinding status of all main stakeholders (4%; 95% CI 1% to 7%). Only 18% (95% CI 12% to 24%) included information on randomisation type, method and concealed allocation. Most trials reported participants' sex/gender (95%; 95% CI 92% to 98%) and information on inclusion and exclusion criteria (78%; 95% CI 72% to 84%). Only 20% (95% CI 14% to 26%) of trials were pre-registered. No trials deposited data in open repositories. Conclusions: These results will aid the sports medicine and orthopaedics community in developing tailored interventions to improve reporting. While authors typically mention blinding, randomisation and other factors, essential details are often missing. Greater acceptance of open science practices, like pre-registration and open data, is needed. As these practices have been widely encouraged, we discuss systemic interventions that may improve clinical trial reporting

Reproducibility of freehand vs. foam cast as well as the intrarater reliability of foam cast ultrasound scans assessing the muscle architecture and tissue organization of the gastrocnemius medialis and vastus lateralis muscles

BackgroundThis study compares the reproducibility of freehand (FH) vs. foam cast (FC) scans and investigates the intrarater reliability of the ultrasound FC muscle architecture and tissue organization measurements of the gastrocnemius medialis (GM) and vastus lateralis (VL) muscles with fixed and repositioning FC scans.MethodsThirteen young adults (22 ± 3 years) underwent repeated sagittal B-mode ultrasound measurements of GM and VL. FH, FC, and repositioned FC scans were conducted. Muscle architecture measurements included muscle thickness (MT), pennation angle (PA), and fascicle length (FL). Spatial frequency analysis assessed muscle tissue organization.ResultsMT decreased from 2.1 to 1.8 cm in GM and from 2.4 to 2.2 cm in VL with the FC compared with the FH. Reproducibility between the FH and the FC showed poor to good intraclass correlation coefficients (ICCs) for MT (0.46–0.77) and PA (0.09–0.86) as well as poor to moderate ICCs for FL (0.41), with very low to moderate test–retest variability (TRV) (4%–18%). Tissue organization indicated low to good ICCs (0.21–0.80) with low to moderate TRV (4%–19.5%). The re-scanning results of fixed FC indicated excellent ICCs for MT (0.95–0.996), good for PA (0.77–0.90), and moderate for FL (0.73–0.76), with low TRV (5%–10%) for both muscles. Tissue organization displayed moderate to good ICCs (0.61–0.87) with very low to low TRV (4%–9%). For repositioned FC scans in GM and VL, MT showed good to excellent ICCs (0.86–0.98) with very low to low TRV (2%–8%). PA and FL demonstrated moderate to good ICCs (0.57–0.75), with very low to moderate TRV (2%–13%). Tissue organization revealed ICCs ranging from poor to good (0.13–0.87) for both muscles, with low to moderate TRV (5%–18%).ConclusionThe FC systematically reduced MT by 2–3 mm. Furthermore, reproducibility revealed low ICCs and high data variability for several muscle architecture and tissue organization parameters. Thus, switching methods within a single study is not recommended. Nevertheless, FC ultrasound scans demonstrated excellent intrarater reliability for assessing MT. In the case of fixed FC scans particularly, moderate to excellent ICCs were observed for all muscle architecture and tissue organization parameters, accompanied by very low to low variability. Therefore, FC scans are recommended for investigating acute effects on muscle architecture and tissue organization when the FC remains on the leg throughout the period of measurements

Reliability of assessing skeletal muscle architecture and tissue organization of the gastrocnemius medialis and vastus lateralis muscle using ultrasound and spatial frequency analysis

IntroductionThe purpose of this study was to investigate inter- and intra-rater reliability as well as the inter-rater interpretation error of ultrasound measurements assessing skeletal muscle architecture and tissue organization of the gastrocnemius medialis (GM) and vastus lateralis (VL) muscle.MethodsThe GM and VL of 13 healthy adults (22 ± 3 years) were examined thrice with sagittal B-mode ultrasound: intraday test-retest examination by one investigator (intra-rater) and separate examinations by two investigators (inter-rater). Additionally, images from one investigator were analysed by two interpretators (interpretation error). Muscle architecture was assessed by muscle thickness [MT], fascicle length [FL], as well as superior and inferior pennation angle [PA]. Muscle tissue organization was determined by spatial frequency analysis (SFA: peak spatial frequency radius, peak −6 dB width, PSFR/P6, normalized peak value of amplitude spectrum [Amax], power within peak [PWP], peak power percent). Reliability of ultrasound examination and image interpretation are presented as intraclass correlation coefficient (ICC), test-retest variability, standard error of measurement as well as bias and limits of agreement.ResultsGM and VL demonstrated excellent ICCs for inter- and intra-rater reliability, along with excellent ICCs for interpretation error of MT (0.91–0.99), showing minimal variability (<5%) and SEM% (<5%). Systematic bias for MT was less than 1 mm. For PA and FL poor to good ICCs for inter- and intra-rater reliability were revealed (0.41–0.90), with moderate variability (<12%), low SEM% (<10%) and systematic bias between 0.1–1.4°. Tissue organization analysis indicated moderate to good ICCs for inter- and intra-rater reliability. Notably, Amax and PWP consistently held the highest ICC values (0.77–0.87) across all analyses but with higher variability (<24%) and SEM% (<18%), compared to lower variability (<9%) and SEM% (<8%) in other tissue organization parameters. Interpretation error of all muscle tissue organization parameters showed excellent ICCs (0.96–0.999) with very low variability (≤1%) and SEM% (<2%), except Amax & PWP (TRV%: <6%; SEM%: <7%).ConclusionOur findings demonstrated excellent inter- and intra-rater reliability for MT. However, agreement for PA, FL, and SFA parameters was not as strong. Additionally, MT and all SFA parameters exhibited excellent agreement for inter-rater interpretation error. Therefore, the SFA seems to offer the possibility of objectively and reliably evaluating ultrasound images

Practical Application of Sociology in Systems Engineering

No abstract availabl

Ivermectin for the control of scabies outbreaks in the UK

On July 9, 2019, WHO updated its model list of essential medicines to include oral ivermectin for ectoparasitic infections.1 This recommendation follows the 2017 WHO categorisation of scabies as a neglected tropical disease. The list covers the “minimum medicine needs for a basic health-care system, listing the most efficacious, safe and cost-effective medicines for priority conditions”.1 In the UK, scabies outbreaks are a substantial public health burden in care homes for older people

An efficient and high-throughput approach for experimental validation of novel human gene predictions

AbstractA highly automated RT-PCR-based approach has been established to validate novel human gene predictions with no prior experimental evidence of mRNA splicing (ab initio predictions). Ab initio gene predictions were selected for high-throughput validation using predicted protein classification, sequence similarity to other genomes, colocalization with an MPSS tag, or microarray expression. Initial microarray prioritization followed by RT-PCR validation was the most efficient combination, resulting in approximately 35% of the ab initio predictions being validated by RT-PCR. Of the 7252 novel genes that were prioritized and processed, 796 constituted real transcripts. In addition, high-throughput RACE successfully extended the 5′ and/or 3′ ends of >60% of RT-PCR-validated genes. Reevaluation of these transcripts produced 574 novel transcripts using RefSeq as a reference. RT-PCR sequencing in combination with RACE on ab initio gene predictions could be used to define the transcriptome across all species