Complete Genome Sequence of Listeria monocytogenes Strain DPC6895, a Serotype 1/2b Isolate from Bovine Raw Milk

Listeria monocytogenes is a foodborne pathogen and is the causative agent of listeriosis among humans and animals. The draft genome sequence of L. monocytogenes DPC6895, a serotype 1/2b strain isolated from the raw milk of a cow with subclinical bovine mastitis, is reported

Complete Genome Sequences of vB_LmoS_188 and vB_LmoS_293, Two Bacteriophages with Specificity for Listeria monocytogenes Strains of Serotypes 4b and 4e

Listeria monocytogenes is responsible for the rare disease listeriosis, which is associated with the consumption of contaminated food products. We report here the complete genome sequences of vB_LmoS_188 and vB_LmoS_293, phages isolated from environmental sources and that have host specificity for L. monocytogenes strains of the 4b and 4e serotypes

Relative pavement performance for dual and wide-based tyre assemblies using a finite element method

There is a need to assess the realistic tire contact pressure created by a tire in contact with a pavement. The contact pressure is a function of tire type, axle loading, and tire inflation pressure (TiP). The research carried out considered dual tire and wide-based tire assemblies across a range of axle loading and TiP. These contact pressures were incorporated into a finite element package (CAPA-3D) and modelled on a simple pavement structure. The strains from this modelling were sorted to produce key strains associated with the mechanisms of surface distress, near surface distress, deep asphalt distress, and the subgrade. The main distress mechanisms were top down cracking, asphalt cracking/rutting, bottom-up fatigue cracking, and subgrade rutting. This gave a method to fairly compare the dual and wide-based tire assemblies with the same axle loading and TiP. The analysis gave interesting results for the different distress mechanisms of the pavement. The wide-based tire gives consistently higher shear strains for all the areas of distress investigated. There is great variation in surface and near surface shear strains due to the different combinations of axle loading and TiP. It is clear that the wide-based tire is a more damaging tire for all combinations of TiP and axle loading. It is also apparent that how these factors interact has a great influence on the damaging potential of a tire

How Should Justice Policy Treat Young Offenders?

The justice system in the United States has long recognized that juvenile offenders are not the same as adults, and has tried to incorporate those differences into law and policy. But only in recent decades have behavioral scientists and neuroscientists, along with policymakers, looked rigorously at developmental differences, seeking answers to two overarching questions: Are young offenders, purely by virtue of their immaturity, different from older individuals who commit crimes? And, if they are, how should justice policy take this into account? A growing body of research on adolescent development now confirms that teenagers are indeed inherently different from adults, not only in their behaviors, but also (and of course relatedly) in the ways their brains function. These findings have influenced a series of Supreme Court decisions relating to the treatment of adolescents, and have led legislators and other policymakers across the country to adopt a range of developmentally informed justice policies. New research is showing distinct changes in the brains of young adults, ages 18 to 21, suggesting that they too may be immature in ways that are relevant to justice policy. This knowledge brief from the MacArthur Foundation Research Network on Law and Neuroscience considers the implications of this new research

Intrinsic symmetry groups of links with 8 and fewer crossings

We present an elementary derivation of the "intrinsic" symmetry groups for knots and links of 8 or fewer crossings. The standard symmetry group for a link is the mapping class group \MCG(S^3,L) or \Sym(L) of the pair $(S^3,L)$. Elements in this symmetry group can (and often do) fix the link and act nontrivially only on its complement. We ignore such elements and focus on the "intrinsic" symmetry group of a link, defined to be the image $\Sigma(L)$ of the natural homomorphism \MCG(S^3,L) \rightarrow \MCG(S^3) \cross \MCG(L). This different symmetry group, first defined by Whitten in 1969, records directly whether $L$ is isotopic to a link $L'$ obtained from $L$ by permuting components or reversing orientations. For hyperbolic links both \Sym(L) and $\Sigma(L)$ can be obtained using the output of \texttt{SnapPea}, but this proof does not give any hints about how to actually construct isotopies realizing $\Sigma(L)$. We show that standard invariants are enough to rule out all the isotopies outside $\Sigma(L)$ for all links except $7^2_6$, $8^2_{13}$ and $8^3_5$ where an additional construction is needed to use the Jones polynomial to rule out "component exchange" symmetries. On the other hand, we present explicit isotopies starting with the positions in Cerf's table of oriented links which generate $\Sigma(L)$ for each link in our table. Our approach gives a constructive proof of the $\Sigma(L)$ groups.Comment: 72 pages, 66 figures. This version expands the original introduction into three sections; other minor changes made for improved readabilit

Forensic Investigation of Cyberstalking Cases using Behavioural Evidence Analysis

Behavioural Evidence Analysis (BEA) is, in theory, useful in developing an understanding of the offender, the victim, the crime scene, and the dynamics of the crime. It can add meaning to the evidence obtained through digital forensic techniques and assist investigators with reconstruction of a crime. There is, however, little empirical research examining the application of BEA to actual criminal cases, particularly cyberstalking cases. This study addresses this gap by examining the utility of BEA for such cases in terms of understanding the behavioural and motivational dimensions of offending, and the way in which digital evidence can be interpreted. It reports on the forensic analysis of 20 cyberstalking cases investigated by Dubai Police in the last five years. Results showed that BEA helps to focus an investigation, enables better understanding and interpretation of victim and offender behaviour, and assists in inferring traits of the offender from available digital evidence. These benefits can help investigators to build a stronger case, reduce time wasted to mistakes, and to exclude suspects wrongly accused in cyberstalking cases

Antioxidant Properties and Beneficial Cardiovascular Effects of a Natural Extract of Pomegranate in Healthy Volunteers: A Randomized Preliminary Single-Blind Controlled Study

From MDPI via Jisc Publications RouterHistory: received 2022-09-20, accepted 2022-10-25, epub 2022-10-28, collection 2022-11Peer reviewed: TrueAcknowledgements: Acknowledgments: The authors would like to acknowledge the support of all volunteers who participated in the study. They are grateful for the supply of pomegranate extract, Pomanox® from Euromed S.A., Mollet del Vallès, Barcelona, Spain. We are grateful for Gordon McDougall, the James Hutton Institute, Invergowrie, Scotland for carrying out the LC/MS/MS analysis, and Marta Pulido, for editing the manuscript.Article version: VoRPublication status: PublishedPomegranates are known to possess anti-hypertensive, anti-atherogenic and cardioprotective effects mainly due to their pleiotropic effects on various cellular pathways, especially those triggered by oxidative stress. The aim of this study was to investigate the effect of natural standardized pomegranate (PE) extract on cardiovascular risk factors in 24 healthy volunteers who participated in a randomized, single-blind placebo-controlled study. There were 12 subjects in the PE group and 12 in the placebo group. Variables were measured at baseline and after 14 and 28 days of supplementation are anthropometry, BP, pulse wave velocity, fat and lean body mass, salivary and urinary cortisol, and cortisone, total phenolics, antioxidant capacity and lipid peroxidation. Urinary total phenolics excretion and antioxidant capacity were significantly increased after 14 and 28 days of PE intake. At day 28, there were also statistically significant decreases in systolic and diastolic blood pressure (BP), pulse wave velocity, body fat and fat mass, as well as an increase in lean body mass. Significant changes in the placebo group were not found. Glucocorticoid levels showed a significant decrease in saliva cortisol at day 28 (morning) in the PE group, and cortisol/cortisone ratio was significantly decreased following 28 days of PE intake at morning, noon, and evening. Urine free cortisol was significantly reduced at day 14. These findings suggest that pomegranate extract intake may improve antioxidant and oxidative stress status and play a beneficial role in the attenuation of some cardiovascular risk factors. Future studies should concentrate on overweight and older people

Assessment of medication adherence in Saudi patients with type II diabetes mellitus in Khobar city, Saudi Arabia

Objective: Medication adherence is defined as taking medications as advised and prescribed by health care professionals for stated duration. Diabetes mellitus (DM) is one of the most common chronic illnesses in Saudi Arabia. This study aimed to document medication adherence in Saudi patients with type 2 diabetes. Methods: A quantitative cross-sectional study was conducted in Saudi out-patients with type 2 DM in the city of Khobar, Saudi Arabia. The study used the General Medication Adherence Scale (GMAS) to document medication adherence in this population. Data was analyzed through SPSS version 23. Study was ethically approved. Results: Data was collected from 212 patients. Few patients (35.8%) had high adherence to anti diabetic medications. The correlation between HbA1c level and adherence score was negative and significantly strong (ρ = -0.413, p < 0.0001). Most patients (N = 126, 59.4%) modified their medication therapy during month of Ramadan and on Eid occassion. Education level was not a determinant of adherence in this population. Conclusion: This study highlighted that medication adherence is influenced by religious and social factors. Patient counseling is required to improve patient beliefs and increase awareness of adhering to prescribed anti diabetic pharmacotherapy. A pharmacist can play constructive role of a disease educator and patient counselor