Estrategia de marketing digital para pyme de seguridad informática

Tesis (Maestría en Dirección de Negocios) -- Universidad Nacional de Córdoba. Facultad de Ciencias Económicas; Argentina, 2017.Este trabajo estudia el diseño de una estrategia de marketing digital para una Pyme familiar “SCG-consultora” dedicada a la consultoría de Seguridad Informática. La empresa trabaja bajo la modalidad B2B o “Negocio a Negocio” ya que no apunta a consumidores finales sino a otras empresas. Hace ya unos años que se busca ampliar el mercado objetivo apuntando a consolidarse como empresa prestadora de: - un mayor rango de servicios como el SOC (Security Operation Center) basado en el monitoreo remoto permanente de amenazas, y el asesoramiento para casos de ransomware. - a un mayor número de clientes en un mercado global y local con demanda creciente como las pymes, a las que les sería ideal contar con servicios como el SOC, ya que gozarían de un servicio con profesionales especializados adaptable a presupuestos acotados, sin la necesidad de contar con un departamento propio de seguridad informática. La confianza es clave para SCG y es uno de sus valores fundamentales a través de los cuales construye su sólida trayectoria, sabiendo la responsabilidad que implica trabajar con infraestructuras críticas como la información de cada empresa. La seguridad informática es una disciplina trasversal que afecta a cualquier persona o entidad privada o pública, el mercado no necesita ser validado y los productos que se ofrecen ya fueron prestados con éxito.Fil: Casanovas, José Ignacio. Universidad Nacional de Córdoba. Facultad de Ciencias Económicas; Argentina

Antiangiogenic effect of gemcitabine following metronomic administration in a pancreas cancer model

Gemcitabine shows a marked antitumor effect as a result of its cytotoxic action toward proliferative cells. In this article, we aim to investigate the potential antitumor and antiangiogenic effect of gemcitabine following a metronomic schedule that involves the regular administration of cytotoxic drugs at doses lower than standard treatment. In vitro results showed that human endothelial cells are more sensitive to gemcitabine (IC50 3 nmol/L) than pancreatic tumor cells (IC50 20 nmol/L). For in vivo studies, we used an orthotopic implantation model of human pancreatic carcinoma in nude mice. Gemcitabine was administered i.p. following a low-dose schedule (1 mg/kg/d for a month) and compared with the conventional schedule (100 mg/kg days 0, 3, 6, and 9 postimplantation). Metronomic treatment effect on established tumor was equivalent to standard administration. The measure of CD31 endothelial marked area allowed us to show an in vivo antiangiogenic effect of this drug that was further enhanced by using metronomic administration. This effect correlated with an induction of thrombospondin-1, a natural inhibitor of angiogenesis. Our results allow us to hypothesize that, in addition to a direct antiproliferative or cytotoxic antiendothelial cell effect, a secondary effect involving thrombospondin-1 induction might provide an explanation for the specificity of the effects of metronomic gemcitabine treatment

Exploring Vision-Related Quality of Life : A Qualitative Study Comparing Patients' Experience of Cataract Surgery with a Standard Monofocal IOL and an Enhanced Monofocal IOL

To explore quality of life related with intermediate vision of patients before and after cataract surgery, and to make patients' experience available for the design of future scales that assess visual function related with intermediate distance. A qualitative research methodology based on thematic content analysis was used to explore vision-related quality of life based on the experiences of patients with cataract. Patients were recruited at the Service of Ophthalmology of the Hospital de Sant Pau (Barcelona, Spain). Data were collected through nineteen semi-structured interviews conducted with patients diagnosed with cataract and implanted with a standard aspheric monofocal intraocular lens (IOL) (Tecnis ® ZA9003) (n = 6), an enhanced monofocal IOL (Tecnis ® Eyhance ICB000) (n = 6), and patients from the waiting list (n = 7). The data analysis consisted in coding, aggregation, and theme development of the transcribed audios. Patients on waiting lists reported difficulty and insecurity in performing daily and meaningful tasks related to near visual ranges (eg: threading a needle, reading price tags), intermediate (eg: using a computer or dialling numbers on a smartphone), and distant (eg: recognizing faces, walking on uneven surfaces). Patients after surgery with the standard IOL reported improvement in performing activities mainly in the distant visual range, but also the need for a better communication with clinical staff to adjust their own expectations on the results of the surgery. Finally, patients implanted with the enhanced IOL reported satisfaction and improved visual function in performing daily activities, especially those related to the intermediate visual range. Our exploratory study found that patients after cataract surgery with the enhanced IOL reported a better performance in activities that require the intermediate vision. These results will inform the development of scales to assess vision-related quality of life in the intermediate visual range prioritizing outcomes according to patients' daily and meaningful activities

Protumorigenic effects of Snail-expression fibroblasts on colon cancer cells

et al.Snail1 is a transcriptional factor that plays an important role in epithelial–mesenchymal transition and in the acquisition of invasive properties by epithelial cells. In colon tumors, Snail1 expression in the stroma correlates with lower specific survival of cancer patients. However, the role(s) of Snail1 expression in stroma and its association with patients' survival have not been determined. We used human primary carcinoma-associated fibroblasts (CAFs) or normal fibroblasts (NFs) and fibroblast cell lines to analyze the effects of Snail1 expression on the protumorigenic capabilities in colon cancer cells. Snail1 expression was higher in CAFs than in NFs and, as well as α-SMA, a classic marker of activated CAFs. Moreover, in tumor samples from 50 colon cancer patients, SNAI1 expression was associated with expression of other CAF markers, such as α-SMA and fibroblast activation protein. Interestingly, coculture of CAFs with colon cells induced a significant increase in epithelial cell migration and proliferation, which was associated with endogenous SNAI1 expression levels. Ectopic manipulation of Snail1 in fibroblasts demonstrated that Snail1 expression controlled migration as well as proliferation of cocultured colon cancer cells in a paracrine manner. Furthermore, expression of Snail1 in fibroblasts was required for the coadjuvant effect of these cells on colon cancer cell growth and invasion when coxenografted in nude mice. Finally, cytokine profile changes, particularly MCP-3 expression, in fibroblasts are put forward as mediators of Snail1-derived effects on colon tumor cell migration. In summary, these studies demonstrate that Snail1 is necessary for the protumorigenic effects of fibroblasts on colon cancer cells.This research was supported by the PI12/02037, Fundación Científica AECC, SAF2010-20750, S2010/BMD-2344, RTICC-RD12/0036/0041 and by the Fundación Banco Santander. Antonio García de Herreros’ laboratory was supported by RTICC-RD12/0036/0005 and SAF 2010-16089. Ma Jesús Larriba’s laboratory was supported by RD12/0036/0021. Cristina Peña and José Miguel García are recipients of Miguel Servet Contracts from the Instituto de Salud Carlos III.Peer reviewe

Barreras idiomáticas en la Atención Primaria de Salud. Percepción de los profesionales sanitarios y bases para estrategias de mejora

Comunicación oral presentada en la Segunda Conferencia Internacional de Comunicación en Salud, celebrada el 23 de octubre de 2015 en la Universidad Carlos III de MadridObjetivo: conocer la percepción de los profesionales de Atención Primaria de Salud sobre las dificultades en la atención a la población de culturas e idiomas diversos. Diseñar estrategias de mejora a partir de las opiniones de los profesionales. Metodología: estudio de diseño cualitativo, interpretativo y perspectiva sociocontructivista cuya finalidad es realizar un análisis narrativo del contenido de las opiniones de los profesionales sobre sus dificultades en la atención a pacientes de otras culturas e idiomas. Estudio multicéntrico desarrollado en 6 Equipos de Atención Primaria (EAP) de Barcelona ciudad con elevado porcentaje de población immigrada adscrita y de perfil cultural: paquistaní, filipino, chino, latinoamericano y magrebí. Población de estudio: profesionales del EAP. Muestreo teórico, intencionado y razonado. Dentro de un EAP, se han seleccionado profesionales de diferentes perfiles para conseguir la máxima variabilidad discursiva. Las variables de perfil profesional son profesión, edad, sexo y antigüedad profesional. Técnicas de generación de la información: grupos focales. Recogida de datos por vídeograbación y transcripción literal. Análisis de contenido temático. El texto se ha fragmentado en citas que son codificadas y se agrupan en categorías emergentes. Resultados: las categorías emergentes son: Relación del profesional con pacientes de culturas diversas (barreras idiomáticas, culturales y cómo mejorar); Abordaje de la enfermedad (incertidumbre durante la atención, dificultades en la sintomatología); Abordaje de los estilos de vida en prevención primaria i secundaria (incumplimiento de las recomendaciones: dieta y fármacos, terapias alternativas y hábitos no saludables). Conclusiones: hay barreras idiomáticas importantes que dificultan la anamnesis del paciente y la identificación de los síntomas. Los profesionales sanitarios plantean medidas de mejora: Necesidad de mayor número de mediadores en el EAP y mayor disponibilidad horaria de los mismos. El papel del mediador es crucial, sobre todo si es dispone de formación sanitaria (agente de salud)

Cross section measurements of 155,157Gd(n, γ) induced by thermal and epithermal neutrons

Neutron capture cross section measurements on Gd and Gd were performed using the time-of-flight technique at the n_TOF facility at CERN on isotopically enriched samples. The measurements were carried out in the n_TOF experimental area EAR1, at 185 m from the neutron source, with an array of 4 CD liquid scintillation detectors. At a neutron kinetic energy of 0.0253 eV, capture cross sections of 62.2(2.2) and 239.8(8.4) kilobarn have been derived for Gd and Gd, respectively, with up to 6% deviation relative to values presently reported in nuclear data libraries, but consistent with those values within 1.6 standard deviations. A resonance shape analysis has been performed in the resolved resonance region up to 181 eV and 307 eV, respectively for Gd and Gd, where on average, resonance parameters have been found in good agreement with evaluations. Above these energies and up to 1 keV, the observed resonance-like structure of the cross section has been analysed and characterised. From a statistical analysis of the observed neutron resonances we deduced: neutron strength function of 2. 01 (28) × 10 and 2. 17 (41) × 10 ; average total radiative width of 106.8(14) meV and 101.1(20) meV and s-wave resonance spacing 1.6(2) eV and 4.8(5) eV for n + Gd and n + Gd systems, respectively

A New Basal Sauropod Dinosaur from the Middle Jurassic of Niger and the Early Evolution of Sauropoda

The early evolution of sauropod dinosaurs is poorly understood because of a highly incomplete fossil record. New discoveries of Early and Middle Jurassic sauropods have a great potential to lead to a better understanding of early sauropod evolution and to reevaluate the patterns of sauropod diversification.A new sauropod from the Middle Jurassic of Niger, Spinophorosaurus nigerensis n. gen. et sp., is the most complete basal sauropod currently known. The taxon shares many anatomical characters with Middle Jurassic East Asian sauropods, while it is strongly dissimilar to Lower and Middle Jurassic South American and Indian forms. A possible explanation for this pattern is a separation of Laurasian and South Gondwanan Middle Jurassic sauropod faunas by geographic barriers. Integration of phylogenetic analyses and paleogeographic data reveals congruence between early sauropod evolution and hypotheses about Jurassic paleoclimate and phytogeography.Spinophorosaurus demonstrates that many putatively derived characters of Middle Jurassic East Asian sauropods are plesiomorphic for eusauropods, while South Gondwanan eusauropods may represent a specialized line. The anatomy of Spinophorosaurus indicates that key innovations in Jurassic sauropod evolution might have taken place in North Africa, an area close to the equator with summer-wet climate at that time. Jurassic climatic zones and phytogeography possibly controlled early sauropod diversification

First Results of the 140^{140}Ce(n,γ)141^{141}Ce Cross-Section Measurement at n_TOF

An accurate measurement of the $^{140}$Ce(n,γ) energy-dependent cross-section was performed at the n_TOF facility at CERN. This cross-section is of great importance because it represents a bottleneck for the s-process nucleosynthesis and determines to a large extent the cerium abundance in stars. The measurement was motivated by the significant difference between the cerium abundance measured in globular clusters and the value predicted by theoretical stellar models. This discrepancy can be ascribed to an overestimation of the $^{140}$Ce capture cross-section due to a lack of accurate nuclear data. For this measurement, we used a sample of cerium oxide enriched in $^{140}$Ce to 99.4%. The experimental apparatus consisted of four deuterated benzene liquid scintillator detectors, which allowed us to overcome the difficulties present in the previous measurements, thanks to their very low neutron sensitivity. The accurate analysis of the p-wave resonances and the calculation of their average parameters are fundamental to improve the evaluation of the $^{140}$Ce Maxwellian-averaged cross-section