Sourcing drugs with stable isotopes

ManuscriptCarbon (δ13C) and nitrogen (δ15N) isotope ratios at natural abundance levels are useful tools in determining the region-of-origin for both cocaine and heroin. Here we show that cocaine originating from different geographic regions of South America exhibited pronounced differences in their δ13C and δ15N values. The distinct isotope-ratio combinations allow reliable determination of the region-of-origin for the major coca growing regions along the Andean Ridge

Quantifying the Impact of Replication on the Quality-of-Service in Cloud Databases

Cloud databases achieve high availability by automatically replicating data on multiple nodes. However, the overhead caused by the replication process can lead to an increase in the mean and variance of transaction response times, causing unforeseen impacts on the offered quality-of-service (QoS). In this paper, we propose a measurement-driven methodology to predict the impact of replication on Database-as-a-Service (DBaaS) environments. Our methodology uses operational data to parameterize a closed queueing network model of the database cluster together with a Markov model that abstracts the dynamic replication process. Experiments on Amazon RDS show that our methodology predicts response time mean and percentiles with errors of just 1% and 15% respectively, and under operational conditions that are significantly different from the ones used for model parameterization. We show that our modeling approach surpasses standard modeling methods and illustrate the applicability of our methodology for automated DBaaS provisioning

5% lidocaine medicated plaster double effect in a case of orofacial localized neuropathic pain

Roberto Casale,1,2 Yuriy Romanenko,2,3 Massimo Allegri4–6 1Department of Clinical Neurophysiology and Pain Rehabilitation Unit, Foundation "Salvatore Maugeri", Research and Care Institute, IRCCS, Pavia, Italy; 2EFIC Montescano Pain School, Montescano, Italy; 3Department of Neurology, Lugansk City Hospital 4, Lugansk, Ukraine; 4Department of Clinical, Surgical, Diagnostic and Pediatric Sciences University of Pavia, Pavia, Italy; 5Pain Therapy Service Fondazione IRCCS Policlinico San Matteo, Pavia, Italy; 6SIMPAR group, Pavia, Italy Abstract: Localized neuropathic pain (LNP) is a type of neuropathic pain that is characterized by “consistent and limited area(s) of maximum pain associated with negative or positive sensory signs and/or spontaneous symptoms characteristic of neuropathic pain”. This definition encompasses a huge number of neuropathic orofacial pain syndromes. We present a case report of a patient who was affected with sleep apnea syndrome treated with nocturnal oxygen mask delivery, in whom orofacial LNP hampered the wearing of a mask due to unbearable burning and throbbing pain. The application of 5% lidocaine medicated plaster during the night led to an impressive reduction of both the pain level and the size of the painful area due to the plaster's pharmacological mechanisms, which were associated with a secondary benefit due to its mechanical protective action. This case report shows how these two factors could be of clinical value and have to be considered more systematically in the treatment of LNP in reducing pain and the size of the painful area. Keywords: trigeminal pain, localized neuropathic pain, topical treatment, 5% lidocaine medicated plaste

Flora and Fauna in East Asian Art

Flora and Fauna in East Asian Art is the fourth annual exhibition curated by students enrolled in the Art History Methods course. This exhibition highlights the academic achievements of six student curators: Samantha Frisoli ’18, Daniella Snyder ’18, Gabriella Bucci ’19, Melissa Casale ’19, Keira Koch ’19, and Paige Deschapelles ’20. The selection of artworks in this exhibition considers how East Asian artists portrayed similar subjects of flora and fauna in different media including painting, prints, embroidery, jade, and porcelain. This exhibition intends to reveal the hidden meanings behind various representations of flora and fauna in East Asian art by examining the iconography, cultural context, aesthetic and function of each object.https://cupola.gettysburg.edu/artcatalogs/1025/thumbnail.jp

Examination on total ozone column retrievals by Brewer spectrophotometry using different processing software

The availability of long-term records of the total ozone content (TOC) represents a valuable source of information for studies on the assessment of short-and long-term atmospheric changes and their impact on the terrestrial ecosystem. In particular, ground-based observations represent a valuable tool for validating satellite-derived products. To our knowledge, details about software packages for processing Brewer spectrophotometer measurements and for retrieving the TOC are seldom specified in studies using such datasets. The sources of the differences among retrieved TOCs from the Brewer instruments located at the Italian stations of Rome and Aosta, using three freely available codes (Brewer Processing Software, BPS; O3Brewer software; and European Brewer Network (EUBREWNET) level 1.5 products) are investigated here. Ground-based TOCs are also compared with Ozone Monitoring Instrument (OMI) TOC retrievals used as an independent dataset since no other instruments near the Brewer sites are available. The overall agreement of the BPS and O3Brewer TOC data with EUBREWNET data is within the estimated total uncertainty in the retrieval of total ozone from a Brewer spectrophotometer (1%). However, differences can be found depending on the software in use. Such differences become larger when the instrumental sensitivity exhibits a fast and dramatic drift which can affect the ozone retrievals significantly. Moreover, if daily mean values are directly generated by the software, differences can be observed due to the configuration set by the users to process single ozone measurement and the rejection rules applied to data to calculate the daily value. This work aims to provide useful information both for scientists engaged in ozone measurements with Brewer spectrophotometers and for stakeholders of the Brewer data products available on Web-based platforms

Survival probabilities of loggerhead sea turtles (<i>Caretta caretta</i>) estimated from capture-mark-recapture data in the Mediterranean Sea

Las probabilidades de supervivencia de la tortuga boba (Caretta caretta) se han estimado por primera vez en el Mediterráneo analizando datos de 3254 marcajes y 134 recapturas en esta región. La mayoría de las tortugas eran juveniles encontrados en el mar. Las recapturas fueron reavistamientos de individuos vivos y recuperaciones de individuos muertos. Los datos se analizaron mediante el modelo de Baker, versión modificada del de Cormack-Jolly-Seber que puede combinar recaptura, reavistamientos de individuos vivos e individuos recuperados muertos. Se obtuvo una probabilidad de supervivencia anual de 0.73 (IC 95% = 0.67-0.78; n=3254), y debe considerarse como una estima conservativa debido a una desconocida, aunque no insignificante, tasa de perdida de marcados. Este estudio ofrece una estima preliminar de las probabilidades de supervivencia de los estadios de desarrollo "en el mar" para la población mediterránea amenazada de tortuga boba marina, y proporciona las primeras observaciones sobre la magnitud de la sospechada mortalidad inducida por el hombre en la región. El modelo, utilizado aquí por primera vez en tortugas marinas podría ser utilizado para obtener estimas de supervivencia a partir de otros datos con pocas o sin recapturas reales, pero con otros tipos de datos de recaptura frecuentemente producidos por programas de marcado de estos animales de amplia distribución