Ferritin and Iron Studies in Anaemia and Chronic Disease

Anaemia is a condition in which the number of red cells necessary to meet the body's physiological requirements is insufficient. Iron deficiency anaemia (IDA) and the anaemia of chronic disease (ACD) are the two most common causes of anaemia worldwide; iron homeostasis plays a pivotal role in the pathogenesis of both diseases. An understanding of how iron studies can be used to distinguish between these diseases is therefore essential, not only for diagnosis but also in guiding management. This review will primarily focus on IDA and ACD; however iron overload in anaemia will also be briefly discussed

Global Diffusion in a Realistic Three-Dimensional Time-Dependent Nonturbulent Fluid Flow

We introduce and study the first model of an experimentally realizable three-dimensional time-dependent nonturbulent fluid flow to display the phenomenon of global diffusion of passive-scalar particles at arbitrarily small values of the nonintegrable perturbation. This type of chaotic advection, termed {\it resonance-induced diffusion\/}, is generic for a large class of flows.Comment: 4 pages, uuencoded compressed postscript file, to appear in Phys. Rev. Lett. Also available on the WWW from http://formentor.uib.es/~julyan/, or on paper by reques

Nonlinear Dynamics of the Perceived Pitch of Complex Sounds

We apply results from nonlinear dynamics to an old problem in acoustical physics: the mechanism of the perception of the pitch of sounds, especially the sounds known as complex tones that are important for music and speech intelligibility

Behavioural variability, physical activity, rumination time, and milk characteristics of dairy cattle in response to regrouping

We gratefully thank the farm staff and the Lely Farm Management Support Ireland and UK manager, Mr Bas Van Santen, for technical assistance and data retrieval from the Lely T4C software database and Dr Sharon Mitchell for assistance with the laboratory analyses. This work has already been published as part of a PhD thesis (Marumo et al. (2021a)).Peer reviewe

Heteroclinic intersections between Invariant Circles of Volume-Preserving Maps

We develop a Melnikov method for volume-preserving maps with codimension one invariant manifolds. The Melnikov function is shown to be related to the flux of the perturbation through the unperturbed invariant surface. As an example, we compute the Melnikov function for a perturbation of a three-dimensional map that has a heteroclinic connection between a pair of invariant circles. The intersection curves of the manifolds are shown to undergo bifurcations in homologyComment: LaTex with 10 eps figure

Reactive dynamics of inertial particles in nonhyperbolic chaotic flows

Anomalous kinetics of infective (e.g., autocatalytic) reactions in open, nonhyperbolic chaotic flows are important for many applications in biological, chemical, and environmental sciences. We present a scaling theory for the singular enhancement of the production caused by the universal, underlying fractal patterns. The key dynamical invariant quantities are the effective fractal dimension and effective escape rate, which are primarily determined by the hyperbolic components of the underlying dynamical invariant sets. The theory is general as it includes all previously studied hyperbolic reactive dynamics as a special case. We introduce a class of dissipative embedding maps for numerical verification.Comment: Revtex, 5 pages, 2 gif figure

Long-range correlation and multifractality in Bach's Inventions pitches

We show that it can be considered some of Bach pitches series as a stochastic process with scaling behavior. Using multifractal deterend fluctuation analysis (MF-DFA) method, frequency series of Bach pitches have been analyzed. In this view we find same second moment exponents (after double profiling) in ranges (1.7-1.8) in his works. Comparing MF-DFA results of original series to those for shuffled and surrogate series we can distinguish multifractality due to long-range correlations and a broad probability density function. Finally we determine the scaling exponents and singularity spectrum. We conclude fat tail has more effect in its multifractality nature than long-range correlations.Comment: 18 page, 6 figures, to appear in JSTA

Antenatal corticosteroid therapy (ACT) and size at birth: A population-based analysis using the Finnish medical birth register

© 2019 Rodriguez et al. Background Antenatal corticosteroid therapy (ACT) is used clinically to prepare the fetal lung for impending preterm birth, but animal and human studies link corticosteroids to smaller birth size. Whether ACT is associated with birth size is debated; therefore, we assessed differences in birth size in treated versus untreated pregnancies. Methods and findings This observational register-based study used data from the Finnish Medical Birth Register (FMBR) covering all births in Finland (January 1, 2006–December 31, 2010). We used unadjusted and adjusted regression analyses as well as propensity score matching (PSM) to analyze whether birth size differed by ACT exposure. PSM provides a stringent comparison, as subsamples were created matched on baseline and medical characteristics between treated and untreated women. All analyses were stratified by timing of birth. The primary study outcome was birth size: birth weight (BWT), birth length (BL), ponderal index (PI), and head circumference (HC) measured immediately after birth and recorded in the FMBR. Additional analyses explored indicators of neonatal health in relation to ACT exposure and birth size. A total of 278,508 live-born singleton births with ≥24 gestational completed weeks were registered in the FMBR during the 5-year study period. Over 4% of infants were born preterm, and 4,887 women were treated with ACT (1.75%). More than 44% of the exposed infants (n = 2,173) were born at term. First, results of unadjusted regression analyses using the entire sample showed the greatest reductions in BWT as compared to the other analytic methods: very preterm −61.26 g (±SE 24.12, P < 0.01), preterm −-232.90 g (±SE 17.24, P < .001), near term −171.50 g (±SE 17.52, P < .001), and at term −-101.95 g (±SE 10.89, P < .001). Second, using the entire sample, regression analyses adjusted for baseline and medical conditions showed significant differences in BWT between exposed and unexposed infants: very preterm −61.54 g (±SE 28.62, P < .03), preterm −222.78 g (±SE 19.64, P < .001), near term −159.25 g (±SE 19.14, P < .001), and at term −91.62 g (±SE 11.86, P < .03). Third, using the stringent PSM analyses based on matched subsamples, infants exposed to ACT weighed less at birth: −220.18 g (±SE 21.43, P < .001), −140.68 g (±SE 23.09, P < .001), and −89.38 g (±SE 14.16, P < .001), born preterm, near term, and at term, respectively. Similarly, significant reductions in BL and HC were also observed using the three analytic methods. There were no differences among postterm infants regardless of analytic method. Likewise, we observed no differences with respect to PI. Additional analyses showed that exposed and unexposed infants had generally similar Apgar scores at birth, yet the ACT-treated infants received greater medical care during the first 7 days of life and beyond. Our study is mainly limited by lack of data in FMBR specifying the interval between treatment and birth as well as other potential confounders that could not be tested. Conclusions In this study, ACT was consistently associated with reduction in birth size for infants born preterm, near term, or at term. Further investigation is warranted alongside reevaluation of guidelines. Efforts need to be made to correctly identify and target patients who will deliver preterm. Reduced growth should be considered when deliberating early care decisions.Swedish Research Council for Health, Working Life, and Welfare (FAS 20111483; https://forte.se/) and VINNOVA Sweden’s Innovation Agency (200801003; https://www.vinnova.se/), both to AR; Academy of Finland EGEA project (285547; https://www.aka.fi/en/) and EU H2020 LifeCycle Action (grant agreement 733206) to MRJ; and EU H2020 DynaHEALTH action (grant agreement 633595; https://ec.europa.eu/programmes/horizon2020/) to MRJ (PI) and AR (collaborator

NUISANCE: a neutrino cross-section generator tuning and comparison framework

NUISANCE is an open source C++ framework which facilitates detailed studies of neutrino interaction cross-section models implemented in Monte Carlo neutrino event generators. It provides a host of automated methods to perform comparisons of multiple generators to published cross-section measurements and each other. External reweighting libraries are used to allow the end-user to evaluate the impact of model parameters variations in the generators with data, or to tune the generator predictions to arbitrary dataset combinations. The design is modular and focusses on ease-of-use to allow new datasets and more generators to be added without requiring detailed understanding of the entire NUISANCE package. We discuss the motivation for the NUISANCE framework and suggested usage cases, alongside a description of its core structure

Husimi Transform of an Operator Product

It is shown that the series derived by Mizrahi, giving the Husimi transform (or covariant symbol) of an operator product, is absolutely convergent for a large class of operators. In particular, the generalized Liouville equation, describing the time evolution of the Husimi function, is absolutely convergent for a large class of Hamiltonians. By contrast, the series derived by Groenewold, giving the Weyl transform of an operator product, is often only asymptotic, or even undefined. The result is used to derive an alternative way of expressing expectation values in terms of the Husimi function. The advantage of this formula is that it applies in many of the cases where the anti-Husimi transform (or contravariant symbol) is so highly singular that it fails to exist as a tempered distribution.Comment: AMS-Latex, 13 page