Curvature Corrections to Dynamics of Domain Walls

The most usual procedure for deriving curvature corrections to effective actions for topological defects is subjected to a critical reappraisal. A logically unjustified step (leading to overdetermination) is identified and rectified, taking the standard domain wall case as an illustrative example. Using the appropriately corrected procedure, we obtain a new exact (analytic) expression for the corresponding effective action contribution of quadratic order in the wall width, in terms of the intrinsic Ricci scalar $R$ and the extrinsic curvature scalar $K$. The result is proportional to $cK^2-R$ with the coefficient given by $c\simeq 2$. The resulting form of the ensuing dynamical equations is obtained in terms of the second fundamental form and the Dalembertian of its trace, K. It is argued that this does not invalidate the physical conclusions obtained from the "zero rigidity" ansatz $c=0$ used in previous work.Comment: 19 pages plain TeX, 2 figures include

Geometry of Deformations of Relativistic Membranes

A kinematical description of infinitesimal deformations of the worldsheet spanned in spacetime by a relativistic membrane is presented. This provides a framework for obtaining both the classical equations of motion and the equations describing infinitesimal deformations about solutions of these equations when the action describing the dynamics of this membrane is constructed using {\it any} local geometrical worldsheet scalars. As examples, we consider a Nambu membrane, and an action quadratic in the extrinsic curvature of the worldsheet.Comment: 20 pages, Plain Tex, sign errors corrected, many new references added. To appear in Physical Review

Psychedelics for brain injury: A mini-review

Objective: Stroke and traumatic brain injury (TBI) are among the leading causes of disability. Even after engaging in rehabilitation, nearly half of patients with severe TBI requiring hospitalization are left with major disability. Despite decades of investigation, pharmacologic treatment of brain injury is still a field in its infancy. Recent clinical trials have begun into the use of psychedelic therapeutics for treatment of brain injury. This brief review aims to summarize the current state of the science's relevance to neurorehabilitation, and may act as a resource for those seeking to understand the precedence for these ongoing clinical trials.Methods: Narrative mini-review of studies published related to psychedelic therapeutics and brain injury.Results: Recent in vitro, in vivo, and case report studies suggest psychedelic pharmacotherapies may influence the future of brain injury treatment through modulation of neuroinflammation, hippocampal neurogenesis, neuroplasticity, and brain complexity.Conclusions: Historical data on the safety of some of these substances could serve in effect as phase 0 and phase I studies. Further phase II trials will illuminate how these drugs may treat brain injury, particularly TBI and reperfusion injury from stroke

Eating As Treatment (EAT): A Stepped-Wedge, Randomized Controlled Trial of a Health Behavior Change Intervention Provided by Dietitians to Improve Nutrition in Patients With Head and Neck Cancer Undergoing Radiation Therapy (TROG 12.03)

Purpose: Malnutrition in head and neck cancer (HNC) treatment is common and associated with poorer morbidity and mortality outcomes. This trial aimed to improve nutritional status during radiation therapy (RT) using a novel method of training dietitians to deliver psychological techniques to improve nutritional behaviors in patients with HNC. Methods and Materials: This trial used a stepped-wedge, randomized controlled design to assess the efficacy of the Eating As Treatment (EAT) program. Based on motivational interviewing and cognitive behavioral therapy, EAT was designed to be delivered by oncology dietitians and integrated into their clinical practice. During control steps, dietitians provided treatment as usual, before being trained in EAT and moving into the intervention phase. The training was principles based and sought to improve behavior-change skills rather than provide specific scripts. Patients recruited to the trial (151 controls, 156 intervention) were assessed at 4 time points (the first and the final weeks of RT, and 4 and 12 weeks afterward). The primary outcome was nutritional status at the end of RT as measured by the Patient-Generated Subjective Global Assessment. Results: Patients who received the EAT intervention had significantly better scores on the primary outcome of nutritional status at the critical end-of-treatment time point (β = −1.53 [−2.93 to −.13], P =.03). Intervention patients were also significantly more likely than control patients to be assessed as well-nourished at each time point, lose a smaller percentage of weight, have fewer treatment interruptions, present lower depression scores, and report a higher quality of life. Although results were not statistically significant, patients who received the intervention had fewer and shorter unplanned hospital admissions. Conclusions: This trial is the first of its kind to demonstrate the effectiveness of a psychological intervention to improve nutrition in patients with HNC who are receiving RT. The intervention provides a means to ameliorate malnutrition and the important related outcomes and consequently should be incorporated into standard care for patients receiving RT for HNC

The dynamics of curved gravitating walls

We examine the dynamics of a self-gravitating domain wall using the $\lambda \Phi^4$ model as a specific example. We find that the Nambu motion of the wall is quite generic and dominates the wall motion even in the presence of gravity. We calculate the corrections to this leading order motion, and estimate the effect of the inclusion of gravity on the dynamics of the wall. We then treat the case of a spherical gravitating thick wall as a particular example, solving the field equations and calculating the corrections to the Nambu motion analytically for this specific case. We find that the presence of gravity retards collapse in this case.Comment: 19 pages revtex, 3 figures, references added, equations correcte

Psychoactive substances and the political ecology of mental distress

The goal of this paper is to both understand and depathologize clinically significant mental distress related to criminalized contact with psychoactive biotic substances by employing a framework known as critical political ecology of health and disease from the subdiscipline of medical geography. The political ecology of disease framework joins disease ecology with the power-calculus of political economy and calls for situating health-related phenomena in their broad social and economic context, demonstrating how large-scale global processes are at work at the local level, and giving due attention to historical analysis in understanding the relevant human-environment relations. Critical approaches to the political ecology of health and disease have the potential to incorporate ever-broadening social, political, economic, and cultural factors to challenge traditional causes, definitions, and sociomedical understandings of disease. Inspired by the patient-centered medical diagnosis critiques in medical geography, this paper will use a critical political ecology of disease approach to challenge certain prevailing sociomedical interpretations of disease, or more specifically, mental disorder, found in the field of substance abuse diagnostics and the related American punitive public policy regimes of substance abuse prevention and control, with regards to the use of biotic substances. It will do this by first critically interrogating the concept of "substances" and grounding them in an ecological context, reviewing the history of both the development of modern substance control laws and modern substance abuse diagnostics, and understanding the biogeographic dimensions of such approaches. It closes with proposing a non-criminalizing public health approach for regulating human close contact with psychoactive substances using the example of cannabis use

Effective action and motion of a cosmic string

We examine the leading order corrections to the Nambu effective action for the motion of a cosmic string, which appear at fourth order in the ratio of the width to radius of curvature of the string. We determine the numerical coefficients of these extrinsic curvature corrections, and derive the equations of motion of the worldsheet. Using these equations, we calculate the corrections to the motion of a collapsing loop, a travelling wave, and a helical breather. From the numerical coefficients we have calculated, we discuss whether the string motion can be labelled as `rigid' or `antirigid,' and hence whether cusp or kink formation might be suppressed or enhanced.Comment: 24 pages revtex, 12 figure

High Exposure Facility Technical Description

The High Exposure Facility is a collimated high-level gamma irradiator that is located in the basement of the 318 building. It was custom developed by PNNL back in 1982 to meet the needs for high range radiological instrument calibrations and dosimeter irradiations. At the time no commercially available product existed that could create exposure rates up to 20,000 R/h. This document is intended to pass on the design criteria that was employed to create this unique facility, while maintaining compliance with ANSI N543-1974, "General Safety Standard for Installations Using Non-Medical X-Ray and Sealed Gamma-Ray Sources, Energies up to 10 MeV.

Kinematics, Abundances, and Origin of Brightest Cluster Galaxies

We present kinematic parameters and absorption line strengths for three brightest cluster galaxies, NGC 6166, NGC 6173 and NGC 6086. We find that NGC 6166 has a velocity dispersion profile which rises beyond 20 arcsec from the nucleus, with a halo velocity dispersion in excess of 400 km/s. All three galaxies show a positive and constant h4 Hermite moment. The rising velocity dispersion profile in NGC 6166 thus indicates an increasing mass-to-light ratio. Rotation is low in all three galaxies, and NGC 6173 and NGC 6086 show possible kinematically decoupled cores. All three galaxies have Mg2 gradients similar to those found in normal bright ellipticals, which are not steep enough to support simple dissipative collapse models, but these could be accompanied by dissipationless mergers which would tend to dilute the abundance gradients. The [Mg/Fe] ratios in NGC 6166 and NGC 6086 are higher than that in NGC 6173, and if NGC 6173 is typical of normal bright ellipticals, this suggests that cDs cannot form from late mergers of normal galaxies.Comment: 21 pages, accepted for publication in MNRA