EUROPE 2020 SI-LAB: A New Center for Economic and Social Development in Sicily

The debate on the determinants of regional and local development has been stimulated recently by the European strategy for smart, sustainable and inclusive growth defined as Europe 2020. We present the objectives and structure of a new laboratory (SI-LAB) for the development of Sicilian economy promoted by the University of Palermo. In particular, we highlight the fundamental issues related to the incoming functioning of the Lab as a new oganization devoted to analyzing public policy issues, and fostering new ways of entrepreurship at the local level

The First 1000 Days of Life: How Changes in the Microbiota Can Influence Food Allergy Onset in Children

Background: Allergic disease, including food allergies (FA)s, has been identified as a major global disease. The first 1000 days of life can be a “window of opportunity” or a “window of susceptibility”, during which several factors can predispose children to FA development. Changes in the composition of the gut microbiota from pregnancy to infancy may play a pivotal role in this regard: some bacterial genera, such as Lactobacillus and Bifidobacterium, seem to be protective against FA development. On the contrary, Clostridium and Staphylococcus appear to be unprotective. Methods: We conducted research on the most recent literature (2013–2023) using the PubMed and Scopus databases. We included original papers, clinical trials, meta-analyses, and reviews in English. Case reports, series, and letters were excluded. Results: During pregnancy, the maternal diet can play a fundamental role in influencing the gut microbiota composition of newborns. After birth, human milk can promote the development of protective microbial species via human milk oligosaccharides (HMOs), which play a prebiotic role. Moreover, complementary feeding can modify the gut microbiota’s composition. Conclusions: The first two years of life are a critical period, during which several factors can increase the risk of FA development in genetically predisposed children

Effect of Intravitreal Brolucizumab in the Treatment of Polypoidal Choroidal Vasculopathy With Foveal Lipid Exudation.

A 71-year-old woman with a history of blurred vision in her right eye for nearly two months came to our attention. A complete ophthalmological evaluation, including best-corrected visual acuity measurement, fundus examination, spectral-domain optical coherence tomography, fluorescein angiography, and indocyanine green angiography, was performed. Multimodal imaging showed the presence of a polypoidal choroidal vasculopathy (PCV) lesion surrounded by diffuse hard exudates in the macular area. Our patient received three monthly intravitreal injections of brolucizumab during the loading phase, followed by an intravitreal injection every eight weeks for a total of 48 weeks of follow-up. The therapy appeared to be effective for improving both visual and anatomical outcomes revealing an important regression of the PCV and an almost complete reabsorption of lipid exudates. Intravitreal brolucizumab could be considered an effective treatment in the management of lipid exudation in PCV patients

Is the Sardinian Blue Zone the New Shangri-La for mental health? Evidence on depressive symptoms and its correlates in late adult life span

Background: An area of extraordinary longevity (i.e., Sardinian Blue Zone) characterized by a very high prevalence of long-lived successful agers has been validated in Sardinia, an Italian island located in the Mediterranean Sea. Aims: This study was primarily aimed at examining whether dietary habits (intake of vegetables and fruit, animal-derived proteins, and carbohydrates-rich food), time spent on hobbies, subjective physical health, and socio-cultural context (Sardinian Blue Zone vs. another Sardinian rural area) predicted self-reported depressive symptoms in older adults recruited in the Sardinian Blue Zone and another Sardinian rural area not being characterized by a higher prevalence of long-lived individuals. Methods: Three hundred and eighteen community-dwellers, age 65 years and older, 188 females and 130 males (Mage = 79.1 years, SD = 6.9 years) were recruited from the Sardinian Blue Zone and another Sardinian rural area. Each participant individually completed a battery of instruments to assess lifestyle, food habits, perceived physical health, and depressive symptoms through the CES-D inventory. Results: Significant associations were found between depressive signs, perceived physical health, time spent gardening, proteins, and carbohydrates intake, respectively. Approximately 17% of the variance in the CES-D condition was predicted by socio-cultural context, perceived physical health, and gardening. Participants recruited in the Sardinian Blue Zone spent more time gardening and self-reported better physical health. Conclusions: current results suggest that a socio-cultural context where people age well (i.e., the Sardinian Blue Zone), and a healthy and physically active lifestyle are crucial for promoting well-being in late adulthood

The AdS/CFT correspondence in two dimensions

We review recent progress in understanding the anti-de Sitter/conformal field theory correspondence in the context of two-dimensional dilaton gravity theory.Comment: Contribution to the Proceedings of the Euroconference on "Brane New World and Noncommutative Geometry", Turin, October 200

Elastic Chiral Waveguides with Gyro-Hinges

This article presents a novel chiral structure, consisting of Euler–Bernoulli beams connected to gyroscopic spinners.Anew type of boundary condition is introduced, which is referred to as a gyrohinge. In this system, flexural waves are coupled with rotational motion.Time-harmonic conditions are derived by assuming small nutation angles of the spinners. It is shown that the eigenfrequencies of a finite beam with gyro-hinges at one or both ends change dramatically with the moments of inertia and the spin and precession rates of the spinners. The formulation is then extended to elastic beams with periodically-spaced gyro-hinges, whose dispersion properties are investigated in detail. In particular, it is shown how stop-bands and standing modes are affected by the introduction of gyroscopic spinners at the junctions. It is also demonstrated that a periodic system composed of beams connected by gyro-hinges represents a good approximation of a gyrobeam, a theoretical structural element consisting of an elastic beam possessing a continuous distribution of stored angular momentum. The gyricity coefficient of a gyrobeam is then interpreted in terms of the physical parameters of the system of beams with gyroscopic spinners. This article opens a new perspective on the design and practical implementation of chiral mechanical systems

Wave Characterisation in a Dynamic Elastic Lattice: Lattice Flux and Circulation

A novel characterisation of dispersive waves in a vector elastic lattice is presented in the context of wave polarisation. This proves to be especially important in analysis of dynamic anisotropy and standing waves trapped within the lattice. The operators of lattice flux and lattice circulation provide the required quantitative description, especially in cases of intermediate and high frequency dynamic regimes. Dispersion diagrams are conventionally considered as the ultimate characteristics of dynamic properties of waves in periodic systems. Generally, a waveform in a lattice can be thought of as a combination of pressure-like and shear-like waves. However, a direct analogy with waves in the continuum is not always obvious. We show a coherent way to characterise lattice waveforms in terms of so-called lattice flux and lattice circulation. In the long wavelength limit, this leads to well-known interpretations of pressure and shear waves. For the cases when the wavelength is comparable with the size of the lattice cell, new features are revealed which involve special directions along which either lattice flux or lattice circulation is zero. The cases of high frequency and wavelength comparable to the size of the elementary cell are considered, including dynamic anisotropy and dynamic neutrality in structured solids

Compressive Sensing-Based Harmonic Sources Identification in Smart Grids

Identifying the prevailing polluting sources would help the distribution system operators in acting directly on the cause of the problem, thus reducing the corresponding negative effects. Due to the limited availability of specific measurement devices, ad hoc methodologies must be considered. In this regard, compressive sensing (CS)-based solutions are perfect candidates. This mathematical technique allows recovering sparse signals when a limited number of measurements are available, thus overcoming the lack of power quality meters. In this article, a new formulation of the ell _{1} -minimization algorithm for CS problems, with quadratic constraint, has been designed and investigated in the framework of the identification of the main polluting sources in smart grids. A novel whitening transformation is proposed for this context. This specific transformation allows the energy of the measurement errors to be appropriately estimated, and thus, better identification results are obtained. The validity of the proposal is proven by means of several simulations and tests performed on two distribution networks for which suitable measurement systems are considered along with a realistic quantification of the uncertainty sources

Current Insights on Early Life Nutrition and Prevention of Allergy

The incidence of allergic diseases in childhood appears to have significantly increased over the last decades. Since environmental factors, including diet, have been thought to play a significant role in the development of these diseases, there is great interest in identifying prevention strategies related to early nutritional interventions. Breastfeeding is critical for the immune development of newborns and infants through immune-modulating properties and it impacts the establishment of a healthy gut microbiota. However, the evidence for a protective role of breastfeeding against the development of food allergy in childhood is controversial, and there is little evidence to support the benefits of an antigen avoidance diet during lactation. Although it is not possible to draw a definitive conclusion about the protective role of breast milk against allergic diseases, exclusive breastfeeding is still recommended throughout the first 6 months of life due to associated health benefits. Furthermore, recommendations regarding complementary feeding in infancy have been significantly modified over the last few decades. Several studies have shown that delayed exposure to allergenic foods does not have a role in allergy prevention and recent guidelines recommend against delaying the introduction of complementary foods after 6 months of age, both in high- and low-risk infants. However, trials investigating this dietary approach have reported equivocal results so far. This review summarizes the available high-quality evidence regarding the efficacy of the principal dietary interventions proposed in early life to prevent allergic diseases in children

Quality of information of websites dedicated to obesity: a systematic search to promote high level of information for Internet users and professionals

Background: The Internet is increasingly used as a source of information. This study investigates with a multidimensional methodology the quality of information of websites dedicated to obesity treatment and weight-loss interventions. We compared websites in English, a language that it is used for the international scientific divulgation, and in Italian, a popular local language. Methods: Level of Evidence: Level I, systematic review search on four largely used search engines. Duplicated and unrelated websites were excluded. We checked: popularity with PageRank; technological quality with Nibbler; readability with the Flesch Reading Ease test or the Gulpease readability index; quality of information with the DISCERN scale, the JAMA benchmark criteria, and the adherence to the Health on the Net Code. Results: 63 Italian websites and 41 English websites were evaluated. English websites invested more in the technological quality especially for the marketing, experience of the user, and mobile accessibility. Both the Italian and English websites were of poor quality and readability. Conclusions: These results can inform guidelines for the improvement of health information and help Internet users to achieve a higher level of information. Users must find benefits of treatment, support to the shared decision-making, the sources used, the medical editor's supervision, and the risk of postponing the treatment