Editorial

Peer reviewedFinal Accepted Versio

Editorial

Peter Tschmuck. Editorial, International Journal of Music Business Research, Vol. 3 (2), October 2014.This October 2014 issue of the International Journal of Music Business Research opens with the award-winning paper from the 4th Vienna Music Business Research Days 2013. In this Francisco Bernardo & Luís Gustavo Martins of the Catholic University of Portugal in Porto pose the crucial question of whether, in the digital age, disintermediation is re-shaping the music industry and fostering independent approaches to the market. Aspects of Bernardo & Martins' article are echoed in the subsequent paper by O'Hare entitled, "Creativity, Innovation and Entrepreneurship in Music Business Education". The author argues these days a music business education is essential to achieve success in the music business. The third article in this volume is a contribution by Beatrice Jetto of the University of Technology and Notre Dame University in Sydney, Australia. In this she focuses on the relationship between music blogs and the music industry by analysing 18 semi-structured interviews with bloggers specialising in music.Peer reviewedFinal Published versio

Corrigendum: Calibrating spectrometers for measurements of the spectral irradiance caused by solar radiation (2020 Metrologia 57 065027)

We correct an error in equation (60) of the original publication

Calibrating spectrometers for measurements of the spectral irradiance caused by solar radiation

Measuring the spectral irradiance of solar radiation is required in many fields of science and technology. In this work, we present an in-depth discussion of the measuring procedure and required corrections for such measurements. We also describe our measurement uncertainty analysis, which is based on a Monte-Carlo procedure in accordance with the Guide to the expression of uncertainty in measurement (JCGM, Paris, 2008). For this purpose, fifteen uncertainty sources are identified, analyzed and described analytically. As a specific application example, we describe the instrumentation and procedure for determining the spectral irradiance of a solar simulator at the ISO/IEC 17 025 accredited solar cell calibration laboratory ISFH CalTeC and the corresponding measurement uncertainty analysis. Moreover, we provide a Python implementation for this calculation along with the paper. We show that for state-of-the-art instrumentation, significant uncertainty contributions arise from the reference lamp (primary calibration standard), stray light and signal-to-noise ratio. If sharp spectral features are present (which is common, e.g. for Xenon lamps), spectral bandwidth and wavelength uncertainty also contribute significantly to the overall uncertainty. © 2020 BIPM & IOP Publishing Lt

Genetic diversification of persistent Mycobacterium abscessus within cystic fibrosis patients

Mycobacterium (M.) abscessus infections in Cystic Fibrosis (CF) patients cause a deterioration of lung function. Treatment of these multidrug-resistant pathogens is associated with severe side-effects, while frequently unsuccessful. Insight on M. abscessus genomic evolvement during chronic lung infection would be beneficial for improving treatment strategies. A longitudinal study enrolling 42 CF patients was performed at a CF center in Berlin, Germany, to elaborate phylogeny and genomic diversification of in-patient M. abscessus. Eleven of the 42 CF patients were infected with M. abscessus. Five of these 11 patients were infected with global human-transmissible M. abscessus cluster strains. Phylogenetic analysis of 88 genomes from isolates of the 11 patients excluded occurrence of M. abscessus transmission among members of the study group. Genome sequencing and variant analysis of 30 isolates from 11 serial respiratory samples collected over 4.5 years from a chronically infected patient demonstrated accumulation of gene mutations. In total, 53 genes exhibiting non-synonymous variations were identified. Enrichment analysis emphasized genes involved in synthesis of glycopeptidolipids, genes from the embABC (arabinosyltransferase) operon, betA (glucose-methanol-choline oxidoreductase) and choD (cholesterol oxidase). Genetic diversity evolved in a variety of virulence- and resistance-associated genes. The strategy of M. abscessus populations in chronic lung infection is not clonal expansion of dominant variants, but to sustain simultaneously a wide range of genetic variants facilitating adaptation of the population to changing living conditions in the lung. Genomic diversification during chronic infection requires increased attention when new control strategies against M. abscessus infections are explored.Peer Reviewe

How to classify, diagnose, treat and follow-up extragonadal germ cell tumors? A systematic review of available evidence

Purpose To present the current evidence and the development of studies in recent years on the management of extragonadal germ cell tumors (EGCT). Methods A systematic literature search was conducted in Medline and the Cochrane Library. Studies within the search period (January 2010 to February 2021) that addressed the classifcation, diagnosis, prognosis, treatment, and follow-up of extragonadal tumors were included. Risk of bias was assessed and relevant data were extracted in evidence tables. Results The systematic search identifed nine studies. Germ cell tumors (GCT) arise predominantly from within the testis, but about 5% of the tumors are primarily located extragonadal. EGCT are localized primarily mediastinal or retroperitoneal in the midline of the body. EGCT patients are classifed according to the IGCCCG classifcation. Consecutively, all mediastinal non-seminomatous EGCT patients belong to the “poor prognosis” group. In contrast mediastinal seminoma and both retroperitoneal seminoma and non-seminoma patients seem to have a similar prognosis as patients with gonadal GCTs and metastasis at theses respective sites. The standard chemotherapy regimen for patients with a EGCT consists of 3–4 cycles (good vs intermediate prognosis) of bleomycin, etoposid, cisplatin (BEP); however, due to their very poor prognosis patients with non-seminomatous mediastinal GCT should receive a dose-intensifed or high-dose chemotherapy approach upfront on an individual basis and should thus be referred to expert centers Ifosfamide may be exchanged for bleomycin in cases of additional pulmonary metastasis due to subsequently planned resections. In general patients with non-seminomatous EGCT, residual tumor resection (RTR) should be performed after chemotherapy. Conclusion In general, non-seminomatous EGCT have a poorer prognosis compared to testicular GCT, while seminomatous EGGCT seem to have a similar prognosis to patients with metastatic testicular seminoma. The current insights on EGCT are limited, since all data are mainly based on case series and studies with small patient numbers and non-comparative studies. In general, systemic treatment should be performed like in testicular metastatic GCTs but upfront dose intensifcation of chemotherapy should be considered for mediastinal non-seminoma patients. Thus, EGCT should be referred to interdisciplinary centers with utmost experience in the treatment of germ cell tumors