704 research outputs found
MR Imaging of Reynolds Dilatancy in the Bulk of Smooth Granular Flows
Article / Letter to editorLeiden Instituut Onderzoek Natuurkund
Matrix and Stimulus Sample Sizes in the Weighted MDS Model: Empirical Metric Recovery Functions
The only guidelines for sample size that exist in the multidimensional scaling (MDS) literature are a set of heuristic "rules-of-thumb" that have failed to live up to Young's (1970) goal of finding func tional relationships between sample size and metric recovery. This paper develops answers to two im portant sample-size questions in nonmetric weight ed MDS settings, both of which are extensions of work reported in MacCallum and Cornelius (1977): (1) are the sample size requirements for number of stimuli and number of matrices compensatory? and (2) what type of functional relationships exist between the number of matrices and metric recov ery ? The graphs developed to answer the second question illustrate how such functional relation ships can be defined empirically in a wide range of MDS and other complicated nonlinear models.Yeshttps://us.sagepub.com/en-us/nam/manuscript-submission-guideline
Real-Reward Testing for Probabilistic Processes (Extended Abstract)
We introduce a notion of real-valued reward testing for probabilistic
processes by extending the traditional nonnegative-reward testing with negative
rewards. In this richer testing framework, the may and must preorders turn out
to be inverses. We show that for convergent processes with finitely many states
and transitions, but not in the presence of divergence, the real-reward
must-testing preorder coincides with the nonnegative-reward must-testing
preorder. To prove this coincidence we characterise the usual resolution-based
testing in terms of the weak transitions of processes, without having to
involve policies, adversaries, schedulers, resolutions, or similar structures
that are external to the process under investigation. This requires
establishing the continuity of our function for calculating testing outcomes.Comment: In Proceedings QAPL 2011, arXiv:1107.074
Yoctocalorimetry: phonon counting in nanostructures
It appears feasible with nanostructures to perform calorimetry at the level
of individual thermal phonons. Here I outline an approach employing
monocrystalline mesoscopic insulators, which can now be patterned from
semiconductor heterostructures into complex geometries with full, three-
dimensional relief. Successive application of these techniques also enables
definition of integrated nanoscale thermal transducers; coupling these to a dc
SQUID readout yields the requisite energy sensitivity and temporal resolution
with minimal back action. The prospect of phonon counting opens intriguing
experimental possibilities with analogies in quantum optics. These include
fluctuation-based phonon spectroscopy, phonon shot noise in the energy
relaxation of nanoscale systems, and quantum statistical phenomena such as
phonon bunching and anticorrelated electron-phonon exchange.Comment: 27 pages, 8 figure
FANCD2 re-expression is associated with glioma grade and chemical inhibition of the Fanconi Anaemia pathway sensitises gliomas to chemotherapeutic agents.
Brain tumours kill more children and adults under 40 than any other cancer. Around half of primary brain tumours are glioblastoma multiforme (GBMs) where treatment remains a significant challenge. GBM survival rates have improved little over the last 40 years, thus highlighting an unmet need for the identification/development of novel therapeutic targets and agents to improve GBM treatment. Using archived and fresh glioma tissue, we show that in contrast to normal brain or benign schwannomas GBMs exhibit re-expression of FANCD2, a key protein of the Fanconi Anaemia (FA) DNA repair pathway, and possess an active FA pathway. Importantly, FANCD2 expression levels are strongly associated with tumour grade, revealing a potential exploitable therapeutic window to allow inhibition of the FA pathway in tumour cells, whilst sparing normal brain tissue. Using several small molecule inhibitors of the FA pathway in combination with isogenic FA-proficient/deficient glioma cell lines as well as primary GBM cultures, we demonstrate that inhibition of the FA pathway sensitises gliomas to the chemotherapeutic agents Temozolomide and Carmustine. Our findings therefore provide a strong rationale for the development of novel and potent inhibitors of the FA pathway to improve the treatment of GBMs, which may ultimately impact on patient outcome
General Axisymmetric Solutions and Self-Tuning in 6D Chiral Gauged Supergravity
We re-examine the properties of the axially-symmetric solutions to chiral
gauged 6D supergravity, recently found in refs. hep-th/0307238 and
hep-th/0308064. Ref. hep-th/0307238 finds the most general solutions having two
singularities which are maximally-symmetric in the large 4 dimensions and which
are axially-symmetric in the internal dimensions. We show that not all of these
solutions have purely conical singularities at the brane positions, and that
not all singularities can be interpreted as being the bulk geometry sourced by
neutral 3-branes. The subset of solutions for which the metric singularities
are conical precisely agree with the solutions of ref. hep-th/0308064.
Establishing this connection between the solutions of these two references
resolves a minor conflict concerning whether or not the tensions of the
resulting branes must be negative. The tensions can be both negative and
positive depending on the choice of parameters. We discuss the physical
interpretation of the non-conical solutions, including their significance for
the proposal for using 6-dimensional self-tuning to understand the small size
of the observed vacuum energy. In passing we briefly comment on a recent paper
by Garriga and Porrati which criticizes the realization of self-tuning in 6D
supergravity.Comment: 27 pages, 1 figure; JHEP3 style; Some references added, and
discussion of tension constraints and unwarped solutions made more explici
Quintessential Maldacena-Maoz Cosmologies
Maldacena and Maoz have proposed a new approach to holographic cosmology
based on Euclidean manifolds with disconnected boundaries. This approach
appears, however, to be in conflict with the known geometric results [the
Witten-Yau theorem and its extensions] on spaces with boundaries of
non-negative scalar curvature. We show precisely how the Maldacena-Maoz
approach evades these theorems. We also exhibit Maldacena-Maoz cosmologies with
[cosmologically] more natural matter content, namely quintessence instead of
Yang-Mills fields, thereby demonstrating that these cosmologies do not depend
on a special choice of matter to split the Euclidean boundary. We conclude that
if our Universe is fundamentally anti-de Sitter-like [with the current
acceleration being only temporary], then this may force us to confront the
holography of spaces with a connected bulk but a disconnected boundary.Comment: Much improved exposition, exponent in Cai-Galloway theorem fixed,
axionic interpretation of scalar explained, JHEP version. 33 pages, 3 eps
figure
"Dark energy" in the Local Void
The unexpected discovery of the accelerated cosmic expansion in 1998 has
filled the Universe with the embarrassing presence of an unidentified "dark
energy", or cosmological constant, devoid of any physical meaning. While this
standard cosmology seems to work well at the global level, improved knowledge
of the kinematics and other properties of our extragalactic neighborhood
indicates the need for a better theory. We investigate whether the recently
suggested repulsive-gravity scenario can account for some of the features that
are unexplained by the standard model. Through simple dynamical considerations,
we find that the Local Void could host an amount of antimatter
() roughly equivalent to the mass of a typical
supercluster, thus restoring the matter-antimatter symmetry. The antigravity
field produced by this "dark repulsor" can explain the anomalous motion of the
Local Sheet away from the Local Void, as well as several other properties of
nearby galaxies that seem to require void evacuation and structure formation
much faster than expected from the standard model. At the global cosmological
level, gravitational repulsion from antimatter hidden in voids can provide more
than enough potential energy to drive both the cosmic expansion and its
acceleration, with no need for an initial "explosion" and dark energy.
Moreover, the discrete distribution of these dark repulsors, in contrast to the
uniformly permeating dark energy, can also explain dark flows and other
recently observed excessive inhomogeneities and anisotropies of the Universe.Comment: 6 pages, accepted as a Letter to the Editor by Astrophysics and Space
Scienc
Is the evidence for dark energy secure?
Several kinds of astronomical observations, interpreted in the framework of
the standard Friedmann-Robertson-Walker cosmology, have indicated that our
universe is dominated by a Cosmological Constant. The dimming of distant Type
Ia supernovae suggests that the expansion rate is accelerating, as if driven by
vacuum energy, and this has been indirectly substantiated through studies of
angular anisotropies in the cosmic microwave background (CMB) and of spatial
correlations in the large-scale structure (LSS) of galaxies. However there is
no compelling direct evidence yet for (the dynamical effects of) dark energy.
The precision CMB data can be equally well fitted without dark energy if the
spectrum of primordial density fluctuations is not quite scale-free and if the
Hubble constant is lower globally than its locally measured value. The LSS data
can also be satisfactorily fitted if there is a small component of hot dark
matter, as would be provided by neutrinos of mass 0.5 eV. Although such an
Einstein-de Sitter model cannot explain the SNe Ia Hubble diagram or the
position of the `baryon acoustic oscillation' peak in the autocorrelation
function of galaxies, it may be possible to do so e.g. in an inhomogeneous
Lemaitre-Tolman-Bondi cosmology where we are located in a void which is
expanding faster than the average. Such alternatives may seem contrived but
this must be weighed against our lack of any fundamental understanding of the
inferred tiny energy scale of the dark energy. It may well be an artifact of an
oversimplified cosmological model, rather than having physical reality.Comment: 12 pages, 5 figures; to appear in a special issue of General
Relativity and Gravitation, eds. G.F.R. Ellis et al; Changes: references
reformatted in journal style - text unchange
Categorizing Different Approaches to the Cosmological Constant Problem
We have found that proposals addressing the old cosmological constant problem
come in various categories. The aim of this paper is to identify as many
different, credible mechanisms as possible and to provide them with a code for
future reference. We find that they all can be classified into five different
schemes of which we indicate the advantages and drawbacks.
Besides, we add a new approach based on a symmetry principle mapping real to
imaginary spacetime.Comment: updated version, accepted for publicatio
- …