Rest Interval Length Does Not Affect Total Exercise Volume During Lower Body Resistance Training

Please refer to the pdf version of the abstract located adjacent to the title

Role of AMPA Receptor Cycling in Synaptic Transmission and Plasticity

AbstractCompounds known to disrupt exocytosis or endocytosis were introduced into CA1 pyramidal cells while monitoring excitatory postsynaptic currents (EPSCs). Disrupting exocytosis or the interaction of GluR2 with NSF caused a gradual reduction in the AMPAR EPSC, while inhibition of endocytosis caused a gradual increase in the AMPAR EPSC. These manipulations had no effect on the NMDAR EPSC but prevented the subsequent induction of LTD. These results suggest that AMPARs, but not NMDARs, cycle into and out of the synaptic membrane at a rapid rate and that certain forms of synaptic plasticity may utilize this dynamic process

Use of population viability analysis and reserve selection algorithms in regional conservation plans

Current reserve selection algorithms have difficulty evaluating connectivity and other factors necessary to conserve wide-ranging species in developing landscapes. Conversely, population viability analyses may incorporate detailed demographic data, but often lack sufficient spatial detail or are limited to too few taxa to be relevant to regional conservation plans. We developed a regional conservation plan for mammalian carnivores in the Rocky Mountain region using both a reserve selection algorithm (SITES) and, a spatially explicit population model (PATCH). The spatially explicit population model informed reserve selection and network design by producing data on the locations of population sources, the degree of threat to those areas from landscape change, the existence of thresholds to population viability as the size of the reserve network increased, and the effect of linkage areas on population persistence. A 15% regional decline in carrying capacity for large carnivores was predicted within 25 years if no addition to protected areas occurred. Increasing the percentage of the region in reserves from the current 17.2% to 36.4% would result in a 1-4% increase over current carrying capacity, despite the effects of landscape change. The population model identified linkage areas that were not chosen by the reserve selection algorithm, but whose protection strongly affected population viability. A reserve network based on carnivore conservation goals incidentally protected 76% of ecosystem types, but was poor at capturing localized rare species. Although it is unlikely that planning for focal species requirements alone will capture all facets of biodiversity, when used in combination with other planning foci, it may help to forestall the effects of loss of connectivity on a larger group of threatened species and ecosystems. A better integration of current reserve selection tools and spatial simulation models should produce reserve designs that are simultaneously biologically realistic and taxonomically inclusive

A programme evaluation of \u27First Steps\u27: A peer-conceived, developed and led self-management intervention for people after a Parkinson\u27s diagnosis

\ua9 The Author(s) 2023. Objective: A diagnosis of Parkinson\u27s often leads to uncertainty about the future and loss of perceived control. Peer support may offer a means to address these concerns and promote self-management. Design: A programme evaluation of the feasibility and potential effects of ‘First Steps’, utilising a pragmatic step wedge approach. Comparing First Steps (intervention) to (control) conditions. Setting: In the community at four sites in southern England. Participants: Newly diagnosed (≤ 12months) people with Parkinson\u27s. Intervention: First Steps was a 2-day peer-conceived, developed and led intervention to support self-management. Main measures: At 0, 12 and 24 weeks anxiety and depression (Hospital, Anxiety and Depression Scale, HADS), daily functioning (World Health Organisation Disability Assessment Schedule, WHODAS), physical activity, quality of life (EQ5D), carer strain and service utilisation were assessed. Results: Between February 2018 and July 2019, 36 participants were enrolled into intervention and 21 to control conditions, all were included in statistical analysis. Lost to follow up was n = 1 (intervention) and n = 1 adverse event was reported (control, unrelated). Of the 36 allocated to the intervention n = 22 participants completed both days of First Steps during the study period. Completion of outcome measures was >95% at 24 weeks. Small effects favouring the intervention were found for HADS (odds ratio (OR) = 2.06, 95% confidence interval (CI) 0.24:17.84), Carer Strain Index (OR = 2.22, 95% CI 0.5:9.76) and vigorous (d = 0.42, 95% CI −0.12:0.97) and total physical activity (d = 0.41, 95% CI −0.13:0.95). EQ5D, WHOSDAS and service utilisation, was similar between groups. Conclusions: First Steps was feasible and safe and we found potential to benefit physical activity, mental health and carer strain. Further research with longer-term follow up is warranted

Schottky mass measurements of heavy neutron-rich nuclides in the element range 70\leZ \le79 at the ESR

Storage-ring mass spectrometry was applied to neutron-rich $^{197}$Au projectile fragments. Masses of $^{181,183}$Lu, $^{185,186}$Hf, $^{187,188}$Ta, $^{191}$W, and $^{192,193}$Re nuclei were measured for the first time. The uncertainty of previously known masses of $^{189,190}$W and $^{195}$Os nuclei was improved. Observed irregularities on the smooth two-neutron separation energies for Hf and W isotopes are linked to the collectivity phenomena in the corresponding nuclei.Comment: 10 pages, 9 figures, 2 table

Centrality dependence of charged antiparticle to particle ratios near mid-rapidity in d+Au collisions at sqrt(s_NN)=200 GeV

The ratios of the yields of charged antiparticles to particles have been obtained for pions, kaons, and protons near mid-rapidity for d+Au collisions at sqrt(s_NN) = 200 GeV as a function of centrality. The reported values represent the ratio of the yields averaged over the rapidity range of 0.1<y_pi<1.3 and 0<y_(K,p)<0.8, where positive rapidity is in the deuteron direction, and for transverse momenta 0.1<p_(T)^(pi,K)<1.0 GeV/c and 0.3<p_(T)^(p)<1.0 GeV/c. Within the uncertainties, a lack of centrality dependence is observed in all three ratios. The data are compared to results from other systems and model calculations.Comment: 6 pages, 4 figures, submitted to PR

Event-by-event fluctuations of azimuthal particle anisotropy in Au+Au collisions at sqrt(s_NN) = 200 GeV

This paper presents the first measurement of event-by-event fluctuations of the elliptic flow parameter v_2 in Au+Au collisions at sqrt(s_NN) = 200GeV as a function of collision centrality. The relative non-statistical fluctuations of the v_2 parameter are found to be approximately 40%. The results, including contributions from event-by-event elliptic flow fluctuations and from azimuthal correlations that are unrelated to the reaction plane (non-flow correlations), establish an upper limit on the magnitude of underlying elliptic flow fluctuations. This limit is consistent with predictions based on spatial fluctuations of the participating nucleons in the initial nuclear overlap region. These results provide important constraints on models of the initial state and hydrodynamic evolution of relativistic heavy ion collisions.Comment: 5 pages, 2 figures, Published in Phys. Rev. Lett

Non-flow correlations and elliptic flow fluctuations in gold-gold collisions at sqrt(s_NN)= 200 GeV

This paper presents results on event-by-event elliptic flow fluctuations in Au+Au collisions at sqrt(s_NN)=200Gev, where the contribution from non-flow correlations has been subtracted. An analysis method is introduced to measure non-flow correlations, relying on the assumption that non-flow correlations are most prominent at short ranges (Delta eta < 2). Assuming that non-flow correlations are of the order that is observed in p+p collisions for long range correlations (Delta eta > 2), relative elliptic flow fluctuations of approximately 30-40% are observed. These results are consistent with predictions based on spatial fluctuations of the participating nucleons in the initial nuclear overlap region. It is found that the long range non-flow correlations in Au+Au collisions would have to be more than an order of magnitude stronger compared to the p+p data to lead to the observed azimuthal anisotropy fluctuations with no intrinsic elliptic flow fluctuations.Comment: 9 pages, 7 figures, Published in Phys. Rev.

Evidence of Final-State Suppression of High-p_T Hadrons in Au + Au Collisions Using d + Au Measurements at RHIC

Transverse momentum spectra of charged hadrons with ${p_{T} <}$ 6 GeV/c have been measured near mid-rapidity (0.2 $< \eta <$ 1.4) by the PHOBOS experiment at RHIC in Au + Au and d + Au collisions at ${\sqrt{s_{_{NN}}} = \rm {200 GeV}}$. The spectra for different collision centralities are compared to ${p + \bar{p}}$ collisions at the same energy. The resulting nuclear modification factor for central Au + Au collisions shows evidence of strong suppression of charged hadrons in the high-$p_{T}$ region (${>2}$ GeV/c). In contrast, the d + Au nuclear modification factor exhibits no suppression of the high-$p_{T}$ yields. These measurements suggest a large energy loss of the high-$p_{T}$ particles in the highly interacting medium created in the central Au + Au collisions. The lack of suppression in d + Au collisions suggests that it is unlikely that initial state effects can explain the suppression in the central Au + Au collisions.Comment: 3 pages, 4 figures, International Europhysics Conference on High Energy Physics EPS (July 17th-23rd 2003) in Aachen, German

Charged-Particle Pseudorapidity Distributions in Au+Au Collisions at sqrt(s_NN)=62.4 GeV

The charged-particle pseudorapidity density for Au+Au collisions at sqrt(s_NN)=62.4 GeV has been measured over a wide range of impact parameters and compared to results obtained at other energies. As a function of collision energy, the pseudorapidity distribution grows systematically both in height and width. The mid-rapidity density is found to grow approximately logarithmically between AGS energies and the top RHIC energy. As a function of centrality, there is an approximate factorization of the centrality dependence of the mid-rapidity yields and the overall multiplicity scale. The new results at sqrt(s_NN)=62.4 GeV confirm the previously observed phenomenon of ``extended longitudinal scaling'' in the pseudorapidity distributions when viewed in the rest frame of one of the colliding nuclei. It is also found that the evolution of the shape of the distribution with centrality is energy independent, when viewed in this reference frame. As a function of centrality, the total charged particle multiplicity scales linearly with the number of participant pairs as it was observed at other energies.Comment: 6 pages, 7 figures, submitted to Phys. Rev. C - Rapid Communication