A contribution to the quantification of crustal shortening and kinematics of deformation across the Western Andes ( ∼ 20–22° S)

The Andes are an emblematic active Cordilleran orogen. Mountain building in the Central Andes (∼20∘ S) started by the Late Cretaceous to early Cenozoic along the subduction margin and propagated eastward. In general, the structures sustaining the uplift of the western flank of the Andes are dismissed, and their contribution to mountain building remains poorly constrained. Here, we focus on two sites along the Western Andes at ∼20–22∘ S in the Atacama desert, where structures are well exposed. We combine mapping from high-resolution satellite images with field observations and numerical trishear forward modeling to provide quantitative constraints on the kinematic evolution of the investigated field sites. When upscaling our local field interpretations to the regional scale, we identify two main structures: (1) the Andean Basement Thrust, a west-vergent thrust system placing Andean Paleozoic basement over Mesozoic strata, and (2) a series of west-vergent thrusts pertaining to the West Andean Thrust System, deforming primarily Mesozoic units. From our interpreted sections, we estimate that both structures together accommodate at least ∼6–9 km of shortening across the sole investigated ∼7–17 km wide field sites. This multi-kilometric shortening represents only a fraction of the total shortening accommodated across the whole Western Andes. The timing of the main deformation recorded in the folded Mesozoic series can be bracketed between ∼68 and ∼29 Ma – and possibly between ∼68 and ∼44 Ma – from dated deformed geological layers, with a subsequent significant slowing-down of shortening rates. Even though the structures forming the Western Andes only absorbed a small fraction of the total shortening across the whole orogen, their contribution was relatively significant at the earliest stages of Andean mountain building before deformation proceeded eastward.</p

Histoquímica de la fase progámica en Capsicum Pubescens

Capsicum pubescens Ruiz & Pav. (Solanaceae), conocido como ‘ají rocoto’, en Argentina se cultiva principalmente en el NO del territorio. En esta especie existe un amplio rango de variación en el nivel de compatibilidad, pero se desconocen los mecanismos que la regulan.Fil: Bo, M. L. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas, Físicas y Naturales; Argentina.Fil: Bo, M. L. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto Multidisciplinario de Biología Vegetal; Argentina.Fil: Cosa, M. T. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas, Físicas y Naturales; Argentina.Fil: Carrizo García, C. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas, Físicas y Naturales; Argentina.Fil: Carrizo García, C. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto Multidisciplinario de Biología Vegetal; Argentina.Fil: Cosa, M. T. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto Multidisciplinario de Biología Vegetal; Argentina.Ciencias de las Plantas, Botánic

Exposure to Hexachlorobenzene during Pregnancy and Children’s Social Behavior at 4 Years of Age

BACKGROUND: Hexachlorobenzene (HCB) is an organochlorine chemical that has been used in agriculture and industrial processes. Behavioral impairment after HCB exposure has been described in animal models, but little information is available in humans. OBJECTIVES: Our goal was to study the association of prenatal exposure to HCB with the social behavior of preschool children. METHODS: Two birth cohorts in Ribera d’Ebre and Menorca (Spain) were set up between 1997 and 1999 (n = 475). The California Preschool Social Competence Scale and the Attention-Deficit Hyperactivity Disorder (ADHD) were scored by each 4-year-old child’s teacher. Organochlorine compounds were measured in cord serum. Children’s diet and parental sociodemographic information were obtained through questionnaire. RESULTS: Children with concentrations of HCB > 1.5 ng/mL at birth had a statistically significant increased risk of having poor Social Competence [relative risk (RR) = 4.04; 95% confidence interval (CI), 1.76–9.58] and ADHD (RR = 2.71; 95% CI, 1.05–6.96) scores. No association was found between HCB and the cognitive and psychomotor performance of these children. CONCLUSIONS: Prenatal exposure to current concentrations of HCB in Spain is associated with a decrease in the behavioral competence at preschool ages. These results should be considered when evaluating the potential neurotoxicologic effects of HCB

CO observations of water-maser post-AGB stars and detection of a high-velocity outflow in IRAS 15452-5459

Many aspects of the evolutionary phase in which Asymptotic Giant Branch stars (AGB stars) are in transition to become Planetary Nebulae (PNe) are still poorly understood. An important question is how the circumstellar envelopes of AGB stars switch from spherical symmetry to the axially symmetric structures frequently observed in PNe. In many cases there is clear evidence that the shaping of the circumstellar envelopes of PNe is linked to the formation of jets/collimated winds and their interaction with the remnant AGB envelope. Because of the short evolutionary time, objects in this phase are rare, but their identification provides valuable probes for testing evolutionary models. We have observed (sub)millimeter CO rotational transitions with the APEX telescope in a small sample of stars hosting high-velocity OH and water masers. These targets are supposed to have recently left the AGB, as indicated by the presence of winds traced by masers, with velocities larger than observed during that phase. We have carried out observations of several CO lines, ranging from J=2-1 up to J=7-6. In IRAS 15452-5459 we detect a fast molecular outflow in the central region of the nebula and estimate a mass-loss rate between 1.2x10^{-4} Msun yr^{-1} (assuming optically thin emission) and 4.9x10^{-4} Msun yr^{-1} (optically thick emission). We model the SED of this target taking advantage of our continuum measurement at 345 GHz to constrain the emission at long wavelengths. For a distance of 2.5 kpc, we estimate a luminosity of 8000 Lsun and a dust mass of 0.01 Msun. Through the flux in the [CII] line (158 um), we calculate a total mass of about 12 Msun for the circumstellar envelope, but the line is likely affected by interstellar contamination.Comment: 12 pages, 9 figures, accepted for publication on A&

Sulfur sequestration promotes multicellularity during nutrient limitation

The behaviour of Dictyostelium discoideum depends on nutrients. When sufficient food is present these amoebae exist in a unicellular state, but upon starvation they aggregate into a multicellular organism. This biology makes D. discoideum an ideal model for investigating how fundamental metabolism commands cell differentiation and function. Here we show that reactive oxygen species-generated as a consequence of nutrient limitation-lead to the sequestration of cysteine in the antioxidant glutathione. This sequestration limits the use of the sulfur atom of cysteine in processes that contribute to mitochondrial metabolism and cellular proliferation, such as protein translation and the activity of enzymes that contain an iron-sulfur cluster. The regulated sequestration of sulfur maintains D. discoideum in a nonproliferating state that paves the way for multicellular development. This mechanism of signalling through reactive oxygen species highlights oxygen and sulfur as simple signalling molecules that dictate cell fate in an early eukaryote, with implications for responses to nutrient fluctuations in multicellular eukaryotes

Anti-inflammatory effects of antidepressant and atypical antipsychotic medication for the treatment of major depression and comorbid arthritis: a case report

Extent: 4p.Introduction: This case report describes the effects of psychotropic treatment, quetiapine in particular, on systemic inflammation, pain, general functioning and major depression in the treatment of a woman with arthritis. Case presentation: A 49-year-old Caucasian Australian woman with arthritis, pain and depression was treated with a course of escitalopram, mirtazapine and quetiapine. Pain levels, general functioning and degree of depressive symptoms were evaluated with a visual analogue scale. Systemic inflammation had been assessed by C-reactive protein serum levels since 2003. C-reactive protein levels, physical pain, symptoms of arthritis and depression decreased significantly during the past 12 months of treatment with quetiapine, while treatment with selective serotonin reuptake inhibitors and mirtazapine remained the same. Conclusions: We suggest that the treatment particularly with quetiapine may have anti-inflammatory effects in arthritis and comorbid major depression, which eventually led to a remission of pain and depression and to normal general function.Bernhard T Baune, Harris Eyr

Europe, listen and respond. Enhancing the European Commission´s online public consultation tool.

Fac. de Ciencias de la InformaciónFALSEpu

First Results from High Angular Resolution ALMA Observations Toward the HL Tau Region

We present Atacama Large Millimeter/submillimeter Array (ALMA) observations from the 2014 Long Baseline Campaign in dust continuum and spectral line emission from the HL Tau region. The continuum images at wavelengths of 2.9, 1.3, and 0.87 mm have unprecedented angular resolutions of 0.075 arcseconds (10 AU) to 0.025 arcseconds (3.5 AU), revealing an astonishing level of detail in the circumstellar disk surrounding the young solar analogue HL Tau, with a pattern of bright and dark rings observed at all wavelengths. By fitting ellipses to the most distinct rings, we measure precise values for the disk inclination (46.72pm0.05 degrees) and position angle (+138.02pm0.07 degrees). We obtain a high-fidelity image of the 1.0 mm spectral index ($\alpha$), which ranges from $\alpha\sim2.0$ in the optically-thick central peak and two brightest rings, increasing to 2.3-3.0 in the dark rings. The dark rings are not devoid of emission, we estimate a grain emissivity index of 0.8 for the innermost dark ring and lower for subsequent dark rings, consistent with some degree of grain growth and evolution. Additional clues that the rings arise from planet formation include an increase in their central offsets with radius and the presence of numerous orbital resonances. At a resolution of 35 AU, we resolve the molecular component of the disk in HCO+ (1-0) which exhibits a pattern over LSR velocities from 2-12 km/s consistent with Keplerian motion around a ~1.3 solar mass star, although complicated by absorption at low blue-shifted velocities. We also serendipitously detect and resolve the nearby protostars XZ Tau (A/B) and LkHa358 at 2.9 mm.Comment: 11 pages, 5 figures, 2 tables, accepted for publication in the Astrophysical Journal Letter

Epigenetics modifications and Subclinical Atherosclerosis in Obstructive Sleep Apnea: The EPIOSA study.

Background Obstructive sleep apnea (OSA) is associated with increased risk for cardiovascular morbidity and mortality. Epidemiological and animal models studies generate hypotheses for innovative strategies in OSA management by interferig intermediates mechanisms associated with cardiovascular complications. We have thus initiated the Epigenetics modification in Obstructive Sleep Apnea (EPIOSA) study (ClinicalTrials.gov identifier: NCT02131610). Methods/design EPIOSA is a prospective cohort study aiming to recruit 350 participants of caucasian ethnicity and free of other chronic or inflammatory diseases: 300 patients with prevalent OSA and 50 non-OSA subjects. All of them will be follow-up for at least 5 years. Recruitment and study visits are performed in single University-based sleep clinic using standard operating procedures. At baseline and at each one year follow-up examination, patients are subjected to a core phenotyping protocol. This includes a standardized questionnaire and physical examination to determine incident comorbidities and health resources utilization, with a primary focus on cardiovascular events. Confirmatory outcomes information is requested from patient records and the regional Department of Health Services. Every year, OSA status will be assessed by full sleep study and blood samples will be obtained for immediate standard biochemistry, hematology, inflammatory cytokines and cytometry analysis. For biobanking, aliquots of serum, plasma, urine, mRNA and DNA are also obtained. Bilateral carotid echography will be performed to assess subclinical atherosclerosis and atherosclerosis progression. OSA patients are treated according with national guidelines. Discussion EPIOSA will enable the prospective evaluation of inflammatory and epigenetics mechanism involved in cardiovascular complication of treated and non-treated patients with OSA compared with non OSA subjects