Multi-objective optimisation of product quality in the manufacture of Ti-6AI-4V prostheses

[EN] This paper presents a multi-objective optimisation procedure for optimising the quality of prostheses and manufacturing productivity. The aim of this procedure is to develop machining performance models through a minimal and progressive Design of Experiment (DoE), which models the variables of interest by linear regressions or Surface Response Models (SRMs). The multi-objective optimisation is based on desirability functions, which are defined according to the relative importance of each variable of interest. The procedure was implemented to optimise a process of manufacturing spherical turned components for Ti-6Al-4V hip prostheses with special requirements as regards surface roughness Ra, Rz and geometrical form toleranceThis work has been partially supported by Fundació Caixa-Castelló Bancaixa under the research project INV-2009-39. The authors are grateful to Miguel Angel Aymerich and Arcadi Sanz, who assisted in the experimental part. The authors extend their acknowledgements to Lafitt Company for its collaboration. Additional support was provided by Tecnológico de Monterrey through the research group in Mechatronics and Intelligent Machines.Abellán Nebot, JV.; Siller Carrillo, HR.; Vila, C.; Rodríguez González, CA. (2010). Multi-objective optimisation of product quality in the manufacture of Ti-6AI-4V prostheses. Journal of Manufacturing Technology Research. 5(3):353-369. https://doi.org/10.1504/IJMR.2010.033471S3533695

Flavonoid and Capsaicinoid Contents and Consumption of Mexican Chili Pepper (Capsicum annuum L.) Landraces

There is insufficient evidence to identify the precise health effects of chili pepper consumption. However, there is evidence of their topical use as an analgesic to decrease pain from rheumatoid arthritis, osteoarthritis, neuralgias, neuropathic diabetes, neuronal dysfunctions and inflammation, among others. In this work, the diversity and variety of consumed forms of chilis in Mexico, flavonoid and capsaicinoid content in fruits, and their potential health uses are documented, based on various research results and bibliographic information. In Mexico, more than 150 landraces of wild and cultivated origins are consumed and preserved and are distributed throughout the country; the greatest diversity is concentrated in the central and south-southeastern regions. Consumption per capita in urban households is from 8 to 9 kg, and in rural communities, it varies from 14 to 17 kg. Chili peppers contain up to 23 flavonoids and 20 capsaicinoids, differing among landraces because of crop management, maturation of fruits, postharvest management and ecological-environmental influences. Flavonoids and capsaicinoids confer antioxidant, anticarcinogenic properties on the fruit and have lipolytic and preventative effects on chronic degenerative diseases. However, in vitro and in vivo experimental trials of capsaicinoids and flavonoids with beneficial effects must be conducted with regard to human health

Variación del crecimiento en vivero entre procedencias de Pinus pseudostrobus Lindl.

Pinus pseudostrobus is a species with timber harvesting, distributed over a wide altitudinal gradient of 1,600-3,250 m, suggesting a genetic variance, which can be exploited by selecting trees that provide seeds in order to produce plants with high relative growth rates. Therefore, survival and early growth of Pinus pseudostrobus were evaluated under nursery conditions, based on the variation in offsprings of 38 outstanding trees (provenances) in natural stands from Sierra Norte of Oaxaca, Mexico. Seeds were sowing in February 2013 at a nursery located in Ixtlan de Juarez, near the collection site, to 2030 masl and a temperate climate. Survival from 54-166 days after planting (dap) was evaluated, five readings of plant height, basal stem diameter, four readings of number of brachyblasts were recorded, and the relative growth rate for plant height was estimated. Using analysis of variance and mean tests, significant differences among provenances were determined in all variables. In the evaluation, the plants in the nursery showed an exponential growth, an average of 0,8 to 1,5 mm in height/day of 54-166 dap and an average of 1-2 brachyblasts on primary and secondary branches per day in a range of 82-166 dap. From total provenances, four showed high growing rate.Pinus pseudotrobus es una especie con aprovechamiento maderable, distribuida en un amplio gradiente altitudinal, de 1.600 a 3.250 m, lo que sugiere una varianza genética que puede ser aprovechada mediante la selección de árboles que provean semillas que generen plantas con altas tasas de crecimiento relativo. Por lo anterior, se evaluó la sobrevivencia y crecimiento inicial de Pinus pseudostrobus en vivero, con base en la variación de progenies de 38 árboles sobresalientes (procedencias) en rodales naturales de la Sierra Norte de Oaxaca, México. La siembra se realizó en febrero de 2013 en un vivero localizado en Ixtlán de Juárez, cercano a la región de colecta, a 2030 msnm y un clima templado. Además de evaluar la sobrevivencia de 54 a 166 días después de la siembra (dds), se estimaron cinco lecturas de altura de planta, diámetro basal de tallo y cuatro lecturas de número de braquiblastos, y se calculó la tasa de crecimiento relativo para altura de planta. Mediante un análisis de varianza y comparación de medias se determinaron diferencias significativas entre procedencias, en todas las variables. En la evaluación se manifestó un crecimiento exponencial de plantas en vivero, con un promedio de 0,8 a 1,5 mm de altura/día de 54 a 166 dds y un promedio de 1 a 2 braquiblastos en ramillas primarias y secundarias por día en un intervalo de 82 a 166 dds. Del total de procedencias, cuatro de ellas mostraron una alta tasa de crecimiento

Diversity of Common Bean (Phaseolus vulgaris L.) Landraces and the Nutritional Value of their Grains

Grain legumes are considered major sources of dietary proteins, calories, certain minerals and vitamins, and they are the most widely cultivated and consumed crops worldwide. Among them are the common beans, whose major production volumes came from landraces cultivated in traditional farming systems. The objective of this study was to evaluate the phenotypic diversity of a set of common bean landraces from Mexico based on the agromorphological traits and nutritional composition of the grain in the context of traditional farming systems. Different field and laboratory data were collected and complemented with secondary information published in refereed journals and research reports. The results showed that there are significant differences in the morphological and physiological traits of the plant, pod and grain among groups of common bean landraces of different geographic origins, which were associated with different indigenous groups. Similar patterns were observed in the contents of anthocyanins, polyphenols, flavoinds and minerals as well as antioxidant activity. In the evaluated population groups in each region, there are outstanding populations in terms of agromorphological traits and the nutritional value of the grain that can enable a participatory breeding initiative guided by regional objectives. Some populations from Sierra Norte, Oaxaca, presented higher values in Zn and Fe, and populations from Estado de Mexico exhibited high polyphenol and flavonoid values but stable agronomic behaviour

Photon Shielding Features of Quarry Tuff

Abstract. Cantera is a quarry tuff widely used in the building industry; in this work the shielding features of cantera were determined. The shielding characteristics were calculated using XCOM and MCNP5 codes for 0.03, 0.07, 0.1, 0.3, 0.662, 1, 2, and 3 MeV photons. With XCOM the mass interaction coefficients, and the total mass attenuation coefficients, were calculated. With the MCNP5 code a transmission experiment was modelled using a point-like source located 42 cm apart from a point-like detector. Between the source and the detector, cantera pieces with different thickness, ranging from 0 to 40 cm were included. The collided and uncollided photon fluence, the Kerma in air and the Ambient dose equivalent were estimated. With the uncollided fluence the linear attenuation coefficients were determined and compared with those calculated with XCOM. The linear attenuation coefficient for 0.662 MeV photons was compared with the coefficient measured with a NaI(Tl)-based �-ray spectrometer and a 137Cs source

Imposition, resistance, and alternatives in the face of an interregional water crisis in Mexico: El Zapotillo project

En este dossier se analizan los complejos aspectos socio-políticos, económicos, hidrológicos, legales, entre otros, relacionados con la construcción del proyecto El Zapotillo, que incluye un trasvase del Río Verde entre los estados mexicanos de Jalisco y Guanajuato con consecuencias significativas paras las comunidades humanas y los ecosistemas. El Cuaderno de Trabajo presenta doce artículos escritos por especialistas en las diferentes dimensiones del proceso, e incluye el trabajo de estudiantes de doctorado, activistas, y miembros de las comunidades locales afecadas directamente por el proyecto. It is a dossier focused on the complex socio-political, economic, hydrological, legal and other aspects involving the construction of El Zapotillo project, which includes an inter-basin transfer of the Verde River between the Mexican states of Jalisco and Guanajuato with significant consequences for human communities and ecosystems. The Working Paper features twelve articles written by specialists in the different dimensions of the process, and includes the work of doctoral students, activists, and members of the local communities directly affected by the project.ITESO, A.C.Universidad de BernaEl Colegio de JaliscoUNAMUniversidad de GuanajuatoUniversidad de GuadalajaraCartocríticaIMDECCIDEComité Salvemos Temacapulín, Acasico y PalmarejoColectivo de Abogad@

Memoria del I Coloquio de verano de investigación de la Escuela de Negocios de ITESO, 2022

Esta memoria recoge cinco de las ponencias presentadas en el Coloquio de investigación de verano de la ENI, 2022. Son una muestra del trabajo de investigación que hacemos en el Departamento de Economía, Administración y Mercadología (DEAM), en el Centro Universidad Empresa (CUE) y en el Centro para la Gestión de la Innovación y la Tecnología (CEGINT); una investigación con una orientación principalmente práctica y aplicada, enfocada a las micro, pequeñas y medianas empresas y a su contexto socioeconómico. Esperamos que puedan ser ocasión de diálogo y de contribución no sólo al campo académico en el que nos desenvolvemos, sino también a las realidades mismas en las que queremos colaborar para apoyar los esfuerzos hacia una economía y una sociedad más justas y más humanas.ITESO, A.C

Mathematics teacher change in a collaborative environment: to what extent and how

This article reports on a study into how collaborative contexts influence the professional development of an early-career primary teacher, Julia. We describe the process of change by which Julia manages to make her planning to teach mathematics more flexible so as to adapt to student difficulties, and we analyse the role that joint reflection plays in promoting this change. In order to understand the how of this influence, we carried out an analysis of the interactions within the group from Julia’s point of view, following a dialogical approach to discourse. We believe that it is in and through the interactions that Julia constructs her interpretation of the opinions, critiques and suggestions expressed. This interpretation conditions the extent of her involvement and moulds the influence of the context on her professional development. The presence of skilled collaborators (Day, 1993) proved decisive in promoting this development

Autoantibodies against the immunodominant sCha epitope discriminate the risk of sudden death in chronic Chagas cardiomyopathy

In Chagas disease (ChD) caused by Trypanosoma cruzi, new biomarkers to predict chronic cardiac pathology are urgently needed. Previous studies in chagasic patients with mild symptomatology showed that antibodies against the immunodominant R3 epitope of sCha, a fragment of the human basic helix-loop-helix transcription factor like 5, correlated with cardiac pathology. To validate sCha as a biomarker and to understand the origin of anti-sCha antibodies, we conducted a multicenter study with several cohorts of chagasic patients with severe cardiac symptomatology. We found that levels of antibodies against sCha discriminated the high risk of sudden death, indicating they could be useful for ChD prognosis. We investigated the origin of the antibodies and performed an alanine scan of the R3 epitope. We identified a minimal epitope MRQLD, and a BLAST search retrieved several T. cruzi antigens. Five of the hits had known or putative functions, of which phosphonopyruvate decarboxylase showed the highest cross-reactivity with sCha, confirming the role of molecular mimicry in the development of anti-sCha antibodies. Altogether, we demonstrate that the development of antibodies against sCha, which originated by molecular mimicry with T. cruzi antigens, could discriminate electrocardiographic alterations associated with a high risk of sudden death.Ministerio de Economía y competitividad and Fondo Europeo de Desarrollo Regional (SAF2015-63868-R (MINECO/FEDER) to N.G., and SAF2016-75988-R (MINECO/FEDER) to M.F.); Ministerio de Ciencia, Innovación y Universidades-Agencia Estatal de Investigación and Fondo Europeo de Desarrollo Regional (PGC2018-096132-BI00 (MICINN/FEDER) to N.G.); Universidad Autónoma de Madrid-Banco de Santander Inter-University Cooperation Grant with Latin América (CEAL-AL/2015-12 to N.G.); Red de Investigación de Centros de Enfermedades Tropicales (RICET RD12/0018/0004 to M.F.); and Comunidad de Madrid (S-2010/BMD-2332 to M.F.). CBMSO institutional grants from Fundación Ramón Areces and Banco de Santande

Mutational spectrum of GNAL, THAP1 and TOR1A genes in isolated dystonia: study in a population from Spain and systematic literature review

[Objective] We aimed to investigate the prevalence of TOR1A, GNAL and THAP1 variants as the cause of dystonia in a cohort of Spanish patients with isolated dystonia and in the literature.[Methods] A population of 2028 subjects (including 1053 patients with different subtypes of isolated dystonia and 975 healthy controls) from southern and central Spain was included. The genes TOR1A, THAP1 and GNAL were screened using a combination of high-resolution melting analysis and direct DNA resequencing. In addition, an extensive literature search to identify original articles (published before 10 August 2020) reporting mutations in TOR1A, THAP1 or GNAL associated to dystonia was performed.[Results] Pathogenic or likely pathogenic variants in TOR1A, THAP1 and GNAL were identified in 0.48%, 0.57% and 0.29% of our patients, respectively. Five patients carried the variation p.Glu303del in TOR1A. A very rare variant in GNAL (p.Ser238Asn) was found as a putative risk factor for dystonia. In the literature, variations in TOR1A, THAP1 and GNAL accounted for about 6%, 1.8% and 1.1% of published dystonia patients, respectively.[Conclusions] There is a different genetic contribution to dystonia of these three genes in our patients (about 1.3% of patients) and in the literature (about 3.6% of patients), probably due the high proportion of adult-onset cases in our cohort. As regards age at onset, site of dystonia onset, and final distribution, in our population there is a clear differentiation between DYT-TOR1A and DYT-GNAL, with DYT-THAP1 likely to be an intermediate phenotype.This work was supported by the Carlos III Health Institute-European Regional Development Fund (ISCIII-FEDER) [PI14/01823, PI16/01575, PI18/01898, PI19/01576], the Andalusian Regional Ministry of Economics, Innovation, Science and Employment [CVI-02526, CTS-7685], the Andalusian Regional Ministry of Health and Welfare [PI-0741-2010, PI-0471-2013, PE-0210-2018, PI-0459-2018, PE-0186-2019], and the Alicia Koplowitz and Mutua Madrileña Foundations. Pilar Gómez-Garre was supported by the "Miguel Servet" program [MSII14/00018] (from ISCIII-FEDER) and “Nicolás Monardes” program [C-0048-2017] (from the Andalusian Regional Ministry of Health). Silvia Jesús was supported by the "Juan Rodés" program [B-0007-2019] and Daniel Macías-García by the “Río Hortega” program [CM18/00142] (both from ISCIII-FEDER). María Teresa Periñán was supported by the Spanish Ministry of Education [FPU16/05061]. Cristina Tejera was supported by VPPI-US from the University of Seville.Peer reviewe