The Basin of Mexico Hydrogeological Database: Implementation, Queries and Interaction with Open Source Software

Integrated Water Management at the Basin level concept was introduced in the 1990s, and is a goal in every national and local water management plan. Unfortunately this goal has not been achieved mainly due to a lack of both tools and data management, as data must be gathered from different sources, and converted from diverse formats into a consistent database. Compounding this problem is the fact that in some regions different water agencies are in charge of water supply as is the case in the Basin of Mexico, in which Mexico City and its Metropolitan Zone are located. The inhabitants of the Basin of Mexico, which comprises five different political entities and in which different agencies are in charge of water supply rely on the Basins aquifer system as its main water supply source. No regional hydrogeological database in this area however exists therefore a Relational Database Management System was developed, and its use with a Geographic Information System is proposed in order to improve regional data management in the study area. Data stored in this new database (called the Basin of Mexico Hydrogeological Database) comprises data on climatological, borehole and runoff variables, readily providing information for the development of hydrogeological models. A simple example is used to show how geostatistical analysis can be done using the data directly from this database. The structure of the database supports easy maintenance and updating, representing a valuable tool for the development of regional studies

Mexico City's Water Management: In Search of Sustainability

Mexico City is facing water supply problems as its population increases and aquifer overexploitation needs to be stopped. Because of its geographic location the City has continuously faced water related problems such as floods and lack of the resource. Currently the closest water sources have been already tapped and more water will be needed in the near future in order to satisfy the ever increasing demand as the aquifer systems located under the City provide nearly 75% of the total water supply. Water from the aquifers is extracted at a higher rate than they are replenished, causing a mean decline in the ground water table of one meter per year. A high percentage of water used is exported to the Panuco basin without being reused; thus, authorities are trying to implement a program to artificially recharge the aquifer using reclaimed waste water and wells in order to reduce aquifer overdraft and as an alternative to meet the ever increasing water demand. Although the main focus of the present paper is to analyze the artificial recharge program, other water policies such as efficient water use and leak detection in the water supply network will be analyzed as well along with a comparison between importing water from other river basins and use of reclaimed waste water is realized and a new approach is proposed in order to improve water management in the Basin

2D kinematics of the edge-on spiral galaxy ESO 379-G006

We present a kinematical study of the nearly edge-on galaxy ESO 379-G006 that shows the existence of extraplanar ionized gas. With Fabry-Perot spectroscopy at H-alpha, we study the kinematics of ESO 379-G006 using velocity maps and position-velocity diagrams parallel to the major and to the minor axis of the galaxy. We build the rotation curve of the disk and discuss the role of projection effects due to the fact of viewing this galaxy nearly edge-on. The twisting of the isovelocities in the radial velocity field of the disk of ESO 379-G006 as well as the kinematic asymmetries found in some position-velocity diagrams parallel to the minor axis of the galaxy suggest the existence of deviations to circular motions in the disk that can be modeled and explained with the inclusion of a radial inflow probably generated by a bar or by spiral arms. We succeeded in detecting extraplanar Diffuse Ionized Gas in this galaxy. At the same time, from the analysis of position-velocity diagrams, we found some evidence that the extraplanar gas could lag in rotation velocity with respect to the midplane rotation.Comment: 61 pages, 15 figures. Accepted for publication in A

Rotation curve bifurcations as indicators of close recent galaxy encounters

Rotation curves of interacting galaxies often show that velocities are either rising or falling in the direction of the companion galaxy. We seek to reproduce and analyse these features in the rotation curves of simulated equal-mass galaxies suffering a one-to-one encounter, as possible indicators of close encounters. Using simulations of major mergers in 3D, we study the time evolution of these asymmetries in a pair of galaxies, during the first passage. Our main results are: (a) the rotation curve asymmetries appear right at pericentre of the first passage, (b) the significant disturbed rotation velocities occur within a small time interval, of ~ 0.5 Gyr h^-1, and therefore the presence of bifurcation in the velocity curve could be used as an indicator of the pericentre occurrence. These results are in qualitative agreement with previous findings for minor mergers and fly-byes.Comment: 4 pages, 7 figure

Blood-cell-based inflammatory markers as a useful tool for early diagnosis in colorectal cancer

Background: Systemic inflammation seems to be involved in the pathogenetic pathways of colorectal cancer (CRC). Analytical markers that reflect the inflammatory status, such as neutrophil/lymphocyte ratio (NLR), platelet/lymphocyte ratio (PLR) or systemic immune-inflammation index (SII), have been proposed as tools for the prognosis of CRC. Nevertheless, their use for diagnosis has been scarcely investigated. Aims: To analyze the ability of these markers and of a new marker combining SII and hemoglobin concentration, named NP/LHb = neutrophils x platelets]/lymphocytes x hemoglobin], as tools for CRC diagnosis. Furthermore, we studied their association with CRC-related variables. Methods: Case-control study including 214 CRC patients and 214 controls without CRC, matched by age (±5 years) and sex. We collected demographic, CRC-related and laboratory variables to calculate NLR, PLR, SII, and NP/LHb. In the case group, the laboratory variables were collected at two different period times, 6 months (IQR 4–8) before the CRC diagnosis and at the time of the diagnosis. ROC analysis was performed to evaluate the discriminatory accuracy of each index and we calculated Se, Sp, PPV, NPV, and OR to identify the diagnostic performance of each positive marker. Results: NP/LHb showed high Sp (92.06%) and PPV (87.50%) to diagnose patients with CRC. This index exhibited an OR of 14.52 (8.26–25.52) and the best area under the curve (AUC: 0.78) for a positive CRC diagnosis. We found significant differences in all indices according to the presence of CRC, observing the highest values in CRC patients at time of diagnosis, in comparison with the analysis performed in the previous months to diagnosis or with control patients. There were significant differences in all ratios according to TNM stages (p < 0.05). PLR, SII and NP/LHb (but not NLR) showed significant differences according to tumor location (p < 0.05). Right-sided colon cancers presented the highest values, in comparison with left-sided and rectal cancers. Conclusions: Systemic inflammatory cell ratios (especially NP/LHb) change over time with the development of CRC, so they could be useful in its early diagnosis. We suggest that they could be routinely measured in patients with suspicion of CRC, to identify those ones with a higher risk of cancer, considering the high positive predictive value they have shown in our study. Copyright © 2022 Hernandez-Ainsa, Velamazan, Lanas, Carrera-Lasfuentes and Piazuelo

Effect of the Reduction Temperature of PdAg Nanoparticles during the Polyol Process in the Ethanol Electrooxidation Reaction

This work reports the effect of reduction temperature during the synthesis of PdAg catalysts through the polyol process and their evaluation in the ethanol electrooxidation reaction (EOR). The characterization was performed using Transmission Electron Microscopy (TEM) and X-Ray Diffraction (XRD). The electrochemical evaluation for the ethanol electrooxidation reaction was implemented in alkaline medium using chronoamperometry (CA) and cyclic voltammetry (CV). An important effect of the reduction temperature on electroactivity and catalytic stability was observed: both the maximum current density and the catalytic stability were higher in the catalyst synthesized at the highest temperature (135°C). This performance was associated with the extent of the interaction between Pd and Ag which was measured in terms of the structural expansion of Pd

Eficacia analgésica de fentanilo comparado con tramadol asociado a ketorolaco en pacientes post operación cesarea en el hospital nacional docente madre niño San Bartolomé año 2018

En el presente trabajo de investigación se realizó un ensayo clínico controlado y comparativo en el hospital nacional docente madre niño San Bartolomé de Lima. La población de estudio comprende a mujeres psotcesareadas de 20 a 35 años que asistirán al Hospital San Bartolomé en las fechas indicadas. Este grupo poblacional corresponde aproximadamente al 66.2 % del total de usuarias.In the present research work, a controlled and comparative clinical trial was carried out in the national mother-child teaching hospital San Bartolomé de Lima. The study population includes women undergoing work from 20 to 35 years of age who will attend the San Bartolomé Hospital on the dates indicated. This population group corresponds to approximately 66.2% of the total number of user

New H-band Stellar Spectral Libraries for the SDSS-III/APOGEE survey

The Sloan Digital Sky Survey--III (SDSS--III) Apache Point Observatory Galactic Evolution Experiment (APOGEE) has obtained high resolution (R $\sim$ 22,500), high signal-to-noise ratio ($>$ 100) spectra in the H$-$band ($\sim$1.5$-$1.7 $\mu$m) for about 146,000 stars in the Milky Way galaxy. We have computed spectral libraries with effective temperature ($T\rm{_{eff}}$) ranging from 3500 to 8000 K for the automated chemical analy\-sis of the survey data. The libraries, used to derive stellar parameters and abundances from the APOGEE spectra in the SDSS--III data release 12 (DR12), are based on ATLAS9 model atmospheres and the ASS$\epsilon$T spectral synthesis code. We present a second set of libraries based on MARCS model atmospheres and the spectral synthesis code Turbospectrum. The ATLAS9/ASS$\epsilon$T ($T\rm{_{eff}}$ = 3500$-$8000 K) and MARCS/Turbospectrum ($T\rm{_{eff}}$ = 3500$-$5500 K) grids cover a wide range of metallicity ($-$2.5 $\leq$ [M/H] $\leq$ $+$0.5 dex), surface gravity (0 $\leq$ log $g$ $\leq$ 5 dex), microturbulence (0.5 $\leq$ $\xi$ $\leq$ 8 km~s$^{-1}$), carbon ($-$1 $\leq$ [C/M] $\leq$ $+$1 dex), nitrogen ($-$1 $\leq$ [N/M] $\leq$ $+$1 dex), and $\alpha$-element ($-$1 $\leq$ [$\alpha$/M] $\leq$ $+$1 dex) variations, having thus seven dimensions. We compare the ATLAS9/ASS$\epsilon$T and MARCS/Turbospectrum libraries and apply both of them to the analysis of the observed H$-$band spectra of the Sun and the K2 giant Arcturus, as well as to a selected sample of well-known giant stars observed at very high-resolution. The new APOGEE libraries are publicly available and can be employed for chemical studies in the H$-$band using other high-resolution spectrographs.Comment: 45 pages, 11 figures; accepted for publication in the Astronomical Journa

Class IB-Phosphatidylinositol 3-Kinase (PI3K) Deficiency Ameliorates IA-PI3K-Induced Systemic Lupus but Not T Cell Invasion

Abstract Class I PI3K catalyzes formation of 3-poly-phosphoinositides. The family is divided into IA isoforms, activated by Tyr kinases and the IB isoform (PI3Kγ), activated by G protein-coupled receptors. Mutations that affect PI3K are implicated in chronic inflammation, although the differential contribution of each isoform to pathology has not been elucidated. Enhanced activation of class IA-PI3K in T cells extends CD4+ memory cell survival, triggering an invasive lymphoproliferative disorder and systemic lupus. As both IA- and IB-PI3K isoforms regulate T cell activation, and activated pathogenic CD4+ memory cells are involved in triggering systemic lupus, we examined whether deletion of IB could reduce the pathological consequences of increased IA-PI3K activity. IB-PI3Kγ deficiency did not abolish invasion or lymphoproliferation, but reduced CD4+ memory cell survival, autoantibody production, glomerulonephritis, and systemic lupus. Deletion of the IB-PI3Kγ isoform thus decreased survival of pathogenic CD4+ memory cells, selectively inhibiting systemic lupus development. These results validate the PI3Kγ isoform as a target for systemic lupus erythematosus treatment