mSpace meets EPrints: a Case Study in Creating Dynamic Digital Collections

In this case study we look at issues involved in (a) generating dynamic digital libraries that are on a particular topic but span heterogeneous collections at distinct sites, (b) supplementing the artefacts in that collection with additional information available either from databases at the artefact's home or from the Web at large, and (c) providing an interaction paradigm that will support effective exploration of this new resource. We describe how we used two available frameworks, mSpace and EPrints to support this kind of collection building. The result of the study is a set of recommendations to improve the connectivity of remote resources both to one another and to related Web resources, and that will also reduce problems like co-referencing in order to enable the creation of new collections on demand

Interaction induced dimerization in zigzag single wall carbon nanotubes

We derive a low-energy effective model of metallic zigzag carbon nanotubes at half filling. We show that there are three important features characterizing the low-energy properties of these systems: the long-range Coulomb interaction, umklapp scattering and an explicit dimerization generated by interactions. The ratio of the dimerization induced gap and the Mott gap induced by the umklapp interactions is dependent on the radius of the nanotube and can drive the system through a quantum phase transition with SU(2)_1 quantum symmetry. We consider the physical properties of the phases on either side of this transition which should be relevant for realistic nanotubes.Comment: 8 pages, 5 figure

The effect of a local perturbation in a fermionic ladder

We study the effect of a local external potential on a system of two parallel spin-polarized nanowires placed close to each other. For single channel nanowires with repulsive interaction we find that transport properties of the system are highly sensitive to the transverse gradient of the perturbation: the asymmetric part completely reflects the electrons leading to vanishing conductance at zero temperature, while the flat potential remains transparent. We envisage a possible application of this unusual property in the sensitive measurement of local potential field gradients.Comment: 4+ pages, 2 figures, typos correcte

Synoptic observations of Jupiter's radio emissions: Average Statistical properties observed by Voyager

Observations of Jupiter's low frequency radio emissions collected over one month intervals before and after each Voyager encounter were analyzed. Compilations of occurrence probability, average power flux density and average sense of circular polarization are presented as a function of central meridian longitude, phase of Io, and frequency. The results are compared with ground based observations. The necessary geometrical conditions are preferred polarization sense for Io-related decametric emission observed by Voyager from above both the dayside and nightside hemispheres are found to be essentially the same as are observed in Earth based studies. On the other hand, there is a clear local time dependence in the Io-independent decametric emission. Io appears to have an influence on average flux density of the emission down to below 2 MHz. The average power flux density spectrum of Jupiter's emission has a broad peak near 9MHz. Integration of the average spectrum over all frequencies gives a total radiated power for an isotropic source of 4 x 10 to the 11th power W

Cover slip external cavity diode laser

The design of a 671 nm diode laser with a mode-hop-free tuning range of 40 GHz is described. This long tuning range is achieved by simultaneously ramping the external cavity length with the laser injection current. The external cavity consists of a microscope cover slip mounted on piezoelectric actuators. In such a configuration the laser output pointing remains fixed, independent of its frequency. Using a diode with an output power of 5-7 mW, the laser linewidth was found to be smaller than 30 MHz. This cover slip cavity and feedforward laser current control system is simple, economical, robust, and easy to use for spectroscopy, as we demonstrate with lithium vapor and lithium atom beam experiments.Comment: 7 pages, 6 figures, submitted to Review of Scientific Instruments 7/29/0

Enhanced Retention In The Passive-Avoidance Task By 5-HT1A Receptor Blockade Is Not Associated With Increased Activity Of The Central Nucleus Of The Amygdala

The effect of blockade of S-HT1A receptors was investigated on (1) retention in a mildly aversive passive-avoidance task, and (2) spontaneous single-unit activity of central nucleus of the amygdala (CeA) neurons, a brain site implicated in modulation of retention. Systemic administration of the selective S-HT1A antagonist NAN-190 immediately after training markedly-and dose-dependently-facilitated retention in the passive-avoidance task; enhanced retention was time-dependent and was not attributable to variations in wattages of shock received by animals. Systemic administration of NAN-190 had mixed effects on spontaneous single-unit activity of CeA neurons recorded extracellularly in vivo; microiontophoretic application of S-HT, in contrast, consistently and potently suppressed CeA activity. The present findings-that S-HT1A receptor blockade by NAN-190 (1) enhances retention in the passive-avoidance task, and (2) does not consistently increase spontaneous neuronal activity of the CeA-provide evidence that a serotonergic system tonically inhibits modulation of retention in the passive-avoidance task through activation of the S-HT1A receptor subtype at brain sites located outside the CeA

Development of Three-Dimensional Super-Resolution Imaging Using a Double-Helix Point Spread Function

Single-molecule localisation microscopy (SMLM), has allowed for optical microscopy to probe biological systems beyond the diffraction limit. The intrinsic 3D nature of biology has motivated the development of 3D-SMLM with novel techniques, including the double-helix point spread function (DHPSF). A bespoke microscope platform employing the DHPSF transformation was built, achieving ~10 nm lateral and ~20 nm axial localisation precision over a ~4 μm axial depth. Until recently, the DHPSF has been limited by spherical aberration present when imaging away from coverslip surfaces to the study of small volumes close to the coverslip. By matching the refractive index of the objective lens immersion liquid to that of the imaging media, this aberration can be minimised, facilitating large-volume imaging away from unphysiological flat surfaces. The work presented in this thesis illustrates the capabilities of the DHPSF for 3D-SMLM and single-particle tracking (SPT) in previously inaccessible areas of biological samples (e.g. in the nucleus and on the apical cell surface). Application of the DHPSF for SPT in eukaryotic cells are presented; tracking the motion of T-cell membrane proteins on the apical surface and components of the chromosome remodelling complex in the nucleus of embryonic stem cells. For these applications, meansquared displacement and jump distance diffusion analysis methodologies were extended into 3D and benchmarked against simulated datasets. A variety imaging applications that are facilitated by the extended depth of focus of the DHPSF are presented, focusing on quantification of T-cell membrane protein reorganisation upon immunological activation. Finally, the clustering distribution of the T-cell receptor is investigated by Ripley’s K analysis enabled by duel labelling of its position and the outer membrane in primary T cells

LOW DOSE PPARγ AGONIST INHIBITION OF CYST GROWTH IN THE PCK RAT MODEL OF POLYCYSTIC KIDNEY DISEASE

poster abstractPolycystic kidney diseases (PKD) are genetic disorders characterized by fluid-filled cysts in kidney tubules and liver bile ducts that enlarge during the patient’s life commonly progressing to renal failure in midlife. Cyst enlarge-ment is due in part, to Cl- secretion via the cystic fibrosis transmembrane conductance regulator (CFTR) Cl- channel. Our previous studies demonstrat-ed that PPARγ agonists, insulin-sensitizing drugs used to treat diabetes, in-hibit Cl- secretion by renal collecting duct principal cells via decreased CFTR synthesis. The dose response curves for Cl- transport paralleled the EC50’s for receptor transactivation with a leftward shift, suggesting an increased sensitivity for inhibition of Cl- secretion. Our previous preclinical studies showed that high (20 mg/kg BW) dose pioglitazone, a PPARγ agonist, inhib-ited cyst growth in the PCK rat model, which is orthologous to a human form of PKD. PCK rats were fed a diet containing 3 doses of rosiglitazone (4, 0.4, and 0.04 mg/kg BW) for 24 weeks starting at weaning. 4.0 mg/kg BW rosig-litazone is analogous to 20 mg/kg BW pioglitazone used in the previous study. At the end of the study, urine, serum, kidney, liver, and heart were collected for analysis. There was a significant decrease in total kidney weight, kidney weight as a percent of body weight, and renal cyst volume in the lowest does (0.04 mg/kg BW). There was no significance difference in the other doses, and the liver and heart were not changed significantly. This showed both pioglitazone and rosiglitazone were effective in inhibiting cyst growth in the PCK rat indicating a class action of PPARγ agonists. Important-ly, the rodent data substantiated the previous tissue culture data showing that a very low dose of rosiglitazone is effective in treatment of PKD

Multi-Dimensional Simulations of Pair-Instability Supernovae

We present preliminary results from multidimensional numerical studies of pair instability supernova (PSN), studying the fluid instabilities that occur in multiple spatial dimensions. We use the new radiation-hydrodynamics code, CASTRO, and introduce a new mapping procedure that defines the initial conditions for the multidimensional runs in such a way that conservation of physical quantities is guaranteed at any level of resolution.Comment: Accepted for publication in Computer Physics Communications. 3 pages. 2 fig