Hybrid integration methods for on-chip quantum photonics

The goal of integrated quantum photonics is to combine components for the generation, manipulation, and detection of nonclassical light in a phase-stable and efficient platform. Solid-state quantum emitters have recently reached outstanding performance as single-photon sources. In parallel, photonic integrated circuits have been advanced to the point that thousands of components can be controlled on a chip with high efficiency and phase stability. Consequently, researchers are now beginning to combine these leading quantum emitters and photonic integrated circuit platforms to realize the best properties of each technology. In this paper, we review recent advances in integrated quantum photonics based on such hybrid systems. Although hybrid integration solves many limitations of individual platforms, it also introduces new challenges that arise from interfacing different materials. We review various issues in solid-state quantum emitters and photonic integrated circuits, the hybrid integration techniques that bridge these two systems, and methods for chip-based manipulation of photons and emitters. Finally, we discuss the remaining challenges and future prospects of on-chip quantum photonics with integrated quantum emitters. (C) 2020 Optical Society of America under the terms of the OSA Open Access Publishing Agreemen

Experimental Quantum Hamiltonian Learning

Efficiently characterising quantum systems, verifying operations of quantum devices and validating underpinning physical models, are central challenges for the development of quantum technologies and for our continued understanding of foundational physics. Machine-learning enhanced by quantum simulators has been proposed as a route to improve the computational cost of performing these studies. Here we interface two different quantum systems through a classical channel - a silicon-photonics quantum simulator and an electron spin in a diamond nitrogen-vacancy centre - and use the former to learn the latter's Hamiltonian via Bayesian inference. We learn the salient Hamiltonian parameter with an uncertainty of approximately $10^{-5}$. Furthermore, an observed saturation in the learning algorithm suggests deficiencies in the underlying Hamiltonian model, which we exploit to further improve the model itself. We go on to implement an interactive version of the protocol and experimentally show its ability to characterise the operation of the quantum photonic device. This work demonstrates powerful new quantum-enhanced techniques for investigating foundational physical models and characterising quantum technologies

Whether weather matters: Evidence of association between in utero meteorological exposures and foetal growth among Indigenous and non-Indigenous mothers in rural Uganda

Pregnancy and birth outcomes have been found to be sensitive to meteorological variation, yet few studies explore this relationship in sub-Saharan Africa where infant mortality rates are the highest in the world. We address this research gap by examining the association between meteorological factors and birth weight in a rural population in southwestern Uganda. Our study included hospital birth records (n = 3197) from 2012 to 2015, for which we extracted meteorological exposure data for the three trimesters preceding each birth. We used linear regression, controlling for key covariates, to estimate the timing, strength, and direction of meteorological effects on birth weight. Our results indicated that precipitation during the third trimester had a positive association with birth weight, with more frequent days of precipitation associated with higher birth weight: we observed a 3.1g (95% CI: 1.0–5.3g) increase in birth weight per additional day of exposure to rainfall over 5mm. Increases in average daily temperature during the third trimester were also associated with birth weight, with an increase of 41.8g (95% CI: 0.6–82.9g) per additional degree Celsius. When the sample was stratified by season of birth, only infants born between June and November experienced a significant associated between meteorological exposures and birth weight. The association of meteorological variation with foetal growth seemed to differ by ethnicity; effect sizes of meteorological were greater among an Indigenous subset of the population, in particular for variation in temperature. Effects in all populations in this study are higher than estimates of the African continental average, highlighting the heterogeneity in the vulnerability of infant health to meteorological variation in different contexts. Our results indicate that while there is an association between meteorological variation and birth weight, the magnitude of these associations may vary across ethnic groups with differential socioeconomic resources, with implications for interventions to reduce these gradients and offset the health impacts predicted under climate change

Multipurpose silicon photonics signal processor core

[EN] Integrated photonics changes the scaling laws of information and communication systems offering architectural choices that combine photonics with electronics to optimize performance, power, footprint, and cost. Application-specific photonic integrated circuits, where particular circuits/chips are designed to optimally perform particular functionalities, require a considerable number of design and fabrication iterations leading to long development times. A different approach inspired by electronic Field Programmable Gate Arrays is the programmable photonic processor, where a common hardware implemented by a two-dimensional photonic waveguide mesh realizes different functionalities through programming. Here, we report the demonstration of such reconfigurable waveguide mesh in silicon. We demonstrate over 20 different functionalities with a simple seven hexagonal cell structure, which can be applied to different fields including communications, chemical and biomedical sensing, signal processing, multiprocessor networks, and quantum information systems. Our work is an important step toward this paradigm.J.C. acknowledges funding from the ERC Advanced Grant ERC-ADG-2016-741415 UMWP-Chip, I.G. acknowledges the funding through the Spanish MINECO Ramon y Cajal program. D.P. acknowledges financial support from the UPV through the FPI predoctoral funding scheme. D.J.T. acknowledges funding from the Royal Society for his University Research Fellowship.Pérez-López, D.; Gasulla Mestre, I.; Crudgington, L.; Thomson, DJ.; Khokhar, AZ.; Li, K.; Cao, W.... (2017). Multipurpose silicon photonics signal processor core. Nature Communications. 8(1925):1-9. https://doi.org/10.1038/s41467-017-00714-1S1981925Doerr, C. R. & Okamoto, K. Advances in silica planar lightwave circuits. J. Lightw. Technol. 24, 4763–4789 (2006).Coldren, L. A. et al. High performance InP-based photonic ICs—A tutorial. J. Lightw. Technol 29, 554–570 (2011).Soref, R. The past, present, and future of silicon photonics. IEEE J. Sel. Top. Quantum Electron. 12, 1678–1687 (2006).Bogaerts, W. Design challenges in silicon photonics. IEEE J. Sel. Top. Quantum Electron. 20, 8202008 (2014).Bogaerts, W. et al. Nanophotonic waveguides in silicon-on-insulator fabricated with CMOS technology. J. Lightw. Technol. 23, 401–412 (2005).Smit, M. K. et al. An introduction to InP-based generic integration technology. Semicond. Sci. Technol. 29, 083001 (2014).Leinse, A. et al. TriPleX waveguide platform: low-loss technology over a wide wavelength range. Proc. SPIE 8767, 87670E (2013).Kish, F. et al. From visible light-emitting diodes to large-scale III–V photonic integrated circuits. Proc. IEEE 101, 2255–2270 (2013).Heck, M. J. R. et al. Hybrid silicon photonic integrated circuit technology. IEEE J. Sel. Top. Quantum Electron. 19, 6100117 (2013).Sacher, W. et al. Multilayer silicon nitride-on-silicon integrated photonic platforms and devices. J. Lightw. Technol. 33, 901–910 (2015).Asghari, M. Silicon photonics: A low cost integration platform for datacom and telecom applications. In OFC/NFOEC 2008 – 2008 Conference on Optical Fiber Communication/National Fiber Optic Engineers Conference 1–10 (San Diego, USA, 2008).Melati, D. et al. Integrated all-optical MIMO demultiplexer for mode- and wavelength-division-multiplexed transmission. Opt. Lett. 42, 342–345 (2017).Waterhouse, R. & Novak, D. Realizing 5G: microwave photonics for 5G mobile wireless systems. IEEE Microw. Mag. 16, 84–92 (2015).Marpaung, D. et al. Integrated microwave photonics. Laser Photon. Rev. 7, 506–538 (2013).Iezekiel, S., Burla, M., Klamkin, J., Marpaung, D. & Capmany, J. RF engineering meets optoelectronics: Progress in integrated microwave photonics. IEEE Microw. Mag. 16, 28–45 (2015).Technology focus on microwave photonics. Nat. Photon. 5, 723 (2011).Ghelfi, P. et al. A fully photonics-based coherent radar system. Nature 507, 341–345 (2014).Heideman, R. G. TriPleX™-based integrated optical ring resonators for lab-ona-chip-and environmental detection. IEEE J. Sel. Top. Quantum Electron. 18, 1583–1596 (2012).Estevez, M. C., Alvarez, M. & Lechuga, L. Integrated optical devices for lab-on-a-chip biosensing applications. Laser Photon. Rev. 6, 463–487 (2012).Almeida, V. R., Barrios, C. A., Panepucci, R. & Lipson, M. All-optical control of light on a silicon chip. Nature 431, 1081–1084 (2004).Norberg, E. J., Guzzon, R. S., Parker, J. S., Johansson, L. A. & Coldren, L. A. Programmable photonic microwave filters monolithically integrated in InP/InGaAsP. J. Lightw. Technol. 29, 1611–1619 (2011).Wang, J. et al. Reconfigurable radio-frequency arbitrary waveforms synthesized in a silicon photonic chip. Nat. Commun. 6, 5957 (2015).Hill, M. T. et al. A fast low power optical memory based on coupled micro-ring lasers. Nature 432, 206–209 (2004).Slavík, R. et al. Photonic temporal integrator for all-optical computing. Opt. Express 16, 18202–18214 (2008).Sun, C. et al. A monolithically-integrated chip-to-chip optical link in bulk CMOS. IEEE J. Solid-State Circ. 50, 828–844 (2015).Sun, C. et al. Single-chip microprocessor that communicates directly using light. Nature 528, 534–538 (2015).Assefa, S. et al. in Optical Fibre Communication Conference OMM6, https://www.osapublishing.org/abstract.cfm?uri=OFC-2011-OMM6 (Optical Society of America, 2011).Peruzzo, A. et al. Multimode quantum interference of photons in multiport integrated devices. Nat. Commun. 2, 224 (2011).Bonneau, D. et al. Quantum interference and manipulation of entanglement in silicon wire waveguide quantum circuits. N. J. Phys. 14, 045003 (2012).Metcalf, B. J. et al. Multiphoton quantum interference in a multiport integrated photonic device. Nat. Commun. 4, 1356 (2013).Muñoz, P. et al. in 16th International Conference on Transparent Optical Networks (ICTON), 1–4 (Graz, 2014).Ribeiro, A. et al. Demonstration of a 4×4-port universal linear circuit. Optica 3, 1348–1357 (2016).Liu, W. et al. A fully reconfigurable photonic integrated signal processor. Nat. Photon 10, 190–195 (2016).Graydon, O. Birth of the programmable optical chip. Nat. Photon 10, 1 (2016).Pérez, D., Gasulla, I. & Capmany, J. Software-defined reconfigurable microwave photonics processor. Opt. Express 23, 14640–14654 (2015).Miller, D. A. B. Self-configuring universal linear optical component. Photon. Res. 1, 1–15 (2013).Miller, D. A. B. Self-aligning universal beam coupler. Opt. Express 21, 6360–6370 (2013).Clements, W. R. et al. Optimal design for universal multiport interferometers. Optica 3, 1460–1465 (2016).Zhuang, L., Roeloffzen, C. G. H., Hoekman, M., Boller, K.-J. & Lowery, A. J. Programmable photonic signal processor chip for radiofrequency applications. Optica 2, 854–859 (2015).Capmany, J., Gasulla, I. & Pérez, D. Microwave photonics: The programmable processor. Nat. Photon. 10, 6–8 (2016).Pérez, D., Gasulla., Capmany, J. & Soref, R. A. Reconfigurable lattice mesh designs for programmable photonic processors. Opt. Express 24, 12093–12106 (2016).Madsen, C. K. & Zhao, J. H. Optical Filter Design and Analysis: A Signal Processing Approach. 1st edn. (Wiley, 1999).Jinguji, K. Synthesis of coherent two-port lattice-form optical delay-line circuit. J. Lightw. Technol. 13, 73–82 (1995).Jinguji, K. Synthesis of coherent two-port Optical delay-line circuit with ring waveguides. J. Lightw. Technol. 14, 1882–1898 (1996).Madsen, C. K. General IIR optical filter design for WDM applications using all-pass filters. J. Lightw. Technol. 18, 860–868 (2000).Burla, M. et al. On-chip CMOS compatible reconfigurable optical delay line with separate carrier tuning for microwave photonic signal processing. Opt. Express 19, 21475–21484 (2011).Yariv, A. et al. Coupled resonator optical waveguides: a proposal and analysis. Opt. Lett. 24, 711–713 (1999).Hebner, J. E. et al. Distributed and localized feedback in microresonator sequences for linear and nonlinear optics. J. Opt. Soc. Am. B. 21, 1665–1673 (2004).Fandiño, J. S. et al. A monolithic integrated photonic microwave filter. Nat. Photon. 11, 124–129 (2017).Miller, D. A. B. All linear optical devices are mode converters. Opt. Express 20, 23985–23993 (2012).Reck, M. et al. Experimental realization of any discrete unitary operator. Phys. Rev. Lett. 73, 58–61 (1994).Carolan, J. et al. Universal linear optics. Science 349, 711 (2015).Nielsen, M. A. & Chuang, I. L. Quantum Computation and Quantum Information. 1st edn. (Cambridge University Press, 2001).Miller, D. A. B. Perfect optics with imperfect components. Optica 2, 747–750 (2015).Grillanda, S. et al. Non-invasive monitoring and control in silicon photonics using CMOS integrated electronics. Optica 1, 129–136 (2014)

Transcriptomic Analysis of the Salivary Glands of an Invasive Whitefly

<div><h3>Background</h3><p>Some species of the whitefly <em>Bemisia tabaci</em> complex cause tremendous losses to crops worldwide through feeding directly and virus transmission indirectly. The primary salivary glands of whiteflies are critical for their feeding and virus transmission. However, partly due to their tiny size, research on whitefly salivary glands is limited and our knowledge on these glands is scarce.</p> <h3>Methodology/Principal Findings</h3><p>We sequenced the transcriptome of the primary salivary glands of the Mediterranean species of <em>B. tabaci</em> complex using an effective cDNA amplification method in combination with short read sequencing (Illumina). In a single run, we obtained 13,615 unigenes. The quantity of the unigenes obtained from the salivary glands of the whitefly is at least four folds of the salivary gland genes from other plant-sucking insects. To reveal the functions of the primary glands, sequence similarity search and comparisons with the whole transcriptome of the whitefly were performed. The results demonstrated that the genes related to metabolism and transport were significantly enriched in the primary salivary glands. Furthermore, we found that a number of highly expressed genes in the salivary glands might be involved in secretory protein processing, secretion and virus transmission. To identify potential proteins of whitefly saliva, the translated unigenes were put into secretory protein prediction. Finally, 295 genes were predicted to encode secretory proteins and some of them might play important roles in whitefly feeding.</p> <h3>Conclusions/Significance:</h3><p>The combined method of cDNA amplification, Illumina sequencing and <em>de novo</em> assembly is suitable for transcriptomic analysis of tiny organs in insects. Through analysis of the transcriptome, genomic features of the primary salivary glands were dissected and biologically important proteins, especially secreted proteins, were predicted. Our findings provide substantial sequence information for the primary salivary glands of whiteflies and will be the basis for future studies on whitefly-plant interactions and virus transmission.</p> </div

Experiences of lifestyle change among women with gestational diabetes mellitus (GDM): A behavioural diagnosis using the COM-B model in a low-income setting

Lifestyle change can reduce the risk of developing type 2 diabetes among women with prior gestational diabetes mellitus (GDM). While understanding women’s lived experiences and views around GDM is critical to the development of behaviour change interventions to reduce this risk, few studies have addressed this issue in low- and middle- income countries. The aim of the study was to explore women’s lived experiences of GDM and the feasibility of sustained lifestyle modification after GDM in a low-income setting

Large-scale silicon quantum photonics implementing arbitrary two-qubit processing

Photonics is a promising platform for implementing universal quantum information processing. Its main challenges include precise control of massive circuits of linear optical components and effective implementation of entangling operations on photons. By using large-scale silicon photonic circuits to implement an extension of the linear combination of quantum operators scheme, we realize a fully programmable two-qubit quantum processor, enabling universal two-qubit quantum information processing in optics. The quantum processor is fabricated with mature CMOS-compatible processing and comprises more than 200 photonic components. We programmed the device to implement 98 different two-qubit unitary operations ( with an average quantum process fidelity of 93.2 +/- 4.5%), a two-qubit quantum approximate optimization algorithm, and efficient simulation of Szegedy directed quantum walks. This fosters further use of the linear-combination architecture with silicon photonics for future photonic quantum processors