Geographical Variability Affects CCHFV Detection by RT-PCR: A Tool for In-Silico Evaluation of Molecular Assays

The Crimean-Congo hemorrhagic fever virus (CCHFV) is considered to be a major emerging infectious threat, according to the WHO R&D blueprint. A wide range of CCHFV molecular assays have been developed, employing varied primer/probe combinations. The high genetic variability of CCHFV often hampers the efficacy of available molecular tests and can affect their diagnostic potential. Recently, increasing numbers of complete CCHFV genomic sequences have become available, allowing a better appreciation of the genomic evolution of this virus. We summarized the current knowledge on molecular methods and developed a new bioinformatics tool to evaluate the existing assays for CCHFV detection, with a special focus on strains c

Inclusive J/ψ\psi production at midrapidity in pp collisions at s = 13\sqrt{s}~=~13 TeV

We report on the inclusive J/$\psi$ production cross section measured at the CERN Large Hadron Collider in proton-proton collisions at a centre-of-mass energy $\sqrt{s}~=~13$ TeV. The J/$\psi$ mesons are reconstructed in the $\rm e^{+} e^{-}$ decay channel and the measurements are performed at midrapidity ($|y|<0.9$) in the transverse-momentum interval $0< p_{\rm T} <40$ GeV/$c$, using a minimum bias data sample corresponding to an integrated luminosity $L_{\text{int}} = 32.2~\text{nb}^{-1}$ and an Electromagnetic Calorimeter triggered data sample with $L_{\text{int}} = 8.3~\mathrm{pb}^{-1}$. The $p_{\rm T}$-integrated J/$\psi$ production cross section at midrapidity, computed using the minimum bias data sample, is $\text{d}\sigma/\text{d}y|_{y=0} = 8.97\pm0.24~(\text{stat})\pm0.48~(\text{syst})\pm0.15~(\text{lumi})~\mu\text{b}$. An approximate logarithmic dependence with the collision energy is suggested by these results and available world data, in agreement with model predictions. The integrated and $p_{\rm T}$-differential measurements are compared with measurements in pp collisions at lower energies and with several recent phenomenological calculations based on the non-relativistic QCD and Color Evaporation models

Charged-particle multiplicity fluctuations in Pb–Pb collisions at √ sNN = 2.76 TeV

Measurements of event-by-event fluctuations of charged-particle multiplicities in Pb–Pb collisionsat √sNN = 2.76 TeV using the ALICE detector at the CERN Large Hadron Collider (LHC) are presented in the pseudorapidity range |η| < 0.8 and transverse momentum 0.2 < pT < 2.0 GeV/c. The amplitude of the fluctuations is expressed in terms of the variance normalized by the mean of the multiplicity distribution. The η and pT dependences of the fluctuations and their evolution with respect to collision centrality are investigated. The multiplicity fluctuations tend to decrease from peripheral to central collisions. The results are compared to those obtained from HIJING and AMPT Monte Carlo event generators as well as to experimental data at lower collision energies. Additionally, the measured multiplicity fluctuations are discussed in the context of the isothermal compressibility of the high-density strongly-interacting system formed in central Pb–Pb collisions

Production of pions, kaons, (anti-)protons and ϕ\phi mesons in Xe–Xe collisions at sNN\sqrt{s_{\mathrm{NN}}} = 5.44 TeV

The first measurement of the production of pions, kaons, (anti-)protons and $\phi$ mesons at midrapidity in Xe–Xe collisions at $\sqrt{s_{\mathrm{NN}}} = 5.44~\text {TeV}$ is presented. Transverse momentum ($p_{\mathrm{T}}$) spectra and $p_{\mathrm{T}}$-integrated yields are extracted in several centrality intervals bridging from p–Pb to mid-central Pb–Pb collisions in terms of final-state multiplicity. The study of Xe–Xe and Pb–Pb collisions allows systems at similar charged-particle multiplicities but with different initial geometrical eccentricities to be investigated. A detailed comparison of the spectral shapes in the two systems reveals an opposite behaviour for radial and elliptic flow. In particular, this study shows that the radial flow does not depend on the colliding system when compared at similar charged-particle multiplicity. In terms of hadron chemistry, the previously observed smooth evolution of particle ratios with multiplicity from small to large collision systems is also found to hold in Xe–Xe. In addition, our results confirm that two remarkable features of particle production at LHC energies are also valid in the collision of medium-sized nuclei: the lower proton-to-pion ratio with respect to the thermal model expectations and the increase of the $\phi$-to-pion ratio with increasing final-state multiplicity

First measurements of N-subjettiness in central Pb–Pb collisions at √ sNN = 2.76 TeV

The ALICE Collaboration reports the first fully-corrected measurements of the N-subjettiness observable for track-based jets in heavy-ion collisions. This study is performed using data recorded in pp and Pb–Pb collisions at centre-of-mass energies of √s = 7 TeV and √ sNN = 2.76 TeV, respectively. In particular the ratio of 2-subjettiness to 1-subjettiness, τ2/τ1, which is sensitive to the rate of two-pronged jet substructure, is presented. Energy loss of jets traversing the strongly interacting medium in heavy-ion collisions is expected to change the rate of two-pronged substructure relative to vacuum. The results are presented for jets with a resolution parameter of R = 0.4 and charged jet transverse momentum of 40 ≤ pT,jet ≤ 60 GeV/c, which constitute a larger jet resolution and lower jet transverse momentum interval than previous measurements in heavy-ion collisions. This has been achieved by utilising a semi-inclusive hadron-jet coincidence technique to suppress the larger jet combinatorial background in this kinematic region. No significant modification of the τ2/τ1 observable for track-based jets in Pb–Pb collisions is observed relative to vacuum PYTHIA6 and PYTHIA8 references at the same collision energy. The measurements of τ2/τ1, together with the splitting aperture angle ∆R, are also performed in pp collisions at √s = 7 TeV for inclusive jets. These results are compared with PYTHIA calculations at √s = 7 TeV, in order to validate the model as a vacuum reference for the Pb–Pb centre-of-mass energy. The PYTHIA references for τ2/τ1 are shifted to larger values compared to the measurement in pp collisions. This hints at a reduction in the rate of two-pronged jets in Pb–Pb collisions compared to pp collisions

Inclusive, prompt and non-prompt J/ψ{\rm J}/\psi production at midrapidity in p−-Pb collisions at sNN=5.02\sqrt{s_{\rm NN}} = 5.02 TeV

A measurement of inclusive, prompt, and non-prompt ${\rm J}/\psi$ production in p$-$Pb collisions at a nucleon--nucleon centre-of-mass energy $\sqrt{s_{\mathrm{NN}}} = 5.02$ TeV is presented. The ${\rm J}/\psi$ mesons are reconstructed in the dielectron decay channel at midrapidity down to a transverse momentum $p_{\rm T} = 0$. The inclusive ${\rm J}/\psi$ nuclear modification factor $R_{\rm pPb}$ is calculated by comparing the results in p$-$Pb collisions to a measured proton$-$proton reference at the same centre-of-mass energy. Non-prompt ${\rm J}/\psi$ mesons, which originate from the decay of beauty hadrons, are separated from promptly produced ${\rm J}/\psi$ on a statistical basis for $p_{\rm T}$ larger than 1.0 GeV/$c$. These results are based on the data sample collected by the ALICE detector during the 2016 LHC p$-$Pb run, corresponding to an integrated luminosity ${\cal L}_{\rm int} = 292 \pm 11 \; {\rm \mu b}^{-1}$, which is six times larger than the previous publications. The total uncertainty on the $p_{\rm T}$-integrated inclusive ${\rm J}/\psi$ and non-prompt ${\rm J}/\psi$ cross section are reduced by a factor 1.7 and 2.2, respectively. The measured cross sections and $R_{\rm pPb}$ are compared with theoretical models that include various combinations of cold nuclear matter effects. From the non-prompt ${\rm J}/\psi$ production cross section, the ${\rm b\overline{b}}$ production cross section at midrapidity, $\mathrm{d}\sigma_{\rm b\overline{b}}/\mathrm{d}y$, and the total cross section extrapolated over full phase space, $\sigma_{\rm b\overline{b}}$, are derived

KS0\mathrm {K_S}^{0}- and (anti-)Λ\Lambda -hadron correlations in pp collisions at s=13{\sqrt{s}} = 13 TeV

International audienceTwo-particle Azimuthal correlations are measured with the ALICE apparatus in pp collisions at $\sqrt{s} = 13$ TeV to explore strangeness- and multiplicity-related effects in the fragmentation of jets and the transition regime between bulk and hard production, probed with the condition that a strange meson ($\mathrm {K_S}^{0}$) or baryon ($\Lambda$) with transverse momentum $p_{\mathrm T} >3$ GeV/$c$ is produced. Azimuthal correlations between kaons or $\Lambda$ hyperons with other hadrons are presented at midrapidity for a broad range of the trigger ($3< p_\mathrm {T}^\mathrm {trigg} < 20$ GeV/$c$) and associated particle $p_{\mathrm T}$ (1 GeV/$c< p_\mathrm {T}^\mathrm {assoc} < p_\mathrm {T}^\mathrm {trigg}$), for minimum-bias events and as a function of the event multiplicity. The near- and away-side peak yields are compared for the case of either $\mathrm {K_S}^{0}$ or $\Lambda$(${\overline{\Lambda }}$) being the trigger particle with that of inclusive hadrons (a sample dominated by pions). In addition, the measurements are compared with predictions from PYTHIA 8 and EPOS LHC event generators

Direct observation of the dead-cone effect in quantum chromodynamics

At particle collider experiments, elementary particle interactions with large momentum transfer produce quarks and gluons (known as partons) whose evolution is governed by the strong force, as described by the theory of quantum chromodynamics (QCD) [1]. The vacuum is not transparent to the partons and induces gluon radiation and quark pair production in a process that can be described as a parton shower [2]. Studying the pattern of the parton shower is one of the key experimental tools in understanding the properties of QCD. This pattern is expected to depend on the mass of the initiating parton, through a phenomenon known as the dead-cone effect, which predicts a suppression of the gluon spectrum emitted by a heavy quark of mass m and energy E, within a cone of angular size m/E around the emitter [3]. A direct observation of the dead-cone effect in QCD has not been possible until now, due to the challenge of reconstructing the cascading quarks and gluons from the experimentally accessible bound hadronic states. Here we show the first direct observation of the QCD dead-cone by using new iterative declustering techniques [4, 5] to reconstruct the parton shower of charm quarks. This result confirms a fundamental feature of QCD, which is derived more generally from its origin as a gauge quantum field theory. Furthermore, the measurement of a dead-cone angle constitutes the first direct experimental observation of the non-zero mass of the charm quark, which is a fundamental constant in the standard model of particle physics.The direct measurement of the QCD dead cone in charm quark fragmentation is reported, using iterative declustering of jets tagged with a fully reconstructed charmed hadron.In particle collider experiments, elementary particle interactions with large momentum transfer produce quarks and gluons (known as partons) whose evolution is governed by the strong force, as described by the theory of quantum chromodynamics (QCD). These partons subsequently emit further partons in a process that can be described as a parton shower which culminates in the formation of detectable hadrons. Studying the pattern of the parton shower is one of the key experimental tools for testing QCD. This pattern is expected to depend on the mass of the initiating parton, through a phenomenon known as the dead-cone effect, which predicts a suppression of the gluon spectrum emitted by a heavy quark of mass $m_{\rm{Q}}$ and energy $E$, within a cone of angular size $m_{\rm{Q}}$/$E$ around the emitter. Previously, a direct observation of the dead-cone effect in QCD had not been possible, owing to the challenge of reconstructing the cascading quarks and gluons from the experimentally accessible hadrons. We report the direct observation of the QCD dead cone by using new iterative declustering techniques to reconstruct the parton shower of charm quarks. This result confirms a fundamental feature of QCD. Furthermore, the measurement of a dead-cone angle constitutes a direct experimental observation of the non-zero mass of the charm quark, which is a fundamental constant in the standard model of particle physics