826 research outputs found
Axial flow compressor design computer programs incorporating full radial equilibrium. Part 1 - Flow path and radial distribution of energy specified /program 2/
Complete radial equilibrium flow computer progra
Single-stage experimental evaluation of boundary layer bleed techniques for high lift stator blades. Part 3 - Data and performance of unslotted 0.75 hub diffusion factor stator
Boundary layer bleed techniques for high lift compressor stator blade
Single-stage experimental evaluation of boundary layer blowing techniques for high lift stator blades. 4 - Data and performance of double-slotted 0.75 hub diffusion factor stator
Boundary layer hub diffusion-factor stator blowing techniqu
Single-stage experimental evaluation of boundary layer bleed techniques for high lift stator blades. Part 4 - Data and performance of triple-slotted 0.75 hub diffusion factor stator
Performance tests on slotted hub diffusion factor stator with boundary layer blee
Cerebellar infarction requiring surgical decompression in patient with COVID 19 pathological analysis and brief review
© 2020 The Authors Background: This report and literature review describes a case of a COVID-19 patient who suffered a cerebellar stroke requiring neurosurgical decompression. This is the first reported case of a sub-occipital craniectomy with brain biopsy in a COVID-19 patient showing leptomeningeal venous intimal inflammation. Clinical description: The patient is a 48-year-old SARS-COV-2 positive male with multiple comorbidities, who presented with fevers and respiratory symptoms, and imaging consistent with multifocal pneumonia. On day 5 of admission, the patient had sudden change in mental status, increased C-Reactive Protein, ferritin and elevated Interleukin-6 levels. Head CT showed cerebral infarction from vertebral artery occlusion. Given subsequent rapid neurologic decline from cerebellar swelling and mass effect on his brainstem emergent neurosurgical intervention was performed. Brain biopsy found a vein with small organizing thrombus adjacent to focally proliferative intima with focal intimal neutrophils. Conclusion: A young man with COVID-19 and suspected immune dysregulation, complicated by a large cerebrovascular ischemic stroke secondary to vertebral artery thrombosis requiring emergent neurosurgical intervention for decompression with improved neurological outcomes. Brain biopsy was suggestive of inflammation from thrombosed vessel, and neutrophilic infiltration of cerebellar tissue
Extreme magnesium isotope fractionation at outcrop scale records the mechanism and rate at which reaction fronts advance
Isotopic fractionation of cationic species during diffusive transport provides novel means of constraining the style and timing of metamorphic transformations. Here we document a major (~1‰) decrease in the Mg isotopic composition of the reaction front of an exhumed contact between rocks of subducted crust and serpentinite, in the Syros mélange zone. This isotopic perturbation extends over a notable length-scale (~1 m), implicating diffusion of Mg through an intergranular fluid network over a period of ~100 kyr. These novel observations confirm models of diffusion-controlled growth of reaction zones formed between rocks of contrasting compositions, such as found at the slab-mantle interface in subduction zones. The results also demonstrate that diffusive processes can result in exotic stable isotope compositions of major elements with implications for mantle xenoliths and complex intrusions
The Thermal Structure of Gas in Pre-Stellar Cores: A Case Study of Barnard 68
We present a direct comparison of a chemical/physical model to
multitransitional observations of C18O and 13CO towards the Barnard 68
pre-stellar core. These observations provide a sensitive test for models of low
UV field photodissociation regions and offer the best constraint on the gas
temperature of a pre-stellar core. We find that the gas temperature of this
object is surprisingly low (~7-8 K), and significantly below the dust
temperature, in the outer layers (Av < 5 mag) that are traced by C18O and 13CO
emission. As shown previously, the inner layers (Av > 5 mag) exhibit
significant freeze-out of CO onto grain surfaces. Because the dust and gas are
not fully coupled, depletion of key coolants in the densest layers raises the
core (gas) temperature, but only by ~1 K. The gas temperature in layers not
traced by C18O and 13CO emission can be probed by NH3 emission, with a
previously estimated temperature of ~10-11 K. To reach these temperatures in
the inner core requires an order of magnitude reduction in the gas to dust
coupling rate. This potentially argues for a lack of small grains in the
densest gas, presumably due to grain coagulation.Comment: 33 pages, 11 figures, accepted by Astrophysical Journa
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Reprogramming human T cell function and specificity with non-viral genome targeting.
Decades of work have aimed to genetically reprogram T cells for therapeutic purposes1,2 using recombinant viral vectors, which do not target transgenes to specific genomic sites3,4. The need for viral vectors has slowed down research and clinical use as their manufacturing and testing is lengthy and expensive. Genome editing brought the promise of specific and efficient insertion of large transgenes into target cells using homology-directed repair5,6. Here we developed a CRISPR-Cas9 genome-targeting system that does not require viral vectors, allowing rapid and efficient insertion of large DNA sequences (greater than one kilobase) at specific sites in the genomes of primary human T cells, while preserving cell viability and function. This permits individual or multiplexed modification of endogenous genes. First, we applied this strategy to correct a pathogenic IL2RA mutation in cells from patients with monogenic autoimmune disease, and demonstrate improved signalling function. Second, we replaced the endogenous T cell receptor (TCR) locus with a new TCR that redirected T cells to a cancer antigen. The resulting TCR-engineered T cells specifically recognized tumour antigens and mounted productive anti-tumour cell responses in vitro and in vivo. Together, these studies provide preclinical evidence that non-viral genome targeting can enable rapid and flexible experimental manipulation and therapeutic engineering of primary human immune cells
The Medical Action Ontology: A tool for annotating and analyzing treatments and clinical management of human disease
\ua9 2023Background: Navigating the clinical literature to determine the optimal clinical management for rare diseases presents significant challenges. We introduce the Medical Action Ontology (MAxO), an ontology specifically designed to organize medical procedures, therapies, and interventions. Methods: MAxO incorporates logical structures that link MAxO terms to numerous other ontologies within the OBO Foundry. Term development involves a blend of manual and semi-automated processes. Additionally, we have generated annotations detailing diagnostic modalities for specific phenotypic abnormalities defined by the Human Phenotype Ontology (HPO). We introduce a web application, POET, that facilitates MAxO annotations for specific medical actions for diseases using the Mondo Disease Ontology. Findings: MAxO encompasses 1,757 terms spanning a wide range of biomedical domains, from human anatomy and investigations to the chemical and protein entities involved in biological processes. These terms annotate phenotypic features associated with specific disease (using HPO and Mondo). Presently, there are over 16,000 MAxO diagnostic annotations that target HPO terms. Through POET, we have created 413 MAxO annotations specifying treatments for 189 rare diseases. Conclusions: MAxO offers a computational representation of treatments and other actions taken for the clinical management of patients. Its development is closely coupled to Mondo and HPO, broadening the scope of our computational modeling of diseases and phenotypic features. We invite the community to contribute disease annotations using POET (https://poet.jax.org/). MAxO is available under the open-source CC-BY 4.0 license (https://github.com/monarch-initiative/MAxO). Funding: NHGRI 1U24HG011449-01A1 and NHGRI 5RM1HG010860-04
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